Review
Cell Biology
Xiaoying Chen, Wei Xie, Ming Zhang, Yuhan Shi, Shaofen Xu, Haoyu Cheng, Lihong Wu, Janak L. Pathak, Zhichao Zheng
Summary: This review summarizes the regulatory role of non-coding RNAs in the osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) and discusses their prospects in clinical bone tissue regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Cell Biology
Elia Bosch-Rue, Leire Diez-Tercero, Barbara Giordano-Kelhoffer, Luis M. Delgado, Begona M. Bosch, Mireia Hoyos-Nogues, Miguel Angel Mateos-Timoneda, Phong A. Tran, Francisco Javier Gil, Roman A. Perez
Summary: Bone is the most studied tissue in tissue regeneration field, with tissue engineering seeking to mimic successful regeneration pathways. The use of inorganic ions has therapeutic effects and lower biological risks, with biomaterials playing a key role in controlling their release.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hang Zhou, Kexiao Yu, Haitao Jiang, Rui Deng, Lei Chu, Youde Cao, Yuanyi Zheng, Weizhong Lu, Zhongliang Deng, Bing Liang
Summary: The study successfully synthesized injectable PMM hydrogels that can accelerate bone regeneration and form porous scaffolds, significantly promoting bone cell proliferation, differentiation, and deposition by controlling Mg2+ release. Micro-CT imaging and histological analysis demonstrated that PMM hydrogels effectively stimulated in situ bone regeneration in rat calvarial defects.
Review
Biochemistry & Molecular Biology
Chiara Mazziotta, Carmen Lanzillotti, Maria Rosa Iaquinta, Francesca Taraballi, Elena Torreggiani, John Charles Rotondo, Lucia Oton-Gonzalez, Elisa Mazzoni, Francesca Frontini, Ilaria Bononi, Monica De Mattei, Mauro Tognon, Fernanda Martini
Summary: MSCs are important source for bone regeneration and play a crucial role in osteogenic differentiation. MiRNAs regulate gene expression in osteogenic differentiation of MSCs and are involved in controlling important signaling pathways such as TGF-beta/BMP and Wnt/beta-catenin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Iratxe Macias, Natividad Alcorta-Sevillano, Arantza Infante, Clara Rodriguez
Summary: Bone damage leading to bone loss can be caused by a variety of reasons, including infections, diseases, trauma, or surgery. Current clinical bone surrogates have limitations, leading to extensive research into new therapies for skeletal regeneration of bone defects, such as stimulating host cells or using scaffolds, biomolecules, and stem cells to promote bone healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Gerardo Asensio, Marcela Martin-del-Campo, Rosa Ana Ramirez, Luis Rojo, Blanca Vazquez-Lasa
Summary: Sr/Zn phytate compounds have antimicrobial effects and can form bioactive coatings. Phytic acid has antioxidant and osteogenic properties that are important for bone remodelling. The study explored the antioxidant and osteogenic properties of SrPhy and ZnPhy and found that they can be used in bone regenerative therapies.
Review
Engineering, Biomedical
Weiying Lu, Yang Shi, Zhijian Xie
Summary: Three-dimensional (3D) printing technology has the potential to address the challenges of large bone defect regeneration by facilitating satisfactory revascularization. This review summarizes different designs related to angiogenesis in 3D-printed scaffolds, and proposes structural design suggestions to achieve rapid blood vessel formation.
BIO-DESIGN AND MANUFACTURING
(2023)
Article
Biochemistry & Molecular Biology
Jasmijn Korpershoek, Margot Rikkers, Tommy S. de Windt, Marianna A. Tryfonidou, Daniel B. F. Saris, Lucienne A. Vonk
Summary: This study isolated meniscus progenitor cells by differential adhesion to fibronectin and demonstrated their multipotency. FN-prog from the outer zone formed more colonies and had a higher proliferation rate compared to inner zone FN-prog. These findings suggest that FN-prog may be a promising cell type for meniscus tissue-engineering.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hui Zhang, Nirina Beilfuss, Urszula Zabarylo, Kay Raum, Regina Puts
Summary: In order to rapidly develop precision medicine and patient-oriented treatment strategies, novel technological solutions are urgently needed. This study developed an ultrasound-based tissue engineering acoustophoretic set-up to organize murine mesenchymal stromal cells in an in situ polymerizing 3-D fibrin hydrogel. The structured hydrogels exhibited enhanced expression of osteogenic markers and cell-cycle-progression-associated genes, suggesting the potential for improved regenerative properties in bone healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Esmat Azizipour, Hossein Aghamollaei, Raheleh Halabian, Delaram Poormoghadam, Mostafa Saffari, Maliheh Entezari, Ali Salimi
Summary: Employing hydrogels with bioactive glass nanowhiskers for bone tissue repair showed successful induction of hMSCs differentiation into osteogenic lineage and biomineralization. Cell viability assays confirmed biocompatibility and increased proliferation with BGnW incorporation. Molecular investigations revealed elevated osteogenic markers level, suggesting Gel-Glu-Col/BGnW as a potential candidate for bone tissue regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Wei Cao, Jianfeng Jin, Gang Wu, Nathalie Bravenboer, Marco N. Helder, Janak L. Pathak, Behrouz Zandieh-Doulabi, Jolanda M. A. Hogervorst, Shingo Matsukawa, Lester C. Geonzon, Rommel G. Bacabac, Engelbert A. J. M. Schulten, Jenneke Klein-Nulend
Summary: K-carrageenan promoted adhesion, spreading, metabolic activity, proliferation, and osteogenic differentiation of MC3T3-E1 pre-osteoblasts, indicating its potential as an osteogenic inductive factor for enhancing bone regeneration.
Article
Engineering, Biomedical
M. T. Tavares, S. C. Santos, C. A. Custodio, J. P. S. Farinha, C. Baleizao, J. F. Mano
Summary: A novel PLMA-based nanocomposite was developed for bone repair and regeneration, capable of guiding the differentiation of human bone marrow-derived mesenchymal stem cells without any other osteogenic supplementation.
MATERIALS TODAY BIO
(2021)
Article
Chemistry, Physical
Federica Riva, Nora Bloise, Claudia Omes, Gabriele Ceccarelli, Lorenzo Fassina, Rossella Elena Nappi, Livia Visai
Summary: Recent studies have found stem cells (hFF-MSCs) in ovarian follicular fluid (hFF) with similar properties to MSCs derived from other tissues. These hFF-MSCs, isolated from waste matter after oocyte retrieval, are an untapped source of stem cell materials. This study evaluates the osteogenic capacity of hFF-MSCs seeded on bioglass 58S-coated titanium and their suitability for bone tissue engineering. The findings suggest that hFF-MSCs cultured on bioglass-coated titanium exhibit enhanced osteogenic differentiation, indicating their potential in regenerative medicine and as an alternative to hBM-MSCs in bone tissue engineering models.
Article
Materials Science, Multidisciplinary
Caoxing Huang, Jian Dong, Yunyang Zhang, Senlin Chai, Xucai Wang, Shixiong Kang, Dengguang Yu, Peng Wang, Qing Jiang
Summary: The study demonstrated that electrospun scaffolds incorporating gold nanoparticles have great potential in improving osteogenic bioactivities and bone regeneration, suggesting promising applications in the field of bone tissue engineering.
MATERIALS & DESIGN
(2021)
Article
Cell Biology
Sandra Stamnitz, Agnieszka Krawczenko, Urszula Szalaj, Zaneta Gorecka, Agnieszka Antonczyk, Zdzislaw Kielbowicz, Wojciech Swieszkowski, Witold Lojkowski, Aleksandra Klimczak
Summary: FGF-2 and BMP-2 enhance the osteogenic differentiation potential of MSCs grown on a scaffold, making them promising tools for bone regeneration. This was confirmed through in vitro and in vivo experiments.
Article
Cell Biology
Sujuan Duan, Xiaona Gong, Xing Liu, Wenwen Cui, Kaddie Chen, Longbing Mao, Sun Jun, Ruihao Zhou, Yi Sang, Guofu Huang
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Dentistry, Oral Surgery & Medicine
Su-Han Jin, Rui-Hao Zhou, Xiao-Yan Guan, Jian-Guo Zhou, Jian-Guo Liu
JOURNAL OF PERIODONTAL RESEARCH
(2020)
Article
Oncology
Jun Sun, Xia Qian, Feifei Zhang, Xiaofeng Tang, Cheng Ju, Renfeng Liu, Ruihao Zhou, Zhiping Zhang, Xiao-Bin Lv, Changhua Zhang, Guofu Huang
TRANSLATIONAL CANCER RESEARCH
(2019)
Article
Oncology
Ruihao Zhou, Xiaofeng Tang, Liping Li, Feifei Zhang, Jun Sun, Cheng Ju, Yan Zhou, Renfeng Liu, Yiping Liang, Bin Lv, Zhiping Zhang, Haiyan Hu, Xiao-Bin Lv
CANCER MANAGEMENT AND RESEARCH
(2020)
Article
Clinical Neurology
Hai-Lin Liu, Rui-Hao Zhou, Li-Li Luo, Xue Yuan, Ling Ye, He-Guo Luo
JOURNAL OF PAIN RESEARCH
(2020)
Article
Clinical Neurology
Rui-Hao Zhou, Chan Chen, Su-Han Jin, Jun Li, Zi-Hao Xu, Ling Ye, Jian-Guo Zhou
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2020)
Article
Medicine, Research & Experimental
Lu Chen, Ruihao Zhou, Fuguo Sun, Yan Weng, Ling Ye, Pingliang Yang
Article
Genetics & Heredity
Rui-Hao Zhou, Jing-Tao Zhang, Chan Chen, Zi-Hao Xu, Xiao-Bin Lv, Ling Ye, Ben-Tong Yu
Article
Genetics & Heredity
Zihao Xu, Zilong Wu, Jingtao Zhang, Ruihao Zhou, Ling Ye, Pingliang Yang, Bentong Yu
Article
Biotechnology & Applied Microbiology
Zihao Xu, Zilong Wu, Jingtao Zhang, Ruihao Zhou, Jiane Wu, Bentong Yu
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Medicine, General & Internal
Ping Zheng, Ruihao Zhou, Lu Yin, Xiaorong Yin, Yongqiao Mao, Heng Wang, Ling Ye, Tao Zhu
FRONTIERS IN MEDICINE
(2020)
Letter
Surgery
Wen-Gong Bian, Rui-Hao Zhou, Hai-Lin Liu, He-Guo Luo
ASIAN JOURNAL OF SURGERY
(2022)
Article
Medicine, General & Internal
Peiyi Li, Ce Wang, Ruihao Zhou, Lingcan Tan, Xiaoqian Deng, Tao Zhu, Guo Chen, Weimin Li, Xuechao Hao
Summary: This study aims to develop a mobile app to enhance perioperative adverse event (PAE) management and evaluate its usability, clinical efficacy, and cost-effectiveness. The study will use mixed methods research to assess user needs and measure the app effects through qualitative and quantitative data. The research will be conducted at a hospital in China, and the findings will be disseminated through peer-reviewed publications and conference presentations.
Letter
Anesthesiology
Lu Chen, Ruihao Zhou, Ling Ye, Hui Liu, Pingliang Yang, Bangxiang Yang, Ling Ye
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)