期刊
CARBOHYDRATE POLYMERS
卷 214, 期 -, 页码 221-233出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2019.03.043
关键词
Polypyrrole; Nanoparticles; Photothermal therapy; Hyaluronic acid; Temperature-sensitive
资金
- National Natural Science Foundation of China [81871368]
- Natural Science Foundation Project of CQ CSTC [cstc2018jcyjAX0795, cstc2016jcyjA0068]
- key Projects of Chinese Medicine Research of Chongqing Municipal Health Bureau [ZY201701004]
- Crowd innovation Plan of College of Pharmacy [DXSZCXM201702]
- Primary and Secondary School Innovative Talents Training Project Plan of Chongqing -Eagle Project of Chongqing Municipal Education Commission [CY180408]
This study has developed a versatile nano-system with the combined advantages of photothermal effect, active tumor-targeting, temperature-sensitive drug release, and photoacoustic imaging. The nano-system consists of the core of the phase change material (PCM), the outer polypyrrole (PPY) shell and the hyaluronic acid (HA) modified in the PPY shell. The obtained composite nanoparticles (denoted as DTX/PPN@PPY@HA) were spherical with a mean diameter of about 232.7 nm. In vivo and in vitro photoacoustic imaging experiments show that DTX/PPN@PPY@HA is an effective photoacoustic contrast agent, which can be used for accurate localization of tumor region and real-time guidance of photothermal chemotherapy. DTX/PPN@PPY@HA shows good photothermal effects and temperature-sensitive drug release. In addition, cellular experiments showed that DTX/PPN@PPY@HA could be efficiently internalized into tumor cells and produce significant cytotoxicity with the help of near-infrared (NIR) laser. Furthermore, the remarkable inhibition of DTX/PPN@PPY@HA against tumor growth was achieved in 4T1 tumor-bearing mice model.
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