期刊
BIOMARKERS IN MEDICINE
卷 13, 期 8, 页码 675-684出版社
FUTURE MEDICINE LTD
DOI: 10.2217/bmm-2018-0468
关键词
biomarkers; exosomes; extracellular vesicles; gestational diabetes mellitus; lipidomics; miRNAs; placenta; pregnancy; proteomic; transcriptomics
资金
- National Council of Science and Technology (CONACyT) [290239]
Exosomes are defined as extracellular vesicles that are released from cells upon fusion of an intermediate endocytic compartment -the multivesicular body -with the plasma membrane. Recently, placenta-derived exosomes have gained special attention, since they play a crucial role in the communication between the mother and fetus. It is known that the concentration of placenta-derived exosomes in thematernal bloodstream is higher in patients with preeclampsia or gestational diabetes mellitus. However, their composition in terms of the content of proteins, nucleic acids or lipids is uncertain. In this work, we reviewed the recent advances in placental exosomes characterization through omics-based methods, and their potential to predict gestational diabetes mellitus.
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