Article
Neurosciences
Candela Zorzo, Jorge L. Arias, Marta Mendez
Summary: The study reveals that after reactivating the environmental configuration, spatial memory that has decayed over a period of 45 days can be restored. Male rats show decreased metabolic activity in septal nuclei and thalamic structures, while female rats exhibit reduced metabolism in multiple brain regions, indicating more efficient utilization of these areas when reactivating memories that have decayed over time.
Article
Neurosciences
Candela Zorzo, Jorge L. Arias, Marta Mendez
Summary: The retrieval of spatial memories does not always require the same stimuli configuration, and partial cues can successfully elicit memory. Navigation with contextual changes, especially in females, has received little attention. In this study, memory retrieval was assessed in female rats using the Morris Water Maze spatial reference protocol. The removal or addition of cues did not impair retrieval performance, and using a degraded subset of cues led to increased oxidative metabolism activity in specific brain regions.
BRAIN RESEARCH BULLETIN
(2022)
Article
Cell Biology
Jia Shi, Yi Yang, Ya-Nan Wang, Qing Li, Xue Xing, An-Ying Cheng, Xiao-Na Zhan, Jie Li, Gang Xu, Fan He
Summary: This study reveals the association between metabolism and the progression of vascular calcification in chronic kidney disease (CKD). High phosphate and uremic serum enhance mitochondrial respiration capacity in vascular smooth muscle cells (VSMCs), while glycolysis level remains unchanged. Suppression of cytochrome c oxidase (COX) activity attenuates vascular calcification.
CELL DEATH & DISEASE
(2022)
Article
Psychology, Biological
Alba Gutierrez-Menendez, Sandra Cid-Duarte, Maria Banqueri, Juan A. Martinez, Marta Mendez, Jorge L. Arias
Summary: This study compared the effects of photobiomodulation (PBM) on a rat brain network during the execution of a reversal task, revealing differences in brain activity levels between the control photobiomodulation group and the behavioral photobiomodulation group. These findings contribute to understanding the impact of PBM on active brain networks.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Multidisciplinary Sciences
Gizem Inak, Agnieszka Rybak-Wolf, Pawel Lisowski, Tancredi M. Pentimalli, Rene Juettner, Petar Glazar, Karan Uppal, Emanuela Bottani, Dario Brunetti, Christopher Secker, Annika Zink, David Meierhofer, Marie-Therese Henke, Monishita Dey, Ummi Ciptasari, Barbara Mlody, Tobias Hahn, Maria Berruezo-Llacuna, Nikos Karaiskos, Michela Di Virgilio, Johannes A. Mayr, Saskia B. Wortmann, Josef Priller, Michael Gotthardt, Dean P. Jones, Ertan Mayatepek, Werner Stenzel, Sebastian Diecke, Ralf Kuehn, Erich E. Wanker, Nikolaus Rajewsky, Markus Schuelke, Alessandro Prigione
Summary: Leigh syndrome (LS) is a severe neurometabolic disorder lacking effective models. This study found that LS carrying mutations in SURF1 gene exhibit impaired neuronal morphogenesis due to metabolic deficiencies.
NATURE COMMUNICATIONS
(2021)
Article
Behavioral Sciences
Candela Zorzo, Jorge L. Arias, Marta Mendez
Summary: Memory retrieval in rats trained in the Morris Water Maze was examined under different cue conditions, showing successful retrieval under full and partial cues, but impaired retrieval with extra cues. Brain oxidative metabolism assessment revealed that rats failing to retrieve spatial information in the extra cues condition exhibited lower CCO activity in several limbic regions compared to controls.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Candela Zorzo, Marta Mendez, Alberto M. Pernia, Jorge L. Arias
Summary: Research indicated that rTMS did not enhance spatial memory in healthy rats, but led to changes in metabolic activity in various brain regions.
Article
Multidisciplinary Sciences
Michael B. Powner, Glen Jeffery
Summary: Systemic glucose levels can be modulated through specific solar wavelengths that affect mitochondrial metabolism. Different wavelengths of light have opposing effects on mitochondrial respiration, with longer wavelengths increasing ATP production and shorter wavelengths suppressing metabolism. This study in a bumblebee model found that manipulating mitochondrial activity with specific wavelengths of light significantly altered circulating glucose concentration. This research contributes to our understanding of how light can affect systemic metabolism.
Article
Cell Biology
Sue Ellen Brand, Martha Scharlau, Lois Geren, Marissa Hendrix, Clayre Parson, Tyler Elmendorf, Earl Neel, Kaila Pianalto, Jennifer Silva-Nash, Bill Durham, Francis Millett
Summary: Cytochrome c (Cc) has undergone accelerated evolution from anthropoid primates to humans, with several amino acid changes occurring near the binding site of the Cc:CcO complex. These changes affect the dissociation constant and the role of phosphorylation in regulating mitochondrial electron transport and membrane potential.
Article
Psychology, Biological
Isabel Lopez-Taboada, Saul Saul-Sarria, Guillermo Vallejo, Ana Coto-Montes, Nelida M. Conejo, Hector Gonzalez-Pardo
Summary: Prolonged intake of a Western-type diet rich in fats and sugars and exposure to early life stress can negatively impact neurodevelopment and behavior. This study investigates the combined effects of a high-fat and high-sugar diet and early life stress in male and female rats, specifically looking at spatial learning and memory, behavioral flexibility, and oxidative capacity in different brain regions. The results show gender-specific effects, with males performing better on the HFS diet but experiencing impaired behavioral flexibility. Both maternal separation and the HFS diet increased the metabolic capacity and oxidative stress levels in the prefrontal cortex and hippocampus, although maternal separation seemed to dampen oxidative stress levels. These findings suggest a compensatory effect resulting from the interaction between prolonged exposure to a HFS diet and early life stress.
PHYSIOLOGY & BEHAVIOR
(2022)
Article
Multidisciplinary Sciences
Noah L. Pettit, Ee-Lynn Yap, Michael E. Greenberg, Christopher D. Harvey
Summary: Fos-induced cells contribute to accurate, stable and spatially uniform place codes in the hippocampus and Fos itself has a causal role in shaping these place codes.
Review
Psychology, Multidisciplinary
Anastasia Morandi-Raikova, Uwe Mayer
Summary: This review discusses the functional equivalence of the avian and mammalian hippocampus, focusing on research in domestic chicks. While the hippocampus plays a central role in processing spatial information in both birds and mammals, the structure of this area shows remarkable differences.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Psychology, Multidisciplinary
Gabrielle C. Veloso, Welison Evenston G. Ty
Summary: The study showed that participants who underwent emotional working memory training had significantly lower trait anxiety levels post-training. Emotion regulation was not found to mediate the relationship between working memory training and trait anxiety reduction.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Neurosciences
Angeliki Velli, Chrysoula Iordanidou, Theodora Asimi, Maria-Ioanna Vynichaki, Anastasios Cholevas, Adamantia-Iliana Mantouka, Liesje Nassens, Kleanthi Chalkiadaki, Kyriaki Sidiropoulou
Summary: Gender differences play a role in the differential effects of acute restraint stress on the function of the prefrontal cortex in male and female mice. Females exhibit increased anxiety levels, while males show deficits in the temporal order object recognition task. Corticosterone signaling mediates some of the effects of stress on synaptic plasticity, affecting recency memory and anxiety in males and females differently.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Agnes Moe, Justin Di Trani, John L. Rubinstein, Peter Brzezinski
Summary: Energy conversion in aerobic organisms involves electron transfer from low-potential donors to dioxygen through the membrane-bound respiratory chain. The formation of supercomplex CIII2CIV1/2 facilitates electron transfer by two-dimensional diffusion of cyt. c, increasing QH(2):O-2 oxidoreductase activity and suggesting a regulatory role for supercomplex formation in the respiratory chain.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Education, Scientific Disciplines
Magdalena Mendez-Lopez, M. Carmen Juan, Ramon Molla, Camino Fidalgo
Summary: Neuroanatomy is challenging for psychology students due to its complex spatial visualization and the relationships among brain structures. Implementing technologies like augmented reality (AR) can enhance the learning experience, with students showing a preference for 3D visualization over traditional 2D methods. Overall, students found the AR application to be user-friendly and effective for learning neuroanatomy.
ANATOMICAL SCIENCES EDUCATION
(2022)
Article
Computer Science, Cybernetics
M-Carmen Juan, Miguel Estevan, Magdalena Mendez-Lopez, Camino Fidalgo, Javier Lluch, Roberto Vivo
Summary: This paper presents a virtual reality photography application that incorporates panoramic images to assess short-term spatial memory. A study comparing the performance and subjective experience of using the VR application with and without panoramic photography was conducted. The results show that both applications are effective in assessing short-term spatial memory. The use of panoramic photography was found to be particularly effective for short-term recall and was not influenced by age and gender. Factors such as perceived presence and satisfaction were found to be related to the application's effectiveness.
BEHAVIOUR & INFORMATION TECHNOLOGY
(2023)
Article
Neurosciences
Alba Gutierrez-Menendez, Juan A. Martinez, Marta Mendez, Jorge L. Arias
Summary: The role of light in biological processes is well-known and light devices have been introduced in healthcare to improve body functions. Photobiomodulation (PBM) is a technique that stimulates tissue using red to infrared light. This study found no significant effects of PBM on brain activity and gene expression in young healthy rat brains.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Psychology, Experimental
Tania Llana, Cristina Fernandez-Baizan, Magdalena Mendez-Lopez, Camino Fidalgo, Marta Mendez
Summary: This study reviews empirical research on the use of fNIRS in the neuropsychological assessment of human spatial memory. The findings suggest that fNIRS can complement behavioral results and provide more comprehensive assessments.
Article
Computer Science, Artificial Intelligence
M-Carmen Juan, Magdalena Mendez-Lopez, Camino Fidalgo, Ramon Molla, Roberto Vivo, David Paramo
Summary: A SLAM-based AR app has been developed to assess spatial short-term memory. Visual and auditory stimuli were used, with similar performance outcomes in terms of object placement. However, the group using auditory stimuli took more time and attempts to complete the task. For auditory stimuli, there were correlations among variables in the AR app and other tasks.
JOURNAL ON MULTIMODAL USER INTERFACES
(2022)
Article
Neurosciences
Candela Zorzo, Jorge L. Arias, Marta Mendez
Summary: The retrieval of spatial memories does not always require the same stimuli configuration, and partial cues can successfully elicit memory. Navigation with contextual changes, especially in females, has received little attention. In this study, memory retrieval was assessed in female rats using the Morris Water Maze spatial reference protocol. The removal or addition of cues did not impair retrieval performance, and using a degraded subset of cues led to increased oxidative metabolism activity in specific brain regions.
BRAIN RESEARCH BULLETIN
(2022)
Review
Clinical Neurology
Tania Llana, Candela Zorzo, Magdalena Mendez-Lopez, Marta Mendez
Summary: This systematic review aims to update and analyze the existing evidence on memory impairments in long-COVID-19 patients, considering sample and study design characteristics, as well as exploring associations with epidemiological, clinical, and pathological features. Most studies evaluated verbal memory and found deficits in verbal learning and long-term memory, as well as some impairments in visuospatial memory.
APPLIED NEUROPSYCHOLOGY-ADULT
(2022)
Article
Psychology, Multidisciplinary
Tania Llana, Marta Mendez, Sara Garces-Arilla, Vanesa Hidalgo, Magdalena Mendez-Lopez, M. -Carmen Juan
Summary: This study aimed to explore the association between reported olfactory dysfunction and subjective and objective cognitive performance in long-COVID patients, as well as the relationship between emotional symptoms and cognition. The results showed that acute olfactory dysfunction was related to cognitive deficits in objective tests, and mood disturbances were associated with self-reported and objective memory. These findings contribute to understanding the neuropsychological and emotional aspects of long-COVID.
FRONTIERS IN PSYCHOLOGY
(2023)
Review
Behavioral Sciences
Candela Zorzo, Lucia Solares, Marta Mendez, Magdalena Mendez-Lopez
Summary: This systematic review analyzes the evidence of structural and functional alterations in the hippocampus and related cortices caused by SARS-CoV-2 infection, finding that the virus can lead to changes in hippocampal structure and connectivity, resulting in neuropsychological sequelae such as memory deficits.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Psychology, Biological
Alba Gutierrez-Menendez, Marta Mendez, Jorge L. Arias
Summary: Spatial memory encodes, stores, evaluates, and recovers spatial information, and is mainly supported by the hippocampus and its interaction with other structures. Sex differences in spatial tasks have been found in adults, but few studies have examined sex differences in early postnatal development. This study analyzed the performance and metabolic brain activity of juvenile male and female rats in a spatial reference memory task, revealing faster consolidation in females.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Neurosciences
Sara Garces-Arilla, Camino Fidalgo, Magdalena Mendez-Lopez, Jorge Osma, Teresa Peiro, Alicia Salvador, Vanesa Hidalgo
Summary: This study found that women with high neuroticism and moderate extraversion are more susceptible to psychological stress during real-life examinations, exhibiting higher levels of perceived stress, emotional dysregulation, and negative affect. Compared to other women, they also experience higher levels of state anxiety two days before and shortly after the examination. However, their cortisol response is similar to that of other women.
ANXIETY STRESS AND COPING
(2023)
Editorial Material
Computer Science, Software Engineering
Victoria D. Chamizo, Pierre Bourdin, Magdalena Mendez-Lopez, Juan Jose Santamaria
FRONTIERS IN VIRTUAL REALITY
(2023)
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)