期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 63, 期 10, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00955-19
关键词
Enterobacter cloacae complex; avibactam; omega loop
资金
- University of Pittsburgh Department of Medicine
- National Institutes of Health [R00EY028222, K08AI114883, R03AI144636, R01AI104895, R21AI135522]
We report patient-to-patient transmission of Enterobacter hormaechei isolates with reduced susceptibility to ceftazidime-avibactam due to production of KPC-40, a variant of KPC-3 with a two-amino-acid insertion in the fl-loop region (L167_E168dup). The index patient had received a prolonged course of ceftazidime-avibactam therapy, whereas the second patient had not received the agent and still became colonized with the KPC-40-producing strain. The complex dynamics of KPC (Klebsiella pneumoniae carbapenemase) described here highlight several key diagnostic and therapeutic considerations.
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