Article
Materials Science, Ceramics
Krishna K. Pawar, Sawanta S. Mali, Yuvraj H. Navale, Vikas B. Patil, Kiran K. Sharma, Chang K. Hong, Pramod S. Patil
Summary: Porous nanoarchitectures of metal oxide semiconductors offer high surface area and active sites for various applications. The fabrication of porous Indium oxide nanocubes through a surfactant-based biogenic hydrothermal method and nanoscale Kirkendall effect were reported. The resulting PINC-based film sensor exhibited high sensitivity and selectivity towards NO2 gas.
CERAMICS INTERNATIONAL
(2021)
Article
Spectroscopy
Hui Guo, Xiaohui Ren, Xinyue Song, Xin Li
Summary: In this study, a 300 nm-sized silver-coated silica (SiO2@Ag) surface-enhanced Raman scattering (SERS) substrate was fabricated. SiO2@Ag@molecular imprinted polymers (SiO2@Ag@MIPs) were designed based on SiO2@Ag to selectively detect amoxicillin by coating a molecular imprinted layer thinner than 10 nm on SiO2@Ag. The prepared SERS-active substrate showed excellent enhancement for amoxicillin, with enhancement factors of 1.63 x 106 for SiO2@Ag@MIPs and 2.97 x 105 for SiO2@Ag, respectively. The SiO2@Ag@MIPs core-shell hybrids served as sensitive SERS substrates, achieving a minimum detectable concentration of amoxicillin as low as 2.7 x 10-9 M, while the detection limit for SiO2@Ag was 2.7 x 10-7 M. A linear relationship between intensities of characteristic peaks and concentrations of amoxicillin was established. Both SiO2@Ag and SiO2@Ag@MIPs substrates showed high sensitivity and could be used for qualitative and semi-quantitative analysis of amoxicillin in aqueous media with good linear correlations. Based on these findings, SiO2@Ag@MIPs hold promise for the detection of actual samples and expansion of practical applications.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Spectroscopy
Nguyen Tran Truc Phuong, Thi Xoan Hoang, Nguyen La Ngoc Tran, Lam Gia Phuc, Viet-Duc Phung, Hanh Kieu Thi Ta, Ta Ngoc Bach, Nhu Hoa Thi Tran, Kieu The Loan Trinh
Summary: The use of dye in food is harmful to human health and prohibited, but still exists due to benefits like cheap prices and abundant resources. Research shows that surface-enhanced Raman scattering (SERS) is a powerful technique for sensitive detection of ultra-low concentration Rhodamine B, thus aiding in preventing health risks to human.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Analytical
Li Guo, Jing Huang, Yaxin Chen, Bohan Zhang, Minbiao Ji
Summary: In this study, metal-lined hollow-core fiber (MLHCF) was used to improve the sensitivity of stimulated Raman scattering (SRS) in sensing dilute solutions. By extending the light-matter interaction volume, MLHCF showed significant enhancement and suppressed cross-phase modulation (XPM) background at a certain fiber length. The fiber-enhanced SRS (FE-SRS) method has potential in sensitive detection of molecules in solution and gas phases.
Article
Chemistry, Analytical
Tao Xie, Pan Li, Jiazheng Wang, Ronglu Dong, Liangbao Yang
Summary: The catassembly method allows for the rapid and simple self-assembly of highly repeatable large-scale multilayers with small nanoparticles. The plasmonic multilayers formed using this method demonstrate high sensitivity and stability for SERS sensing applications.
ANALYTICAL CHEMISTRY
(2023)
Review
Chemistry, Physical
Ryan D. Norton, Hoa T. Phan, Stephanie N. Gibbons, Amanda J. Haes
Summary: This review discusses the recent advances in quantitative SERS detection, focusing on intermolecular interactions, surface selection rules, and target molecule solubility and accessibility. The impacts of surface selection rules and enhancement mechanisms on the activation and deactivation of normal Raman modes in SERS are explored. The review also summarizes the experimental conditions that can be used to tune the molecular affinity to and density near SERS substrates.
ANNUAL REVIEW OF PHYSICAL CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Jun Dong, Wanting Zhou, Chengyuan Yang, Haoran Wu, Qingyan Han, Chengyun Zhang, Wei Gao, Xuewen Yan, Mengtao Sun
Summary: The absorption and scattering frequencies of surface plasmon resonance can be adjusted by changing the morphology, size, structure, arrangement, and gap between noble metal nanoparticles. This enhances the local electromagnetic field on the substrate surface, promoting surface-enhanced Raman spectroscopy.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Multidisciplinary Sciences
Lukas Grote, Martin Seyrich, Ralph Dohrmann, Sani Y. Harouna-Mayer, Federica Mancini, Emilis Kaziukenas, Irene Fernandez-Cuesta, Cecilia A. Zito, Olga Vasylieva, Felix Wittwer, Michal Odstrczil, Natnael Mogos, Mirko Landmann, Christian G. Schroer, Dorota Koziej
Summary: Understanding morphological changes of nanoparticles in solution is crucial for tailoring the functionality of energy devices. However, there is a lack of experimental methods that can visualize these processes in solution and provide three-dimensional information. This study demonstrates the use of X-ray ptychography for in situ 3D imaging of the formation and hollowing of nanoparticles in solution at high temperature.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Puran Pandey, Kihoon Shin, A-Rang Jang, Min-Kyu Seo, Woong-Ki Hong, Jung Inn Sohn
Summary: This study demonstrates highly sensitive multiplex-detection of organic dyes using SERS substrates with self-assembly arrays of porous AuAg alloy (p-AuAg) NPs, showing excellent enhancement, reproducibility, and detection limits. The high-density built-in and inter nanogaps in the self-assembly arrays of p-AuAg NPs contribute to the significant enhancement of electromagnetic field, supporting potential pathways for practical SERS applications.
JOURNAL OF ALLOYS AND COMPOUNDS
(2021)
Article
Biophysics
Hao-Cheng Hu, Shao-Hua Wu, Lei-Xin Jin, Jian-Jun Sun
Summary: This work proposes a novel SERS biosensing platform for highly sensitive detection of DNA adenine methylation with the combination of heated Au electrode and strand displacement amplification strategy. The proposed biosensors exhibit high sensitivity in detecting the Dam MTase activity and have the potential for detecting Dam MTase activity in real biological samples.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
Zhengying Peng, Youyuan Chen, Pengkun Yin, Fan He, Daibing Luo, Yixiang Duan, Qingwen Fan, Zhimei Wei, Qingyu Lin
Summary: A highly sensitive cytosensor based on surface-enhanced Raman scattering (SERS) was developed for rapid tumor cell detection in biological samples. This cytosensor exhibited good linearity and a low limit of detection, demonstrating high sensitivity and reproducibility.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Yanzhao Pang, Mingliang Jin
Summary: A highly aligned AgNW array film was prepared using a self-assembly method, which showed excellent signal reproducibility and detection ability at low concentrations. The uniform distribution of hot spots inside the AgNW substrate amplified the SERS signal.
Article
Nanoscience & Nanotechnology
Shuang Lin, Haoyu Guan, Yuqi Liu, Shinian Huang, Junming Li, Wuliji Hasi, Yizhuo Xu, Jixin Zou, Bin Dong
Summary: Tuning and controlling the plasmon coupling of noble metal nanoparticles are crucial for enhancing their responses in near-field and far-field. A novel heterogeneous plasmonic assembly with a controllable hot spot model was proposed in this work, showing significant enhancement for SERS behavior in point-to-facet hotspots. The binary assemblies of Au NS doping in Au@Ag NCs demonstrate excellent sensitivity and high reproducibility in the identification of ketamine, indicating a new avenue for fabricating plasmonic metal materials with collective LSPR properties and sensitive SERS behavior.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Analytical
Yuxue Zhang, Gang Wu, Jiata Wei, Yanlei Ding, Yingming Wei, Qiqi Liu, Hailan Chen
Summary: A surface-enhanced Raman scattering immunochromatographic assay using Au-core Ag-shell nanoparticles has been developed for the rapid, ultrasensitive, and quantitative detection of rotavirus. The method shows high sensitivity, selectivity, reproducibility, and accuracy in detecting rotavirus in clinical samples.
Article
Nanoscience & Nanotechnology
Yanlin Li, Wenyuan Duan, Jian Wei
Summary: The study synthesized CoFe2O4/Ag nanostructures as SERS substrates with high sensitivity, good stability, and excellent magnetic response for efficient separation and reusability.
ACS APPLIED NANO MATERIALS
(2021)
Article
Chemistry, Physical
Jieun Shin, Sungwoo Lee, Sungjae Yoo, Insub Jung, Soohyun Lee, Jeongwon Kim, Jiwoong Son, Ji-Eun Kim, Jae-Myoung Kim, Jwa-Min Nam, Sungho Park
Summary: To enhance the near-field focusing around nanoscale metal particles, we designed large-sized gold double nanorings with nanoscale gaps between them. These gaps resemble hot halos where single-particle surface-enhanced Raman scattering occurs. The synthesis of these gold nanohalos was achieved using a novel strategy based on hexagonal gold nanoplates as templates. The resulting nanohalos exhibited near-field focusing, confirmed by both experimental measurements and theoretical simulation. The study also revealed a correlation between the distances of intra-nanogaps and particle sizes of gold nanohalos on single-particle surface-enhanced Raman scattering, with high enhancement factors and reproducibility.
CHEMISTRY OF MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Sungeun Go, Sungjae Yoo, Jiwoong Son, Soohyun Lee, Jaewon Lee, Sungwoo Lee, Jeongwon Kim, Minsun Park, Woocheol Park, Jae-Myoung Kim, Jwa-Min Nam, Sungho Park
Summary: The development of a stepwise synthetic strategy for Au ring-in-a-triangle nanoframes is crucial for highly amplified near-field focusing and successful single-particle surface-enhanced Raman scattering (SERS). The presence of inscribed nanorings plays a significant role in enhancing the lightning rod effect. The evaluation of single-particle SERS and the construction of two-dimensional SERS substrates contribute to the outstanding linearity of the calibration curve and the lowest limit of detection.
Article
Chemistry, Multidisciplinary
Woongsun Choi, Eunhye Park, Seojin Bae, Kyung-Hak Choi, Sangeun Han, Kuk-Hui Son, Do Young Lee, Il-Joo Cho, Hyejeong Seong, Kyo Seon Hwang, Jwa-Min Nam, Jungkyu Choi, Hyojin Lee, Nakwon Choi
Summary: This study presents a novel technology, SWITCH, for PCR-free, multiplex SNP genotyping with a single reporting fluorophore. The technology successfully demonstrated 4-plex detection of warfarin-associated SNP targets with excellent specificity.
Article
Chemistry, Multidisciplinary
Soohyun Lee, Insub Jung, Jiwoong Son, Sungwoo Lee, Minsun Park, Ji-Eun Kim, Woocheol Park, Jaewon Lee, Jwa-Min Nam, Sungho Park
Summary: We report a synthetic approach for the fabrication of intertwined heterometallic nanorings, in which three differently sized metal rings overlap concentrically. The synthetic method allows control over the core ring component and tunable gap distance. The narrow circular nanogaps between inner and outer Au rings enhance electromagnetic near-field, enabling surface-enhanced Raman scattering at the single-particle level. In particular, when the middle ring component is Pt, the in situ SERS measurement of electrochemical reactions on Pt domains can be monitored due to the near-field focusing assisted by plasmonic Au nanorings.
Editorial Material
Chemistry, Multidisciplinary
Nanshu Lu, Jwa-Min Nam
Review
Chemistry, Multidisciplinary
Da Yeon Choi, Suhyun Kim, Jeong-Wook Oh, Jwa-Min Nam
Summary: DNA-modified gold nanoparticles play important roles in constructing three-dimensional assembly structures and biomedical applications. As ligand molecules, DNA strands can facilitate the building block function of gold nanoparticles due to their inherent bonding nature. Additionally, the negative electrostatic character of DNA backbones ensures the stability and robustness of colloidal gold nanoparticles in various aqueous environments. Therefore, DNA conjugation to gold nanoparticle surfaces is a crucial step for stabilizing, controlling, and utilizing DNA-modified gold nanoparticles, and the appropriate conjugation strategy should be chosen and implemented based on specific applications. This review discusses various DNA conjugation strategies to gold nanoparticles with different functional groups, as well as the importance of DNA grafting density and directional grafting strategies in constructing three-dimensional nanoparticle assembly structures through DNA hybridization.
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Jae-Myoung Kim, Jiyeon Kim, Kyungin Choi, Jwa-Min Nam
Summary: Metal nanostructures with a tunable plasmonic gap are synthesized for various applications. A plasmonic nanostructure with tunable dual nanogaps, called Au dual-gap nanodumbbells (AuDGNs), is designed and synthesized with high yield. These AuDGNs enable label-free on-particle SERS detection assays and show high specificity and sensitivity without the need for Raman dyes.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Niko Hildebrandt, Mihye Lim, Namjun Kim, Da Yeon Choi, Jwa-Min Nam
Summary: Plasmonic metal nanoparticles and semiconductor quantum dots are widely used nanomaterials in optical biosensing and bioimaging. While their combination for fluorescence quenching via nanosurface energy transfer or Forster resonance energy transfer is common, metal-QD nanohybrids for plasmon-enhanced fluorescence have been less prevalent. This article discusses the challenges in optimizing distances, orientations, and spectral overlap for maximum plasmon-enhanced fluorescence and reviews the different nanomaterials, their combinations, and applications in advanced optical biosensing and bioimaging.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Jiwoong Son, Gyeong-Hwan Kim, Yeonhee Lee, Chungyeon Lee, Seungsang Cha, Jwa-Min Nam
Summary: This article discusses the principles and applications of surface-enhanced Raman scattering (SERS) and focuses on the design principles and key issues of plasmonic nanoparticle substrates. The article highlights the limited controllability and uniformity of plasmonic nanoparticles, as well as the challenges in molecular modification chemistry and analytical protocols for SERS. The article also introduces recent advances in the uniform and controllable synthesis of plasmonic nanoparticle systems and the emerging machine learning-based analysis for quantitative SERS. Overall, this perspective provides insights into the challenges and potential solutions in utilizing plasmonic nanoparticle systems for reliable quantitative measurement of molecules.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Jeongwon Kim, Sungwoo Lee, Jiwoong Son, Jieun Kim, Hajir Hilal, Minsun Park, Insub Jung, Jwa-Min Nam, Sungho Park
Summary: Rational design of plasmonic colloidal assemblies via bottom-up synthesis is challenging but can demonstrate unprecedented optical properties that are strongly related to the shape and spatial arrangement of the assembly. In this study, plasmonic cyclic Au nanosphere hexamers (PCHs) were successfully synthesized and showed excellent performance in single-particle surface-enhanced Raman scattering signals.
Article
Chemistry, Multidisciplinary
Kunlun Jiang, Jingrui Wu, Ji-Eun Kim, Sujin An, Jwa-Min Nam, Yung-Kang Peng, Jung-Hoon Lee
Summary: A novel plasmonic cross-linking colorimetric PCR (PPTccPCR) assay is proposed by integrating plasmonic magnetic nanoparticle (PMN)-based PPT-PCR with gold nanoparticle (AuNP) cross-linking colorimetry. This method enables visual detection of target DNA with concentrations as low as 5 copies/μL within 40 minutes. The simple and sensitive strategy does not require expensive instrumentation and has high potential for clinical diagnostic applications.
Article
Nanoscience & Nanotechnology
Sung Hun Park, Haedong Park, Jwa-Min Nam, Yonggang Ke, Tim Liedl, Ye Tian, Seungwoo Lee
Summary: Moulding the flow of phononic waves in 3D space is critical for controlling sound and thermal properties. DNA origami-designed 3D crystals can serve as hypersonic 3D phononic crystals (PnCs) with the widest complete phononic bandgap (PnBG). This provides a blueprint for the design and fabrication of mesoscale 3D PnCs with optimal lattice geometry.
Review
Chemistry, Physical
Eunhye Park, So Young Choi, Jieun Kim, Niko Hildebrandt, Jin Seok Lee, Jwa-Min Nam
Summary: This article introduces the important role of nanotechnology in the diagnosis and treatment of COVID-19. For SARS-CoV-2 and its variants, nanomaterial-based diagnostic and therapeutic strategies, including nucleic acid- and antigen-targeting diagnostic methods and viral activity suppression approaches, are discussed.
Review
Chemistry, Multidisciplinary
Seongchan Kim, Taegon Oh, Hyojin Lee, Jwa-Min Nam
Summary: This article reviews the various types of nanoparticles used as delivery vehicles in clinical therapeutic applications, discussing their advantageous properties and functions, as well as the issues and limitations. The strategies to overcome biological barriers and harsh physiological conditions are summarized, and green synthesis methods and their environmental impacts are introduced and discussed. The article also provides perspectives on the biocompatibility, toxicity and environmental consequences of nanoparticles developed for biomedical applications.
MATERIALS CHEMISTRY FRONTIERS
(2022)
Review
Chemistry, Multidisciplinary
Yoonhee Kim, Seungsang Cha, Jae-Ho Kim, Jeong-Wook Oh, Jwa-Min Nam
Summary: The mechanisms underlying the electrochromism of plasmonic metal nanoparticles can be categorized into four types based on the origin of the LSPR shift: capacitive charging model, faradaic reactions, non-faradaic reactions, and electrochemically active functional molecule-mediated mechanism. Recent efforts have focused on synchronizing simulation with experimental results and overcoming the inherently small LSPR change of plasmonic metal nanoparticles.
