Review
Biochemistry & Molecular Biology
Nicola Antonio di Meo, Davide Loizzo, Savio Domenico Pandolfo, Riccardo Autorino, Matteo Ferro, Camillo Porta, Alessandro Stella, Cinzia Bizzoca, Leonardo Vincenti, Felice Crocetto, Octavian Sabin Tataru, Monica Rutigliano, Michele Battaglia, Pasquale Ditonno, Giuseppe Lucarelli
Summary: Metabolomic analysis has played an important role in bladder cancer research, aiding in biomarker discovery, understanding pathological behavior, and providing starting points for new diagnostic and therapeutic strategies. However, further research is needed to provide stronger evidence and make these tools feasible in clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Yuxin Zhuang, Jinxin Che, Meijuan Wu, Yu Guo, Yongjin Xu, Xiaowu Dong, Haiyan Yang
Summary: This article summarizes the genetic alterations in double hit lymphoma (DHL) and elucidates their implications on cellular processes, including apoptosis, epigenetic regulations, B-cell receptor signaling, and immune escape. The ongoing and potential therapeutic strategies and targeted drugs based on these alterations are reviewed. Understanding DHL studies will provide insight into the disease and facilitate the discovery of more effective treatment strategies.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Review
Oncology
Jin-Fen Xiao, Andrew W. Caliri, Jason E. Duex, Dan Theodorescu
Summary: This review discusses the presence of unfavorable genetic alterations in the FGFR3 gene in 20% of advanced bladder cancer patients and explores the potential therapeutic strategies targeting these alterations and mechanisms of drug resistance. It also highlights the clinical findings of combining FGFR inhibition with other targeted inhibitors and/or immunotherapy to improve outcomes for patients with suboptimal responses to FGFR3-directed monotherapy.
Article
Genetics & Heredity
Prerna Pandey, Geetika Suyal, Kiran Pasbola, Rinu Sharma
Summary: Esophageal cancer (EC) incidence is increasing globally, with unchanged recurrence and survival rates due to chemoresistance. This study reveals the involvement of miRNA dysregulation and its relation to dysregulated mRNAs in the development of cisplatin resistance in EC. Comparative profiling using NGS identified significant dysregulation of 261 miRNAs and 1892 genes in a cisplatin-resistant EC cell line. Pathway analysis indicated enrichment of EMT and several signaling pathways in the chemoresistant cells. Validation confirmed the dysregulation of specific miRNAs in the resistant cells. Further analysis highlighted the potential role of these miRNAs and their target genes in the regulation of chemoresistance in esophageal cancer.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2023)
Article
Medicine, Research & Experimental
Tereza Buchtova, Lucie Beresova, Katarina Chroma, Tomas Pluhacek, Tibor Beres, Dominika Kaczorova, Petr Tarkowski, Jiri Bartek, Martin Mistrik
Summary: Cannabinoids derived from Cannabis sativa L. have become more accessible for public consumption in the form of cannabis products. Some cannabis-derived drugs have been approved for managing diseases and chemotherapy-induced nausea and vomiting. Preclinical data using human cell culture models suggests that cannabidiol and cannabis extracts may counteract the anticancer effects of platinum-based drugs commonly used in therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Immunology
David J. Benjamin, Robert Hsu
Summary: The treatment of metastatic urothelial carcinoma has undergone significant changes over the past decade, with the approval of various therapies such as immune checkpoint inhibitors, targeted therapies, and antibody drug conjugates. Despite the identification of multiple recurring mutations through next generation sequencing, only one targeted therapy has been developed and approved so far. Erdafitinib, a pan-fibroblast growth factor receptor (FGFR) inhibitor, has shown effectiveness in treating FGFR-altered urothelial carcinoma, especially when combined with immunotherapy. Ongoing trials are evaluating the use of erdafitinib in different settings and exploring other FGFR targeted agents.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Xin Yan, Xiao Zhang, Hua-Hui Wu, Shao-Jie Wu, Xiao-Yu Tang, Tong-Zu Liu, Sheng Li
Summary: In this study, we constructed and validated TCRPI using cell pair algorithms, which could improve survival prediction and clinical response to immunotherapy for bladder urothelial carcinoma (BLCA) patients and contribute to personalized precision immunotherapy strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Yao Wang, Yang Zhang, Peng-Chao Li, Jiajie Guo, Fan Huo, Jintao Yang, Ru Jia, Juan Wang, Qiju Huang, Dan Theodorescu, Hanyang Yu, Chao Yan
Summary: Bladder cancer is a common disease worldwide, often presenting as nonmuscle invasive. Multiple recurrences of bladder cancer lead to decreased quality of life and high costs. Targeted intravesical chemotherapy using a bladder cancer-specific aptamer can reduce toxicity and enhance therapeutic efficacy.
Article
Oncology
Won Sik Ham, Jee Soo Park, Won Sik Jang, Jongchan Kim
Summary: This study retrospectively evaluated the impact of maximal TUR on the oncological outcomes of PC in MIBC patients. The results showed that maximal TUR was associated with improved PFS, pPFS, and CSS, but did not significantly affect OS.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Bessi Qorri, Reza Bayat Mokhtari, William W. Harless, Myron R. Szewczuk
Summary: Drug repurposing in combination with clinical standard chemotherapeutics opens a novel and promising clinical treatment approach for patients with pancreatic cancer. The combination of aspirin and oseltamivir phosphate with chemotherapeutic gemcitabine shows a therapeutic effect on pancreatic cancer cells, modulating cell proliferation, invasion, clonogenicity, and migration.
Article
Oncology
Caterina Fumagalli, Ilaria Betella, Alessandra Rappa, Maria di Giminiani, Michela Gaiano, Luigi Antonio De Vitis, Benedetta Zambetti, Davide Vacirca, Francesco Multinu, Konstantinos Venetis, Nicoletta Colombo, Massimo Barberis, Elena Guerini Rocco
Summary: This study reports the experience of tumor BRCA testing for the clinical management of epithelial ovarian cancer (EOC) in a single-institution diagnostic setting. The results show that tumor BRCA testing can effectively identify pathogenic/likely pathogenic mutations in EOC patients and provide clinical decision guidance for treatment and risk assessment.
Article
Neurosciences
Satomi Chiken, Masahiko Takada, Atsushi Nambu
Summary: Parkinson's disease is a progressive neurodegenerative disorder characterized by dopamine deficiency. Research shows that changes in the neural pathways in PD lead to a reduction in the initiation of movements and subsequently cause akinesia/bradykinesia. Restoring the information flow through these pathways can help recover voluntary movement execution in PD patients.
Article
Oncology
Zhen Yang, Wei Cui, Ruoying Yu, Xinhua Dong, Jian Zhao, Lu Dai, Qiuxiang Ou, Hua Bao, Xue Wu, Chuanxin Wu, Jinhuo Lai
Summary: In this study, the genomic landscape, main mutations, signaling pathways, and HRR pathway gene alterations of CUP patients were investigated. Clinically actionable mutations for targeted therapies were identified in some patients. These results provide important insights for precision treatment of CUP patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Francisco Sadras, Teneale A. Stewart, Melanie Robitaille, Amelia A. Peters, Priyakshi Kalita-de Croft, Patsy S. Soon, Jodi M. Saunus, Sunil R. Lakhani, Sarah J. Roberts-Thomson, Gregory R. Monteith
Summary: The role of calcium signalling pathways in inducing CAF phenotype has not been fully explored. A CAF model was generated by stimulating normal human mammary fibroblast cells with TGF beta 1, leading to altered calcium influx pathways. Upregulation of VGCCs Ca(V)1.2 and Ca(V)3.2 was observed in both the model and patient-derived breast CAFs, and inhibiting these channels impaired CAF activation. Targeting calcium signalling in breast CAFs could have a therapeutic potential.
Article
Oncology
Adrian Wullweber, Reiner Strick, Fabienne Lange, Danijel Sikic, Helge Taubert, Sven Wach, Bernd Wullich, Simone Bertz, Veronika Weyerer, Robert Stoehr, Johannes Breyer, Maximilian Burger, Arndt Hartmann, Pamela L. Strissel, Markus Eckstein
Summary: The study reveals that CIS is the stage of commitment for determining MIBC tumor subtype, which is crucial for patient prognosis and therapy response.
Meeting Abstract
Clinical Neurology
Ashok Kumar, Dheeraj Khurana, Smita Pattanaik, Mukesh Kumar, Manish Modi, Sukhpal Kaur, Sandhya Ghai, Manisha Nagi, Jitender Gairolla, Rajan Chellappa, C. K. Narayanan
Review
Medical Laboratory Technology
Stein Bergan, Merce Brunet, Dennis A. Hesselink, Kamisha L. Johnson-Davis, Pawel K. Kunicki, Florian Lemaitre, Pierre Marquet, Mariadelfina Molinaro, Ofelia Noceti, Smita Pattanaik, Tomasz Pawinski, Christoph Seger, Maria Shipkova, Jesse J. Swen, Teun van Gelder, Raman Venkataramanan, Eberhard Wieland, Jean-Baptiste Woillard, Tom C. Zwart, Markus J. Barten, Klemens Budde, Maja-Theresa Dieterlen, Laure Elens, Vincent Haufroid, Satohiro Masuda, Olga Millan, Tomoyuki Mizuno, Dirk J. A. R. Moes, Michael Oellerich, Nicolas Picard, Linda Salzmann, Burkhard Toenshoff, Ron H. N. van Schaik, Nils Tore Vethe, Alexander A. Vinks, Pierre Wallemacq, Anders Asberg, Loralie J. Langman
Summary: This report provides an updated and comprehensive presentation of consensus on personalized treatment with MPA, including topics such as analytical criteria, pharmacogenetics, biomarker development, and practical intervention aspects. Graded recommendations on target ranges for selected topics, such as the limited sampling strategies for MPA area under the curve, are included to aid in personalized dosing.
THERAPEUTIC DRUG MONITORING
(2021)
Article
Pediatrics
Sayeeda Zahan, Jitendra Kumar Sahu, Priyanka Madaan, Renu Suthar, Smita Pattanaik, Arushi Gahlot Saini, Lokesh Saini, Amit Kumar, Naveen Sankhyan
Summary: Nitrazepam is a safe and feasible treatment alternative for children with resistant West syndrome (WS), resulting in persistent cessation of spasms and electroclinical response in nearly half of patients.
INDIAN JOURNAL OF PEDIATRICS
(2022)
Review
Biochemistry & Molecular Biology
Rui Miguel Marques Bernardino, Ricardo Leao, Rui Henrique, Luis Campos Pinheiro, Prashant Kumar, Prashanth Suravajhala, Hans Christian Beck, Ana Sofia Carvalho, Rune Matthiesen
Summary: The study explores possible strategies for urinary biomarker discovery, especially focused on proteome of urine EVs for PCa. Through reanalysis of proteomics data and network analysis, the findings suggest that urinary EVs may provide potential biomarkers with higher protein coverage compared to other sample sources and may fully characterize the heterogeneity of PCa.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Ankit P. Jain, Janani Sambath, Gajanan Sathe, Irene A. George, Akhilesh Pandey, Erik W. Thompson, Prashant Kumar
Summary: This study developed a targeted proteomics method to accurately measure the abundance of EMT-associated proteins in cancer cell lines, and revealed discrepancies between proteomic and transcriptomic data. The study also found that changes in the EMT proteome may play a role in tumor transformation across different types of cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Smrita Singh, Mohd Younis Bhat, Gajanan Sathe, Champaka Gopal, Jyoti Sharma, Anil K. Madugundu, Neha S. Joshi, Akhilesh Pandey
Summary: Gastric cancer is categorized into intestinal, diffuse, and indeterminate subtypes based on histology. Despite differences in histology, demographics, and outcomes, the intestinal and diffuse subtypes are treated similarly. This study identified a differential proteomic signature between diffuse and intestinal subtypes, including proteins such as GREM1, BAG2, OLFM4, TRIP6, and MAGE-A9.
Article
Microbiology
Nupur S. Munjal, Dikscha Sapra, K. T. Shreya Parthasarathi, Abhishek Goyal, Akhilesh Pandey, Manidipa Banerjee, Jyoti Sharma
Summary: This study explores the role of ion channels in SARS-CoV-2 infection and uses machine learning algorithms to predict protein-protein interactions between SARS-CoV-2 proteins and human ion channels. The study identifies FDA-approved drugs that interact with these ion channels and suggests potential pathways for therapeutic management of SARS-CoV-2 infection. The research highlights the importance of further experimental validation and drug repurposing approaches.
Article
Medicine, General & Internal
Sewanti Limaye, Darshana Patil, Dadasaheb Akolkar, Navin Srivastava, Revati Patil, Sachin Apurwa, Sanket Patil, Jinumary John, Rahul Gosavi, Prabhu Nesargikar, Prashant Kumar, Vineet Datta, Chirantan Bose, Zarrine Raazi, Ajay Srinivasan, Rajan Datar
Summary: This report demonstrates that angiogenesis inhibitors can be safely and effectively used in combination with cytotoxic anti-cancer agents for the treatment of gastric cancers.
CLINICAL CASE REPORTS
(2021)
Article
Oncology
K. T. Shreya Parthasarathi, Susmita Mandal, Smrita Singh, Seetaramanjaneyulu Gundimeda, Mohit Kumar Jolly, Akhilesh Pandey, Jyoti Sharma
Summary: The alterations in ion channels and their interactions with EMT-related genes play a crucial role in breast cancer development and prognosis.
Review
Oncology
Hardik Sheth, Sewanti Limaye, Prashant Kumar, Aditya Shreenivas
Summary: We report a case of an elderly male with FGFR2-altered advanced adenocarcinoma of the gallbladder who failed two prior lines of chemotherapy but had sustained response and stable disease on sequential FGFR-directed targeted therapy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Cell Biology
Krithika Badarinath, Binita Dam, Sunny Kataria, Ravindra K. Zirmire, Rakesh Dey, Gaurav Kansagara, Johan Ajnabi, Akshay Hegde, Randhir Singh, Tafheem Masudi, Janani Sambath, Sasikala P. Sachithanandan, Prashant Kumar, Akash Gulyani, You-Wen He, Sudhir Krishna, Colin Jamora
Summary: In this study, the transcription factor Snail is found to play a role in maintaining the stemness of epidermal keratinocytes in cutaneous squamous cell carcinoma (cSCC) models through the secretion of Mindin protein and activation of the Src-STAT3 pathway. Disruption of this signaling module attenuates tumorigenesis in human cSCC.
Article
Cell Biology
Irene A. George, Gajanan Sathe, Vivek Ghose, Anuradha Chougule, Pratik Chandrani, Vijay Patil, Vanita Noronha, R. Venkataramanan, Sewanti Limaye, Akhilesh Pandey, Kumar Prabhash, Prashant Kumar
Summary: In this study, we investigated the differential expression of proteins and altered phosphorylation in neoadjuvant chemotherapy-resistant tongue cancer patients. The study revealed differential and extensive phosphorylation of keratins, as well as a kinase signature associated with resistance to neoadjuvant chemotherapy. Pathway analysis showed enrichment of Rho GTPase signaling and hyperphosphorylation of proteins involved in cell motility, invasion, and drug resistance. Targeting these kinases could potentially help with the clinical management of neoadjuvant chemotherapy-resistant tongue cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Ajay Balakrishnan, Antony George Francis Thottian, K. Govind Babu, Prashant Kumar
Summary: This study developed a method for culturing CTCs using Matrigel (R) as a carrier, and correlated the decrease in cell viability after drug treatment with patient improvement. The combination of short-term culturing and drug susceptibility testing provides a novel approach to predict patient response to treatment.
Review
Medical Laboratory Technology
Smita Pattanaik, Arihant Jain, Jasmina Ahluwalia
Summary: Drug-induced hematological disorders can range from life-threatening conditions to mild abnormalities, with pathophysiological mechanisms varying from pharmacological effects to immune reactions. Predicting these reactions is challenging, but pharmacogenomics is evolving for better management, even though incorporation into routine practice remains limited.
THERAPEUTIC DRUG MONITORING
(2021)
Article
Pharmacology & Pharmacy
C. V. N. Harish, Devaraj Belavigi, Amol N. Patil, Smita Pattanaik, Ashish Kakkar, Kripa Shankar Kasudhan
Summary: The Drug Information Center (DIC) service newly initiated in a tertiary care hospital in North India has received over 98% approval from hospital clinicians. Timely responses to clinicians' queries were significantly associated with their satisfaction level, while academic experiences did not affect satisfaction among clinical colleagues. The interpretation ability of on-call pharmacology postgraduate students was significantly associated with clinicians' satisfaction level.
JOURNAL OF PHARMACY PRACTICE
(2021)