期刊
KOREAN JOURNAL OF INTERNAL MEDICINE
卷 34, 期 3, 页码 470-479出版社
KOREAN ASSOC INTERNAL MEDICINE
DOI: 10.3904/kjim.2019.108
关键词
Extracellular vesicles; Cells; Communication; Kidney
资金
- National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2017R1D1A3B03029800]
- Soonchunhyang University Research Fund
Many cells in the nephron release extracellular vesicles (EVs). EVs envelop nucleic acids, proteins, and lipids. The surfaces of EVs express donor cell-specific markers, ligands, and major histocompatibility complex molecules. They are involved in cell-to-cell communication, immune modulation, and the removal of unwanted materials from cells. EVs have been studied as biomarkers of specific diseases and have potential therapeutic applications. Recent research has emphasized the functions of EVs in the kidney. This review provides an overview of recent findings related to the roles of EVs in the nephron, and their utility as biomarkers and therapeutic factors in renal disease.
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