期刊
APPLIED MATHEMATICAL MODELLING
卷 71, 期 -, 页码 286-297出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.apm.2019.01.044
关键词
Elastic net; Conditional mutual information; Cancer diagnosis; Microarray data classification
资金
- Key Project of Science and Technology of Henan Province [182102410069]
Due to the advantage of achieving a better performance under weak regularization, elastic net has attracted wide attention in statistics, machine learning, bioinformatics, and other fields. In particular, a variation of the elastic net, adaptive elastic net (AEN), integrates the adaptive grouping effect. In this paper, we aim to develop a new algorithm: Adaptive Elastic Net with Conditional Mutual Information (AEN-CMI) that further improves AEN by incorporating conditional mutual information into the gene selection process. We apply this new algorithm to screen significant genes for two kinds of cancers: colon cancer and leukemia. Compared with other algorithms including Support Vector Machine, Classic Elastic Net, Adaptive Lasso and Adaptive Elastic Net, the proposed algorithm, AEN-CMI, obtains the best classification performance using the least number of genes. (C) 2019 Elsevier Inc. All rights reserved.
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