Article
Nutrition & Dietetics
Melanie Le Sayec, Yifan Xu, Manolo Laiola, Fabiola Alvarez Gallego, Daphne Katsikioti, Chandler Durbidge, Uku Kivisild, Sarah Armes, Manon Lecomte, Pascale Fanca-Berthon, Emilie Fromentin, Florian Plaza Onate, J. Kennedy Cruickshank, Ana Rodriguez-Mateos
Summary: Berry (poly)phenol consumption improves arterial function in prehypertensive middle-aged individuals, possibly through modulation of gut microbiome richness and composition.
CLINICAL NUTRITION
(2022)
Editorial Material
Microbiology
Jan Claesen, J. Mark Brown
Summary: This study comprehensively cataloged pathways involved in trimethylamine metabolism and identified key bacterial players in the process. It also discovered new TMA-reducing genera that have potential for probiotic strategies or targeted microbiome interventions.
Review
Biochemistry & Molecular Biology
Panagiotis D. Papadopoulos, Christina Tsigalou, Pipitsa N. Valsamaki, Theocharis G. Konstantinidis, Chrysoula Voidarou, Eugenia Bezirtzoglou
Summary: The collection of normal microorganisms in our gut plays a significant role in our health, while dysbiosis in the gut microbial pool has been proven to be crucial in the pathophysiology of various diseases, including cardiovascular disease. In addition to traditional risk factors, research has also highlighted the involvement of gut bacteria and their metabolites in the pathogenesis of CVD.
Review
Nutrition & Dietetics
Hala Elzayat, Ghaidaa Mesto, Farah Al-Marzooq
Summary: Inflammatory bowel disease (IBD) is a complex disorder characterized by chronic inflammation of the gastrointestinal tract (GIT). Recent research has shown the significant role of the oral and gut microbiome in the development and progression of IBD and their impact on overall gut health. The interconnected oral and gut microbiome, as complex microbial communities, are implicated in IBD pathogenesis, and understanding their relationship can provide insights into disease management and prevention strategies.
Article
Cardiac & Cardiovascular Systems
Ina Nemet, Xinmin S. Li, Arash Haghikia, Lin Li, Jennifer Wilcox, Kymberleigh A. Romano, Jennifer A. Buffa, Marco Witkowski, Ilja Demuth, Maximilian Koenig, Elisabeth Steinhagen-Thiessen, Fredrik Backhed, Michael A. Fischbach, W. H. Wilson Tang, Ulf Landmesser, Stanley L. Hazen
Summary: Precision microbiome modulation has the potential to be a new treatment strategy for cardiovascular disease. This study used stable isotope dilution mass spectrometry to measure gut microbial metabolites and found that certain metabolites derived from aromatic amino acids are associated with adverse cardiovascular outcomes.
EUROPEAN HEART JOURNAL
(2023)
Article
Nutrition & Dietetics
Yong Li, Yifan Xu, Caroline Le Roy, Jiaying Hu, Claire J. Steves, Jordana T. T. Bell, Tim D. D. Spector, Rachel Gibson, Cristina Menni, Ana Rodriguez-Mateos
Summary: This study found significant associations between phenolic acid metabolites, gut microbiome, and cardiovascular disease risk. Certain beverages and foods, especially coffee, tea, red wine, and berries, are rich in phenolic acids and negatively correlated with cardiovascular disease risk. The gut microbiome, particularly the genus 5-7N15, partially mediates the negative association between urinary (poly)phenols and cardiovascular risk.
Article
Cardiac & Cardiovascular Systems
Yuxuan Zhang, Xinyi Zhang, Delong Chen, Jia Lu, Qinyan Gong, Jiacheng Fang, Jun Jiang
Summary: There is a causal relationship between gut microbiome components and the risk of CVDs, with Oxalobacter genus positively associated with CAD risk and Clostridiaceae_1 family negatively associated with stroke and ischemic stroke risk.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Catarina J. G. Pinto, Maria Angeles Avila-Galvez, Yilong Lian, Pedro Moura-Alves, Claudia Nunes dos Santos
Summary: The Aryl Hydrocarbon Receptor (AHR) is a ligand-dependent transcription factor that can control complex transcriptional processes in various cell types and has been associated with diseases such as inflammatory bowel diseases (IBD). Different compounds, including xenobiotics, natural compounds, and host-derived metabolites, have been identified as ligands of the AHR. Dietary (poly)phenols, which have been extensively studied for their pleiotropic activities, may also modulate the AHR. However, the extensive metabolism of dietary (poly)phenols in the gut, particularly by the gut microbiota, may result in the production of gut phenolic metabolites that could play a key role in modulating AHR and influencing inflammatory processes in the gut.
Review
Gastroenterology & Hepatology
Jing Xu, Yuejin Yang
Summary: Cardiovascular diseases (CVDs) remain a major global health concern, with recent evidence suggesting that alterations in the gut microbiome may influence the pathogenesis and progression of CVDs. The underlying links are not fully understood, but advances in meta-omics approaches offer a promising new avenue for research and potential insights into cardiovascular diseases.
Review
Cardiac & Cardiovascular Systems
Tyler Alexander Cookson
Summary: Research suggests that gut microbiome has significant influence on blood pressure and associated disorders. Bacterial-derived metabolites can affect various tissues and organs in the body. The extensive metabolic function lost with gut dysbiosis may require combination of bacteria and therapies for restoration.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Hao-Jian Zhang, Yan Wang, Jian-Dong Jiang
Summary: This review explores the relationship between the gut microbiome and the development of atherosclerosis, as well as the interactions between atherosclerosis-related drugs and the intestinal microbiome. It provides further insights into the development of microbiome-based drugs for the treatment of atherosclerosis.
CURRENT DRUG METABOLISM
(2023)
Article
Nutrition & Dietetics
Kristina S. Petersen, Mansi Chandra, Jeremy R. Chen See, Jillian Leister, Fatemeh Jafari, Alyssa Tindall, Penny M. Kris-Etherton, Regina Lamendella
Summary: This study aimed to investigate the effect of walnut-related modulation of gut microbiota composition on microbiota functionality. The results showed that walnut intake increased the alpha-diversity of actively expressed genes and led to the upregulation of certain genes. Additionally, walnut intake may increase the endogenous production of homoarginine through gut microbiota-mediated mechanisms.
CLINICAL NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Medha Priyadarshini, Guadalupe Navarro, Derek J. Reiman, Anukriti Sharma, Kai Xu, Kristen Lednovich, Christopher R. Manzella, Md Wasim Khan, Mariana Salas Garcia, Sarah Allard, Barton Wicksteed, George E. Chlipala, Barbara Szynal, Beatriz Penalver Bernabe, Pauline M. Maki, Ravinder K. Gill, Gary H. Perdew, Jack Gilbert, Yang Dai, Brian T. Layden
Summary: This study aimed to understand the mechanistic underpinnings of the interaction between the maternal gut microbiome (GM) and maternal metabolism during pregnancy. The results showed significant changes in the GM throughout pregnancy, with specific enrichment of gut bacterial taxa at different time points and in different mouse strains. Aberrant tryptophan metabolism was found to be associated with intestinal inflammation and gestational insulin resistance, which could be reversed by inhibiting the activity of a specific enzyme.
Review
Biochemistry & Molecular Biology
Aaron Lerner, Christian Steigerwald, Torsten Matthias
Summary: This review discusses the roles of genetics, environmental factors, as well as nutrients, diets, microbial manipulations, and tight junction function modifiers in the prevention, modulation, or treatment of cardiovascular and metabolic diseases.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2021)
Article
Nutrition & Dietetics
Namrata Iyer, Sinead C. Corr
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease with a multifactorial etiology involving genetic, microbial, and environmental factors. The intestinal epithelium plays a central role in disease pathogenesis, while microbial metabolites are key regulators of gut homeostasis and the pathogenesis of IBD.
Article
Cardiac & Cardiovascular Systems
Christian Heiss, Ana Rodriguez-Mateos, Mariam Bapir, Simon S. Skene, Helmut Sies, Malte Kelm
Summary: This study aims to assess Flow-Mediated Dilation (FMD) values in healthy individuals and provides reference values for cardiovascular health measurement. The study found that FMD values are inversely correlated with age, body mass index (BMI), glucose, cholesterol, and blood pressure. Individuals with higher FMD values are younger and have smaller brachial artery diameter, lower blood pressure and cholesterol. Comparisons with coronary artery disease (CAD) patients also showed that FMD values can be used to exclude cardiovascular disease and determine the health status. The meta-analysis results showed that the average FMD in healthy individuals is 6.4%, with a decline trend associated with age.
CARDIOVASCULAR RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Giuseppe Di Pede, Pedro Mena, Letizia Bresciani, Rosa M. Lamuela-Raventos, Mariem Achour, Ramon Estruch, Rikard Landberg, Sabine E. Kulling, David Wishart, Ana Rodriguez-Mateos, Alan Crozier, Claudine Manach, Daniele Del Rio
Summary: This systematic review summarizes human studies on the absorption, metabolism, distribution and excretion of dietary flavan-3-ols and their metabolites. Forty-nine intervention studies were included, and up to 180 metabolites were quantified in blood and urine samples after flavan-3-ol intake. The main compounds detected were phase 2 conjugates of microbial catabolites, with phenyl-gamma-valerolactones being the most representative ones. The bioavailability of flavan-3-ols was moderate, and it showed intra- and inter-source differences.
MOLECULAR ASPECTS OF MEDICINE
(2023)
Article
Food Science & Technology
Emanuela Casula, Maria Barbara Pisano, Gabriele Serreli, Sonia Zodio, Maria Paola Melis, Giulia Corona, Adele Costabile, Sofia Cosentino, Monica Deiana
Summary: Oxidative stress and inflammation caused by oxidised lipids in the diet, such as oxysterols, are associated with the loss of intestinal barrier integrity, which is a crucial event in intestinal disorders. Probiotic lactobacilli have shown potential in improving intestinal health due to their antioxidant and anti-inflammatory properties. This study aimed to assess the ability of two commercial probiotic strains of lactobacilli to attenuate oxysterols-induced alteration of intestinal permeability in Caco-2 cells. The results indicated that both live bacteria and intracellular components of the probiotics were able to counteract the permeability changes and loss of tight junction proteins, at least partially through modulation of the p38 pathway.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Food Science & Technology
Carolina Saori Ishii Mauro, Maryame Kadiri Hassani, Monica Barone, Maria Teresa Esposito, Yolanda Calle, Volker Behrends, Sandra Garcia, Patrizia Brigidi, Silvia Turroni, Adele Costabile
Summary: This study aims to evaluate the effects of fruit flours from Cerrado and Pantanal plants on the gut microbiota in healthy and post-COVID-19 individuals. The study found specific effects of different flours on the microbiota and discovered that jatoba pulp flour oil has antioxidant properties.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yifan Xu, Yong Li, Xuemei Ma, Wafa Alotaibi, Melanie Le Sayec, Alex Cheok, Eleanor Wood, Sabine Hein, Paul Young Tie Yang, Wendy L. Hall, Chiara Nosarti, Paola Dazzan, Rachel Gibson, Ana Rodriguez-Mateos
Summary: This study compared the agreement between a food frequency questionnaire (FFQ) and a 7-day food diary (7DD) in assessing (poly)phenol intake and explored their associations with urinary and plasma (poly)phenol metabolites. The results showed that FFQ estimated a higher (poly)phenol intake compared to 7DD, and the agreement between the two assessment methods was moderate for major (poly)phenol classes but poor with biomarkers. Therefore, further research using biomarker approaches is needed to increase the accuracy of estimating (poly)phenol exposure in larger populations.
Letter
Nutrition & Dietetics
Melanie Le Sayec, Manon Lecomte, Pascale Fanca-Berthon, Ana Rodriguez-Mateos
CLINICAL NUTRITION
(2023)
Article
Chemistry, Analytical
Ioanna Tsiara, Amelie Riemer, Mario S. P. Correia, Ana Rodriguez-Mateos, Daniel Globisch
Summary: The human body has evolved a multistep clearance process to remove xenobiotics. Non-endogenous metabolites are converted into more hydrophilic compounds through phase I and phase II enzymes. These compounds have important applications in toxicology, nutrition, biomarker discovery, doping control, and microbiome metabolism. We have developed a new methodology using immobilized arylsulfatase and immobilized β-glucuronidase on magnetic beads for the treatment of human urine samples, allowing for separate mass spectrometric investigation of each metabolite class. This new chemical biology strategy provides a valuable tool for studying metabolites in biological samples, with potential applications in metabolomics, nutrition, and microbiome studies.
ANALYTICAL CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Giuseppe Di Pede, Pedro Mena, Letizia Bresciani, Mariem Achour, Rosa M. Lamuela-Raventos, Ramon Estruch, Rikard Landberg, Sabine E. Kulling, David Wishart, Ana Rodriguez-Mateos, Michael N. Clifford, Alan Crozier, Claudine Manach, Daniele Del Rio
Summary: This work systematically assessed the pharmacokinetics, urinary recovery, and bioavailability of hydroxycinnamic acids (HCAs) and their metabolites. It was found that C-6-C-3 cinnamic acids, such as caffeic and ferulic acid, had the highest blood concentrations, while their excretion in urine was lower than hydroxybenzene catabolites. A comprehensive study investigating the ADME of HCAs from different dietary sources is urgently required.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Oghenerukevwe Anne Obayiuwana, Volker Behrends, Yolanda Calle-Patino, Monica Barone, Silvia Turroni, Patrizia Brigidi, Adele Costabile, Giulia Corona
Summary: This study evaluated the effects of cooking and digestion on the phenolic acid profile and gut microbiota composition of Nigerian wholegrains. The results showed that cooking and digestion significantly affected the levels of phenolic acids in all grains, and colonic fermentation had an impact on the relative abundance of gut microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Christle Coxon, Piril Hepsomali, Karen Brandt, David Vauzour, Adele Costabile
Summary: In this preliminary study, researchers examined the associations between mental and sleep health and personality traits as well as dietary identity in individuals who follow vegan and vegetarian diets. The findings suggest that both personality traits and dietary identity are related to mental and sleep health in individuals who follow plant-based diets.
HEALTH SCIENCE REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Emily K. Woolf, Janee D. Terwoord, Nicole S. Litwin, Allegra R. Vazquez, Sylvia Y. Lee, Nancy Ghanem, Kiri A. Michell, Brayden T. Smith, Lauren E. Grabos, Nathaniel B. Ketelhut, Nate P. Bachman, Meghan E. Smith, Melanie Le Sayec, Sangeeta Rao, Christopher L. Gentile, Tiffany L. Weir, Ana Rodriguez-Mateos, Douglas R. Seals, Frank A. Dinenno, Sarah A. Johnson
Summary: Estrogen-deficient postmenopausal women with high blood pressure experience oxidative stress-mediated suppression of endothelial function. Blueberries have been shown to improve endothelial function and reduce oxidative stress. This study aimed to investigate the efficacy of blueberries in improving endothelial function and blood pressure in postmenopausal women with above-normal blood pressure.
Review
Nutrition & Dietetics
Marion Mackonochie, Ana Rodriguez-Mateos, Simon Mills, Vivien Rolfe
Summary: This review assesses the evidence supporting the use of herbs and spices in the diet for the prevention or treatment of MetS and its associated health conditions. Results indicate that many common herbs and spices have beneficial effects in preventing and treating MetS and associated disorders.
Review
Obstetrics & Gynecology
Tamy Colonetti, Diandra Limas Carmo Teixeira, Antonio Jose Grande, Maria Laura Rodrigues Uggioni, Jaqueline Generoso, Seeromanie Harding, Ana Rodriguez-Mateos, Peterson Rech, Fabio Rosa Silva, Indianara Toreti, Luciane Ceretta, Maria Ines Rosa
Summary: This systematic review and meta-analysis found lower gut microbiota diversity in pregnant women with pre-eclampsia compared to healthy controls. However, there is insufficient evidence to determine changes in gut microbiota composition. The study highlights the potential importance of targeting the gut microbiota as a new treatment approach for reducing complications during pregnancy.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yifan Xu, Yong Li, Jiaying Hu, Rachel Gibson, Ana Rodriguez-Mateos
Summary: This study developed a novel (poly)phenol-rich diet score (PPS) and found that high adherence to the PPS diet is associated with (poly)phenol intake and urinary biomarkers. This suggests that PPS can be used to characterize diets rich in (poly)phenols at a population level.
Article
Biochemistry & Molecular Biology
Melanie Le Sayec, Diogo Carregosa, Khadija Khalifa, Chiara de Lucia, Dag Aarsland, Claudia N. Santos, Ana Rodriguez-Mateos
Summary: This study investigated the presence of (poly)phenol and methylxanthine metabolites in plasma and cerebrospinal fluid from individuals at risk of dementia and predicted their transport mechanism across the blood-brain barrier using in silico modeling. The results suggest that (poly)phenols and methylxanthines can cross the blood-brain barrier via passive diffusion or transport carriers to exert neuroprotective effects.
