期刊
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 15, 2020
卷 15, 期 -, 页码 1-22出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-pathmechdis-012418-013013
关键词
bile duct; liver development; biliary disease; differentiation; morphogenesis; gene network
类别
资金
- D.G. Higher Education and Scientific Research of the French Community of Belgium [ARC 15/20-065]
- Fonds pour la Formation a la Recherche dans l'Industrie et dans l'Agronomie in Belgium [1.E071.18, 1.E053.19F]
- Assistance Publique-Hopitaux de Paris in France (grant iLITE)
The involvement of the biliary tract in the pathophysiology of liver diseases and the increased attention paid to bile ducts in the bioconstruction of liver tissue for regenerative therapy have fueled intense research into the fundamental mechanisms of biliary development. Here, I review the molecular, cellular and tissular mechanisms driving differentiation and morphogenesis of the intrahepatic and extrahepatic bile ducts. This review focuses on the dynamics of the transcriptional and signaling modules that promote biliary development in human and mouse liver and discusses studies in which the use of zebrafish uncovered unexplored processes in mammalian biliary development. The review concludes by providing a framework for interpreting the mechanisms that may help us understand the origin of congenital biliary diseases.
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