Article
Endocrinology & Metabolism
Taja Knific, Melisa Lazarevic, Janez Zibert, Nika Obolnar, Natasa Aleksovska, Jasna Suput Omladic, Tadej Battelino, Magdalena Avbelj Stefanija
Summary: This study evaluated the effects of gonadotropin-releasing hormone analog (GnRHa) on final height (FH) in children with central precocious puberty (CPP) and identified factors that predict FH. The results showed that using body weight-adjusted GnRHa dosing can delay the onset of menarche and reach target height. However, individualized decision-making remains challenging in therapeutic intervention.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Chin-Hui Tseng, Yann-Jinn Lee, Chi-Yu Huang, Yi-Lei Wu, Lu-Ting Wang, Chao-Hsu Lin, Bi-Wen Cheng, Fu-Sung Lo, Yu-Jun Chang, Wei-Hsin Ting
Summary: This study aimed to explore the impact of gonadotropin-releasing hormone agonists (GnRHa) on final adult height (FAH) in girls with early and fast puberty. The results showed that GnRHa treatment can restore the target height in some girls with poor height development, especially those with predicted adult height lower than 153 cm and shorter than their target height. Younger age at initiation of treatment and faster growth velocity during treatment are associated with better height gain.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Sara Prosperi, Francesco Chiarelli
Summary: During the COVID-19 pandemic, the implementation of strict measures like lockdowns and school closures caused significant disruptions in the lives of children and adolescents, leading to a sedentary lifestyle, increased use of electronic devices, and higher levels of stress-related symptoms. Studies have reported an increase in early and precocious puberty cases during this period, suggesting a potential role of environmental and lifestyle factors in triggering earlier pubertal onset. It is important to further investigate the exact impact of COVID-19 on pubertal development through global studies and long-term research.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Yuzhen Shi, Ziyi Ma, Xi Yang, Yanqin Ying, Xiaoping Luo, Ling Hou
Summary: This study investigated the effectiveness and safety of combining GnRHa with rhGH in the treatment of girls with CPP. The results showed that the combination therapy produced better height gains, suppressed the gonadal axis, delayed bone age progression, and had good safety and efficacy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Han Chen, Ming Ni, Yun Xu, Li-Yong Zhong
Summary: Children with intracranial germ cell tumors may experience premature sexual development caused by either GnRH-dependent or GnRH-independent factors. This retrospective study found that GnRH-independent precocious puberty often regressed together with tumor regression.
ENDOCRINE-RELATED CANCER
(2022)
Article
Pediatrics
Wenyong Wu, Xiaoyun Zhu, Yun Chen, Xiaohong Yang, Ying Zhang, Ruimin Chen
Summary: The aim of this study was to develop a model for predicting the adult height (AH) of girls with idiopathic central precocious puberty (ICPP) who received gonadotropin-releasing hormone analog (GnRHa) treatment. A unique model based on multiple linear regression was developed and verified using data from 258 girls with ICPP. The model incorporated variables of height SDS, height SDS for bone age, and target height, and showed good discrimination and calibration in both internal and external validation.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Engineering, Environmental
Hung-Tsung Wu, Chi-Chen Chiang, Chung-Teng Wang, Yue-Hwa Chen, Shih-Yuan Hsu, Yang-Ching Chen
Summary: The consumption of nonnutritive sweeteners (NNS) is increasing worldwide, and a study has found that acesulfame potassium (AceK), one of the most widely used NNS, is associated with an increased risk of precocious puberty in girls. Animal studies have also shown that AceK ingestion can accelerate puberty onset and increase the expression of brain gonadotropin-releasing hormone (GnRH). Cellular experiments have revealed that AceK treatment can increase reactive oxygen species production, activate protein kinase A (PKA), and increase the expression of GnRH.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Endocrinology & Metabolism
Patrizia Bruzzi, Lara Valeri, Marcello Sandoni, Simona Filomena Madeo, Barbara Predieri, Laura Lucaccioni, Lorenzo Iughetti
Summary: This study aimed to evaluate the efficacy of GnRHas in the treatment of idiopathic central precocious puberty (ICPP) in girls. The results showed that BMI at diagnosis and transient metabolic complications during treatment did not impact the long-term outcomes of GnRHas therapy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Silvia Ciancia, Daniel Klink, Margarita Craen, Martine Cools
Summary: This study examines the impact of early puberty suppression and gender-affirming hormones on final height in trans boys and trans girls. The results show that these treatments do not affect height, but trans adolescents tend to achieve a final height in line with their sex registered at birth, rather than their experienced gender.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Eun Hye Yang, Ha Young Jo, Su Jeong Park, Hye Won Yoo, Soo-Han Choi, Hye-Young Kim, Kyung Hee Park, Young Mi Kim, Min Jung Kwak
Summary: The study aimed to investigate the effectiveness of gonadotropin-releasing hormone (GnRH) agonist treatment in preserving final height in patients with central precocious puberty (CPP) or early puberty (EP). Medical records of 40 CPP patients and 206 EP patients were retrospectively analyzed. Predicted adult height (PAH) was measured at baseline, after treatment completion, and at final follow-up. Both CPP and EP groups showed significantly increased PAH after treatment, with no difference in the amount of increase between groups.
ANNALS OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Maria Elisabeth Street, Davide Ponzi, Roberta Renati, Maddalena Petraroli, Tiziana D'Alvano, Claudia Lattanzi, Vittorio Ferrari, Dolores Rollo, Stefano Stagi
Summary: Neuro-biological variations in sexual maturation timing are evolutionary strategies influenced by internal and external environmental conditions. Central precocious puberty (CPP) has increased among adopted and COVID-19 pandemic children. Previously, it was believed that better nutrition, environmental stability, and psychological wellbeing contributed to CPP in adopted children. However, data collected during the pandemic suggests other factors related to fear and stress may also trigger early puberty. This review investigates the neurobiological and evolutionary mechanisms of puberty, analyzing the similarities between CPP during the pandemic and in adopted children to identify potential triggers, particularly stress-related activation of the hypothalamic-pituitary-gonadal axis and its correlation with rapid sexual maturation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pediatrics
Rujiang Zheng, Qiuli Chen, Huamei Ma, Juncheng Liu, Huadong Chen, Jianbo Liang, Hongshan Chen, Jun Zhang, Yanhong Li, Song Guo, Bing Wang, Minlian Du
Summary: We report a rare case of bilateral HCG-secreting gonadoblastomas in a 5.25-year-old girl with Turner syndrome and gonadal Y chromosome mosaicism. The patient initially presented with enlarged breasts and later developed virilization symptoms. The importance of serum beta-HCG and AFP detection for the diagnosis of precocious puberty, as well as the presence of Y chromosome and occurrence of gonadal tumors in Turner syndrome, is emphasized.
FRONTIERS IN PEDIATRICS
(2022)
Article
Endocrinology & Metabolism
Dogus Vuralli, Nazli E. Gonc, Zeynep Alev Ozon, Nurgun Kandemir, Ayfer Alikasifoglu
Summary: The study aimed to determine which girls with idiopathic CPP (iCPP) will benefit from GnRHa treatment in terms of height gain. The most important factor influencing height gain was the chronological age (CA) at treatment onset. Girls treated before 6.4 years of age showed significant height gain, while those treated after 8.3 years did not reach the target. Advanced bone age (BA), basal estradiol (E-2), and pubertal stage were significant factors affecting height gain in girls treated between 6.4 and 8.3 years, with all cases meeting certain criteria showing significant height gain.
CLINICAL ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Nao Shibata, Hiromi Nyuzuki, Sunao Sasaki, Yohei Ogawa, Masayasu Okada, Keisuke Nagasaki
Summary: Tumors producing hCG can cause peripheral precocious puberty, as demonstrated in the discussed case of a young girl. Despite its rarity, the case highlights the possibility of peripheral precocious puberty in girls due to hCG-producing tumors. Treatment led to symptom relief and resolution of tumor-related precocious puberty.
Review
Pediatrics
Anastasios Papadimitriou, Dimitrios T. Papadimitriou
Summary: In recent decades, girls are experiencing puberty at an earlier age. Exposure to endocrine-disrupting chemicals has been linked to changes in puberty timing, but studies have inconsistent results. The majority of girls with precocious puberty show a growth pattern unrelated to EDC exposure, indicating that EDCs have only a minor effect on the timing of puberty onset in girls.
Article
Endocrinology & Metabolism
Ana Carolina Bueno, Monica F. Stecchini, Junier Marrero-Gutierrez, Candy Bellido More, Leticia Ferro Leal, Debora Cristiane Gomes, Daniel Ferreira de Lima Neto, Silvia Regina Brandalise, Izilda Aparecida Cardinalli, Jose Andres Yunes, Thais Junqueira, Carlos Alberto Scrideli, Carlos Augusto Fernandes Molina, Fernando Silva Ramalho, Silvio Tucci, Fernanda Borchers Coeli-Lacchini, Ayrton Custodio Moreira, Leandra Ramalho, Ricardo Zorzetto Nicoliello Vencio, Margaret De Castro, Sonir Roberto R. Antonini
Summary: This study found that VDR hypermethylation and underexpression may be predictive and prognostic biomarkers for pediatric adrenocortical tumors.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Pediatrics
Viviane Cunha Cardoso, Carlos Grandi, Rita C. Silveira, Jose Luiz Bandeira Duarte, Maria Candida Ferrarez Bouzada Viana, Daniela Marques de Lima Mota Ferreira, Jose Mariano Sales Alves Jr, Lais Furlan Embrizi, Carolina Boschi Gimenes, Nathalia Moura de Mello e Silva, Fernanda Pegoraro de Godoi Melo, Paulyne Stadler Venzon, Dafne Barcala Gomez, Marynea Silva do Vale, Maria Regina Bentlin, Marina Carvalho de Moraes Barros, Laura Emilia Monteiro Bigelli Cardoso, Edna Maria de Albuquerque Diniz, Jorge Hecker Luz, Sergio Tadeu Martins Marba, Joao Henrique Carvalho Leme de Almeida, Davi Casale Aragon, Fabio Carmona
Summary: This study aims to evaluate the predictive value of selected growth phenotypes for neonatal morbidity and mortality in preterm infants <30 weeks and compare them with INTERGROWTH-21st (IG21). The results show that the selected growth phenotypes differ from IG21 in predicting adverse neonatal outcomes and have poor accuracy.
JORNAL DE PEDIATRIA
(2023)
Article
Neurosciences
Itiana Castro Menezes, Cristiane von Werne Baes, Fernanda Viana Figaro-Drumond, Brisa Burgos Dias Macedo, Ana Carolina Bueno, Riccardo Lacchini, Marcelo Feijo de Mello, Margaret de Castro, Mario Francisco Juruena
Summary: The study found that basal aldosterone levels may be a biomarker for differentiating between bipolar disorder and major depressive disorder. Cortisol and ELS also play a role in distinguishing these two mood disorders.
Article
Endocrinology & Metabolism
Rui M. Patricio Da Silva-Junior, Ana Carolina Bueno, Clarissa Silva Martins, Fernanda Coelli-Lacchini, Jorge Guilherme Okanobo Ozaki, Danillo Cunha De Almeida-E-Silva, Junier Marrero-Gutierrez, Antonio Carlos dos Santos, Carlos Garcia-Peral, Helio Rubens Machado, Marcelo Volpon dos Santos, Paula Lamparelli Elias, Ayrton C. Moreira, Leandro M. Colli, Ricardo Z. N. Vencio, Sonir R. Antonini, Margaret de Castro
Summary: This study explored pituitary tumors in a heterogeneous ethnic population by evaluating methylome and transcriptome signatures. Unsupervised hierarchical clustering analysis revealed three clusters associated with functioning, nonfunctioning, and ACTH-secreting tumors. Differential methylated and expressed genes were found to be associated with tumor clinical presentation and WHO classifications. The clustering of pituitary development/differentiation-related transcripts also supported the classification. Making the data publicly available enables further research on the pathogenesis and prognosis of pituitary tumors.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Aline Faccioli Bodoni, Fernanda Borchers Coeli-Lacchini, Juliana Lourenco Gebenlian, Lays Martin Sobral, Cristiana Bernadelli Garcia, Wilson Araujo Silva Junior, Kamila Chagas Peronni, Leandra Naira Zambelli Ramalho, Fernando Silva Ramalho, Ayrton C. Moreira, Margaret De Castro, Andreia Machado Leopoldino, Sonir Roberto Rauber Antonini
Summary: This study reveals the crucial role of NNT in adrenal steroidogenesis and highlights the association between NNT mutations and familial glucocorticoid deficiency (FGD).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cell Biology
Ana Carolina Bueno, Candy Bellido More, Junier Marrero-Gutierrez, Danillo C. de Almeida E. Silva, Leticia Ferro Leal, Ana Paula Montaldi, Fernando Silva Ramalho, Ricardo Zorzetto Nicoliello Vencio, Margaret de Castro, Sonir Roberto R. Antonini
Summary: The therapeutic potential of vitamin D receptor (VDR) signaling in adrenocortical carcinoma (ACC) cells was evaluated. The study found that VDR was hypermethylated and underexpressed in ACC cells. Treatment with calcitriol and seocalcitol restored VDR signaling, resulting in antiproliferative effects and impaired Wnt/B-catenin signaling. In vivo experiments showed that seocalcitol constrained the growth of ACC xenografts and reduced tumor steroid secretion without side effects. These findings suggest that VDR signaling may be a potential therapeutic target for ACC.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Paula Conde Lamparelli Elias, Marcelo Volpon, Giovana de Gobbi Azevedo, Helio Machado, Gabriel Henrique Marques Goncalves, Antonio Carlos Santos, Livia M. Mermejo, Margaret de Castro, Ayrton C. Moreira
Summary: Postoperative complications after transsphenoidal surgery (TSS) are rare, but can include partial hypopituitarism, meningitis, cerebrospinal fluid leaks, visual deficits, and cerebrovascular complications. This case report highlights an unexpected mesencephalic infarct following TSS, likely induced by cerebral vasospasm due to minor subarachnoid hemorrhage. Vigilance for vasospasm is important, especially for patients with significant suprasellar extension. It is essential to inform patients about this potential complication prior to TSS due to its significant neurological impact.
ENDOCRINOLOGY DIABETES AND METABOLISM CASE REPORTS
(2023)
Article
Multidisciplinary Sciences
Camila Maciel de Oliveira, Luiza Borcony Bolognese, Mercedes Balcells, Davi Casale Aragon, Roberto Luis Zagury, Clemente Nobrega, Chunyu Liu
Summary: Klivo, a Brazilian startup, has developed a digital therapeutic product for managing type 2 diabetes. The study aims to evaluate the management of daily life habits in patients with type 2 diabetes and measure clinically significant outcomes. This research will provide insights into improving the health of patients with type 2 diabetes and other cardiometabolic conditions using a digital therapeutic strategy.
Review
Endocrinology & Metabolism
Marina Lanciotti Campanini, Joao Paulo Almeida, Clarissa Silva Martins, Margaret de Castro
Summary: Research over the past 20 years has provided important insights into the molecular pathogenesis of craniopharyngiomas. Different molecular differences between the adamantinomatous (ACP) and papillary (PCP) subtypes have been identified, revealing their distinct genetic profiles and signaling pathways. Mutations in CTNNB1 and BRAF genes are prevalent in ACP and PCP, respectively, leading to specific cellular changes. Understanding these pathways is crucial for the development of targeted therapies.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2023)
Article
Microbiology
Juannicelle Godoi, Silvia Negrini, Davi Aragon, Paulo Rocha, Fabiana Amaral, Bento Negrini, Sara Teixeira, Aparecida Yamamoto, Heloisa Bettiol, Marisa Mussi-Pinhata
Summary: Normocephalic children exposed to the Zika virus during pregnancy do not have a higher risk of neurodevelopmental abnormalities at two years of age.
Meeting Abstract
Endocrinology & Metabolism
Mariana Peduti Halah, Ana Carolina Maia Teodozio, Davi Casale Aragon, Paula Conde lamparelli Elias, Margaret de Castro, Ayrton Custodio Moreira, Sonir Roberto Rauber Antonini
HORMONE RESEARCH IN PAEDIATRICS
(2023)
Meeting Abstract
Endocrinology & Metabolism
Ana Carolina Maia Teodozio, Mariana Peduti Halah, Davi Casale Aragon, Paula Lamparelli Elias, Margaret de Castro, Ayrton Custodio Moreira, Sonir Roberto Rauber Antonini
HORMONE RESEARCH IN PAEDIATRICS
(2023)
Article
Pediatrics
Walusa Assad Goncalves-Ferri, Cristina Helena Faleiros Ferreira, Lara Malosso Sgarbi Albuquerque, Julia Belcavelo Contin Silva, Mariel Versiane Caixeta, Fabio Carmona, Cristina Calixto, Davi Casale Aragon, Gerson Crott, Marisa M. Mussi-Pinhata, Anelise Roosch, Lourenco Sbragia
Summary: This study describes the steps and management of applying hypothermia in preterm infants using low technology and presents the safety aspects of the initiative. The results show that controlled hypothermia for preterm infants with NEC is safe when performed through passive methods with incubator servo-control for temperature management.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)