期刊
ANNALS OF BIOMEDICAL ENGINEERING
卷 48, 期 1, 页码 169-180出版社
SPRINGER
DOI: 10.1007/s10439-019-02324-y
关键词
TAVR; Coronary flow; Neo-sinus; Flow Stasis; Thrombosis; Particle image velocimetry
资金
- BME Gurley Foundation
- Mary and James Wesley Fellowship Endowment
- Wallace H Coulter Endowed Chair
Transcatheter heart valve (THV) leaflet thrombosis in the neo-sinus and associated reduced leaflet motion is of clinical concern due to risks of embolism and worsened valve hemodynamics. Flow stasis in the neo-sinus (the space between the native and THV leaflets) is a known risk factor, but the role of proximal coronary flow is yet to be investigated. We tested two replicas of FDA approved commercial THVs-intra-annular and supra-annular (similar to the SAPIEN 3 and CoreValve families)-in a left heart simulator with coronary flow. Velocity fields in the left coronary cusp (LCC) and non (NCC) neo-sinus were quantified using high speed particle image velocimetry and particle residence times (PRT) were computed to evaluate flow stasis in the region. The supra-annular THV LCC neosinus had shorter PRT than its NCC neo-sinus (0.66 +/- 0.00 vs. 0.76 +/- 0.04, p = 0.038), while the intra-annular THV LCC neo-sinus had similar PRT to its NCC neo-sinus (1.93 +/- 0.05 vs. 1.92 +/- 0.03 cycles, p = 0.889). The supraannular valve LCC and NCC neo-sinuses had shorter PRT than their intra-annular valve counterparts (p < 0.001). These results showed that coronary flow reduces flow stasis in the supra-annular THV neo-sinus and, ostensibly, thrombosis risk in the region. This effect was not significant in the intra-annular valve.
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