GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network
出版年份 2019 全文链接
标题
GWAS and enrichment analyses of non-alcoholic fatty liver disease identify new trait-associated genes and pathways across eMERGE Network
作者
关键词
NAFLD, Fatty liver, Genetic polymorphism, GWAS, PheWAS, Polygenic risk score
出版物
BMC Medicine
Volume 17, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2019-07-17
DOI
10.1186/s12916-019-1364-z
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- NASH in Lean Individuals
- (2019) Ramy Younes et al. SEMINARS IN LIVER DISEASE
- The role of xanthine oxidoreductase and uric acid in metabolic syndrome
- (2018) Maria Giulia Battelli et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Genetic variants in COL13A1, ADIPOQ and SAMM50 , in addition to the PNPLA3 gene, confer susceptibility to elevated transaminase levels in an admixed Mexican population
- (2018) Elena Larrieta-Carrasco et al. EXPERIMENTAL AND MOLECULAR PATHOLOGY
- Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity
- (2018) John B. Harley et al. NATURE GENETICS
- A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease
- (2018) Noura S. Abul-Husn et al. NEW ENGLAND JOURNAL OF MEDICINE
- Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers
- (2018) Takahisa Kawaguchi et al. PLoS One
- HSD17B13 is a Hepatic Retinol Dehydrogenase Associated with Histological Features of Non-Alcoholic Fatty Liver Disease
- (2018) Yanling Ma et al. HEPATOLOGY
- The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases
- (2017) Naga Chalasani et al. HEPATOLOGY
- Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling
- (2017) Daniel A Giles et al. NATURE MEDICINE
- Functional mapping and annotation of genetic associations with FUMA
- (2017) Kyoko Watanabe et al. Nature Communications
- Silencing of FABP1 ameliorates hepatic steatosis, inflammation, and oxidative stress in mice with nonalcoholic fatty liver disease
- (2017) Takako Mukai et al. FEBS Open Bio
- Next-generation genotype imputation service and methods
- (2016) Sayantan Das et al. NATURE GENETICS
- The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog)
- (2016) Jacqueline MacArthur et al. NUCLEIC ACIDS RESEARCH
- Th17 involvement in nonalcoholic fatty liver disease progression to non-alcoholic steatohepatitis
- (2016) Carla Melisa Chackelevicius et al. WORLD JOURNAL OF GASTROENTEROLOGY
- PPARgene: A Database of Experimentally Verified and Computationally Predicted PPAR Target Genes
- (2016) Li Fang et al. PPAR Research
- XGR software for enhanced interpretation of genomic summary data, illustrated by application to immunological traits
- (2016) Hai Fang et al. Genome Medicine
- Regulation of Inflammation by IL-17A and IL-17F Modulates Non-Alcoholic Fatty Liver Disease Pathogenesis
- (2016) Daniel A. Giles et al. PLoS One
- A Novel Approach to High-Quality Postmortem Tissue Procurement: The GTEx Project
- (2015) Latarsha J. Carithers et al. BIOPRESERVATION AND BIOBANKING
- Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study
- (2015) Rohit Loomba et al. GASTROENTEROLOGY
- A Novel Approach to High-Quality Postmortem Tissue Procurement: The GTEx Project
- (2015) Latarsha J. Carithers et al. Biopreservation and Biobanking
- Specificity protein (Sp) transcription factors and metformin regulate expression of the long non-coding RNA HULC
- (2015) Shruti U. Gandhy et al. Oncotarget
- Extracting research-quality phenotypes from electronic health records to support precision medicine
- (2015) Wei-Qi Wei et al. Genome Medicine
- MAGMA: Generalized Gene-Set Analysis of GWAS Data
- (2015) Christiaan A. de Leeuw et al. PLoS Computational Biology
- Second-generation PLINK: rising to the challenge of larger and richer datasets
- (2015) Christopher C Chang et al. GigaScience
- R PheWAS: data analysis and plotting tools for phenome-wide association studies in the R environment
- (2014) Robert J. Carroll et al. BIOINFORMATICS
- Association of polymorphisms in GCKR and TRIB1 with nonalcoholic fatty liver disease and metabolic syndrome traits
- (2014) Aya Kitamoto et al. ENDOCRINE JOURNAL
- TRIB1 downregulates hepatic lipogenesis and glycogenesis via multiple molecular interactions
- (2014) Yuumi Ishizuka et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- Nonalcoholic fatty liver disease: an emerging threat to obese and diabetic individuals
- (2013) Howard C. Masuoka et al. Annals of the New York Academy of Sciences
- IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice
- (2013) Isaac T.W. Harley et al. HEPATOLOGY
- Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan
- (2013) Takuya Kitamoto et al. HUMAN GENETICS
- Role ofFDFT1polymorphism for fibrosis progression in patients with chronic hepatitis C
- (2013) Albert F. Stättermayer et al. LIVER INTERNATIONAL
- Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis
- (2013) Quentin M. Anstee et al. Nature Reviews Gastroenterology & Hepatology
- The global NAFLD epidemic
- (2013) Rohit Loomba et al. Nature Reviews Gastroenterology & Hepatology
- Genetic Analysis of 16 NMR-Lipoprotein Fractions in Humans, the GOLDN Study
- (2012) Aldi T. Kraja et al. LIPIDS
- Hepatic expression and serum levels of syndecan 1 (CD138) in patients with nonalcoholic fatty liver disease
- (2012) Yusuf Yilmaz et al. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
- Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals
- (2012) Zari Dastani et al. PLoS Genetics
- Pitfalls of merging GWAS data: lessons learned in the eMERGE network and quality control procedures to maintain high data quality
- (2011) Rebecca L. Zuvich et al. GENETIC EPIDEMIOLOGY
- Endpoints and clinical trial design for nonalcoholic steatohepatitis
- (2011) Arun J. Sanyal et al. HEPATOLOGY
- Expression and Characterization of a PNPLA3 Protein Isoform (I148M) Associated with Nonalcoholic Fatty Liver Disease
- (2011) Yongcheng Huang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Unknown
- (2011) Alexander Moschen et al. MOLECULAR MEDICINE
- Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
- (2011) John C Chambers et al. NATURE GENETICS
- HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants
- (2011) L. D. Ward et al. NUCLEIC ACIDS RESEARCH
- Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits
- (2011) Elizabeth K. Speliotes et al. PLoS Genetics
- GCTA: A Tool for Genome-wide Complex Trait Analysis
- (2010) Jian Yang et al. AMERICAN JOURNAL OF HUMAN GENETICS
- LocusZoom: regional visualization of genome-wide association scan results
- (2010) R. J. Pruim et al. BIOINFORMATICS
- PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene-disease associations
- (2010) J. C. Denny et al. BIOINFORMATICS
- Genome-Wide Association Study Identifies Variants Associated With Histologic Features of Nonalcoholic Fatty Liver Disease
- (2010) Naga Chalasani et al. GASTROENTEROLOGY
- Heritability of Nonalcoholic Fatty Liver Disease
- (2009) Jeffrey B. Schwimmer et al. GASTROENTEROLOGY
- A Sequence Variation (I148M) in PNPLA3 Associated with Nonalcoholic Fatty Liver Disease Disrupts Triglyceride Hydrolysis
- (2009) Shaoqing He et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region
- (2009) Jeffrey C Barrett et al. NATURE GENETICS
- Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks
- (2009) Xia Yang et al. NATURE GENETICS
- Uric Acid: The Oxidant-Antioxidant Paradox
- (2008) Yuri Y. Sautin et al. NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
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