Article
Nanoscience & Nanotechnology
Yuanying Zhang, Nan Yang, Ziyi Dong, Jiahui Wu, Rui Liao, Yanling Zhang, Gege Zhang, Mengfei Ren, Feng Wang, Xiaochen Dong, Pingping Liang
Summary: Avoiding the low specificity of phototheranostic reagents at the tumor site is a major challenge. Angiogenesis in the tumor is not only the premise of tumor occurrence but also the basis of tumor growth, invasion, and metastasis, making it an ideal strategy for tumor therapy. Biomimetic cancer cell membrane-coated nanodrugs (mBPP NPs) have been prepared with homotypic cancer cell membranes, protocatechuic acid, and a near-infrared phototherapeutic agent diketopyrrolopyrrole derivative for photodynamic/photothermal synergistic therapy. The mBPP NPs show high biocompatibility, excellent phototoxicity, and antiangiogenic ability, and can specifically bind to tumor cells and vasculature after intravenous injection, providing a novel avenue for cancer treatment.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Physical
Liangliang Cai, Ronghua Ni, Xiaofei Ma, Rongrong Huang, Zhiyuan Tang, Jinqiu Xu, Yong Han, Yuehua Guo, Zhifeng Gu
Summary: Nanomicelles combining nanotechnology-assisted photothermal therapy (PTT) and a novel HSP90 inhibitor AT13387 can achieve mutually synergistic PTT/molecularly targeted therapy (MTT) for the precise treatment of triple-negative breast cancer (TNBC).
Article
Nanoscience & Nanotechnology
Miguel Gisbert-Garzaran, Daniel Lozano, Kotaro Matsumoto, Aoi Komatsu, Miguel Manzano, Fuyuhiko Tamanoi, Maria Vallet-Regi
Summary: In this study, mesoporous silica nanoparticles were used as a platform to engineer a versatile nanomedicine capable of addressing biological barriers encountered in tumor drug delivery. The nanoparticles demonstrated high biocompatibility and cytotoxic effect in both 2D and 3D in vitro cell cultures and a tumor-bearing chicken embryo model, showing efficient endosomal escape and tumor penetration.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Maximilian A. Beach, Serena L. Y. Teo, Moore Z. Chen, Samuel A. Smith, Colin W. Pouton, Angus P. R. Johnston, Georgina K. Such
Summary: Nanoparticles have the potential to revolutionize drug delivery, but overcoming endosomal escape remains a significant challenge. Recent research focuses on designing nanoparticles that can escape endosomes in response to biological stimuli such as pH changes, which can improve drug delivery efficiency.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Multidisciplinary Sciences
Jinhyung Lee, Ian Sands, Wuxia Zhang, Libo Zhou, Yupeng Chen
Summary: The study introduced a new class of nanoparticles, Janus base nanopieces (NPs), for efficient delivery of RNA cargoes into cell cytoplasm with improved endosomal escape ability and low cytotoxicity. Proof-of-concept experiments indicated that NPs could be promising candidates for future antiviral delivery applications.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Multidisciplinary
Ajmal Zarinwall, Mazdak Asadian-Birjand, Didem Ag Seleci, Viktor Maurer, Alexandra Trautner, Georg Garnweitner, Hendrik Fuchs
Summary: This study investigates the potential of glycosylated triterpenoids as endosomal escape enhancers to enhance the efficacy of superparamagnetic iron oxide nanoparticle-based toxin therapy. Results show a significant enhancement in tumor cell cytotoxicity and specificity, indicating a promising approach for targeted tumor therapy.
Article
Engineering, Biomedical
Pei-Wei Shueng, Lu-Yi Yu, Hsin-Cheng Chiu, Hui-Ching Chang, Yen-Ling Chiu, Tzu-Yu Kuo, Yu-Wei Yen, Chun-Liang Lo
Summary: Recent studies suggest that immunotherapy alone for cancer treatment is not viable, and combination with other strategies is necessary. A newly designed micelle can enhance ROS levels in the entire tumor tissue, inhibiting cancer cell growth and boosting immune response through various mechanisms.
Article
Nanoscience & Nanotechnology
Hongmei Kang, Lamei Chen, Qin Li, Huan Chen, Liangke Zhang
Summary: In this study, a hyaluronic acid-modified ruthenium nanoaggregate and glucose oxidase-loaded manganese dioxide nanoflowers have been prepared. These nanomaterials can generate oxygen in the tumor microenvironment, alleviate tumor tissue hypoxia, and achieve high-temperature ablation of solid tumors. Additionally, they can consume glucose in the presence of oxygen, reduce tumor nutrient supply, and produce cytotoxic hydroxyl radicals, thereby enhancing the antitumor effect. The nanomaterials can also actively target tumor cells, improving the overall therapeutic effect.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Jianmeng Zhu, Yimin Yang, Jian Wang, Wenzhong Hong, Yiping Li, Zhen Wang, Kaiqiang Li, Zhen Wang
Summary: This study synthesized folate-modified nanomicelles that can release drugs in response to tumor tissue acidity and magnetic field stimulation, achieving targeted delivery to cancer cells. Experimental results demonstrated that these dual-responsive nanomicelles can enhance drug uptake and anticancer efficacy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Yang Liu, Yi Zhao, Haimei Li, Xiaoyang Zhang, Zichen Wang, Wenyan She, Fenglei Jiang, Yi Liu, Peng Jiang
Summary: In this study, a dual-targeted, multifunctional nanoplatform (FAA@CM) was successfully synthesized for trimodal imaging-guided photothermal/chemodynamic synergistic therapy. The nanoplatform achieved highly precise tumor-specific delivery through dual-targeting capability derived from 4T1 cell membrane cloaking and magnetic targeting. It exhibited trimodal imaging capabilities and enabled complete elimination of 4T1 tumors in mice.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Yuxin Yang, Haijun Ning, Tianping Xia, Jianjun Du, Wen Sun, Jiangli Fan, Xiaojun Peng
Summary: An amphiphilic siRNA-photosensitizer conjugate (siPLK1-NB) that can self-assemble into nanoparticles has been developed for efficient siRNA delivery and lysosomal escape. These nanoparticles exhibit rapid cell endocytosis and outstanding tumor-targeting property. The reactive oxygen species generated after photoactivation can disrupt the lysosome membrane structure and facilitate siRNA escape, leading to effective inhibition of tumor cell growth.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Medicinal
Yun Qu, Xinxin Wang, Zhichao Pei, Yuxin Pei
Summary: This study successfully constructed a nanoparticle with cancer-targeting and mitochondria-targeting abilities, exhibiting good biocompatibility and phototherapeutic efficiency.
Article
Chemistry, Multidisciplinary
Xueying Tang, Jiashuo Zhang, Dezhi Sui, Qiongfen Yang, Tianyu Wang, Zihan Xu, Xiaoya Li, Xin Gao, Xinyang Yan, Xinrong Liu, Yanzhi Song, Yihui Deng
Summary: This study developed a SA-modified mRNA vaccine that achieved successful DC targeting and efficient endosomal/lysosomal escape, resulting in higher transfection efficiency and lower side effects in DCs.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Chemistry, Physical
Li Ye, Hongmei Liu, Xin Fei, Ding Ma, Xiaozhen He, Qianyun Tang, Xue Zhao, Hanbing Zou, Xiaojing Chen, Xianming Kong, Peifeng Liu
Summary: A surface modification strategy was used to enhance the endosomal escape ability of dendrimer DGL polymers, improving gene transfection efficiency. This strategy involved designing a library of PBA-modified DGL polymers to screen for efficient siRNA vectors, with one candidate showing nearly 90% gene silencing in cells. Furthermore, the PBA modification not only improved siRNA cellular uptake but also endowed DGL polymers with the ability to escape endosomes.
Article
Nanoscience & Nanotechnology
Xueluer Mu, Ying Tang, Fapu Wu, Huihui Ma, Siwei Huang, Mingchen Liang, Junyan Yang, Yingxi Lu, Xianfeng Zhou, Zhibo Li
Summary: Photothermal therapy allows precise treatment at the disease site. The development of Cy7-TCF-IMC nanosaucers presents a promising approach for imaging-guided precision therapy, showing effective antitumor therapy results.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Xiujun Gao, Ke Bao, Yanqiu Zhang, Liyan Liu, Ying Li, Chunhong Hu, Yuqing Zhao, Wei Lu, Xi Wei
Summary: Chemotherapy and sonodynamic therapy synergistically improve the therapeutic outcomes of hepatocellular carcinoma. In this study, ultrasound-responsive multi-functional nanoparticles loaded with doxorubicin and curcumin-gold were developed. The nanoparticles exhibited high specificity to liver tumor cells, could escape from lysosomes, and enhanced drug delivery to the nucleus. The findings suggest that these nanoparticles have potential as novel antitumor agents for hepatocellular carcinoma treatment.
ADVANCED FUNCTIONAL MATERIALS
(2023)