Article
Biochemistry & Molecular Biology
Ana Paula Varela Sanches, Josilene Lopes de Oliveira, Maira Schuchter Ferreira, Bruna de Souza Lima, Josiane Erica Miyamoto, Lais Angelica de Paula Simino, Marcio Alberto Torsoni, Adriana Souza Torsoni, Marciane Milanski, Leticia Ignacio-Souza
Summary: The aim of this study was to investigate the parameters of maternal-fetal outcomes in a diet-induced obesity model. Females who were obese and glucose intolerant prior to pregnancy had lower placental efficiency and lower birth weight pups compared to the controls. The study found that maternal obesity disrupts the proportionality between maternal and fetal outcomes during pregnancy, which could be due to hormonal signaling issues and inflammation in the maternal metabolic environment. Maternal obesity also alters placental thickness, fatty acid transport, and the expression of growth factors. Lower expression of epidermal growth factor receptor (EGFR) mRNA in obese mothers may have contributed to placental rupture and adverse fetal outcomes. Maintaining maternal glucose homeostasis and overexpression of placental growth factor (PGF) likely protected the placenta and fetuses from damage.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Szu-Wei Huang, Yu-Che Ou, Kuo-Shu Tang, Hong-Ren Yu, Li-Tung Huang, You-Lin Tain, I-Chun Lin, Jiunn-Ming Sheen, Chih-Yao Hou, Ching-Chou Tsai, Mao-Meng Tiao
Summary: Maternal high-fat diet can lead to weight gain, intrahepatic lipid accumulation, alterations in serum short-chain fatty acid profile, intestinal tight junctions, and dysbiosis. Prenatal metformin alleviates the effects of high-fat diet on maternal rats and reduces inflammation and apoptosis in fetal liver and intestines, indicating potential benefits for pregnant obese women.
LIPIDS IN HEALTH AND DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Bruna de Souza Lima, Ana Paula Varela Sanches, Maira Schuchter Ferreira, Josilene Lopes de Oliveira, Jane K. Cleal, Leticia Ignacio-Souza
Summary: Maternal obesity can have an impact on the health of offspring, particularly during critical periods. Studies have shown that diet and nutritional status play a crucial role in fetal outcomes and placental development. Specifically, a high-fat diet can be considered as a nutritional insult that impairs the maternal-placental axis, thus affecting offspring development and outcomes.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Review
Genetics & Heredity
Beguem Harmancioglu, Seray Kabaran
Summary: Maternal high-fat diet during pregnancy is associated with excessive weight gain and fetal fat mass increase. It also leads to increased activation of proinflammatory cytokines. Maternal insulin resistance and inflammation contribute to increased adipose tissue lipolysis, resulting in elevated levels of free fatty acids in the fetus (>35% of energy from fat).
FRONTIERS IN GENETICS
(2023)
Article
Endocrinology & Metabolism
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Excess maternal energy intake leads to long-term disorders in offspring's brown adipose tissue (BAT), affecting blood lipid panel and BAT structure. It also influences the methylation levels and expression of genes involved in thermogenesis and fatty acid oxidation in BAT.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Arzu Kabasakal Cetin, Tugba Alkan Tug, Atila Gulec, Asli Akyol
Summary: The study showed that maternal taurine supplementation has modest protective effects against cafeteria diet-induced maternal obesity. However, in the setting of normal pregnancy, taurine supplementation may lead to increased neonatal mortality. Further research is needed to explore the optimal dosage of taurine supplementation and its long-term effects on offspring.
Article
Endocrinology & Metabolism
Brian Akhaphong, Brigid Gregg, Doga Kumusoglu, Seokwon Jo, Kanakadurga Singer, Joshua Scheys, Jennifer DelProposto, Carey Lumeng, Ernesto Bernal-Mizrachi, Emilyn U. Alejandro
Summary: Maternal high-fat diet before and during pregnancy may predispose female offspring to insulin resistance in adulthood.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Stephanie E. O'Hara, Kelly M. Gembus, Lisa M. Nicholas
Summary: Exposure to compromised nutritional environment during early life may lead to long-term consequences such as increased risk of type 2 diabetes and obesity in adult offspring. Studies focus on understanding the impact of these exposures on islet morphology and beta-cell function to determine the mechanisms behind the increased risk of diabetes in offspring.
Article
Physiology
Monika Slupecka-Ziemilska, Paulina Grzesiak, Pawel Kowalczyk, Piotr Wychowanski, Jaroslaw Wolinski
Summary: Maternal exposure to a high fat diet during gestation and lactation influences small intestinal growth and maturation in rat pups at 21 days old, leading to changes in body weight, BMI, adiposity, histomorphometry, brush border enzyme activity, and intestinal contractility. Offspring from the maternal HFD group showed upregulated mRNA expression of cyclooxygenase-2, suggesting a programming towards obesity. These results emphasize the significant role of maternal diet preferences in the developmental programming of metabolic diseases.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Jiaqi Cui, Lin Song, Rui Wang, Shuyuan Hu, Zhao Yang, Zengtie Zhang, Bo Sun, Wei Cui
Summary: This study suggests that maternal metformin during gestation and lactation has the potential to overcome the negative effects of perinatal exposure to a high-fat diet in offspring. This is achieved by altering myogenesis, mitochondrial biogenesis, and dynamics through the AMPK/mTOR pathways in skeletal muscle.
Article
Developmental Biology
Mandy Busse, Stefanie Langwisch, Kerry Tedford, Klaus-Dieter Fischer, Ana Claudia Zenclussen
Summary: B cell participation in early embryo/fetal development and the underlying molecular pathways have been explored in this study. The study suggests that B cell-specific MyD88 and IL10 expression is crucial for appropriate embryo development, and IL10+8 cells play a role in regulating uterine blood flow during pregnancy. Furthermore, B cell-specific CD19, MyD88, and IL10 expression influences susceptibility towards preterm birth.
Article
Nutrition & Dietetics
Rui Qin, Ye Ding, Qun Lu, Yangqian Jiang, Jiangbo Du, Ci Song, Hong Lv, Siyuan Lv, Shiyao Tao, Lei Huang, Xin Xu, Cong Liu, Tao Jiang, Zhixu Wang, Hongxia Ma, Guangfu Jin, Yankai Xia, Zhibin Hu, Feng Zhang, Yuan Lin
Summary: This study aimed to evaluate the associations between maternal dietary patterns and intrauterine parameters. The results showed that maternal dietary patterns were associated with fetal head circumference, and unhealthy dietary patterns might have adverse effects on fetal growth.
FRONTIERS IN NUTRITION
(2022)
Review
Nutrition & Dietetics
Sanjay Basak, Ranjit K. Das, Antara Banerjee, Sujay Paul, Surajit Pathak, Asim K. Duttaroy
Summary: Obesity in pregnancy has various effects on fetal neurodevelopment, such as disturbing the transport of essential long-chain PUFAs for brain development and altering the maternal gut microbiota, which further affects fetal brain development.
Article
Biochemistry & Molecular Biology
Kate J. Claycombe-Larson, Amy N. Bundy, Terry Kuntz, Junguk Hur, Kathleen M. Yeater, Shanon Casperson, Dale C. Brunelle, James N. Roemmich
Summary: Maternal dietary fat and vegetable substitution can have significant effects on placental and fetal growth as well as fetal brain gene expression. The findings suggest that vegetable supplementation may protect against the negative impacts of a high-fat diet on fetal development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Review
Nutrition & Dietetics
Natassia Rodrigo, Sonia Saad, Carol Pollock, Sarah J. Glastras
Summary: Maternal obesity has serious implications for both mother and offspring, with potential transgenerational effects. Research using rodent models plays a crucial role in studying the impacts of maternal obesity and exploring intervention strategies to mitigate these effects. Further understanding of the pathophysiology of obesity and its interaction with reproductive health is essential for public health efforts.
Article
Pediatrics
Jenny Voggel, Jasmine Mohr, Kai-Dietrich Nuesken, Jorg Doetsch, Eva Nuesken, Miguel A. Alejandre Alcazar
Summary: This review addresses the impact of perinatal circumstances on kidney health, highlighting the vulnerability of the kidney during the perinatal period to acute kidney injury (AKI) and chronic kidney disease (CKD). It provides a comprehensive overview of various insults during the perinatal period and discusses future preventive, therapeutic, and regenerative directions.
SEMINARS IN FETAL & NEONATAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Charlotte Schoemig, Laura Oberholz, Gregor Fink, Jenny Voggel, Maria Wohlfarth, Joerg Doetsch, Kai-Dietrich Nuesken, Eva Nuesken
Summary: Fetal growth restriction (FGR) is associated with long-term neurocognitive impairment, especially in males. This study examined the cellular composition of the hippocampus and mTOR signaling in male rat FGR offspring and found that different causes of FGR led to dysregulation of hippocampal cellular proliferation and mTOR signaling in different ways. A low-protein diet resulted in decreased cell density, while prenatal surgical stress caused hyperproliferation possibly through increased mTOR signaling.
Article
Endocrinology & Metabolism
Thorben Hoffmann, Yousef Ashraf Tawfik Morcos, Ruth Janoschek, Eva-Maria Turnwald, Antje Gerken, Annette Mueller, Gerhard Sengle, Joerg Doetsch, Sarah Appel, Eva Hucklenbruch-Rother
Summary: This study assessed the potential effects of obesity, gestational diabetes mellitus (GDM), and other clinical parameters on maternal and fetal umbilical plasma asprosin concentrations and placental asprosin expression. The results showed correlations between asprosin levels and various factors, suggesting that asprosin may play a role in pregnancy complications.
ENDOCRINE CONNECTIONS
(2022)
Article
Immunology
Tobias Kretschmer, Eva-Maria Turnwald, Ruth Janoschek, Maria Wohlfarth, Marion Handwerk, Joerg Doetsch, Eva Hucklenbruch-Rother, Sarah Appel
Summary: Obesity in western societies contributes to pregnancy complications and adverse birth outcomes. The inflammatory environment caused by obesity disturbs fetal development and placental function, leading to inadequate nutrient supply. Treatment with MR16-1 shows limited effects in improving placental dysfunction and fetal growth restriction in obese mice.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Vivi F. H. Jensen, Anne-Marie Molck, Jette Nowak, Maria Wohlfarth, Eva Nuesken, Damien Demozay, Kai-Dietrich Nuesken, Ingrid B. Bogh
Summary: Maternal malnutrition can lead to foetal growth restriction and increase the risk of diseases in children. This study investigates the changes in placental nutrient transporters during maternal hypoglycaemia in different stages of gestation in rats. The results suggest that the increase in placental nutrient transporters during maternal hypoglycaemia reflects an adaptive response to optimize foetal nutrient supply and development during limited glucose availability.
Article
Biochemistry & Molecular Biology
Jenny Voggel, Gregor Fink, Magdalena Zelck, Maria Wohlfarth, Julia M. Post, Laura Bindila, Manfred Rauh, Kerstin Amann, Miguel A. Alejandre Alcazar, Joerg Doetsch, Kai-Dietrich Nuesken, Eva Nuesken
Summary: Modifying the dietary n-3/n-6 PUFA ratio can effectively reduce inflammation and hypercoagulability in the kidneys affected by IUGR, and the intervention diet can mitigate the adverse protein signatures associated with IUGR.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jaco Selle, Katrin Bohl, Katja Hoepker, Rebecca Wilke, Katharina Dinger, Philipp Kasper, Bastian Abend, Bernhard Schermer, Roman-Ulrich Mueller, Christine Kurschat, Kai-Dietrich Nuesken, Eva Nuesken, David Meyer, Soni Savai Pullamsetti, Bjoern Schumacher, Joerg Doetsch, Miguel A. Alejandre Alcazar
Summary: Chronic Kidney Disease (CKD) is strongly associated with age-related renal function decline, hypertension, and diabetes, which are consequences of obesity. The mechanisms determining susceptibility to CKD remain insufficiently understood. Perinatal metabolic disorders after intrauterine growth restriction or maternal obesity adversely affect kidney structure and function. Perinatal obesity causes premature aging-associated processes that determine the susceptibility for CKD early in life.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Ruth Janoschek, Marion Handwerk, Eva Hucklenbruch-Rother, Lisa Schmitz, Inga Bae-Gartz, Philipp Kasper, Jan-Wilm Lackmann, Tobias Kretschmer, Christina Vohlen, Andrea Mesaros, Martin Purrio, Alexander Quaas, Joerg Doetsch, Sarah Appel
Summary: The variety of obesogenic diets used in rodent studies is vast and difficult to summarize. Standardization is lacking, and individual compositions lead to individual effects, making the choice of diet ingredients crucial for the outcome and interpretation of obesity studies. This study aimed to compare the individual effects of three commonly used obesogenic diets, focusing on differences in sugar and fat content. The results demonstrated differentiated consequences depending on the fat source and/or fat and sugar quantity, highlighting the importance of conscious selection of diet for reliable and accurate obesity research results.
NUTRITION & METABOLISM
(2023)
Article
Physiology
Kai-Dietrich Nuesken, Eva Nuesken
Article
Urology & Nephrology
Kai-Dietrich Nuesken