Article
Clinical Neurology
Guiliang Zheng, Yupeng Liu, Jingchun He, Shuna Li, Qing Zhang, Maoli Duan, Jun Yang, Yulian Jin
Summary: Wide endolymphatic sac decompression has a higher vertigo control rate, better improvement of QOL, and relatively higher hearing stability or improvement rate after surgery in patients with MD compared with LESD and ESMS.
FRONTIERS IN NEUROLOGY
(2022)
Review
Otorhinolaryngology
Joseph D. Tang, Anthony J. Grady, Christopher J. Nickel, Lindsey E. Ryan, Alexander Malone, Leah Canvasser, Kestutis Paul Boyev
Summary: This study systematically reviewed the literature on endolymphatic sac tumors to better understand their clinical presentation, treatment options, and outcomes. The results showed that a high degree of suspicion is needed for early diagnosis, and complete resection is the standard of care. The routine use of adjuvant radiation therapy is not strongly supported by evidence.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Review
Clinical Neurology
G. Liu, J. C. Benson, C. M. Carr, J. I. Lane
Summary: This study aimed to characterize the normal appearance of the vestibular aqueduct on MR images, with a focus on enhancement. The results showed that enhancement was more commonly seen and more intense on postgadolinium FLAIR images compared to T1 fat-saturated images, and should not be mistaken for pathology.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ping Lei, Yangming Leng, Jing Li, Renhong Zhou, Bo Liu
Summary: This study found that anatomical variations of the inner ear may be a predisposing factor in the pathogenesis of unilateral Meniere's disease (MD), but have less impact on ipsilateral delayed endolymphatic hydrops (DEH).
EUROPEAN RADIOLOGY
(2022)
Article
Clinical Neurology
Lisa M. H. de Pont, Maartje T. P. M. Houben, Thijs O. Verhagen, Berit M. Verbist, Mark A. van Buchem, Claire C. Bommelje, Henk M. Blom, Sebastiaan Hammer
Summary: This study aimed to investigate whether non-visualization of the ED-ES system is a discriminative radiological feature for MD, and whether different angular trajectories of the ED-ES system are associated with distinguishable clinical features. The results showed that non-visualization of the ED-ES system is significantly associated with MD, and the MD-140 subtype is associated with a longer disease duration, a higher prevalence of bilateral MD, and a trend toward a male preponderance.
FRONTIERS IN NEUROLOGY
(2023)
Article
Surgery
Munehisa Fukushima, Shiro Akahani, Hidenori Inohara, Noriaki Takeda
Summary: This case report describes a 5-year course of MD in a patient where EH was repeatedly observed, and the use of PPT device reduced vertiginous episodes according to a decrease in EH volume, suggesting that PPT may inhibit the development of EH. A larger study group size is needed to further test these preliminary findings on EH changes.
FRONTIERS IN SURGERY
(2021)
Article
Multidisciplinary Sciences
Keiji Honda, Hyun Jae Lee, Andrew J. Griffith, Isabelle Roux
Summary: Research on mutant mouse models of human hearing and balance disorders has unveiled changes in the development and function of neurosensory epithelia, but limited knowledge exists about the endolymphatic sac. Difficulty in visualizing and microdissecting this tissue, largely due to its single-cell layer composition, hinders further understanding of this understudied part of the inner ear.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Clinical Neurology
David Bachinger, Bernhard Schuknecht, Julia Dlugaiczyk, Andreas H. Eckhard
Summary: Bilateral progression of Meniere's disease correlates with radiological markers of endolymphatic sac hypoplasia. With over two-thirds of patients progressing bilaterally, this predictive tool may become a crucial guide for future therapeutic management.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Yangming Leng, Ping Lei, Cen Chen, Yingzhao Liu, Kaijun Xia, Bo Liu
Summary: By measuring anatomical variables of the endolymphatic sac and duct using MRI, vestibular migraine can be differentiated from unilateral Meniere's disease. However, the diagnostic value of these variables is low and further research is needed.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Tadashi Kitahara, Tadao Okayasu, Taeko Ito, Hiroto Fujita, Keita Ueda
Summary: In patients with Meniere's disease, surgical results showed a significant reduction in plasma vasopressin levels after endolymphatic sac drainage surgery, leading to good surgical outcomes. However, in recurrent Meniere's disease, an increase in plasma vasopressin levels post-surgery was associated with recurrent vertigo attacks and sensorineural hearing loss. Therefore, maintaining low plasma vasopressin levels may be crucial for effective treatment of Meniere's disease.
FRONTIERS IN NEUROLOGY
(2021)
Article
Surgery
De-Jun Zhang, Ze-Ming Fu, Fang Guo, Yi-Ning Wan, Guo-Fang Guan
Summary: Endolymphatic sac tumor (ELST) is a rare group of low-grade malignant tumors originating from the endolymphatic sac of the inner ear. The lack of specificity in clinical manifestations makes timely diagnosis difficult, leading to challenges in the treatment of advanced ELSTs. This case report highlights the successful use of the transotic approach for tumor resection, emphasizing the importance of complete surgical resection and careful management of important structures.
JOURNAL OF CRANIOFACIAL SURGERY
(2023)
Article
Otorhinolaryngology
Anquan Peng, Junjiao Hu, Qin Wang, Xueying Pan, Zhiwen Zhang, Wenqi Jiang, Yichao Chen, Chao Huang
Summary: The study demonstrates that both endolymphatic duct blockage surgery and endolymphatic sac drainage surgery have the potential to reduce EH in certain MD patients, while endolymphatic sac decompression surgery did not show reversal of EH.
JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2021)
Article
Otorhinolaryngology
Jennifer L. Spiegel, Ivelina Stoycheva, Bernhard G. Weiss, Mattis Bertlich, Tobias Rader, Martin Canis, Friedrich Ihler
Summary: This study investigated the safety and efficacy of endolymphatic mastoid shunt surgery (EMSS) in patients with Meniere's Disease (MD) according to the 2015 diagnostic criteria. The results showed that EMSS was beneficial for two-thirds of patients with MD, improving vertigo control without causing significant hearing or vestibular complications. Therefore, EMSS should be considered before resorting to destructive treatment options.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Review
Otorhinolaryngology
Riddhijyoti Talukdar, Sridhar Epari, Ayushi Sahay, Amit Choudhari, Archya Dasgupta, Abhishek Chatterjee, Tejpal Gupta
Summary: Endolymphatic sac tumour (ELST) is a rare low-grade locally aggressive neoplasm that typically arises as part of VHL syndrome or sporadically. Gross total resection is the best chance for cure, with radiotherapy reserved for unresectable disease or as salvage therapy for recurrent or progressive tumors.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Otorhinolaryngology
Feitian Li, Yibo Zhang, Wei Li, Qianru Wu, Dedi Kong, Xunbei Shi, Chunfu Dai
Summary: This study proposed a novel grading system for endolymphatic sac tumors (ELSTs) to determine the optimal surgical approach. Surgical resection remains the primary treatment option for ELSTs, and long-term follow-up is crucial for postoperative monitoring.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Otorhinolaryngology
Robert Mlynski, David Bachinger, Theresa Langanke, Susen Lailach, Marcus Neudert, Nora M. Weiss
Summary: This study compared the COMOT-15 and the ZCMEI-21 in assessing HRQoL in chronic otitis media patients. Both questionnaires exhibited satisfactory psychometric properties with subtle differences. The COMOT-15 focuses on hearing while the ZCMEI-21 provides a comprehensive assessment of the COM symptom complex.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Nora Weiss, Torben Stallbaum, Jannik Botzen, David Baechinger, Wilma Grossmann, Hans Edgar Bernd, Robert Mlynski
Summary: Mastoid cavity obliteration is a surgical challenge with no significant difference found between the materials used in terms of recurrence rate, hearing outcomes, and health-related quality of life within the 13.5-month observation period of both groups. Regular clinical follow-up, including ear microscopy, is necessary for chronic middle ear disease to detect recurrent cholesteatoma early and prevent revision surgeries.
LARYNGO-RHINO-OTOLOGIE
(2022)
Article
Audiology & Speech-Language Pathology
P. Roman-Naranjo, M. D. C. Moleon, I. Aran, A. Escalera-Balsera, A. Soto-Varela, D. Bachinger, M. Gomez-Finana, A. H. Eckhard, J. A. Lopez-Escamez
Summary: Rare variants in the MYO7A gene were found to be associated with familial Meniere's disease, with co-segregation of variants in other genes like CDH23, PCDH15, or ADGRV1. These genes may affect the structure of hair cell stereocilia in familial MD.
Article
Neurosciences
Jonas Fellmann, David Baechinger, Adrian Dalbert, Christof Roeoesli, Alexander Huber, Vincent G. Wettstein
Summary: This study aimed to investigate the effects of preoperative vestibular prehabilitation on postural stability during walking and handicap of dizziness in patients with vestibular schwannoma (VS). However, the results showed that vestibular prehab had no effect on these measures.
JOURNAL OF VESTIBULAR RESEARCH-EQUILIBRIUM & ORIENTATION
(2022)
Correction
Otorhinolaryngology
Nora Weiss, Torben Stallbaum, Jannik Botzen, David Bachinger, Wilma Grossmann, Hans Edgar Bernd, Robert Mlynski
LARYNGO-RHINO-OTOLOGIE
(2021)
Article
Oncology
Pablo Roman-Naranjo, Alberto M. Parra-Perez, Alba Escalera-Balsera, Andres Soto-Varela, Alvaro Gallego-Martinez, Ismael Aran, Nicolas Perez-Fernandez, David Baechinger, Andreas H. Eckhard, Rocio Gonzalez-Aguado, Lidia Frejo, Jose A. Lopez-Escamez
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, General & Internal
Adrian Dalbert, David Baechinger, Michael Soyka, Christof Roeoesli, Ilhan Inci, Mace M. Schuurmans, Yvonne Achermann, Alexander Huber
Summary: This study describes the use of calcium sulfate beads as an antibiotic carrier in a patient with chronic mastoiditis complicated by otogenic meningitis caused by Burkholderia cenocepacia. The findings suggest that calcium sulfate matrix may serve as a potential local antibiotic carrier in complicated mastoiditis cases.
CLINICAL CASE REPORTS
(2022)
Article
Clinical Neurology
Marc Basil Schmid, David Bachinger, Athina Pangalu, Dominik Straumann, Julia Dlugaiczyk
Summary: This study aimed to identify patients who developed acute unilateral peripheral vestibulopathy (AUPVP) after COVID-19 vaccination. A retrospective analysis of medical records was conducted, and it was found that 8 out of 26 AUPVP patients developed acute vestibular symptoms within 30 days after vaccination. Two patients showed recovery of vestibular function, while the remaining six patients displayed different patterns of organ damage. This study highlights the importance of monitoring and reporting cases of AUPVP after COVID-19 vaccination.
FRONTIERS IN NEUROLOGY
(2022)
Article
Otorhinolaryngology
Nora M. Weiss, Tabita M. Breitsprecher, Alexander Pscheidl, David Baechinger, Stefan Volkenstein, Stefan Dazert, Robert Mlynski, Soenke Langner, Peter Roland, Anandhan Dhanasingh
Summary: This study evaluates the volume of the vestibular aqueduct (VA) in different types of inner ear malformations and compares 3D-reconstructed VA volume to 2D measurements. The results show that patients with inner ear malformations have larger VA volumes compared to controls. The study suggests that 3D reconstruction and VA volumetry may provide additional information for diagnosing enlarged vestibular aqueduct (EVA) in cases with or without additional inner ear malformations.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Otorhinolaryngology
David Baechinger, Tabita M. Breitsprecher, Alexander Pscheidl, Anandhan Dhanasingh, Robert Mlynski, Stefan Dazert, Soenke Langner, Nora M. Weiss
Summary: This study aimed to refine the definition of a narrow internal auditory canal (IAC) by measuring the IAC volume in both control patients and patients with inner ear malformations (IEMs). The results showed significantly smaller IAC volumes in patients with IEMs. The study suggests that radiologic assessment of the IAC is crucial in patients with severe sensorineural hearing loss undergoing cochlear implantation.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Paula Robles-Bolivar, David Bachinger, Alberto M. Parra-Perez, Pablo Roman-Naranjo, Alba Escalera-Balsera, Alvaro Gallego-Martinez, Andreas H. Eckhard, Jose A. Lopez-Escamez
Summary: A novel variant in CENPP gene was identified in a Swiss family with low-frequency sensorineural hearing loss (SNHL). This study reveals the potential role of CENPP gene in SNHL.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Clinical Neurology
Tabita M. Breitsprecher, Alexander Pscheidl, David Bachinger, Stefan Volkenstein, Anandhan Dhanasingh, Vincent Van Rompaey, Robert Mlynski, Stefan Dazert, Paul Van de Heyning, Sonke Langner, Peter Roland, Nora M. Weiss
Summary: This study evaluates the volumes of the cochlea and vestibular system in different types of Inner Ear Malformations (IEMs) and finds that quantitative reference values for IEM obtained in this study were consistent with existing qualitative diagnostic characteristics. A cutoff value of less than 60 mm(3) for cochlear volume may indicate an abnormally small cochlea. Normal reference values for volumes of the cochlea and vestibular system may aid in diagnosing IEM.
OTOLOGY & NEUROTOLOGY
(2022)
Article
Clinical Neurology
Eva Mosimann, David Bachinger, Andreas Eckhard, Philipp Reddiess, Dorothe Veraguth, Christof Roosli, Alexander Huber, Anthony De Vere-Tyndall, Sebastian Winklhofer, Julia Dlugaiczyk, Adrian Dalbert
Summary: This study investigates the prevalence of endolymphatic hydrops in candidates for cochlear implantation with profound sensorineural hearing loss and its impact on audiovestibular function. The results suggest that around one third of candidates have endolymphatic hydrops, but it does not affect cochlear function preservation and may increase the risk of loss of otolith function after cochlear implantation.
OTOLOGY & NEUROTOLOGY
(2022)
Article
Pathology
Muriel D. Brada, Elisabeth J. Rushing, David Bachinger, Loris Zoller, Irene A. Burger, Martin W. Hullner, Holger Moch, Alexander Huber, Andreas H. Eckhard, Niels J. Rupp
HEAD & NECK PATHOLOGY
(2022)
Article
Music
David Baechinger
Summary: By the beginning of his fourth decade, Robert Schumann suffered from hearing disorders and vertigo, which were previously regarded independently and possibly linked to a psychological/functional disorder, as well as syphilis. This essay examines the medical plausibility and musicological significance of a presumed otosyphilis in Schumann, drawing on diary entries, letters, and contemporary accounts.
ARCHIV FUR MUSIKWISSENSCHAFT
(2021)