Article
Psychology, Biological
Milena Radoman, Stephanie M. Gorka
Summary: Individuals with high intolerance of uncertainty (IU) display maladaptive responses to uncertain outcomes and IU is a risk factor for psychiatric disorders. This study examined the relationship between IU and anterior insula (AIC) using fMRI. IU was correlated with increased functional connectivity between the AIC and dorsal anterior cingulate cortex (dACC) and right dorsolateral prefrontal cortex (dlPFC) in the U-threat model. These findings suggest that salience and central executive control networks may underlie IU expression.
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2023)
Article
Neurosciences
Ellen L. Terry, Jared J. Tanner, Josue S. Cardoso, Kimberly T. Sibille, Song Lai, Hrishikesh Deshpande, Georg Deutsch, Catherine C. Price, Roland Staud, Burel R. Goodin, David T. Redden, Roger B. Fillingim
Summary: This study found different relationships between pain, catastrophizing, and functional connectivity in non-Hispanic black (NHB) and non-Hispanic white (NHW) groups, providing evidence for a potentially important role of ethnicity/race in the interrelationships among pain, catastrophizing, and resting-state functional connectivity.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Clinical Neurology
Victoria A. Grunberg, Ryan A. Mace, Sarah M. Bannon, Jonathan Greenberg, Jafar Bakhshaie, Ana-Maria Vranceanu
Summary: The study suggests that pain catastrophizing and mindfulness are important intervention targets to enhance emotional functioning for chronic pain patients, and should be considered simultaneously in interventions.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Medicine, General & Internal
Monica Magarinos Lopez, Maria Jose Lobato Rodriguez, Angela Menendez Garcia, Sophie Garcia-Cid, Ana Royuela, Augusto Pereira
Summary: The study found that women with CPP have high levels of neuroticism, low extraversion, and low conscientiousness, along with moderate to severe levels of depression, high levels of trait and state anxiety, catastrophizing, and low pain acceptance. These psychological factors are important to consider in developing interventions to improve the clinical course of CPP.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Yuanliang Zhu, Dan Li, Yucheng Zhou, Yue Hu, Zhangyu Xu, Lei Lei, Fangyuan Xu, Jianxiong Wang
Summary: High-frequency repetitive transcranial magnetic stimulation (HF rTMS) on the dorsolateral prefrontal cortex (DLPFC) can relieve chronic pain and accompanying depressive symptoms, particularly showing significant analgesic effects in the mid-term and long-term.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Psychiatry
Yuanyuan Chen, Peijun Ju, Qingrong Xia, Peng Cheng, Jianliang Gao, Loufeng Zhang, Hua Gao, Xialong Cheng, Tao Yu, Junwei Yan, Qiru Wang, Cuizhen Zhu, Xulai Zhang
Summary: This study aimed to investigate the association between pain catastrophizing and comorbidity of major depressive disorder (MDD) and chronic pain (CP). The results showed that pain catastrophizing and anxiety were more severe in the comorbidity group compared to the MDD-only group and healthy control group. Pain catastrophizing and anxiety may potentially impact the comorbidity of depression and chronic pain.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Anesthesiology
Hung-Yu Liu, Kun-Hsien Chou, Pei-Lin Lee, Yen-Feng Wang, Shih-Pin Chen, Kuan-Lin Lai, Ching-Po Lin, Shuu-Jiun Wang, Wei-Ta Chen
Summary: This study used magnetic resonance imaging to investigate the neural structures and networks associated with widespread pain in fibromyalgia patients. The findings revealed that as the number of pain areas increased, the volume of the right anterior insular cortex decreased. Additionally, there was an increasing number of neural substrates in subcortical regions that showed structural covariance with the right anterior insular cortex. Conversely, the strength of structural covariance between the right anterior insular cortex and other brain regions, such as the precuneus, frontal cortex, anterior and posterior cingulate, and lingual gyri, decreased.
Article
Anesthesiology
Josep Roman-Juan, Elisabet Sanchez-Rodriguez, Ester Sole, Elena Castarlenas, Mark P. Jensen, Jordi Miro
Summary: The purpose of this study was to examine the associations between anxiety, depressive symptoms, and pain catastrophizing with pain medication use in adolescents with chronic pain, and to explore if these associations differed by sex. The results showed that pain catastrophizing was a unique predictor of pain medication use. There was no moderating effect of sex on the associations between psychological factors and pain medication use.
Article
Psychology, Multidisciplinary
Line Caes, Cynthia van Gampelaere, Eline Van Hoecke, Myriam Van Winckel, Kristien Kamoen, Liesbet Goubert
Summary: This study explored how daily fluctuations in children's pain intensity, as perceived by parents, moderated the impact of parental catastrophic thoughts on daily parental distress and goals regarding their child's pain. Results showed that high levels of perceived child pain intensity exacerbated parental distress, especially for those with high levels of catastrophic thinking. Perceived child pain intensity also influenced parental endorsement of pain control and activity engagement goals, highlighting the complexity of parental responses to their child's pain.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Psychology, Multidisciplinary
Hee Jun Kim, Timothy J. Meeker, Ju-Yang Jung, Ji-Won Kim, Hyoun-Ah Kim
Summary: This study explored factors associated with chronic secondary musculoskeletal pain in rheumatic diseases. It found that psychological and social factors play a role in pain intensity and interference. Females are more directly affected by depressive symptoms, while pain catastrophizing affects both males and females.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Neurosciences
Hyun Jung Jee, Elaine Zhu, Mengqi Sun, Weizhuo Liu, Qiaosheng Zhang, Jing Wang
Summary: Pain catastrophizing is a clinical phenomenon where patients amplify the negative value of pain or similar non-painful stimuli. A study on rats found that repeated noxious stimuli may lead to hyperactivity in the anterior cingulate cortex (ACC) and cause increased avoidance of subthreshold stimuli. Inhibiting the activity of ACC may play a role in treating pain catastrophizing.
Review
Clinical Neurology
Xianwei Che, Robin F. H. Cash, Xi Luo, Hong Luo, Xiaodong Lu, Feng Xu, Yu-Feng Zang, Paul B. Fitzgerald, Bernadette M. Fitzgibbon
Summary: The study found that high-frequency rTMS stimulation of the DLPFC has significant short-term analgesic effects on neuropathic pain. There is also an overall pain reduction in the midterm and long term, as well as significant analgesic effect on provoked pain following HF-rTMS over the DLPFC.
Article
Psychiatry
Deepika E. Slawek, Madiha Syed, Chinazo O. Cunningham, Chenshu Zhang, Jonathan Ross, Merrill Herman, Nancy Sohler, Haruka Minami, Frances R. Levin, Julia H. Arnsten, Joanna L. Starrels
Summary: Through analyzing chronic pain patients, this study identified four distinct groups with varying levels of pain catastrophizing and mental health symptoms. Patients with high pain catastrophizing and high mental health symptoms showed the worst pain intensity and quality of life, emphasizing the importance of addressing pain catastrophizing in treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Review
Anesthesiology
Emanuele M. Giusti, Marco Lacerenza, Gian Mauro Manzoni, Gianluca Castelnuovo
Summary: This study found a significant association between psychological predictors and chronic postsurgical pain, with state anxiety being the most explanatory factor. Optimism, psychological distress, and other psychological predictors are consistently associated with chronic postsurgical pain.
Review
Behavioral Sciences
Brandon C. Yarns, Justina T. Cassidy, Amy M. Jimenez
Summary: Experts have recently introduced research-driven subtypes of chronic pain based on proposed underlying mechanisms, with nociplastic pain potentially involving factors such as brain plasticity and emotion regulation. Data suggest a correlation between anger, anger regulation, and the presence/severity of nociplastic pain.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Meeting Abstract
Clinical Neurology
Nora Eszlari, Bence Bruncsics, Andras Millinghoffer, Gabor Hullam, Peter Petschner, Xenia Gonda, Gerome Breen, Peter Antal, Gyorgy Bagdy, Bill Deakin, Gabriella Juhasz
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Psychiatry
Natalia Kocsel, Ferenc Koteles, Attila Galambos, Gyongyi Kokonyei
Summary: The study revealed that self-critical rumination may have a long-term negative impact on psychological functioning, especially when resting HRV is lower, leading to more severe somatic symptom distress. However, prospectively, the interaction between self-critical rumination and resting HRV did not significantly predict somatic symptom distress.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2022)
Article
Multidisciplinary Sciences
Peter Petschner, Daniel Baksa, Gabor Hullam, Dora Torok, Andras Millinghoffer, J. F. William Deakin, Gyorgy Bagdy, Gabriella Juhasz
Summary: The study identified key genes possibly related to migraine and depression in the European cohort, including PRDM16, 1p31.1, REST, HPSE2, and ADGRL2. Both main and interaction effect SNPs of these genes enhanced the predictive power of the neural network classifier.
Article
Nutrition & Dietetics
Nora Eszlari, Bence Bruncsics, Andras Millinghoffer, Gabor Hullam, Peter Petschner, Xenia Gonda, Gerome Breen, Peter Antal, Gyorgy Bagdy, John Francis William Deakin, Gabriella Juhasz
Summary: The study revealed that optimal folate intake was associated with lower worry levels, but not with rumination. Genetic associations for worry were not specific, while past-oriented rumination showed a more distinct genetic background. This suggests potential benefits of folate in anxiety disorders and highlights the importance of considering genetic and environmental factors for personalized interventions.
Article
Multidisciplinary Sciences
Kinga Gecse, Dora Dobos, Csaba Sandor Aranyi, Attila Galambos, Daniel Baksa, Natalia Kocsel, Edina Szabo, Dorottya Pap, David Virag, Krisztina Ludanyi, Gyongyi Kokonyei, Miklos Emri, Gyorgy Bagdy, Gabriella Juhasz
Summary: This study demonstrates that plasma tryptophan plays a role in altering periaqueductal gray matter functional connectivity in migraine patients. Migraineurs showed higher plasma tryptophan levels compared to healthy controls. The correlation between altered functional connectivity in regions responsible for fear-cascade and pain modulation and plasma tryptophan concentration was only observed in migraine patients, suggesting increased sensitivity to tryptophan in these individuals. Trait-anxiety and depressive symptoms were correlated with periaqueductal gray matter functional connectivity in migraine patients, and the effect of tryptophan on these correlations was explored.
SCIENTIFIC REPORTS
(2022)
Article
Behavioral Sciences
Dora Dobos, Edina Szabo, Daniel Baksa, Kinga Gecse, Natalia Kocsel, Dorottya Pap, Terezia Zsombok, Lajos R. Kozak, Gyongyi Kokonyei, Gabriella Juhasz
Summary: Stress, a major trigger for migraines, can be reduced by behavioral techniques such as autogenic training (AT). Our pilot study explored the effect of AT on functional brain changes related to migraines and stress. We found that after a 16-week training course, migraineurs showed decreased activation in migraine-associated brain regions when exposed to fearful visual stimuli. Additionally, we observed changes in brain activation patterns between healthy subjects and migraineurs. These findings suggest that AT may influence emotional perception, emotional and motor response integration, and cognitive control, while also reducing activation in regions involved in migraine attacks.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Behavioral Sciences
Peter P. Ujma, Nora Eszlari, Andras Millinghoffer, Bence Bruncsics, Dora Torok, Peter Petschner, Peter Antal, Bill Deakin, Gerome Breen, Gyorgy Bagdy, Gabriella Juhasz
Summary: The study used polygenic scores (PGSs) to assess the molecular genetic effects on educational attainment in Hungary, and found that PGS is significantly associated with the attainment of a college degree and the number of education years in Hungarian samples. The study also compared the PGS effect sizes between Hungarian and English participants, showing higher PGS effect sizes in Hungarian participants attending higher education after the fall of Communism, though the difference was not statistically significant due to lack of statistical power.
BRAIN AND BEHAVIOR
(2022)
Article
Psychiatry
Janos Bokor, Sara Sutori, Dora Torok, Zsofia Gal, Nora Eszlari, Dorka Gyorik, Daniel Baksa, Peter Petschner, Gianluca Serafini, Maurizio Pompili, Ian M. Anderson, Bill Deakin, Gyorgy Bagdy, Gabriella Juhasz, Xenia Gonda
Summary: The study found that IL6 variants interact with childhood or recent adversities to influence suicidal behavior, with no significant clumps affecting hopelessness. The results may contribute to understanding the role of neuroinflammation and IL-6 in suicide, providing new biological markers for suicidal behavior.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Daniel Baksa, Edina Szabo, Natalia Kocsel, Attila Galambos, Andrea Edit Edes, Dorottya Pap, Terezia Zsombok, Mate Magyar, Kinga Gecse, Dora Dobos, Lajos Rudolf Kozak, Gyorgy Bagdy, Gyongyi Kokonyei, Gabriella Juhasz
Summary: This study used fMRI to investigate brain activity differences in episodic migraine subgroups with different circadian attack onset peaks. The results showed that there were significant differences in brain activation between subgroups, indicating heterogeneity within migraine patients and alterations in sensitivity to threatening fearful stimuli.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Cell Biology
Kinga Gecse, Andrea Edes, Tamas Nagy, Adrienn Demeter, David Virag, Marton Kiraly, Borbala Dalmadi Kiss, Krisztina Ludanyi, Zsuzsanna Kornyei, Adam Denes, Gyorgy Bagdy, Gabriella Juhasz
Summary: Altered tryptophan metabolism may increase susceptibility to migraines by interfering with neural and brain hypersensitivity, as well as interacting with chemokines and cytokines that control vascular and inflammatory processes.
Article
Multidisciplinary Sciences
Natalia Kocsel, Zsolt Horvath, Melinda Reinhardt, Edina Szabo, Gyongyi Kokonyei
Summary: The study found a significant association between nonproductive thoughts, somatic symptoms, and subjective well-being, with gender having a minimal impact on these relationships while age playing a crucial moderating role.
Article
Clinical Neurology
Zsofia Gal, Dora Torok, Xenia Gonda, Nora Eszlari, Ian Muir Anderson, Bill Deakin, Gabriella Juhasz, Gyorgy Bagdy, Peter Petschner
Summary: Evidence from a population genetic database showed that variation in the CLDN5 gene can modulate the effects of the IL6 gene variant in stress-induced depression in humans. The interaction among interleukin-6, claudin-5, and recent stress may be involved in the development of depression. These genetic polymorphisms may help to identify individuals at higher risk for stress-induced depression.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Brigitte Biro, Renata Cserjesi, Natalia Kocsel, Attila Galambos, Kinga Gecse, Lilla Nora Kovacs, Daniel Baksa, Gabriella Juhasz, Gyongyi Kokonyei
Summary: Emotional flexibility refers to the ability to adjust emotional responses in different environmental contexts. A study found that providing contextual cues can activate specific brain regions, leading to changes in emotional responses and interpretation of emotional situations, thereby supporting emotional flexibility.
Article
Chemistry, Medicinal
Nora Eszlari, Zsolt Bagyura, Andras Millinghoffer, Tamas Nagy, Gabriella Juhasz, Peter Antal, Bela Merkely, Gyorgy Bagdy
Summary: This study investigated the associations of CTNNA2 gene-wide single-nucleotide polymorphisms (SNPs) with psychiatric and cardiovascular risk factors, with rumination playing a mediating role in these associations. CTNNA2 genetics may serve as biomarkers, and increasing the expression or function of CTNNA2 protein may be a potential new therapeutic approach in psychiatric disorders with perseverative negative thinking such as depression.
