Review
Biochemistry & Molecular Biology
Annarosa Floreani, Daniela Gabbia, Sara De Martin
Summary: Primary biliary cholangitis (PBC) is a rare autoimmune liver disease with limited treatment options. Ursodeoxycholic acid (UDCA) is the first-line therapy but is ineffective for a significant portion of patients. Obeticholic acid (OCA) is an effective second-line treatment for UDCA-non responders. Future therapies for PBC are promising.
Review
Biochemistry & Molecular Biology
Annarosa Floreani, Daniela Gabbia, Sara De Martin
Summary: Ursodeoxycholic acid is the first-line therapy for PBC, but new pharmacological agents are being proposed for UDCA-non-responders. Obeticholic acid and fibrates have shown effectiveness in improving biochemistry alteration and symptoms of PBC. Other new agents with different mechanisms of action are also under clinical evaluation for PBC treatment.
Article
Immunology
Haolong Li, Haoting Zhan, Linlin Cheng, Yuan Huang, Xiaomeng Li, Songxin Yan, Yongmei Liu, Li Wang, Yongzhe Li
Summary: This study analyzed the plasma lipid profiles of patients with primary biliary cholangitis (PBC) and Sjogren's syndrome (SS). The results showed that PBC patients had 115 upregulated lipids compared to healthy controls, and 17 lipids were associated with disease activity and could differentiate UDCA responders from non-responders. Compared to SS, PBC patients had 44 upregulated lipids, and 8 lipids were identified as potential diagnostic markers for PBC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Weijia Han, Chunyang Huang, Qi Zhang, Shuhui Tao, Xiaomin Hu, Jianguo Xu, Ronglong Jiang, Bin Xu, Yanmin Liu, Jinlin Hou
Summary: The study found that the TB level in PBC patients treated with UCDA for 12 months is associated with a distinct gut microbiome profile. Lower bacterial diversity was observed in patients with elevated TB levels, along with differential abundance of certain bacterial genera. The findings indicate a potential relationship between gut microbiota dysbiosis and TB levels in PBC patients.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Biochemistry & Molecular Biology
Yaqin Zhang, Ziying Jiao, Mingwei Chen, Bing Shen, Zongwen Shuai
Summary: Primary biliary cholangitis (PBC) is an autoimmune-mediated liver disease characterized by progressive damage and destruction of bile duct epithelial cells. Non-coding RNA plays a crucial role in the pathogenesis and biological processes of PBC and can serve as potential biomarkers for diagnosis and treatment.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Gastroenterology & Hepatology
Yuki Yamashita, Takeji Umemura, Takefumi Kimura, Satoru Joshita, Junko Hirohara, Toshiaki Nakano, Atsumasa Komori, Atsushi Tanaka
Summary: This study showed that baseline ALBI grade is a simple non-invasive predictor for prognosis in PBC, and it is significantly associated with histological stage and disease progression. ALBI score/grade can be used to assess liver function and predict mortality and the need for liver transplantation in PBC patients.
Article
Medicine, Research & Experimental
Haifu Zhang, Shuojun Li, Yonghang Feng, Qinxia Zhang, Biyun Xie
Summary: Fibrates have shown promising results in improving liver biochemical parameters and relieving pruritus symptoms in patients with primary biliary cholangitis (PBC), without significantly increasing the incidence of treatment-related side effects.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Mayumi Yamaguchi, Takeharu Asano, Takahiro Arisaka, Hirosato Mashima, Atsushi Irisawa, Masaya Tamano
Summary: The use of pemafibrate (PEM) is effective in PBC patients with dyslipidemia, particularly in those who are refractory to UDCA monotherapy. Patients using both UDCA and BEZ may benefit from switching to PEM, especially if they have renal damage.
HEPATOLOGY RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Kyung-Ah Kim, Hwa Young Choi, Moran Ki, Eun Sun Jang, Sook-Hyang Jeong
Summary: This study investigated the epidemiology and outcomes of primary biliary cholangitis (PBC) in South Korea between 2009 and 2019. The results showed a significant increase in the incidence and prevalence of PBC during this period. Male sex and low adherence to UDCA treatment were associated with worse prognosis for PBC.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Pharmacology & Pharmacy
Guilherme Grossi Lopes Cancado, Claudia Alves Couto, Laura Vilar Guedes, Michelle Harriz Braga, Debora Raquel Benedita Terrabuio, Eduardo Luiz Rachid Cancado, Maria Lucia Gomes Ferraz, Cristiane Alves Villela-Nogueira, Mateus Jorge Nardelli, Luciana Costa Faria, Elze Maria Gomes de Oliveira, Vivian Rotman, Daniel Ferraz de Campos Mazo, Valeria Ferreira de Almeida e Borges, Liliana Sampaio Costa Mendes, Liana Codes, Mario Guimaraes Pessoa, Izabelle Venturini Signorelli, Cynthia Levy, Paulo Lisboa Bittencourt
Summary: This exploratory study aimed to evaluate the long-term biochemical response of different fibrates, including ciprofibrate, in patients with UDCA-unresponsive primary biliary cholangitis (PBC). The study found that combination therapy with fibrates significantly improved the biochemical parameters of PBC patients, with a notable decrease in ALT and ALP after 2 years of treatment and improvement in GGT in the first year. Ciprofibrate appeared to be as effective as bezafibrate in the treatment response rates at 1 and 2 years.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Gastroenterology & Hepatology
Abigail Medford, Jonathan Childs, Ashleigh Little, Sanjukta Chakraborty, Leonardo Baiocchi, Gianfranco Alpini, Shannon Glaser
Summary: The liver plays a crucial role in various metabolic and regulatory processes in the body. Primary biliary cholangitis (PBC) is a chronic autoimmune disease characterized by bile duct inflammation and loss of tolerance to mitochondrial antigens. Ursodeoxycholic acid (UDCA) is currently the first-line treatment for PBC, but additional therapeutics can also be used to manage symptoms and slow disease progression. Liver transplantation is the only potentially curative option for end-stage liver disease or intractable pruritus. This review aims to provide insights into the pathogenesis of PBC and discuss current therapeutic strategies.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Guilherme Grossi Lopes Cancado, Michelle Harriz Braga, Maria Lucia Gomes Ferraz, Cristiane Alves Villela-Nogueira, Debora Raquel Benedita Terrabuio, Eduardo Luiz Rachid Cancado, Mateus Jorge Nardelli, Luciana Costa Faria, Nathalia Mota de Faria Gomes, Elze Maria Gomes Oliveira, Vivian Rotman, Maria Beatriz Oliveira, Simone Muniz Carvalho Fernandes da Cunha, Marlone Cunha-Silva, Liliana Sampaio Costa Mendes, Claudia Alexandra Pontes Ivantes, Liana Codes, Valeria Ferreira Borges, Fabio Heleno de Lima Pace, Mario Guimaraes Pessoa, Izabelle Venturini Signorelli, Gabriela Perdomo Coral, Paulo Lisboa Bittencourt, Cynthia Levy, Claudia Alves Couto
Summary: AMA-negative PBC patients in a large non-white admixed Brazilian cohort are similar to their AMA-positive counterparts with subtle differences observed in clinical and laboratory features, such as younger age at onset, earlier onset of first symptoms, higher frequency of type 2 diabetes, and differences in certain biochemical markers.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Eric F. Martin
Summary: The number of liver transplantation for primary biliary cholangitis (PBC) has decreased over the years, but it remains an important and curative option for progressive PBC patients. Recent studies from the Global PBC Study Group have provided valuable insights into the changes in PBC before and after liver transplantation.
CLINICS IN LIVER DISEASE
(2022)
Article
Gastroenterology & Hepatology
Anna Reig, Carmen Alvarez-Navascues, Mercedes Vergara, Elena Gomez-Dominguez, Adolfo Gallego-Moya, Indhira M. Perez-Medrano, Emilio Fabrega, Manuel Hernandez-Guerra, Marina Berenguer, Pamela Estevez, Ana Arencibia, Rosa M. Morillas, Diana Horta, Agustin Albillos, Marta Casado, Gema De la Cruz, Eva Fernandez-Bonilla, Esther Molina, Lander Hijona, Moises Diago, Conrado M. Fernandez-Rodriguez, Jesus M. Gonzalez-Santiago, Margarita Sala, Judith Gomez-Camarero, Manuel Romero-Gomez, Francisco Suarez, Victor Vargas, Carlos Ferre-Aracil, Raul J. Andrade, Nadia Chahri, Albert Pares
Summary: The therapy of OCA and fibrates can improve hepatic biochemistry and the GLOBE score in patients with primary biliary cholangitis, and simultaneous treatment with both can also improve ALP levels.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Kazuhito Kawata, Satoru Joshita, Shinji Shimoda, Yuki Yamashita, Maho Yamashita, Kensuke Kitsugi, Shingo Takatori, Kazuyoshi Ohta, Jun Ito, Shin Shimoyama, Hidenao Noritake, Takafumi Suda, Kenichi Harada
Summary: The URS can predict the biochemical response to UDCA treatment in PBC patients, as well as reflect histopathological features before treatment. This scoring system can identify inadequate histological response to UDCA treatment in the Scheuer classification and the Nakanuma system.
HEPATOLOGY RESEARCH
(2021)
Review
Gastroenterology & Hepatology
Hirsh D. Trivedi, Emily W. Lopes, Jeremy Glissen Brown, Shaan Dudani, Michelle Lai, Joseph D. Feuerstein, Theodore T. Pierce
Summary: This meta-analysis found no association between steroids and nonalcoholic fatty liver disease (NAFLD) among patients with inflammatory bowel disease (IBD). Therefore, steroids may not need to be withheld from patients with IBD for the purposes of preventing NAFLD.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Annika Bergquist, Tobias J. Weismueller, Cynthia Levy, Christian Rupp, Deepak Joshi, Jeremy Shanika Nayagam, Aldo J. Montano-Loza, Ellina Lytvyak, Ewa Wunsch, Piotr Milkiewicz, Roman Zenouzi, Christoph Schramm, Nora Cazzagon, Annarosa Floreani, Ingalill Friis Liby, Miriam Wiestler, Heiner Wedemeyer, Taotao Zhou, Christian P. Strassburg, Eirini Rigopoulou, George Dalekos, Manasa Narasimman, Xavier Verhelst, Helena Degroote, Mette Vesterhus, Andreas E. Kremer, Bennet Buendgens, Fredrik Rorsman, Emma Nilsson, Kristin Kaasen Jorgensen, Erik von Seth, Martin Cornillet Jeannin, Nils Nyhlin, Harry Martin, Stergios Kechagias, Kristine Wiencke, Marten Werner, Benedetta Terziroli Beretta-Piccoli, Marco Marzioni, Helena Isoniemi, Johanna Arola, Agnes Wefer, Jonas Soderling, Martti Farkkila, Henrike Lenzen
Summary: This study compares different follow-up strategies in patients with PSC and finds that scheduled imaging can improve survival. There are considerable variations in follow-up strategies across centers, but multiple factors may contribute to this result.
LIVER INTERNATIONAL
(2023)
Article
Medicine, Research & Experimental
Emre Batuhan Kenger, Fatih Eren, Fatma Esra Gunes
Summary: This study evaluates the relationship between the nutritional status, anthropometric measurements, and dietary inflammatory index (DII) of professional football players. The results show that the football players have an anti-inflammatory diet and a positive correlation between DII scores and abdominal adiposity. Furthermore, there is a negative correlation between fiber consumption and abdominal adiposity, and a positive correlation between carbohydrate and fat consumption and body weight.
CLINICAL AND EXPERIMENTAL HEALTH SCIENCES
(2023)
Letter
Medical Laboratory Technology
Corey Markus, Suzette Coat, Hanns-Ulrich Marschall, Susan Matthews, Tze Ping Loh, Wayne Rankin, William M. M. Hague
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Acoustics
Lars-Philip Paulus, Alexandra L. Wagner, Adrian Buehler, Roman Raming, Jorg Juengert, David Simon, Koray Tascilar, Alexander Schnell, Josefine Guenther, Ulrich Rother, Werner Lang, Andre Hoerning, Georg Schett, Markus F. Neurath, Joachim Woelfle, Maximilian J. Waldner, Ferdinand Knieling, Adrian P. Regensburger
Summary: Multispectral optoacoustic tomography (MSOT) shows promise as a reliable and stable imaging technique for diagnosing inflammatory bowel diseases. This study demonstrates the high reliability and temporal stability of MSOT in imaging the human intestine during fasting and after food intake.
Meeting Abstract
Gastroenterology & Hepatology
F. Colapietro, P. Maisonneuve, E. Lytvyak, U. Beuers, R. Verdonk, A. van der Meer, B. van Hoek, S. J. Kuiken, H. Brouwer, E. J. van der Wouden, P. Muratori, A. Aghemo, A. van den Berg, G. N. Dalekos, M. Robles, R. J. Andrade, A. J. Montano-Loza, F. F. van den Brand, C. D. Slooter, G. Macedo, R. Liberal, Y. de Boer, A. Lleo
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Huan Su, Madhuri Haque, Svea Becker, Karolina Edlund, Julia Duda, Qingbi Wang, Johanna Reissing, Hanns-Ulrich Marschall, Lena S. Candels, Mohamed Mohamed, Wilhelm Sjoland, Lijun Liao, Stephan A. Drexler, Till Strowig, Joerg Rahnenfuehrer, Jan G. Hengstler, Maximilian Hatting, Christian Trautwein
Summary: This study used a mouse model to investigate the impact of the PNPLA3 I148M polymorphism on the progression of NAFLD. It was found that mice with the PNPLA3 I148M genotype showed exacerbated NAFLD, which was associated with changes in microbiota composition and liver gene expression, leading to a stronger inflammatory response and enhanced liver fibrosis progression.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Kalliopi Zachou, Kalliopi Azariadis, Ellina Lytvyak, Romee J. A. L. M. Snijders, Atsushi Takahashi, Nikolaos K. Gatselis, Mercedes Robles, Raul J. Andrade, Christoph Schramm, Ansgar W. Lohse, Atsushi Tanaka, Joost P. H. Drenth, Aldo J. Montano-Loza, George N. Dalekos, International Autoimmune Hepatitis Group (IAIHG) International Autoimmune Hepatitis Group
Summary: This study investigated the prevalence and clinical significance of non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) in patients with autoimmune hepatitis (AIH). The presence of NAFLD/NASH in AIH patients is associated with disease severity and prognosis, and concurrent type 2 diabetes and dyslipidemia are associated with worse outcomes. Therefore, closer follow-up is needed for patients with concurrent AIH and NAFLD or AIH and components of metabolic syndrome.
Article
Sport Sciences
Emre B. Kenger, Fatih Eren, Tugce Ozlu, Fatma E. Gunes
Summary: This study revealed a significant relationship between the microbiota profiles, nutritional status, and anthropometric measurements of professional Turkish football players, supporting a bidirectional interaction between microbiota and sports. Future studies are needed to further clarify the relationship between microbiota and sports health/performance.
JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
(2023)
Article
Gastroenterology & Hepatology
Anne-Sofie H. Jensen, Marie Winther-Sorensen, Johan Burisch, Annika Bergquist, Henriette Ytting, Lise L. Gluud, Nicolai J. Wewer Albrechtsen
Summary: Patients with autoimmune liver diseases have a significantly increased risk of diabetes. Increased awareness of diabetes risk in patients with autoimmune liver diseases is warranted.
LIVER INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Mara Caputo, Ying Xia, Sumit Kumar Anand, Emmelie Cansby, Emma Andersson, Hanns-Ulrich Marschall, Alfred Koenigsrainer, Andreas Peter, Margit Mahlapuu
Summary: Nonalcoholic steatohepatitis (NASH), characterized by liver steatosis, inflammation, and fibrosis, is found to be correlated with the incidence and severity of hepatocellular carcinoma (HCC). MST3 and MST4 are identified to play a critical role in promoting HCC progression, and targeting them may provide a novel strategy for liver cancer treatment.
Review
Gastroenterology & Hepatology
Romelia Barba Bernal, Bryan Ferrigno, Esli Medina Morales, Cristina M. Castro, Daniela Goyes, Hirsh Trivedi, Vilas R. Patwardhan, Alan Bonder
Summary: Primary biliary cholangitis is an autoimmune cholestatic liver disease that can progress to chronic liver disease and cirrhosis. Ursodeoxycholic acid and obeticholic acid are approved medications, but around 40% of patients have an incomplete response. Other therapeutic options such as peroxisome proliferator-activated receptor agonists and fibroblast growth factor-19 agonists are being investigated, but more research is needed to determine their effectiveness and explore new therapeutic targets.
TURKISH JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Public, Environmental & Occupational Health
Jodie A. Stearns, Hayford M. Avedzi, Desmond Yim, John C. Spence, Farshad Labbaf, Carminda G. Lamboglia, Fiona Ko, Ciara Farmer, Ellina Lytvyak, Megan Kennedy, Yeong-Bae Kim, Hui Ren, Karen K. Lee
Summary: This umbrella review found positive associations between built environment attributes and physical activity outcomes in older adults, particularly in the domains of transport walking, total walking, and total physical activity. However, the causality of these associations cannot be determined due to the predominantly cross-sectional nature of the included studies. Future longitudinal and experimental studies are needed to inform the design of age-friendly communities.
PUBLIC HEALTH REVIEWS
(2023)
Review
Gastroenterology & Hepatology
Esli Medina-Morales, Romelia Barba Bernal, Heike Gerger, Daniela Goyes, Hirsh D. Trivedi, Bryan Ferrigno, Vilas Patwardhan, Alan Bonder
Summary: We aim to summarize the current management of pruritus in primary biliary cholangitis (PBC) by evaluating the efficacy and safety of pharmacological therapies. Pruritus is a common symptom of PBC, and evidence regarding the most effective antipruritic agents available is lacking. New pharmacotherapy for PBC has shown promising antipruritic effects.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Ayse Sakalli Kani, Ahmet Ozercan, Haluk Tarik Kani, Fatih Eren, Kemal Sayar, Yusuf Yilmaz
Summary: This study aimed to investigate the variations in chronotype, night-eating patterns, and sleep quality in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and analyze their correlation with disease severity and fibrosis. The results showed that patients with non-morningness chronotype had poorer sleep quality and a higher prevalence of night-eating behavior. In addition, age and poor sleep quality significantly impacted the presence of advanced fibrosis.