期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 362, 期 3, 页码 462-477出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201900750
关键词
dearomatization; electrochemistry; radicals; three-dimensional structures
资金
- Qilu University of Technology (Shandong Academy of Sciences) [0412048811]
- Natural Science Foundation of Shandong Province [ZR2018BB017]
- National Natural Science Foundation of China [21801144, 81872744, 51602164]
- Program for Scientific Research Innovation Team in Colleges and Universities of Shandong Province
Dearomatization reactions represent a versatile approach for the preparation of three-dimensionally (3D) privileged cyclic moieties from simple planar aromatic compounds. However, exogeneous oxidants are required for most of the radical and oxidative dearomatizations. Therefore, sustainable procedures are in high demand, especially those in the absence of external oxidizing reagents. Fortunately, electrolytic dearomatization protocols can fulfill the above requirements due to the manipulation of traceless electrons instead of chemicals during the processes. Nevertheless, sustainable electrochemical dearomative transformations have been far less frequently investigated than the well-developed chemical dearomatization reactions. Herein, we summarize representative breakthroughs in the electrochemical dearomative transformation of indoles, furans and activated arenes (phenols and anisoles) for the synthesis of complicated skeletons. Hopefully, this interesting simplicity-to-complexity synthetic logic will inspire more innovations from the electroorganic community. 1 Introduction 2 Typical Pathways for the Electrochemical Dearomatization of Indoles 2.1 Electrochemical Dearomatization of Indoles via Ionic Processes 2.2 Electrochemical Dearomatization of Indoles via the Catalytic Radical Process 2.3 Electrochemical Dearomatization of Indoles via Other Mechanisms 3 Electrochemical Dearomatization of Furans 4 Oxidative Dearomatization of Phenol and Anisole Derivatives 5 Conclusion and Outlook
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