Article
Multidisciplinary Sciences
Xianzhe Yu, Binjie Zhang, Cailing Fan, Qianqian Yan, Shenglin Wang, Hui Hu, Qinxi Dong, Gengyu Du, Yanan Gao, Chaoyuan Zeng
Summary: D-amino acids are biologically significant, but their identification remains challenging due to their structural similarities. In this study, a chiral fluorescent probe was developed to specifically detect D-arginine and enable both quantitative and qualitative determination of its concentration and enantiomeric configuration.
Article
Biology
Masanobu Yoshikawa, Takugi Kan, Kosuke Shirose, Mariko Watanabe, Mitsumasa Matsuda, Kenji Ito, Mitsuru Kawaguchi
Summary: High concentrations of d-aspartic acid and low concentrations of d-serine and d-alanine were found in the parotid, submandibular, and sublingual glands in rats. Enzymes including d-amino acid oxidase, d-aspartate oxidase, and serine racemase were detected in these major salivary glands. The N-methyl-d-aspartic acid receptor subunits NR1 and NR2D were also present. These findings suggest that d-amino acids play a physiological role in the endocrine and exocrine functions of salivary glands.
Article
Biochemistry & Molecular Biology
Akina Osaki, Marie Aoyama, Masashi Mita, Kenji Hamase, Masato Yasui, Jumpei Sasabe
Summary: This study investigated the origin of D-serine in the mouse brain and found that besides the known source of D-serine through the enzymatic synthesis, there is an endogenous, SR-independent source of D-serine which may contribute to the baseline activity of NMDARs.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Elizabeth Bester, Anel Petzer, Jacobus P. Petzer
Summary: Inhibition of DAAO represents a potential treatment for schizophrenia by increasing NMDA receptor function. The compounds studied in this research not only showed inhibition of DAAO, but also demonstrated potential as MAO inhibitors for the treatment of depression and Parkinson's disease.
BIOORGANIC CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Glenn Dallerac, Xia Li, Pierre Lecouflet, Nadege Morisot, Silvia Sacchi, Rachel Asselot, Thu Ha Pham, Brigitte Potier, David J. G. Watson, Staffan Schmidt, Gregoire Levasseur, Pascal Fossat, Andrey Besedin, Jean-Michel Rivet, Joseph T. Coyle, Ginetta Collo, Loredano Pollegioni, Jan Kehr, Micaela Galante, Kevin C. Fone, Alain M. Gardier, Thomas Freret, Angelo Contarino, Mark J. Millan, Jean-Pierre Mothet
Summary: The study reveals the crucial role of D-serine in regulating glutamatergic transmission in the prefrontal cortex through D1 and D3 receptors, which are essential components in the dopamine-glutamate dialogue. In vivo microdialysis showed that D1 and D3 receptors modulate extracellular levels and activity of D-serine in the PFC via the cAMP/PKA signaling cascade. Furthermore, D-serine is necessary for the cognitive enhancement by D3 receptor blockade, as demonstrated in novel object recognition memory test.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Letter
Biochemistry & Molecular Biology
Yusuke Gonda, Chiharu Ishii, Masashi Mita, Naoto Nishizaki, Yoshiyuki Ohtomo, Kenji Hamase, Toshiaki Shimizu, Jumpei Sasabe
Summary: Astrocytic DAO specifically regulates D-serine in the hindbrain, without affecting D-amino acid levels in the forebrain or periphery.
Article
Endocrinology & Metabolism
Haiyan Jiang, He Zhang, Xue Jiang, Shengzhou Wu
Summary: The study suggests that reduced levels of DAAO in the retinas of diabetic animals contribute to neurovascular abnormalities. Overexpression of DAAO through virus injection can prevent loss of retinal ganglion cells and disruption of the blood-retinal barrier in diabetic rats.
Review
Chemistry, Medicinal
Siqi Du, Michael Wey, Daniel W. Armstrong
Summary: Investigations on the occurrence and biochemical roles of free D-amino acids and D-amino acid-containing peptides and proteins in living systems have increased in frequency and significance. Their occurrence and roles may vary substantially with progression from microbiotic to evermore advanced macrobiotic systems. Many biosynthetic and regulatory pathways have been understood, and important uses for D-amino acids in plants, invertebrates, and vertebrates have been reviewed. The occurrence and role of D-amino acids in human disease are also presented separately due to its importance.
Article
Psychiatry
Barbara Lombardo, Marco Pagani, Arianna De Rosa, Marcella Nunziato, Sara Migliarini, Martina Garofalo, Marta Terrile, Valeria D'Argenio, Alberto Galbusera, Tommaso Nuzzo, Annaluisa Ranieri, Andrea Vitale, Eleonora Leggiero, Anna Di Maio, Noemi Barsotti, Ugo Borello, Francesco Napolitano, Alessandra Mandarino, Marco Carotenuto, Uriel Heresco-Levy, Massimo Pasqualetti, Paolo Malatesta, Alessandro Gozzi, Francesco Errico, Francesco Salvatore, Lucio Pastore, Alessandro Usiello
Summary: The study suggests that D-aspartate plays an important role in neurodevelopment and functioning, and the dysmetabolism of D-aspartate is associated with neurodevelopmental disorders such as schizophrenia. Using a mouse model, the researchers found that early occurrence of D-aspartate can influence neurodevelopment and lead to social recognition memory deficits.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Pharmacology & Pharmacy
Tsugumi Shindo, Hiroki Shikanai, Akane Watarai, Sachiko Hiraide, Kenji Iizuka, Takeshi Izumi
Summary: This study found that the dysfunction of D-serine metabolism associated with AD/HD leads to NMDA receptor dysfunction. Inhibiting DAAO enzyme can increase D-serine levels and improve AD/HD-like behaviors.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Robin Roychaudhuri, Moataz M. Gadalla, Timothy West, Solomon H. Snyder
Summary: The study reveals the presence of endogenous D-cysteine in mammals and introduces a novel bioluminescent assay for its quantitative estimation in tissues. The findings highlight the enrichment of D-cysteine in embryonic brains and its higher levels in human brain white matter compared to gray matter.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Biophysics
Shouhei Takamatsu, Inyoung Lee, Jinhee Lee, Ryutaro Asano, Wakako Tsugawa, Kazunori Ikebukuro, Jeffrey E. Dick, Koji Sode
Summary: This study reports a novel sensing principle for o-serine using transient potentiometry based o-serine sensor with engineered DAAOx. The sensor showed rapid and sensitive signals, suitable for monitoring with different time resolution and concentration ranges.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biochemistry & Molecular Biology
Tetsuya Miyamoto, Toshiyuki Moriya, Masumi Katane, Yasuaki Saitoh, Masae Sekine, Kumiko Sakai-Kato, Tairo Oshima, Hiroshi Homma
Summary: In this study, a novel D-amino acid aminotransferase (TM0831) was identified and characterized in Thermotoga maritima. TM0831 exhibited aminotransferase and racemase activities, and was involved in the production of D-amino acids in T. maritima.
Article
Cell Biology
Shunsuke Takagi, Matthew D. Puhl, Thea Anderson, DarrickT Balu, Joseph T. Coyle
Summary: This study reveals the important role of d-serine synthesized by SR in GABAergic medium spiny neurons in the striatum in mediating dopaminergic stimulant effects.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tomokazu Ito, Natsumi Muto, Haruna Sakagami, Miho Tanaka, Hisashi Hemmi, Tohru Yoshimura
Summary: In recent years, it has been found that most existing organisms do not depend on D-amino acids for growth, limiting our understanding of their biological functions. However, researchers have discovered an Escherichia coli strain lacking major D-Ala and D-Glu biosynthetic enzymes that can grow well when supplemented with certain D-amino acids. This finding provides a new platform for further research on D-amino acid-metabolizing enzymes.