Editorial Material
Cell Biology
Zhangyuan Yin, Daniel J. Klionsky
Summary: Macroautophagy/autophagy plays a crucial role in aging and age-related diseases. A recent study showed that a newly designed dietary regimen, called intermittent time-restricted feeding (iTRF), can extend the healthspan and lifespan of flies through the circadian rhythm-dependent activation of autophagy. Specifically, the induction of autophagy during the night is both necessary and sufficient for the health benefits of iTRF. This study suggests that novel interventions promoting night-specific autophagy could be used to promote healthy aging.
Article
Nutrition & Dietetics
Walter Currenti, Justyna Godos, Sabrina Castellano, Giuseppe Caruso, Raffaele Ferri, Filippo Caraci, Giuseppe Grosso, Fabio Galvano
Summary: The study found that individuals adherent to time-restricted eating (TRF) were less likely to have cognitive impairment, especially those who had breakfast. This suggests that time-restricted eating may have a positive association with cognitive status and can potentially benefit brain health.
Article
Nutrition & Dietetics
Abbi R. Hernandez, Cory Watson, Quinten P. Federico, Rachel Fletcher, Armen Brotgandel, Thomas W. Buford, Christy S. Carter, Sara N. Burke
Summary: Time-restricted feeding may be a feasible alternative for enhancing late life cognitive and physical health. Regardless of dietary composition, time-restricted-fed rats had better cognitive performance than ad libitum-fed rats, which is associated with gut microbiome diversity and composition.
Article
Immunology
Krisztina Ella, Agnes R. Sudy, Zsofia Bur, Bence Koos, Armin S. Kisiczki, Attila Mocsai, Krisztina Kaldi
Summary: Time restricted eating can reduce the symptoms of autoinflammatory joint arthritis and modulate the rhythm and inflammatory potential of leukocytes, leading to a milder reactivity of the immune system.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jennifer A. Davis, Jodi R. Paul, Stefani D. Yates, Elam J. Cutts, Lori L. McMahon, Jennifer S. Pollock, David M. Pollock, Shannon M. Bailey, Karen L. Gamble
Summary: Changing meal timing can rescue the cognitive and hippocampal impairments induced by HFD, even without altering body composition and total caloric intake. This suggests that short-term time-restricted feeding is an effective intervention for HFD-induced cognitive deficits and hippocampal dysfunction.
Review
Biochemistry & Molecular Biology
Christopher Livelo, Yiming Guo, Girish C. Melkani
Summary: Nearly 50% of adults will suffer from obesity in the U.S. by 2030, which can lead to high economic and healthcare burdens, elevated mortality rates, and reduced health span. Recent studies have shown that time-restricted feeding/eating (TRF; TRE in humans) may be an effective alternative therapy for obesity. It has been found that TRF can modulate skeletal muscle function, metabolism, and structure, offering potential insights for future research on TRF as a solution to obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Theresa Bushman, Te-Yueh Lin, Xiaoli Chen
Summary: Time-restricted feeding (TRF) is an effective strategy for weight loss and metabolic health, acting on multiple pathways within adipose tissue. This study investigated the impact of TRF on lipid metabolism in different adipose tissue depots in obese mice. The results showed that TRF reduced weight gain, restored adipogenesis and increased lipid storage in white adipose tissues.
Article
Microbiology
Amy Ontai-Brenning, Randy Hamchand, Jason M. Crawford, Andrew L. Goodman
Summary: Mammals exhibit daily fasting and feeding patterns that affect the gut environment. The gut commensal Bacteroides thetaiotaomicron uses ppGpp to adapt to the host's feeding cycle and maintain population size during the fasting phase. ppGpp is also important for colonization of the mucous layer during the fasting phase.
Editorial Material
Endocrinology & Metabolism
Hong Long, Satchidananda Panda
Summary: A new study has shown that a novel intermittent time-restricted feeding (iTRF) dietary regimen can extend the healthy lifespan of Drosophila by driving a clock-dependent rise in autophagy each night.
NATURE REVIEWS ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Tianfei Hou, Wen Su, Marilyn J. Duncan, Vsevolozhskaya A. Olga, Zhenheng Guo, Ming C. Gong
Summary: The study reveals that restricting the timing of food intake can prevent nondipping blood pressure in diabetic mice and effectively restore disrupted blood pressure circadian rhythm.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Nutrition & Dietetics
Bret M. Rust, Matthew J. Picklo, Lin Yan, Aaron A. Mehus, Huawei Zeng
Summary: Time-restricted feeding is an effective method to reduce the risk of obesity-related metabolic diseases by altering nutrient absorption, fecal microbiome, and lipidome. The study found that different feeding timing and fat content can affect fecal fatty acid levels and the composition of microbiota.
Article
Cell Biology
Jian Chen, Zhe-Xiang Fan, De-Cong Zhu, Yi-Long Guo, Ke Ye, Damao Dai, Zhi Guo, Zhi-Qi Hu, Yong Miao, Qian Qu
Summary: This study revealed the complex changes in dermal white adipose tissue (dWAT) during aging, showing altered inflammatory regulators and inhibitory effects on hair growth. The results highlight the potential role of dWAT in regulating aging hair follicles.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Nutrition & Dietetics
Beiwen Wu, Karen White, May Thu Thu Maw, Jeanne Charleston, Di Zhao, Eliseo Guallar, Lawrence J. Appel, Jeanne M. Clark, Nisa M. Maruthur, Scott J. Pilla
Summary: Adherence to meal timing and food consumption was high in a controlled feeding study, where participants followed a time-restricted intake of meals. Strategies such as careful screening, participant orientation, flexibility in beverages and seasonings, and frequent contact between participants and staff were used to optimize adherence.
Article
Neurosciences
Yong-Xia Xu, Guo-Ying Liu, Qian Jiang, Han-Qi Bi, Shi-Chan Wang, Ping-Ping Zhang, Chao-Bing Gao, Gui-Hai Chen, Wen-Hui Cheng, Guan-Jun Chen, De-Fa Zhu, Ming-Kui Zhong, Qi Xu
Summary: Research suggests that restricted feeding can help improve metabolic health in aged mice by reducing body weight, blood glucose, and cholesterol levels, without severely impacting sleep patterns.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biology
Walter Currenti, Justyna Godos, Sabrina Castellano, Giuseppe Caruso, Raffaele Ferri, Filippo Caraci, Giuseppe Grosso, Fabio Galvano
Summary: This study investigated the association between time-restricted feeding (TRF) and mental health outcomes in adults in southern Italy. It found that individuals older than 70 years who had a feeding time window of 8 hours were less likely to show signs of mental health distress. Adjusting for breakfast nullified the association, while adjusting for dinner did not change it. Further research is needed to explore these findings in elderly individuals.
CHRONOBIOLOGY INTERNATIONAL
(2021)
Review
Oncology
Ezio Laconi, Fabio Marongiu, James DeGregori
BRITISH JOURNAL OF CANCER
(2020)
Article
Cell Biology
Francesca Passaretta, Domenico Bosco, Lucia Centurione, Maria Antonietta Centurione, Fabio Marongiu, Roberta Di Pietro
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Neurosciences
Angela Sanna, Paolo Follesa, Monica Puligheddu, Antonino Cannas, Mariangela Serra, Maria Giuseppina Pisu, Sabino Dagostino, Paolo Solla, Paolo Tacconi, Francesco Marrosu
NEUROSCIENCE LETTERS
(2020)
Article
Nutrition & Dietetics
Noemie Gensous, Francesco Ravaioli, Chiara Pirazzini, Roberto Gramignoli, Ewa Ellis, Gianluca Storci, Miriam Capri, Stephen Strom, Ezio Laconi, Claudio Franceschi, Paolo Garagnani, Fabio Marongiu, Maria Giulia Bacalini
Article
Neurosciences
Angela Sanna, Paolo Follesa, Paolo Tacconi, Mariangela Serra, Maria Giuseppina Pisu, Viola Cocco, Michela Figorilli, Giovanni Defazio, Monica Puligheddu
Summary: SCA 38 is a cerebellar movement disorder caused by mutations in the ELOVL5 gene, and in a study, cerebellar iTBS treatment was shown to improve clinical symptoms of SCA 38 patients, potentially influenced by the BDNF gene polymorphism.
Article
Nutrition & Dietetics
Monica Serra, Fabio Marongiu, Ezio Laconi
Summary: The study found that chronic moderate caloric restriction and social isolation can synergize to induce anorexia-like behavior in rats, but restoring group-housing conditions can reverse this effect.
Review
Cell Biology
Ezio Laconi, Samuele Cheri, Maura Fanti, Fabio Marongiu
Summary: Cancer often arises in the context of an altered tissue landscape, with aging playing a major role in increasing the risk of neoplastic disease through effects on the microenvironment. Aged tissues are prone to develop clones of altered cells with normal histological appearance, resulting in increased clonogenic potential but decreased proliferative fitness, favoring the emergence of more competitive variant clones. However, specific cellular genotypes may emerge with reduced cooperative and integrative capacity, leading to tissue architecture disruption and progression to overt neoplastic phenotypes.
Review
Oncology
Fabio Marongiu, Samuele Cheri, Ezio Laconi
Summary: Cell competition is a quality control mechanism that relies on fitness comparison among individual cells; the ability of cells to integrate and collaborate within the organismal community is a key component of fitness; cell competition selects against cells with disruptive behavior towards tissue integrity and/or tissue pattern formation.
Article
Biotechnology & Applied Microbiology
Antonio Palomba, Alessandro Tanca, Marcello Abbondio, Rosangela Sau, Monica Serra, Fabio Marongiu, Cristina Fraumene, Daniela Pagnozzi, Ezio Laconi, Sergio Uzzau
Summary: Time-restricted feeding (TR) has a significant impact on gut microbiota (GM) functions, particularly increasing the abundance of enzymes related to carbohydrate and protein metabolism.
NPJ BIOFILMS AND MICROBIOMES
(2021)
Article
Behavioral Sciences
Laura Boi, Sabrina Petralla, Barbara Monti, Giuseppe Talani, Enrico Sanna, Maria Giuseppina Pisu, Giulia Calderisi, Elisabetta Maciocco, Mariangela Serra, Alessandra Concas, Patrizia Porcu
Summary: Analysis of rats treated with hormonal contraceptives showed changes in hippocampal BDNF levels and histone PTMs, but did not affect synaptic plasticity and cognitive performance significantly.
HORMONES AND BEHAVIOR
(2022)
Review
Oncology
Fabio Marongiu, James DeGregori
Summary: Aging is a major risk factor for cancer and other diseases. Recent studies have shown that aging leads to the accumulation of cancer-associated mutations in normal tissues, causing the formation of expanded clones. Additionally, aged tissue microenvironments promote the initiation and progression of malignancies.
MOLECULAR ONCOLOGY
(2022)
Article
Behavioral Sciences
Gabriele Floris, Gino Paolo Asuni, Giuseppe Talani, Francesca Biggio, Maria Giuseppina Pisu, Mary Tresa Zanda, Liliana Contu, Elisabetta Maciocco, Mariangela Serra, Paolo Follesa
Summary: This study investigates the role of the GABA(B)R receptor in alcohol consumption and preference in mice. The results show that mice lacking functional GABA(B)R drink more alcohol, prefer alcohol over water, and have higher blood alcohol concentrations compared to wild-type mice. Additionally, the study suggests that the GABA(B)R receptor modulates the activity of GABA(A) receptors in the hippocampus, potentially influencing alcohol preference in mice.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Maria Giuseppina Pisu, Luca Concas, Carlotta Siddi, Mariangela Serra, Patrizia Porcu
Summary: This article provides an overview of the response of the neuroactive steroid allopregnanolone to stress in females, focusing on the female reproductive function and stress-related neuropsychiatric diseases. The blunted allopregnanolone response to acute stress in females may contribute to their increased vulnerability to stress and affective disorders. These studies highlight the importance of targeting neuroactive steroids as a therapeutic approach for stress-related disorders in women.
Meeting Abstract
Oncology
James DeGregori, Catherine Pham-Danis, Andrii I. Rozhok, Edward J. Evans, Fabio Marongiu, Hannah Scarborough, Curtis J. Henry
Review
Gastroenterology & Hepatology
Fabio Marongiu, Ezio Laconi
WORLD JOURNAL OF HEPATOLOGY
(2020)