Article
Biochemistry & Molecular Biology
Hanif Haidari, Richard Bright, Sanjay Garg, Krasimir Vasilev, Allison J. Cowin, Zlatko Kopecki
Summary: The development of highly potent ultrasmall AgNPs combined with a biocompatible hydrogel has shown promising results in eliminating mature biofilm infections in vivo and promoting wound healing. The treatment exhibited superior antibacterial efficacy and improved wound closure, re-epithelization, and collagen deposition compared to conventional silver-based treatments.
Article
Nanoscience & Nanotechnology
Huimin Chen, Jing Cheng, Xixi Cai, Jinzhi Han, Xu Chen, Lijun You, Caihua Xiong, Shaoyun Wang
Summary: This study develops pH-switchable antibacterial hydrogels based on self-assembled amphiphilic pentapeptides, which can eradicate biofilms and promote healing in infected wounds. In vitro experiments demonstrate that the hydrogels achieve antimicrobial effects through the release of pentapeptides and antibacterial oil. In vivo experiments show that the hydrogels can accelerate wound closure, reduce inflammation, and promote angiogenesis and collagen deposition.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Lin Jin, Yanfei Ma, Ruiya Wang, Shuo Zhao, Zhishuai Ren, Shengnan Ma, Yupeng Shi, Bin Hu, Yuqi Guo
Summary: This study prepared a double structure system that can promote vascularization and anti-inflammatory effect in wound healing while preventing scars.
MATERIALS TODAY ADVANCES
(2022)
Article
Chemistry, Physical
Zejun Xu, Guiting Liu, Li Zheng, Jun Wu
Summary: A hydrogel with enhanced antimicrobial and antioxidant properties (CMGFC) was developed to accelerate diabetic wound healing. The CMGFC hydrogel showed high antibacterial efficiency and strong ROS scavenging ability, protecting cells from oxidative stress. In vivo results demonstrated reduced inflammatory responses, enhanced angiogenesis, and improved wound healing with the CMGFC hydrogel.
Article
Nanoscience & Nanotechnology
Hanif Haidari, Krasimir Vasilev, Allison J. Cowin, Zlatko Kopecki
Summary: A multistimuli-responsive hydrogel loaded with ultrasmall silver nanoparticles offers on-demand release of Ag+ ions triggered by changes in the wound microenvironment, showing high antibacterial efficacy in vivo.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Pingping Sun, Jingmiao Jiao, Xiaoyu Wang, Long Chen, Zhiyong Chen, Kun Zhang, Kai Qu, Xian Qin, Zailiang Yang, Julia Li Zhong, Wei Wu
Summary: A multifunctional nanocomposite hydrogel (CS-HCA-Icps) with a pathological pH-responsive drug release has been developed to promote wound healing impaired by microbial infection. The hydrogel composed of catechol-grafted chitosan (CS-HCA) and a curcumin-Fe3+ coordination nanoparticles (Icps, Cur-Fe3+) exhibits favorable activities in free radical scavenging, anti-bacterial, and anti-inflammatory. It also shows good biocompatibility in vitro and in vivo experiments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Xiaolong Lin, Tao Fu, Yuqing Lei, Jiajia Xu, Sa Wang, Fuming He, Zhijian Xie, Ling Zhang
Summary: This study developed a new antibacterial hydrogel with excellent antimicrobial activity, histocompatibility, and wound healing potential. The hydrogel released antibacterial peptides to inhibit bacterial biofilm formation and regulate inflammatory responses, as well as promote angiogenesis, thereby aiding in the rapid healing of infected wounds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
Lin Jin, Xiaoqing Guo, Di Gao, Yan Liu, Jiahua Ni, Zhiming Zhang, Yiqiao Huang, Guibin Xu, Zhe Yang, Xingcai Zhang, Xianhan Jiang
Summary: This study developed a band-aid with a core-shell structure to modulate vascularization and the immune microenvironment, leading to scarless wound healing. The band-aid released H2S and a growth factor, which controlled macrophage polarization and inhibited excessive inflammation, thereby promoting skin cell proliferation and facilitating wound healing.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Environmental
Xiao-Ling Lei, Kai Cheng, Yong Li, Zi-Tao Zhong, Xiao-Lin Hou, Lai-Bo Song, Fang Zhang, Jian-Hao Wang, Yuan-Di Zhao, Qiu-Ran Xu
Summary: A biodegradable drug-loaded microneedle patch was designed for the treatment of chronic wounds caused by bacterial biofilm infection. The microneedle system loaded with pH-responsive tri-block polymer and antimicrobial peptide showed excellent antibacterial and wound healing effects.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Biomedical
Dong Uk Lee, Se-Chang Kim, Dong Yun Choi, Won-Kyo Jung, Myung Jun Moon
Summary: In this study, a biocompatible and pH-monitorable wound healing dressing with antimicrobial activity was developed through basic amino acid-mediated surface modification, creating cationic amphiphilic surfaces. The basic amino acid-modified polyimide displayed excellent bactericidal, antifouling, and biofilm inhibition performance, as well as wound healing efficacy and biocompatibility. The findings are significant for wound management and potential applications in wearable healthcare devices.
BIOMATERIALS RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Nabanita Mukherjee, Satyajit Ghosh, Jayita Sarkar, Rajsekhar Roy, Debasmita Nandi, Surajit Ghosh
Summary: The inherent mechanical strength and customizable physicochemical properties of amyloids allow for the rational design and synthesis of biomaterials for specific purposes. However, the significant antimicrobial efficacy of these materials has been largely overlooked. This research provides insight into the relationship between self-assembly and antimicrobial activity of amyloid-derived peptide amphiphiles, leading to the development of novel antimicrobial materials with excellent wound healing properties.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Automation & Control Systems
Bonan Sun, Mengmeng Sun, Zifeng Zhang, Yihang Jiang, Bo Hao, Xin Wang, Yanfei Cao, Tony K. F. Chan, Li Zhang
Summary: Researchers have developed magnetic hydrogel micromachines capable of mechanically disrupting biofilms and releasing antibacterial agents, providing a new treatment option for biofilm-related infections in narrow spaces.
ADVANCED INTELLIGENT SYSTEMS
(2023)
Article
Engineering, Environmental
Xiaojia Guo, Xiaowen Shi, Lingyun Chen, Lan Wang, Hongbing Deng, Yumin Du
Summary: An oriented ss-chitin nanofiber hydrogel was successfully fabricated by an electro-assembly process, with the internal structure of the hydrogel easily tuned. The orientation of the hydrogel was influenced by the concentration of nanofibers and pH, and strengthened by increased current density and longer deposition time. Cryogels with extraordinary physical and biological properties were obtained, and when used as wound dressing, the oriented ss-chitin nanofiber cryogels outperformed unoriented structure in promoting cell proliferation and accelerating wound healing.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Bei Wang, Jiayuan Zhao, Wenxin Lu, Yuanya Ma, Xusen Wang, Xiaoli An, Zengjie Fan
Summary: The development of a novel wound dressing with highly effective antibacterial and wound healing properties has been the focus of this study. Through a simple electrostatic interaction method, a novel and injectable hydrogel composed of lactoferrin and lithium magnesium silicate was synthesized. The physical and biological properties of the hydrogel were characterized and it was found to have good antibacterial properties and biocompatibility. The hydrogel was able to effectively promote wound healing in a rat skin wound model, achieving a much higher healing rate compared to other groups.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Multidisciplinary
Min Hu, Xia Wang, Yujing Tang, Xingyue He, Hongdou Shen, Hui Pan, Yinghui Shang, Dongbei Wu, Shengcai Zheng, Qigang Wang
Summary: A photo-enzyme-coupled hydrogel platform with spatio-temporally controlled hydrogel network was constructed through photoenzymatic-initiated radical polymerization, allowing for photo-switchable redox performance. The platform was shown to modulate bidirectional oxidation/antioxidant effects for complicated wound healing and provides ideas for enzyme engineering design.
Review
Materials Science, Biomaterials
Xiaoyan Li, Xiaocui Guo, Mingdi Hu, Rong Cai, Chunying Chen
Summary: Messenger RNA (mRNA) has shown great potential for the treatment of diseases, but there are still challenges in its clinical translation due to issues like uneven distribution, low transfection efficiency, and poor biosafety. This review discusses the design of nanoparticles, particularly lipid nanoparticles, and strategies to improve mRNA delivery by manipulating nano-bio interactions and overcoming biological barriers. Regulating nano-bio interactions could be a significant breakthrough in improving mRNA delivery efficiency, and this review provides new insights for the design of nanoparticle-mediated mRNA delivery systems.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Materials Science, Biomaterials
Xiaoyu Wang, Xuejing Cui, Junguang Wu, Lin Bao, Chunying Chen
Summary: Through integrating tissue imaging, 16s rRNA gene sequencing, and metabolomics techniques, we found that silver nanoparticles and silver nanowires have an impact on the gut microbiota structure in mice. The gut microbiota showed resilience after short-term exposure, but the gut metabolites significantly changed after long-term exposure. This study provides new evidence for the adverse effects of silver nanomaterials on biological hosts.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Materials Science, Biomaterials
Qiaolin Liu, Yuliang Zhao, Huige Zhou, Chunying Chen
Summary: This review summarizes the application of stimuli-responsive nanomaterials in ferroptosis for cancer therapy and proposes future perspectives in the field.
REGENERATIVE BIOMATERIALS
(2023)
Editorial Material
Chemistry, Multidisciplinary
Jillian M. Buriak, Deji Akinwande, Natalie Artzi, C. Jeffrey Brinker, Cynthia Burrows, Warren C. W. Chan, Chunying Chen, Xiaodong Chen, Manish Chhowalla, Lifeng Chi, William Chueh, Cathleen M. Crudden, Dino Di Carlo, Sharon C. Glotzer, Mark C. Hersam, Dean Ho, Tony Y. Hu, Jiaxing Huang, Ali Javey, Prashant V. Kamat, Il-Doo Kim, Nicholas A. Kotov, T. Randall Lee, Young Hee Lee, Yan Li, Luis M. Liz-Marzan, Paul Mulvaney, Prineha Narang, Peter Nordlander, Rahmi Oklu, Wolfgang J. Parak, Andrey L. Rogach, Mathieu Salanne, Paolo Samori, Raymond E. Schaak, Kirk S. Schanze, Tsuyoshi Sekitani, Sara Skrabalak, Ajay K. Sood, Ilja K. Voets, Shu Wang, Shutao Wang, Andrew T. S. Wee, Jinhua Ye
Article
Chemistry, Multidisciplinary
Xudong Geng, Xuancheng Du, Weijie Wang, Chengmei Zhang, Xiangdong Liu, Yuanyuan Qu, Mingwen Zhao, Weifeng Li, Mingzhen Zhang, Kangsheng Tu, Yong-Qiang Li
Summary: Researchers have developed a metabolic reprogramming strategy using a confined cascade nanoreactor for targeted alcohol detoxification and management of alcoholic liver injury (ALI). The nanoreactor enables self-accelerated alcohol degradation with high-efficiency detoxification and blocks the progression of ALI. In experiments, the nanoreactor showed liver targeting and accumulation performance, significantly reduced blood alcohol concentration, and rapidly reversed unconsciousness and acute liver injury. This nanoreactor offers a powerful modality for targeted alcohol detoxification and ALI management and provides a paradigm shift in the treatment of metabolic diseases.
Editorial Material
Chemistry, Analytical
Xiue Jiang, Chunying Chen, Xinrong Zhang
ANALYTICAL CHEMISTRY
(2023)
Article
Engineering, Environmental
Xuejing Cui, Wenjia Lai, Yao Zhao, Chunying Chen
Summary: Exposure to atmospheric particulate matter (PM) is a global concern due to its adverse outcomes. This study reveals that exosomes play a key role in the transfer of PM and the induction of inflammatory responses in macrophages. The release of exosomes from macrophages was stimulated by fine PM2.5, with F1 having a greater effect than F2, through regulation of the P2X7 receptor. These exosomes mediated the transfer of PM2.5 to recipient macrophages, resulting in the activation of NF-kappa B signaling and the release of inflammatory cytokines. Furthermore, these exosomes induced inflammatory responses in the lungs of mice. These findings highlight the importance of assessing exosome secretion and their impact on human health in the presence of atmospheric particulate matter.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Chunying Chen, Huige Zhou, Yanhong Ma, Qing Dai, Zhiyong Tang
Summary: Established in 2003, the National Center for Nanoscience and Technology (NCNST) is China's leading institution in nanoscience and technology. With state-of-the-art equipment and a strong research team, NCNST conducts cutting-edge research and innovation in various areas, including nanosystems and hierarchical fabrication, biological effects and safety of nanomaterials, standardization and measurements for nanotechnology, and theoretical simulations. NCNST aims to foster international cooperation, cultivate young talents, and drive inspiring innovation.
Review
Chemistry, Multidisciplinary
Mingdi Hu, Xiaoyan Li, Zhen You, Rong Cai, Chunying Chen
Summary: Lipid-based nanoparticles (LBNPs) are currently the most promising delivery vehicles for nucleic acid drugs, but their delivery efficiency and safety are largely compromised by a cascade of physiological barriers. This review systematically discusses the five different levels of physiological barriers for LBNP-based nucleic acid delivery and the current coping strategies.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Physical
Gayathri R. Ediriweera, Yixin Chang, Qiaoyun Wang, Yutong Gong, Dewan T. Akhter, Huiwen Pang, Felicity Y. Han, Chunying Chen, Andrew K. Whittaker, Changkui Fu
Summary: A new polymer, poly(2-(methylsulfinyl)ethyl acrylate) (PMSEA), was developed for conjugation with transferrin (Tf) protein to overcome PEG-related immunogenicity and improve the in vivo pharmacokinetic profile of proteins. By using a cleavable thioketal linker, successful protein release was achieved, avoiding the loss of protein activity upon chemical modification. The Tf-PMSEA conjugate significantly improved the in vivo pharmacokinetics and tumor accumulation compared to the PEGylated counterpart, demonstrating the potential of PMSEA as a promising alternative to PEG for therapeutic delivery applications.
CHEMISTRY OF MATERIALS
(2023)
Article
Nanoscience & Nanotechnology
Zhiguo Fang, Chenlei Wang, Jingrun Yang, Zhizheng Song, Chunyu Xie, Yu Ji, Zhongliang Wang, Xiaohui Du, Qiang Zheng, Chunying Chen, Zhiyuan Hu, Yeteng Zhong
Summary: A non-invasive in vivo sO2 imaging technique based on photoluminescence bioimaging in the NIR-IIb window allows for the visualization of sO2 levels in healthy and tumor tissue. Real-time dynamic sO2 imaging reveals cerebral arteries and veins and is consistent with haemodynamic analysis. Tumor-associated vessel sO2 levels can be evaluated using this technique.
NATURE NANOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Xiaoyu Wang, Xuejing Cui, Junguang Wu, Lin Bao, Zhiqiang Tan, Chunying Chen
Summary: This study reveals a previously undocumented gut-central nervous system (CNS) axis, in which peripheral nerve fibers serve as conduits for the translocation of silver nanomaterials (Ag NMs) from the gut to the CNS.
Review
Chemistry, Physical
Jinhui Lin, Xinlian Wang, Dongqi Ni, Yandong Chen, Chunying Chen, Ying Liu
Summary: Cancer poses a significant threat to human health, and traditional treatments such as chemotherapy and radiotherapy are suboptimal and cause significant side effects. Gene therapy offers improved targeting and reduced side effects, and the use of nanocarriers like liposomes enables effective delivery of gene therapy agents. However, combining gene therapy with other therapies using nanocarriers can lead to synergistic therapeutic effects. This review highlights various ways to combine gene therapy with other therapies and emphasizes the role of nanoplatforms in mediating these combined therapies.
Review
Chemistry, Multidisciplinary
Guanyu Liu, Lin Bao, Chunying Chen, Jianfu Xu, Xuejing Cui
Summary: A growing number of nanomaterials are being used in food-related fields and therapeutics. These nanoparticles can cross the intestinal barrier and enter the adjacent mesentery, where their fate is determined by the intricate structure and function of the mesentery. Understanding the interaction between nanomaterials and the mesentery is crucial for the development of safer products and more effective nanomedicines for intestinal disorders.
Article
Chemistry, Physical
Didar Baimanov, Liming Wang, Ke Liu, Mengmeng Pan, Rui Cai, Hao Yuan, Wanxia Huang, Qingxi Yuan, Yunlong Zhou, Chunying Chen, Yuliang Zhao
Summary: This study investigates how the mirrored surface of chiral gold nanoparticles affects their coronal composition and subsequent clearance and distribution in vivo. The researchers found that chiral gold nanoparticles exhibit specific recognition for different coronal components, resulting in distinct cellular uptake and tissue accumulation. This study provides insights into the interaction between chiral nanoparticles and biological systems, which can guide the efficient fabrication of target nanomedicines.
NANOSCALE HORIZONS
(2023)