Article
Microbiology
Kritsada Pruksaphon, Joshua D. Nosanchuk, Kavi Ratanabanangkoon, Sirida Youngchim
Summary: Talaromycosis is an opportunistic fungal disease caused by Talaromyces marneffei. The progression and outcome of the disease depend on the complex interaction between the pathogen and the host's immune response.
Review
Infectious Diseases
Suke Xing, Hui Zhang, Ye Qiu, Mianluan Pan, Wen Zeng, Jianquan Zhang
Summary: Patients with Talaromyces marneffei infection after transplant often present with disseminated infections, involving the respiratory and hematopoietic systems. It is recommended to use a combination of culture, biopsy, and next-generation sequencing for early diagnosis, and adjust the dosage of immunosuppressants timely. Antifungal therapy with amphotericin B followed by itraconazole is effective in treating Talaromyces marneffei infections in transplant recipients.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Respiratory System
Qin Yang, Yue Wu, Xiaonan Li, Yanmin Bao, Wenjian Wang, Yuejie Zheng
Summary: In this study, we analyzed six cases of HIV-negative children with respiratory symptoms as the first manifestation of Talaromyces marneffei (TM) infection. We found various risk factors unrelated to the virus and provided evidence for diagnosis and treatment.
BMC PULMONARY MEDICINE
(2023)
Article
Infectious Diseases
Qiu-Yue Ning, Na Liu, Ji-Zhou Wu, Die-Fei Hu, Qi Wei, Jin-Ai Zhou, Jun Zou, Ning Zang, Guo-Jian Li
Summary: This study investigated serum exosomal miRNAs in AIDS patients with TM infection, identifying three potential biomarkers and exploring their biological functions and pathways.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Pediatrics
Wei Hu, Xiao-Hong Yu, Wei-Qin Wei, Xuan Xiang
Summary: This article presents a case of a child with HIV and T.marneffei infection. The patient exhibited unique clinical manifestations including fever, abdominal pain, lymphadenopathy, hepatosplenomegaly, lower extremity ecchymosis, and bloody stool. The article emphasizes the importance of early laboratory and imaging diagnosis in improving the survival rate and quality of life for children.
Article
Dermatology
Liya He, Xin Mei, Sha Lu, Jianchi Ma, Yongxuan Hu, Dongdong Mo, Xinsheng Chen, Ruiqiang Fan, Liyan Xi, Ting Xie
Summary: The study investigated the characteristics of T. marneffei infection in non-HIV individuals in mainland China. It found that T. marneffei infections in non-HIV individuals are increasing, with atypical symptoms leading to misdiagnosis as other diseases. Accurate diagnosis and timely antifungal agent treatment are crucial for effective management of the disease.
Article
Medicine, General & Internal
Xiao-ling Zhu, Guang-Xiao Tang, Xue-yan Liu, Ran Li, Sheng-xiu Lv, Guang-xian Wang
Summary: T. marneffei infection commonly affects lymph nodes and extranodal organs in HIV patients. Clinical symptoms are non-specific. CT characteristics show multiple lymphadenopathies with heterogeneous enhancement, and involvement of the lungs, liver and spleen, and small intestine.
FRONTIERS IN MEDICINE
(2022)
Review
Immunology
Liang Xu, Xiuxiu Chen, Xuying Yang, Hongtao Jiang, Jianli Wang, Shaowen Chen, Jian Xu
Summary: We present a case of Talaromyces marneffei infection in a renal transplant recipient. The patient showed symptoms of intermittent diarrhea, leukopenia, high fever, cough, anemia, weight loss, gastrointestinal bleeding, and liver function impairment. Imaging studies revealed lung inflammation, lymphadenopathy, and hepatosplenomegaly. The presence of Talaromyces marneffei was confirmed by metagenomics next-generation sequencing and blood culture. The patient responded well to antifungal therapy and was discharged with regular oral voriconazole. This case highlights the importance of prompt diagnosis and effective antifungal treatment in improving the prognosis of Talaromyces marneffei infection after renal transplantation.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Infectious Diseases
Zhiman Xie, Jingzhen Lai, Renping Peng, Minhong Mou, Hao Liang, Chuanyi Ning
Summary: This study reported 31 cases of intestinal T. marneffei infection in Guangxi. Most patients exhibited fever, lymphadenectasis in the abdominal cavity, and chronic intestinal symptoms. The study suggests that intestinal T. marneffei infection should be considered among HIV-infected patients with extremely low CD4+ T-cell counts.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Lipin Liu, Bijun Sun, Wenjing Ying, Danru Liu, Ying Wang, Jinqiao Sun, Wenjie Wang, Mi Yang, Xiaoying Hui, Qinhua Zhou, Jia Hou, Xiaochuan Wang
Summary: This study summarized the clinical and immunological characteristics of opportunistic pathogen Talaromyces marneffei in a group of patients with inborn errors of immunity (IEI). Gene mutations in IL12RB1, IFNGR1, STAT1, STAT3, and CD40LG were found to be associated with T. marneffei infection. The application of metagenomic next-generation sequencing (mNGS) showed high sensitivity and specificity in diagnosing T. marneffei infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Mianluan Pan, Jianquan Zhang
Summary: This case report describes a case of Talaromyces marneffei infection after kidney transplantation. The patient presented with sore throat and odynophagia, and was successfully treated with antifungal therapy using voriconazole.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Mycology
Xiaochun Xue, Jun Zou, Wenjie Fang, Xiaogang Liu, Min Chen, Amir Arastehfar, Macit Ilkit, Yanqing Zheng, Jianglong Qin, Zhipeng Peng, Dongying Hu, Wanqing Liao, Weihua Pan
Summary: Knowledge about the clinical characteristics and prognostic factors of Talaromyces marneffei infection in children, especially in HIV-positive children, is limited. This retrospective study analyzed T. marneffei infection in HIV-positive pediatric inpatients in a tertiary hospital in Southern China between 2014 and 2019. The study found that the prevalence of talaromycosis in AIDS children was 15.3%, with a median age of 8 years. Skin lesion with central umbilication was not common, and all children had very low CD4(+) cell counts on admission. The misdiagnosis rate was high, and blood culture was the main diagnostic method. Amphotericin B was found to be superior to itraconazole in the treatment of talaromycosis in HIV-positive children. Low CD4(+)/CD8(+) ratio and amphotericin B treatment not over 7 days predicted poor prognosis.
Article
Infectious Diseases
Xiu-Jiao Xia, Yan Zhong, Bo Sang, Qiu-Ping Li, Hui-Lin Zhi, Wen-Wen Lv, Hong Shen, Ze-Hu Liu
Summary: This report describes a rare case of mixed infection of Candida albicans and Talaromyces marneffei in the oral cavity and oropharynx, emphasizing the need to pay special attention to the growth of T. marneffei on the culture plate.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2021)
Article
Immunology
Haiyan Ma, Jasper F. W. Chan, Yen Pei Tan, Lin Kui, Chi-Ching Tsang, Steven L. C. Pei, Yu-Lung Lau, Patrick C. Y. Woo, Pamela P. Lee
Summary: The study reveals that T. marneffei yeasts induce IL-1 beta production, with NLRP3 inflammasome playing a crucial role in host immune response. Dectin-1/Syk signaling pathway mediates IL-1 beta production, and NLRP3-ASC-caspase-1 inflammasome facilitates the processing of pro-IL-1 beta into IL-1 beta. Mice deficient in NLRP3 or caspase-1 show higher mortality and fungal load after T. marneffei infection, indicating the important role of NLRP3 inflammasome in host defense.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Mycology
Linlin Wang, Ying Luo, Xiaolin Li, Yixian Li, Yu Xia, Tingyan He, Yanyan Huang, Yongbin Xu, Zhi Yang, Jiayun Ling, Ruohang Weng, Xiaona Zhu, Zhongxiang Qi, Jun Yang
Summary: Talaromyces marneffei (TM) infections in children are rare but severe, and immunodeficiency is one of the predisposing factors, leading to high mortality in some cases.
Article
Pharmacology & Pharmacy
Jun-Ting Tang, Yu-Ye Li, Yi Zhang, Jun Liu, Wei Guan, Rui-Rui Wang, Li-Ping He, Jian-Bo Zhang, Yi-Qun Kuang
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2020)
Article
Dermatology
Yu-Ye Li, Shi-Han Yang, Rui-Rui Wang, Jun-Ting Tang, Hong-Mei Wang, Yi-Qun Kuang
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2020)
Article
Infectious Diseases
Yu-Ye Li, Rong-Jing Dong, Samip Shrestha, Pratishtha Upadhyay, Hui-Qin Li, Yi-Qun Kuang, Xin-Ping Yang, Yun-Gui Zhang
AIDS RESEARCH AND THERAPY
(2020)
Article
Immunology
Danfeng Lu, Hua Sun, Juehua Yu, Yi-Qun Kuang, Kun-Hua Wang
Article
Thermodynamics
Junwen Cui, Zhan Li, Yiqun Kuang, Hong Cheng
ADVANCES IN MECHANICAL ENGINEERING
(2020)
Article
Infectious Diseases
Hong-Bin Li, Na Li, Shu-Ran Wen, Ming-Yue Qiang, Zheng-Hui Yang, Tian-Xiang Dong, Yu-Ye Li, Yi-Qun Kuang
Summary: This study found that micafungin (MCF) enhances antifungal efficacy by altering the immune response of macrophages and reducing the antioxidant activity of the fungus, while itraconazole (ICZ) and amphotericin B (AmB) do not have this effect.
CANADIAN JOURNAL OF INFECTIOUS DISEASES & MEDICAL MICROBIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Xiao-Li Zhang, Ming-Hui Chen, Shi-Tao Geng, Juehua Yu, Yi-Qun Kuang, Hua-You Luo, Kun-Hua Wang
Summary: Probiotics can reduce the incidence of AIDS-related diarrhea in HIV/AIDS patients, with long-term use showing more significant effects than short-term use. However, probiotics have no impact on CD4 cell counts in HIV/AIDS patients. Further research is needed to explore the potential of probiotics as a preventive strategy for AIDS.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Yu-Ye Li, Sunaula Shakya, Heng Long, Lian-Fa Shen, Yi-Qun Kuang
Summary: The study compared the epidemiological trends of leprosy in China, Nepal, and other countries, finding that the prevalence of leprosy is often related to geographical location and socio-economic status, with healthcare conditions also playing a significant role in leprosy incidence.
FRONTIERS IN PUBLIC HEALTH
(2021)
Editorial Material
Cell Biology
Xiao-Yan Zhou, Yi-Qun Kuang, Jian-Bo Zhang, Yu-Ye Li
Summary: The HLA-B*38:97 allele differs from HLA-B*38:02:01:01 by a single nucleotide substitution.
Article
Biochemistry & Molecular Biology
Yue Li, Guo-Fen Re, Yu Zhao, Xiao-Cong Wu, Rui-Yi Zhou, Yi-Qun Kuang, Kun-Hua Wang
Summary: This study investigated the effects of low- and medium-intensity treadmill exercise on methamphetamine reward in male mice. The results showed that long-term medium-intensity exercise reduced the effects of methamphetamine on inflammation markers in the brain and conditioned place preference scores. Low-intensity exercise was less effective. The study suggests that exercise intensity is an important factor affecting dependence level and inflammatory responses in the brain.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Jie Jia, Yu Zhao, Ji-Qun Yang, Dan-Feng Lu, Xiu-Ling Zhang, Jun-Hong Mao, Kun-Hua Wang, Jian-Hua Wang, Yi-Qun Kuang
Summary: Incomplete immune reconstitution can occur in HIV-infected patients despite achieving viral suppression with antiretroviral therapy (ART). A study found that immune non-responders had decreased diversity in B cell receptor repertoire and disrupted cell cycle of B cells. These findings provide important insights into the role of B cell-mediated immune response in immune reconstitution following HIV infection.
Article
Biochemical Research Methods
Jie Jia, Yu Zhao, Jian-Hua Wang, Yi-Qun Kuang
Summary: This study uses single-cell RNA sequencing technology to dissect the transcriptional changes in immune cells with HIV infection. Peripheral blood mononuclear cells (PBMCs) from HIV-infected individuals were isolated and subjected to scRNA-seq on the 103 Genomics protocol and Illumina NovaSeq 6000 sequencing platform. The function and cellular trajectories of B cell subsets and B cell receptor (BCR) repertoire were analyzed after filtering raw sequences data and normalizing gene expression.
Article
Immunology
Jie Jia, Ji-Qun Yang, Ying-Rong Du, Yu Xu, Deshenyue Kong, Xiu-Ling Zhang, Jun-Hong Mao, Gui-Fang Hu, Kun-Hua Wang, Yi-Qun Kuang
Summary: This study reveals the potential role of immunoregulation mechanisms in resistant hypertension among injection drug users.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Review
Microbiology
Shi-Tao Geng, Zun-Yue Zhang, Yue-Xin Wang, Danfeng Lu, Juehua Yu, Jian-Bo Zhang, Yi-Qun Kuang, Kun-Hua Wang
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Medicine, Research & Experimental
Hong-Mei Wang, Yu-Ye Li, Li-Ping He, Ying-Kui Cao, Tian-Xiang Dong, Yi-Qun Kuang
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2019)