Article
Microbiology
Md Rezaul Karim, Zunita Zakaria, Latiffah Hassan, Nik Mohd Faiz, Nur Indah Ahmad
Summary: The prevalence of colistin resistance and its molecular mechanisms were studied in Enterobacteriaceae isolated from chicken and chicken meats. Among 627 isolates, 8.6% demonstrated phenotypic colistin resistance, and 12.96% of these resistant isolates carried mcr genes. Specifically, mcr-1 and mcr-5 genes were detected in 11.11% and 1.85% of the colistin-resistant isolates, respectively. This study also identified the first report of the mcr-5 gene in Malaysia. Further investigations are required to characterize mcr-5 harboring bacteria and their associated plasmids.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Infectious Diseases
Yasuhide Kawamoto, Norihito Kaku, Norihiko Akamatsu, Kei Sakamoto, Kosuke Kosai, Yoshitomo Morinaga, Norio Ohmagari, Koichi Izumikawa, Yoshihiro Yamamoto, Hiroshige Mikamo, Mitsuo Kaku, Kazunori Oishi, Katsunori Yanagihara
Summary: This study investigated the prevalence of colistin resistance and mcr gene carriage in ESBL and CRE isolates in Japan. The results showed that the frequency of colistin resistance and mcr-positive strains is not high in Japan, but continuous monitoring of mcr genes is necessary.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Biochemistry & Molecular Biology
Shengnan Xie, Li Li, Baihe Zhan, Xue Shen, Xuming Deng, Wenxi Tan, Tianqi Fang
Summary: The study identified pogostone as a potential inhibitor of the MCR-1 gene, which can restore the bactericidal activity of colistin against MCR-1-positive bacterial strains and effectively treat severe infections caused by MCR-1-positive Enterobacteriaceae.
Article
Microbiology
Qian Zhao, Yiming Li, Yingxin Tian, Yueyun Shen, Shaolin Wang, Ying Zhang
Summary: In this molecular epidemiological study, the prevalence of MCRPE in Chinese patients from 2009 to 2019 was investigated. The study found a decline in MCRPE prevalence in China after the banning of colistin usage as a feed additive in 2017. However, the permission of colistin usage in clinical therapy may still increase the risk of MCRPE transmission and intractable infections.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Sarrah Landolsi, Rachid Selmi, Linda Hadjadj, Asma Ben Haj Yahia, Kaouther Ben Romdhane, Lilia Messadi, Jean Marc Rolain
Summary: The emergence of multidrug-resistant bacteria is a major concern, and cockroaches may contribute to the spread of these bacteria between the environment and humans. This study investigated the presence of drug-resistant Enterobacteriaceae in cockroaches collected from various locations in Tunisia. The findings suggest that cockroaches can act as carriers of drug-resistant bacteria, posing a risk for nosocomial infections in hospitals.
MICROBIOLOGY SPECTRUM
(2022)
Article
Infectious Diseases
Hongwei Zhou, Siheng Wang, Yuchen Wu, Ning Dong, Xiaoyang Ju, Chang Cai, Ruichao Li, Yan Li, Congcong Liu, Jiayue Lu, Edward Wai-Chi Chan, Sheng Chen, Rong Zhang, Zhangqi Shen
Summary: This study investigated the prevalence of mcr-9 and mcr-10 in Enterobacter cloacae complex (ECC) strains in China and found that the coexistence and co-transfer of mcr genes and carbapenemase genes pose an urgent threat to public health.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Infectious Diseases
Md. Rezaul Karim, Zunita Zakaria, Latiffah Hassan, Nik Mohd Faiz, Nur Indah Ahmad
Summary: This study found that colistin-resistant Enterobacteriaceae isolates recovered from poultry and poultry meats carry multiple drug-resistance genes, including the mcr gene. These isolates often exhibit multi-drug resistance and pose potential threats to infection treatment choices for humans and animals.
Article
Microbiology
Christian Xedzro, Toshi Shimamoto, Liansheng Yu, Hui Zuo, Yo Sugawara, Motoyuki Sugai, Tadashi Shimamoto
Summary: This study reports the emergence of Enterobacter cloacae and Raoultella ornithinolytica carrying the mcr-9.1 gene in vegetables from Japan. The presence of colistin-resistant bacteria in vegetables is a significant public health concern. Monitoring and preventing the dissemination of mcr homologs in the vegetable industry is crucial.
MICROBIOLOGY SPECTRUM
(2023)
Article
Plant Sciences
Ge Song, Yonglin Zhou, Sen Niu, Xuming Deng, Jiazhang Qiu, Li Li, Jianfeng Wang
Summary: The study found that nordihydroguaiaretic acid (NDGA) can restore the antibacterial activity of colistin against resistant E. coli without inducing resistance. NDGA achieves this by directly inhibiting the activity of the resistance gene MCR-1 and damaging the bacterial cell membrane. Experimental results also showed that the combination of NDGA and colistin exhibited a synergistic effect in vivo.
Article
Microbiology
Pegah Kananizadeh, Tatsuya Tada, Satoshi Oshiro, Tomomi Hishinuma, Mari Tohya, Yuki Uehara, Yumi Kumagai, Isao Nagaoka, Kanako Nishi, Masahito Hashimoto, Shin Watanabe, Teruo Kirikae
Summary: Three isolates of the Enterobacter cloacae complex carrying the mcr-9 gene were found to be susceptible to colistin, but the minimum inhibitory concentrations (MICs) varied under different test conditions. Colistin was able to induce the expression of mcr-9 gene in a dose-dependent manner and increase the survival rates of the isolates against human antimicrobial peptide LL-37. Screening of the isolates using specific agar medium revealed the presence of mcr-9 gene and other colistin-resistant isolates.
JOURNAL OF CLINICAL MICROBIOLOGY
(2022)
Review
Immunology
Masego Mmatli, Nontombi Marylucy Mbelle, John Osei Sekyere
Summary: This research found that mcr genes are widely distributed in Enterobacteriaceae species and pose a threat to public health as they are mainly transmitted to humans through food animals. The dissemination of mcr genes is mediated by mobile genetic elements and there are compensatory adaptation mechanisms. Combination therapy is a promising option for managing and treating colistin-resistant Enterobacteriaceae infections.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Medicine, General & Internal
Firdoos Ahmad Gogry, Mohammad Tahir Siddiqui, Insha Sultan, Qazi Mohd Rizwanul Haq
Summary: The global interest in colistin has risen due to the prevalence of multidrug-resistant Gram-negative Enterobacteriaceae, leading to the emergence of colistin-resistant bacteria. However, some Gram-negative species are intrinsically resistant to colistin, and most identified colistin resistance involves modification of lipid A to decrease or remove interaction with colistin. Changes in membrane structure, specifically in the outer membrane lipopolysaccharide (LPS), play a key role in colistin resistance mechanisms. New methods and approaches are being developed to detect and combat colistin resistance, with a focus on developing less toxic and more effective drugs to treat bacterial infections.
FRONTIERS IN MEDICINE
(2021)
Article
Biology
Chen Xu, Chenyu Liu, Kaichao Chen, Ping Zeng, Edward Wai Chi Chan, Sheng Chen
Summary: The drug otilonium bromide restores the activity of colistin against colistin-resistant Gram-negative bacteria and reduces toxicity, it also exhibits synergistic effect in eradicating multidrug-tolerant persisters of Gram-negative bacteria.
COMMUNICATIONS BIOLOGY
(2022)
Article
Infectious Diseases
Shang Lu, Dan Li, Leilei Wang, Yingmin Bi, Minghua Wang, Fan Yang
Summary: This study identified the mcr-1 gene in 15 clinical isolates of Enterobacteriaceae, with promoter variations associated with expression of the mcr-1 gene and ultimately the levels of colistin resistance.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Infectious Diseases
Michael Timmermans, Pierre Wattiau, Olivier Denis, Cecile Boland
Summary: This study identified a reservoir of mobile colistin resistance genes (mcr-1 to -5) in commensal Escherichia coli isolated from healthy pigs, cattle and poultry in Belgium over at least 5 years (2012-2016), highlighting the ongoing presence of colistin resistance genes in these animal populations.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
