期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 361, 期 21, 页码 4933-4940出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201900678
关键词
Manganese; Indole; Lactonization; C-H Activation; 4-Hydroxy-2-alkynoate
资金
- SERB, New-Delhi [EMR/2016/006358]
- Indian Institute of Science, Bangalore
- UGC, New-Delhi
- R L Finechem, Bangalore
A manganese-catalyzed C-H bond alkenylation of indoles at C2-position with 4-hydroxy-2-alkynoates leading to concomitant lactonization under removable directing group strategy has been disclosed. This lactonization strategy exhibits regioselectivity, a broad substrate scope, and a good functional group tolerance furnishing the products in low to high yields. The regioselectivity is guided by the electronic effect of the ester group as well as the steric bulk at the C4-position of the 4-hydroxy-2-alkynoates. After the reaction, the directing group has been readily removed to obtain N-H free indole.
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