期刊
CHEMICAL ENGINEERING JOURNAL
卷 365, 期 -, 页码 30-39出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2019.02.020
关键词
beta-Tricalcium phosphate; Gelatin; Bone regeneration; Bone graft materials; Hydrogels
资金
- Bio & Medical Technology Development Program of the National Research Foundation (NRF) - Korean government (MSIT) [2017M3A9E4048170]
- National Research Foundation of Korea [2017M3A9E4048170] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Maintaining appropriate mechanical strength and tissue volume is important to provide for sufficient alveolar bone growth. Recently, synthetic bone graft materials (BGM) including hydroxyapatite (HA) and beta-tricalcium phosphate (beta-TCP) have been widely studied for alveolar bone regeneration. Here, we applied gelatin-methacrylate (GelMA) hydrogel into the beta-TCP to produce a GelMA/beta-TCP composite (GelMA-B). This reinforced the mechanical strength and regulated the absorption period of beta-TCP. To characterize the physical properties of the formed composite, GelMA-B was tested using a mechanical tester and a rheometer. It was then analyzed for biocompatibility and osteogenic differentiation using human adipose-derived stem cells. Further, the bone regeneration effects of GelMA-B were confirmed by an animal study. The cell viability analysis and qPCR results revealed that GelMA-B showed high cell viability and relatively high bone differentiation ability. In a rheological analysis, GelMA-B showed higher mechanical strength than beta-TCP and GelMA alone. These features were confirmed in the animal study as GelMA-B maintained its volume and shape during regrowth, which can be favorable for alveolar bone regeneration. In addition to the regenerative effect, GelMA-B composite has an advantage for clinical use as the material enables structural molding for customized application.
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