Article
Chemistry, Applied
Xiaoqiang Song, Yan Zhao, Yunen Liu, Wenchang Zhang, Xiaoxue Yuan, Lei Xu, Jinsong Zhang
Summary: In this study, chitin/chitosan sponges with varying degrees of deacetylation were prepared and tested for their hemostatic properties. The chitosan sponge with a deacetylation degree of 48% exhibited the best hemostatic performance, demonstrating the importance of a specific ratio of acetyl amino and amino groups in activating the coagulation system and promoting platelet and erythrocyte adhesion.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Applied
Endarto Yudo Wardhono, Mekro Permana Pinem, Indar Kustiningsih, Mohammad Effendy, Daniele Clausse, Khashayar Saleh, Erwann Guenin
Summary: Low-frequency ultrasonic irradiation is employed as a cost-effective technique for the deacetylation of chitin, resulting in a high deacetylation degree of chitosan with similar characteristics to commercial chitosan. The power-law model is shown to be an effective way to describe this complex reaction process.
CARBOHYDRATE POLYMERS
(2021)
Review
Engineering, Multidisciplinary
Alia Tasnim Hazmi, Farah B. Ahmad, M. H. Maziati Akmal, Aliza Aini Md Ralib, Fathilah Binti Ali
Summary: This study reviews different experimental procedures for the chemical extraction of fungal chitosan and selects the most effective method using PROMETHEE-GAIA analysis. The microwave-assisted organic acid-alkaline treatment extraction method is found to be the most effective for fungal chitosan extraction.
ALEXANDRIA ENGINEERING JOURNAL
(2023)
Article
Multidisciplinary Sciences
Gengxin Hao, Yanyu Hu, Linfan Shi, Jun Chen, Aixiu Cui, Wuyin Weng, Kazufumi Osako
Summary: Chitosan obtained from swimming crab shells via subcritical water pretreatment had lower yield and molecular weight compared to those prepared via sodium hydroxide pretreatment, but exhibited similar molecular structures and better thermal stability. Subcritical water pretreatment showed potential for crustacean shell pretreatment and chitosan preparation.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Rut Fernandez-Marin, Fabio Hernandez-Ramos, Asier M. Salaberria, M. Angeles Andres, Jalel Labidi, Susana C. M. Fernandes
Summary: The study demonstrated that nanochitin can be efficiently extracted from marine waste using microwave irradiation, optimizing the isolation of lobster, shrimp and squid pen nanocrystals while reducing extraction time and acid concentration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Chemistry, Multidisciplinary
Julia Pohling, Kelly Hawboldt, Deepika Dave
Summary: Chitin is a polymer that provides structure and stability to the exoskeleton of crustaceans, insects, and fungal cell walls. However, its commercial utilization has been limited due to its insolubility in solutions. Chemical modifications and mechanical methods are used to make chitin soluble and easier to work with.
Article
Chemistry, Applied
Chinmay C. Satam, J. Carson Meredith
Summary: The study shows that deacetylation can enhance the performance of chitin nanofiber suspension and films, while reducing the energy utilization in the high pressure homogenization process. Oxygen permeability is not affected, and deacetylation can also lower the intensity requirements during extraction.
CARBOHYDRATE POLYMERS
(2021)
Article
Spectroscopy
Andrej Dementjev, Vadimas Dudoitis, Andrius Gelzinis, Ona Gyliene, Rima Binkiene, Dalia Jasineviciene, Vidmantas Ulevicius
Summary: In this study, the deacetylation degree of chitin and chitosan samples was determined using a technique called coherent anti-Stokes Raman spectroscopy (CARS). The CARS response calibration curve was obtained by measuring chitin/chitosan samples with different deacetylation degrees. The capabilities of CARS microscopy were demonstrated by imaging the shell of the black soldier fly larvae and displaying the structural distribution of the deacetylation degree within the shell.
JOURNAL OF RAMAN SPECTROSCOPY
(2023)
Article
Materials Science, Paper & Wood
Daying Liu, Shasha Huang, Hao Wu, Jianming Zhang
Summary: High yield carboxyl beta-chitin nanofibers (CO-ChNFs) were successfully prepared from squid pen beta-chitin with partially deacetylated using the TEMPO/NaClO/NaClO2 oxidation system. This method breaks through the previous limitation of TEMPO oxidation and will facilitate the in-depth research and application of carboxyl beta-chitin nanofibers.
Article
Engineering, Environmental
E. Aguila-Almanza, Sze Shin Low, H. Harnandez-Cocoletzi, A. Atonal-Sandoval, E. Rubio-Rosas, J. Violante-Gonzalez, Pau Loke Show
Summary: After the death of sand crabs, their body carapace can be used as a potential source of chitosan, providing health benefits to human beings. The treated samples showed uniform microscopic structures, good crystal structure, and quality suitable for potential biomedical applications.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Xiangyu Sun, Yiruo Wang, Jiaming Yu, Qifeng Wei, Xiulian Ren
Summary: In this study, a chitosan deacetylation method based on the NADES system was proposed, which enhanced the deacetylation process by interfering with the hydrogen bond network. Chitosan with a deacetylation degree of 83.77% was obtained. The experimental results showed that NADES not only improved the deacetylation degree, but also reduced alkali-induced damage to the molecular weight.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Chemistry, Applied
Eliana Lucanera, Sebastian Anbinder, Carlos Macchi, Alberto Somoza
Summary: This study presents an experimental investigation on the evolution of physicochemical, thermal and nanostructural properties of chitosan samples obtained from squid pens during the deacetylation treatment. Potentiometric titration, capillary viscosimetry, infrared spectroscopy, differential scanning calorimetry, and positron annihilation lifetime spectroscopy were employed for analysis. The results discuss the influence of deacetylation time on the deacetylation degree, molecular weight, thermal parameters, and nanohole size of different samples. The study explores a method for preparing chitosan matrices with tailored nanostructural characteristics for specific applications through the deacetylation process.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Shamala Mane, Ejaj Pathan, Santosh Tupe, Sneha Deshmukh, Deepika Kale, Vandana Ghormade, Bhushan Chaudhari, Mukund Deshpande
Summary: This study extracted cell wall chitosan from fungi of different taxonomic classes and evaluated their properties and antifungal activity. The findings suggest that nanoformulation of fungal chitosan with low molecular weight and high degree of deacetylation has potential in antifungal applications and is biocompatible.
Article
Biochemistry & Molecular Biology
Fang Li, Xinguo You, Qinfeng Li, Di Qin, Mengyang Wang, Shipeng Yuan, Xiguang Chen, Shichao Bi
Summary: This study focused on verifying the structural stability, homogeneous degradation, and deacetylation of chitin in alkali-soluble systems. The results showed significant changes in chitin with an increase in storage time and temperature, but the processed chitins were non-toxic for biomedicine applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Plant Sciences
Qing Zhang, Cheng-Xun He, Ling-Yu Wang, Die Qian, Dan-Dan Tang, Sheng-Nan Jiang, Wen-Wen Chen, Chun-Jie Wu, Wei Peng
Summary: The study found that hydroxy-alpha-sanshool (HAS) can promote browning of white adipose tissue (WAT) through the regulation of the AMPK/SIRT-1/PPAR gamma signaling pathway, which helps combat obesity.
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)