期刊
FRONTIERS IN ENDOCRINOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2019.00323
关键词
unconventional oil and gas; energy expenditure; endocrine disrupting chemicals; developmental origins of health and disease; hydraulic fracturing; metabolism; metabolic disruptors
资金
- NIH [DK088940, R21ES026395, R01ES021394-04S1]
- department of Obstetrics, Gynecology and Women's Health, University of Missouri
- VA-Merit Grant [I01BX003271-01]
- VA Merit Award [1I01BX002567-01]
- United States Environmental Protection Agency Science To Achieve Results Fellowship Assistance Agreement [FP-91747101]
Previous studies conducted in our laboratory have found altered adult health outcomes in animals with prenatal exposure to environmentally relevant levels of unconventional oil and gas (UOG) chemicals with endocrine-disrupting activity. This study aimed to examine potential metabolic health outcomes following a preconception, prenatal and postnatal exposure to a mixture of 23 UOG chemicals. Prior to mating and from gestation day 1 to postnatal day 21, C57BL/6J mice were developmentally exposed to a laboratory-created mixture of 23 UOG chemicals in maternal drinking water. Body composition, spontaneous activity, energy expenditure, and glucose tolerance were evaluated in 7-month-old female offspring. Neither body weight nor body composition differed in 7-month female mice. However, females exposed to 1.5 and 150 mu g/kg/day UOG mix had lower total and resting energy expenditure within the dark cycle. In the light cycle, the 1,500 mu g//kg/day group had lower total energy expenditure and the 1.5 mu g/kg/day group had lower resting energy expenditure. Females exposed to the 150 mu g/kg/day group had lower spontaneous activity in the dark cycle, and females exposed to the 1,500 mu g/kg/day group had lower activity in the light cycle. This study reports for the first time that developmental exposure to a mixture of 23 UOG chemicals alters energy expenditure and spontaneous activity in adult female mice.
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