Lysostaphin and BMP-2 co-delivery reduces S. aureus infection and regenerates critical-sized segmental bone defects

Hydrogel delivery of lysostaphin eliminates orthopedic implant infection byStaphylococcus aureusand supports fracture healing

(2018) Christopher T. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diminished bone regeneration after debridement of posttraumatic osteomyelitis is accompanied by altered cytokine levels, elevated B cell activity, and increased osteoclast activity

(2017) Johannes M. Wagner et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Treatment Options for Nonunion With Segmental Bone Defects

(2017) Muayad Kadhim et al.   JOURNAL OF ORTHOPAEDIC TRAUMA

Multifunctional coatings to simultaneously promote osseointegration and prevent infection of orthopaedic implants

(2016) Jordan Raphel et al.   BIOMATERIALS

Monitoring immune responses in a mouse model of fracture fixation with and without Staphylococcus aureus osteomyelitis

(2016) Edward T.J. Rochford et al.   BONE

Infectious Dose Dictates the Host Response during Staphylococcus aureus Orthopedic-Implant Biofilm Infection

(2016) Debbie Vidlak et al.   INFECTION AND IMMUNITY

Integrin-specific hydrogels functionalized with VEGF for vascularization and bone regeneration of critical-size bone defects

(2016) José R. García et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

d-amino Acid Inhibits Biofilm but not New Bone Formation in an Ovine Model

(2015) Andrew J. Harmata et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

IL-12 Promotes Myeloid-Derived Suppressor Cell Recruitment and Bacterial Persistence duringStaphylococcus aureusOrthopedic Implant Infection

(2015) Cortney E. Heim et al.   JOURNAL OF IMMUNOLOGY

Interleukin-10 production by myeloid-derived suppressor cells contributes to bacterial persistence during Staphylococcus aureus orthopedic biofilm infection

(2015) Cortney E. Heim et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease

(2014) Mark D. Turner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Bone regeneration using an alpha 2 beta 1 integrin-specific hydrogel as a BMP-2 delivery vehicle

(2014) Asha Shekaran et al.   BIOMATERIALS

Myeloid-Derived Suppressor Cells Contribute to Staphylococcus aureus Orthopedic Biofilm Infection

(2014) C. E. Heim et al.   JOURNAL OF IMMUNOLOGY

A Novel Controlled-Release System for Antibacterial Enzyme Lysostaphin Delivery Using Hydroxyapatite/Chitosan Composite Bone Cement

(2014) Bai Xue et al.   PLoS One

Effects of local delivery of d-amino acids from biofilm-dispersive scaffolds on infection in contaminated rat segmental defects

(2013) Carlos J. Sanchez et al.   BIOMATERIALS

Surgical site infection after open reduction and internal fixation of tibial plateau fractures

(2013) Shishui Lin et al.   European Journal of Orthopaedic Surgery and Traumatology

A Single-Stage Treatment Protocol for Presumptive Aseptic Diaphyseal Nonunions

(2013) Louis F. Amorosa et al.   JOURNAL OF ORTHOPAEDIC TRAUMA

Can We Trust Intraoperative Culture Results in Nonunions?

(2013) Michael P. Palmer et al.   JOURNAL OF ORTHOPAEDIC TRAUMA

Current Practice in the Management of Open Fractures Among Orthopaedic Trauma Surgeons. Part B

(2013) William Obremskey et al.   JOURNAL OF ORTHOPAEDIC TRAUMA

Maleimide Cross-Linked Bioactive PEG Hydrogel Exhibits Improved Reaction Kinetics and Cross-Linking for Cell Encapsulation and In Situ Delivery

(2011) Edward A. Phelps et al.   ADVANCED MATERIALS

Murine Immune Response to a ChronicStaphylococcus aureusBiofilm Infection

(2011) Ranjani Prabhakara et al.   INFECTION AND IMMUNITY

Dual-Purpose Bone Grafts Improve Healing and Reduce Infection

(2011) Scott A Guelcher et al.   JOURNAL OF ORTHOPAEDIC TRAUMA

The use of BMP-2 coupled – Nanosilver-PLGA composite grafts to induce bone repair in grossly infected segmental defects

(2010) Zhong Zheng et al.   BIOMATERIALS

The effectiveness of the controlled release of gentamicin from polyelectrolyte multilayers in the treatment of Staphylococcus aureus infection in a rabbit bone model

(2010) Joshua S. Moskowitz et al.   BIOMATERIALS

Development of chitosan-collagen hydrogel incorporated with lysostaphin (CCHL) burn dressing with anti-methicillin-resistant Staphylococcus aureus and promotion wound healing properties

(2010) Fuying Cui et al.   DRUG DELIVERY

Factors affecting the incidence of infection in hip and knee replacement

(2010) C. A. Willis-Owen et al.   JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME

Prevention and Management of Infections Associated With Combat-Related Extremity Injuries

(2009) Clinton K. Murray et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Lysostaphin: an antistaphylococcal agent

(2008) Jaspal K. Kumar   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Bacteriophage lysins as effective antibacterials

(2008) Vincent A Fischetti   CURRENT OPINION IN MICROBIOLOGY