Article
Medicine, Research & Experimental
Daniel J. Farkas, Saadet Inan, Laila N. Heydari, Clare T. Johnson, Pingwei Zhao, Heather B. Bradshaw, Sara Jane Ward, Scott M. Rawls
Summary: This study found that cannabinoid mechanisms contribute to the therapeutic efficacy of the kratom alkaloid MG in a model of chemotherapy-induced peripheral neuropathy, suggesting that co-administration with cannabinoids may increase its therapeutic efficacy.
Article
Biochemistry & Molecular Biology
Xue Bai, Gerard Batalle, Ignacio Martinez-Martel, Olga Pol
Summary: This study found that hydrogen sulfide (H2S) donors can enhance the analgesic effects of the cannabinoid 2 receptor (CB2R) agonist JWH-133 in inflammatory and neuropathic pain conditions. In addition, H2S donors can improve anxiety and depressive mood associated with neuropathic pain caused by sciatic nerve injury. The results suggest that combining CB2R agonists with H2S donors may be a potential approach for treating neuropathic pain and associated emotional disturbances caused by peripheral nerve injury.
Article
Anesthesiology
Elaine F. Toniolo, Achla Gupta, Adriano C. Franciosi, Ivone Gomes, Lakshmi A. Devi, Camila S. Dale
Summary: The interaction between CB1R and opioid receptors may be targeted for the treatment of diabetic neuropathy. CB1R-MOR and CB1R-DOR complexes are involved in diabetic neuropathy, and the peptide endocannabinoid hemopressin shows potential as a therapeutic for this condition.
Review
Biochemistry & Molecular Biology
Alessandra Bennici, Carmen Mannucci, Fabrizio Calapai, Luigi Cardia, Ilaria Ammendolia, Sebastiano Gangemi, Gioacchino Calapai, Daniel Griscti Soler
Summary: Products derived from Cannabis sativa are commonly used for treating chronic neuropathic pain, with nabiximols being the only product approved by regulatory authorities for neuropathic pain and spasticity in European countries and Canada. Safety and risk-benefit profiles of other cannabis preparations widely used for medical purposes remain unclear, highlighting the need for further research on adverse reactions.
Article
Biochemistry & Molecular Biology
Elana Y. Laks, Hongbo Li, Sara Jane Ward
Summary: Despite advancements in dental pain management, orofacial pain remains one of the most common reasons for emergency dental care. This study found that the nonpsychoactive Cannabis constituents, cannabidiol (CBD) and beta-caryophyllene (beta-CP), showed therapeutic potential in reducing orofacial sensitivity and inflammation in a rodent model. Specifically, beta-CP significantly reduced orofacial sensitivity and expression of inflammatory markers, while CBD only decreased the expression of one marker. This preclinical evidence suggests that non-psychoactive cannabinoid-based pharmacotherapy may be beneficial for treating orofacial pain associated with pulp exposure.
Article
Biochemistry & Molecular Biology
Diana E. Sepulveda, Kent E. Vrana, Nicholas M. Graziane, Wesley M. Raup-Konsavage
Summary: Neuropathic pain, a common and difficult-to-treat condition, has limited response to current therapies. This study found that THC and CBD have different effects on mechanical hypersensitivity in a mouse model of neuropathic pain. High THC extract or pure THC showed the most effective treatment for reducing pain, while high CBD extract had some alleviating effect on mechanical hypersensitivity, but not as potent as high THC extract.
Review
Anesthesiology
Samer Narouze
Summary: Cannabinoid-based medications have unique multimodal analgesic mechanisms that modulate diverse pain targets. They are classified into endocannabinoids, phytocannabinoids, and synthetic cannabinoids, exerting analgesic effects in various pain conditions. Interactions with different receptors and modulation of nociception pathways contribute to the analgesic effects of cannabinoids, with significant cross-modulation and synergy with opioids.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2021)
Review
Neurosciences
Mengya Wang, Huayuan Liu, Zegang Ma
Summary: Parkinson's disease is a neurodegenerative disease influenced by the cannabinoid system in the basal ganglia. Modulating the endogenous cannabinoid levels can have an anti-movement disorder effect, suggesting the development of drugs targeting the cannabinoid system as a novel strategy for Parkinson's disease treatment.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Chemistry, Medicinal
Toni Kline, Cong Xu, Faith R. Kreitzer, Dow P. Hurst, Khalil M. Eldeeb, Jim Wager-Miller, Kathleen Olivas, Seon A. Hepburn, John W. Huffman, Ken Mackie, Allyn C. Howlett, Patricia Reggio, Nephi Stella
Summary: The author synthesized fourteen novel alkylindole analogues and evaluated their activities at alkylindole-sensitive GPCRs. They found three characteristics that favor binding to alkylindole-sensitive GPCRs versus CB1R/CB2R and identified novel chemical tools for studying alkylindole-sensitive GPCRs.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Lukasz Zapala, Grzegorz Niemczyk, Piotr Zapala, Artur Wdowiak, Iwona Bojar, Tomasz Kluz, Aleksandra Szopa, Anna Serefko, Piotr Radziszewski, Andrzej Wrobel
Summary: This paper aimed to investigate whether the selective cannabinoid CB1 receptor agonist ACEA could reverse the effects of corticosterone (CORT) on depressive and overactive bladder potential. Through experiments on 48 female rats, it was found that ACEA could restore CORT-induced bladder dysfunction and depressive behavior, as well as regulate urine and other biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
M. Irene Diaz-Reval, Yolitzy Cardenas, Miguel Huerta, Xochitl Trujillo, Enrique Alejandro Sanchez-Pastor, Maria Eva Gonzalez-Trujano, Adolfo Virgen-Ortiz, M. Gicela Perez-Hernandez
Summary: This study aimed to explore the synergistic effect of a non-steroidal anti-inflammatory drug (NSAID) and a cannabinoid agonist in pain management. The combination of ibuprofen and synthetic cannabinoid WIN 55,212-2 showed a synergistic effect mainly mediated by CB2 receptors, with peripheral receptors playing a relevant role.
Article
Pharmacology & Pharmacy
Esty Goldberger, Merav Tauber, Yair Ben-Chaim
Summary: Cannabinoids produce their effects by binding to CB1 and CB2 receptors, and recent studies have shown that membrane potential may modulate the activity of the CB1 receptor. The voltage dependence appears to be agonist-specific, which could contribute to our understanding of the physiological functions mediated by the endocannabinoid system.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Samuel S. Duffy, Jessica P. Hayes, Nathan T. Fiore, Gila Moalem-Taylor
Summary: The article highlights the important role of microglia in the central nervous system, discussing their different states in neurological diseases and the regulatory effects of the endocannabinoid system on their activity.
Article
Biochemistry & Molecular Biology
Jasmine Siew Min Chia, Ahmad Akira Omar Farouk, Tengku Azam Shah Tengku Mohamad, Mohd Roslan Sulaiman, Hanis Zakaria, Nurul Izzaty Hassan, Enoch Kumar Perimal
Summary: The study found that CB1, PPAR alpha, and PPAR gamma are involved in zerumbone's action against mechanical allodynia, while only CB1 and PPAR alpha are involved against thermal hyperalgesia. Molecular docking studies suggest that zerumbone has a favorable binding affinity against the respective agonists on the CB and PPAR receptors studied, indicating its potential in treating neuropathic pain.
Review
Physiology
Raquel Maria P. Campos, Andrey F. L. Aguiar, Yolanda Paes-Colli, Priscila Martins Pinheiro Trindade, Bruna K. Ferreira, Ricardo A. de Melo Reis, Luzia S. Sampaio
Summary: Chronic neuropathic pain, caused by nerve system damage and persistent long-term, directly impacts quality of life. Endocannabinoid system plays a pivotal role in its development. Plant-derived, synthetic, and endocannabinoids are efficient for pain management.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Neurosciences
Isabella Caroline da Silva Dias, Bruno Carabelli, Daniela Kaori Ishii, Helen de Morais, Milene Cristina de Carvalho, Luiz E. Rizzo de Souza, Silvio M. Zanata, Marcus Lira Brandao, Thiago Mattar Cunha, Anete Curte Ferraz, Joice Maria Cunha, Janaina Menezes Zanoveli
MOLECULAR NEUROBIOLOGY
(2016)
Article
Behavioral Sciences
Daiany D. B. Redivo, Anne K. Schreiber, Eliana R. Adami, Deidiane E. Ribeiro, Samia R. L. Joca, Janaina M. Zanoveli, Joice M. Cunha
BEHAVIOURAL BRAIN RESEARCH
(2016)
Article
Neurosciences
Helen de Morais, Yane Costa Chaves, Ana Paula Farias Waltrick, Carlos Henrique Alves Jesus, Karina Genaro, Jose Alexandre Crippa, Joice Maria da Cunha, Janaina Menezes Zanoveli
NEUROSCIENCE LETTERS
(2018)
Article
Endocrinology & Metabolism
Mohamad-Reza Aghanoori, Darrell R. Smith, Shiva Shariati-Ievari, Andrew Ajisebutu, Annee Nguyen, Fiona Desmond, Carlos H. A. Jesus, Xiajun Zhou, Nigel A. Calcutt, Michel Aliani, Paul Fernyhough
MOLECULAR METABOLISM
(2019)
Article
Behavioral Sciences
D. D. B. Redivo, C. H. A. Jesus, B. B. Sotomaior, A. T. Gasparin, J. M. Cunha
BEHAVIOURAL BRAIN RESEARCH
(2019)
Article
Plant Sciences
Samanta Daliana Golin Pacheco, Alexia Thamara Gasparin, Carlos Henrique Alves Jesus, Bruna Bittencourt Sotomaior, Ana Clara Sans Salomao Brunow Ventura, Daiany Darlly Belo Redivo, Daniela de Almeida Cabrini, Josiane de Fatima Gaspari Dias, Marilis Dallarmi Miguel, Obdulio Gomes Miguel, Joice Maria da Cunha
Article
Behavioral Sciences
Maryna Rodrigues Goncalves, Milena Santana da Conceicao, Carlos Henrique Alves Jesus, Alexia Thamara Gasparin, Evelize Stacoviaki Rosa, Joice Maria da Cunha
Summary: This study investigated the acute effects of cannabinoid receptor agonists on mechanical allodynia in rats with experimental diabetes and found that these agonists significantly improved the condition. Furthermore, pre-treatment with cannabinoid receptor antagonists could reverse the effects of these agonists.
BEHAVIOURAL PHARMACOLOGY
(2022)
Article
Neurosciences
Alexia Thamara Gasparin, Evelize Stacoviaki Rosa, Carlos Henrique Alves Jesus, Izonete Cristina Guiloski, Helena Cristina da Silva de Assis, Olair Carlos Beltrame, Rosangela Locatelli Dittrich, Samanta Daliana Golin Pacheco, Janaina Menezes Zanoveli, Joice Maria da Cunha
Summary: The study found that Bixin can significantly alleviate mechanical allodynia, depressive, and anxious-like behaviors in diabetic rats, while restoring oxidative parameters and lowering plasma HbA1 levels.
Article
Behavioral Sciences
Eder Gambeta, Caio C. Sestile, Manoela V. Fogaca, Francisco S. Guimaraes, Elisabeth A. Audi, Joice M. da Cunha, Helio Zangrossi, Paula Shimene de Melo Yamashita, Janaina M. Zanoveli
BEHAVIOURAL PHARMACOLOGY
(2017)
Article
Neurosciences
Erika Ivanna Araya, Carina Fernanda Mattedi Nones, Luiz Eduardo Nunes Ferreira, Caroline Machado Kopruszinski, Joice Maria da Cunha, Juliana Geremias Chichorro
Article
Behavioral Sciences
Isadora Pozzetti Siba, Mariza Bortolanza, Maria Aparecida Barbato Frazao Vital, Roberto Andreatini, Joice Maria da Cunha, Elaine Aparecida Del Bel, Janaina Menezes Zanoveli
BEHAVIOURAL BRAIN RESEARCH
(2017)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.