Article
Critical Care Medicine
Nagat El-Demerdash, Tiffany Pan, Olivia Choi, Manda Saraswati, Raymond C. Koehler, Courtney L. Robertson, Alena Savonenko
Summary: Therapies for pediatric traumatic brain injury (TBI), especially in young children, are limited and can result in long-term consequences. Animal models have provided insights into the mechanisms of pediatric TBI, but it is challenging to demonstrate clinically relevant long-term behavioral and cognitive deficits. This study used a controlled cortical impact (CCI) model of pediatric TBI to assess short- and long-term outcomes through a series of tests. The results showed functional impairments in most tests for TBI rats compared to control groups, particularly in cognitive processes related to fast one-trial learning, memory flexibility, response strategies, and recognition memory in social interactions.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Behavioral Sciences
C. Leonardo Jimenez Chavez, Eliyana Van Doren, Gavin Scheldrup, Emely Rivera, Jose Torres-Gonzalez, Jessica N. Herbert, Christopher J. E. Denning, Sarah Khorsandi, Andrew Garcia, Marian Castro, Karen K. Szumlinski
Summary: This study found that excessive alcohol consumption has a negative impact on emotional regulation and cognition, with females being more susceptible to these effects. By conducting experiments on male and female mice, it was found that long-term binge drinking has an impact on negative affect and cognitive abilities. The findings have potential significance in understanding individual differences in the onset and treatment of alcohol abuse and alcohol use disorder.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Food Science & Technology
Chi Heung Cho, Young Sung Jung, Jong Min Kim, Tae Gyu Nam, Sang-Hoon Lee, Hye Sung Cho, Myoung Chong Song, Ho Jin Heo, Dae-Ok Kim
Summary: The Actinidia eriantha cv. Bidan extract (AEE) showed neuroprotective effects by reducing reactive oxygen species levels and suppressing apoptotic cell death, resulting in improvements in learning and spatial memory in Aβ1-42-treated mice. AEE also increased endogenous antioxidant systems in mouse brain tissue and contained caffeic acid derivatives, suggesting its potential to improve cognitive function as a source of antioxidant phenolics.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Multidisciplinary Sciences
Seema Gul, Sobia Attaullah, Mahdi H. Alsugoor, Sami Bawazeer, Shahid Ali Shah, Sanaullah Khan, Hafiza Sara Salahuddin, Mujeeb Ullah
Summary: This study evaluated the neuroprotective capability of folicitin against scopolamine-induced Alzheimer's disease neuropathology in mice. The results showed that folicitin could reduce oxidative stress, improve memory impairment and synaptic dysfunction, and inhibit hyperglycemia and hyperlipidemia caused by scopolamine. These findings suggest that folicitin has potential in treating Alzheimer's disease.
Review
Behavioral Sciences
Lucia Amendola, Daniel Weary, Gosia Zobel
Summary: Individual variation in responses to anxiety and spatial memory tests is often reported. These variations are related to consistent individual differences in behavior (personality). However, personality differences are rarely considered in anxiety treatment studies. This article focuses on rat literature to describe principles in anxiety and spatial memory tests and discusses the influence of personality and housing conditions on behavioral responses. The authors propose that environmental enrichment can enhance stress resiliency in environmentally sensitive individuals. Incorporating personality measures into study design and analysis can improve research reproducibility.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Pharmacology & Pharmacy
Zahra Gholami Mahmoudian, Ali Ghanbari, Iraj Rashidi, Iraj Amiri, Alireza Komaki
Summary: This study investigated the effects of minocycline on cognitive abilities, antioxidant enzyme activities, neuronal loss, and plaque number in rats with Alzheimer's disease induced by Aβ. The results showed that minocycline improved anxiety behavior, restored learning and memory deficits, and had antioxidant and anti-apoptotic effects.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Leila Karimi-Zandi, Maryam Zahmatkesh, Gholamreza Hassanzadeh, Soheila Hosseinzadeh
Summary: This study found an increase in fractalkine-positive microvesicles in the early stages of Alzheimer's disease, suggesting their potential as a biomarker for early diagnosis.
Article
Behavioral Sciences
Soniya Assudani Patel, Karyn M. Frick, Paul A. Newhouse, Robert S. Astur
Summary: The study examined the role of estradiol in hippocampal-dependent spatial memory in women. Results showed that the high estradiol group demonstrated superior spatial reference memory, while the low estradiol group exhibited the poorest probe trial performance. There were no group differences in performance on the virtual memory tasks.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jagadeesh Dhamodharan, Ganthimathy Sekhar, Arunachalam Muthuraman
Summary: This study aimed to explore the ameliorative potential of gefitinib (GE) in Alzheimer's disease (AD) mice. The results showed that GE significantly improved AD-associated behavioral, biochemical, and histopathological changes by inhibiting EGFR kinase activation and having antioxidant and antilipid peroxidative effects against A beta(1-42) oligomer-induced neurotoxicity.
Article
Neurosciences
Lisa Wintzell, Samuel Klemetz, Stefan Lange, Eric Hanse, Caroline Wass, Joakim Strandberg
Summary: The endogenous peptide antisecretory factor (AF) enhances long-term potentiation (LTP) and spatial learning and memory by disinhibiting GABAergic transmission in the rat hippocampus.
Article
Behavioral Sciences
Amanda Dyer, Maxine De Butte
Summary: This study aimed to examine the effects of chronic low-dose vanadium administration on the behavior of young male rats. The findings suggest that vanadium does not significantly affect exploration, locomotion, or anxiety-like behavior in rats, but does affect novel object recognition performance. Additionally, vanadium administration led to lower latency times in the Morris Water maze task.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Behavioral Sciences
M. Taheri, S. H. Oryan, D. Eslimi Esfahani, H. Mohseni Kouchesfahani, A. Salari
Summary: The hydroalcoholic extract of Artemisia absinthium shows significant improvement in spatial memory and neuronal injury in a rat model of Alzheimer's disease, reducing amyloid-beta plaques and apoptosis.
NEUROBIOLOGY OF LEARNING AND MEMORY
(2021)
Article
Biochemistry & Molecular Biology
Maria Kovalska, Eva Baranovicova, Dagmar Kalenska, Anna Tomascova, Marian Adamkov, Libusa Kovalska, Jan Lehotsky
Summary: This study induced mild hyperhomocysteinemia in adult male Wistar rats using a diet enriched with L-methionine, leading to alterations in plasma metabolome, behavioral patterns, and histomorphological changes in the vulnerable hippocampal CA 1 area. The results suggest that mild hyperhomocysteinemia can have negative effects on nervous tissue, likely due to the changes induced by high methionine intake.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Pochkhidze Nino, Zhvania Mzia, Japaridze Nadezhda, Tizabi Yousef, Lobzhanidze Giorgi, Lordkipanidze Tamar
Summary: Addiction to toluene-containing volatile inhalants is a significant concern, especially among youth. The lasting effects of chronic toluene exposure in different age groups have not been well studied. This study found that adolescent and adult rats showed differential responses to chronic toluene exposure, indicating the importance of considering age-dependent effects in interventions.
NEUROSCIENCE LETTERS
(2023)
Article
Engineering, Biomedical
Aria W. Tarudji, Connor C. Gee, Sarah M. Romereim, Anthony J. Convertine, Forrest M. Kievit
Summary: Utilizing antioxidant nanoparticles NP1, this study demonstrates a potential treatment strategy to reduce secondary spread of traumatic brain injury. The NP1 treatment protected mice from learning and memory deficits induced by injury, likely through reduction of oxidative stress and spread of neuroinflammation. These findings suggest that NP1-mediated reduction in post-traumatic oxidative stress correlates with protection of spatial memory and learning, offering an improved therapeutic approach for TBI.
Article
Oncology
Shi Yu, Yue Hei, Weiping Liu
Article
Biotechnology & Applied Microbiology
Zhengyu Li, Shuaijun Jia, Zhuo Xiong, Qianfa Long, Shaorong Yan, Fu Hao, Jian Liu, Zhi Yuan
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
(2018)
Article
Neurosciences
Yue Hei, Rong Chen, Xicai Yi, Qianfa Long, Dakuan Gao, Weiping Liu
Article
Geriatrics & Gerontology
Yue Hei, Rong Chen, Xicai Yi, Lizhou Wei, Qianfa Long, Weiping Liu
FRONTIERS IN AGING NEUROSCIENCE
(2018)
Letter
Clinical Neurology
Tianwei Wang, Qianfa Long, Ting Gao
Article
Cell Biology
Yue Hei, Xin Zhang, Rong Chen, Yuefei Zhou, Dakuan Gao, Weiping Liu
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2019)
Article
Neurosciences
Shi Yu, Hujing Zhang, Yue Hei, Xicai Yi, Andrius Baskys, Weiping Liu, Qianfa Long
Article
Multidisciplinary Sciences
Zhi-Qin Liu, Jing-Jing Ren, Jun-Long Zhao, Jian Zang, Qian-Fa Long, Jing-Jing Du, Xiao-Tao Jia, Nai-Bing Gu, Zheng-Li Di, Yi-Hua Qian, San-Zhong Li
SCIENTIFIC REPORTS
(2020)
Article
Engineering, Biomedical
Tian Wang, Zhe Jian, Andrius Baskys, Junle Yang, Jianying Li, Hua Guo, Yue Hei, Panpan Xian, Zhongzheng He, Zhengyu Li, Namiao Li, Qianfa Long
Article
Oncology
Jiale Zhang, Yangyang Li, Yuqi Liu, Guangzhi Xu, Yue Hei, Xiaoming Lu, Weiping Liu
Summary: NEAT1 acts as a competitive endogenous RNA for miR-324-5p in glioma, regulating KCTD20 expression and affecting cell proliferation and apoptosis. This NEAT1/miR-324-5p/KCTD20 axis represents a novel regulatory mechanism and potential therapeutic target for human glioma.
Article
Medicine, Research & Experimental
Panpan Xian, Yue Hei, Rui Wang, Tian Wang, Junle Yang, Jianying Li, Zhengli Di, Zhiqin Liu, Andrius Baskys, Weiping Liu, Shengxi Wu, Qianfa Long
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)
