Article
Immunology
Zhichen Zhu, Xiaofang Xie, Hua Yu, Wei Jia, Bin Shan, Bin Huang, Fen Qu, Siqiang Niu, Jinnan Lv, Qizhao Gao, Feinan Qian, Xiangxiang Tian, Yaxuan Zhai, Yicheng Wen, Chengcheng Yang, Jie Zhu, Yiwei Tang, Liang Chen, Hong Du
Summary: This study conducted a genomic analysis on 92 isolates of Enterobacter-caused infections from multiple tertiary health centres in China, revealing that the most common CR-Ent species in China was E. xiangfangensis and the major lineages were ST171 and ST116 E. xiangfangensis. Additionally, the prevalent carbapenemase-encoding plasmid carried by CR-Ent strains was identified as bla(NDM)-harbouring IncX3-type plasmid. This study provides the first detailed genomic and clinical characteristics of CR-Ent in China.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Microbiology
Xiaolin Zhu, Yaru Zhang, Zhangqi Shen, Lining Xia, Jinquan Wang, Li Zhao, Ke Wang, Wenhui Wang, Zhihui Hao, Zhihai Liu
Summary: This study investigated the prevalence of NDM-1-producing multidrug-resistant Proteus mirabilis strains in commercial broilers in China. The results showed that these isolates were resistant to multiple antibiotics, with some carrying NDM-1 genes on transferable plasmids. The genomic analysis indicated diverse genetic backgrounds among the isolates, suggesting a potential threat to the environment and public health.
Article
Veterinary Sciences
Aijuan Li, Runhao Yu, Wenbo Zhao, Stefan Schwarz, Chenglong Li, Hong Yao, Xiang-Dang Du
Summary: This study reports the co-existence of tigecycline and carbapenem resistance genes in porcine Acinetobacter towneri isolate, highlighting the importance of antimicrobial resistance surveillance in food-producing animals.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Infectious Diseases
Hasan Ejaz, Muhammad Usman Qamar, Kashaf Junaid, Sonia Younas, Zeeshan Taj, Syed Nasir Abbas Bukhari, Abualgasim E. Abdalla, Khalid O. A. Abosalif, Naveed Ahmad, Zikria Saleem, Eman H. M. Salem
Summary: The emergence of carbapenem-resistant Acinetobacter calcoaceticus-baumannii complex (CRACB) in clinical environments is a significant global concern. These critical pathogens have shown resistance to a broad spectrum of antibacterial drugs, including carbapenems. CRACB isolates displayed resistance to most antibiotics, except tigecycline and colistin.
Article
Microbiology
Tsegaye Sewunet, Daniel Asrat, Yimtubezinash Woldeamanuel, Abraham Aseffa, Christian G. Giske
Summary: The prevalence of multidrug-resistant isolates of Pseudomonas and Acinetobacter spp. is high in a tertiary hospital in Ethiopia. Clonal spread of carbapenem-resistant A. baumannii is observed in the admission wards. The emergence of bla(NDM-1) in the intensive care and surgical wards poses a severe threat that requires urgent intervention.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Xinhua Luo, Zhe Yin, Lianhua Yu, Jin Zhang, Dakang Hu, Mengqiao Xu, Peng Wang, Fengling Wang, Jiao Feng
Summary: This study thoroughly analyzed the detailed genomic characteristics of clinical strain 211703 of Aeromonas caviae, which co-carried bla(RSA-1) and bla(NDM-1) genes. The strain contained a single chromosome without any plasmids, and 15 different types of resistant genes were identified. The study also revealed the role of mobile genetic elements in facilitating the spread of resistance genes.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Microbiology
Na Liu, Xin Zheng, Qianhui Zhu, Zilong He, Songnian Hu
Summary: Acinetobacter baumannii is a common hospital pathogen that has been increasing in strains carrying the NDM-1 gene. Through investigating 186 strains with the NDM-1 gene, this study aims to provide a theoretical basis for preventing the dissemination of NDM-1 in A. baumannii.
CURRENT MICROBIOLOGY
(2022)
Article
Microbiology
Katerina Tsilipounidaki, Christos-George Gkountinoudis, Zoi Florou, George C. Fthenakis, Vivi Miriagou, Efthymia Petinaki
Summary: The present study reports the detection and molecular characterization of nine blaNDM-1-positive Acinetobacter baumannii isolates isolated from patients in a tertiary care hospital in Central Greece. The isolates were characterized using whole genome sequencing, revealing their multilocus sequencing typing (MLST), bla(NDM-1) environment, resistome, and virulence genes. The results showed that the isolates belonged to four different clones. This is the first report of the emergence of polyclonal bla(NDM-1)-positive Acinetobacter baumannii in Greece. The findings highlight the need for diligent surveillance protocols to limit the horizontal transfer of the bla(NDM-1) gene.
Article
Microbiology
Renqiao Wen, Hongcheng Wei, Tiejun Zhang, Peng Ma, Qin Wang, Chao Li, Zhonghan Li, Changwei Lei, Hongning Wang
Summary: This study investigated the epidemiological characteristics of bla(NDM) in swine and chicken farms in southwestern China. The results showed that bla(NDM) primarily spread through carriers within the same farm and among different farms. Animal-derived and human-derived bla(NDM) strains exhibited a high degree of genetic similarity, suggesting a potential mutual transmission between them.
Article
Zoology
Lu-Chao Lv, Yao-Yao Lu, Xun Gao, Wan-Yun He, Ming-Yi Gao, Kai-Bin Mo, Jian-Hua Liu
Summary: This study characterized NDM-5-producing Enterobacteriaceae from aquatic products in Guangzhou, China, identifying bla(NDM-5) in Citrobacter freundii and Escherichia coli strains on various plasmids. The transfer of bla(NDM-5) between different plasmids was likely facilitated by the Tn7051 transposon, expanding the transmission vectors of this carbapenemase gene.
ZOOLOGICAL RESEARCH
(2022)
Article
Immunology
Carlos R. Kiffer, Thais F. T. Rezende, Daniela Testoni Costa-Nobre, Ana Silvia Scavacini Marinonio, Lucas Hidemitsu Shiguenaga, Debora Nicole Oliveira Kulek, Lavinia Nery Villa Stangler Arend, Ivson Cassiano de Oliveira Santos, Bruna Ribeiro Sued-Karam, Claudio Marcos Rocha-de-Souza, Leticia Kraft, Andre Abreu, Renata Tigulini de Souza Peral, Ana Paula D'Alincourt Carvalho-Assef, Marcelo Pillonetto
Summary: A seven-year surveillance in Brazil revealed a significant increase in resistance genes during the COVID-19 pandemic, particularly bla(NDM) in Enterobacterales and Pseudomonas aeruginosa. However, there was a decrease in bla(KPC) in Enterobacterales and bla(SPM) in P. aeruginosa. These findings are important for informing Antimicrobial Resistance public policies.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Peng Wang, Cuidan Li, Zhe Yin, Xiaoyuan Jiang, Xinyue Li, Xiaofei Mu, Nier Wu, Fei Chen, Dongsheng Zhou
Summary: This study conducted a genomic epidemiology analysis on global Providencia isolates and revealed diverse antimicrobial resistance genes and high resistance ratios in Providencia. The study also investigated the genetic basis for the spread of bla(NDM-1) in Providencia. The findings provide a comprehensive genomic view of species differentiation, antimicrobial resistance prevalence, and plasmid-mediated bla(NDM-1) dissemination in Providencia.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Infectious Diseases
Hao Guo, Lirong Li, Yanmin Chen, Fang He
Summary: We report the genome sequence of a multidrug-resistant A. bereziniae strain co-carrying bla OXA-301 and bla NDM-1 from China. These findings contribute to understanding the genomic characteristics of this pathogen and are of significance for its future prevalence.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2023)
Article
Microbiology
Yanling Feng, Guanhua Xue, Junxia Feng, Chao Yan, Jinghua Cui, Lin Gan, Rui Zhang, Hanqin Zhao, Wenjian Xu, Nannan Li, Shiyu Liu, Shuheng Du, Weiwei Zhang, Hailan Yao, Jun Tai, Lijuan Ma, Ting Zhang, Dong Qu, Yongxiang Wei, Jing Yuan
Summary: The New Delhi metallo-beta-lactamase (NDM) gene confers resistance to most beta-lactam antibiotics, making it crucial to detect this gene in children's clinical samples. The use of the recombinase-aided amplification (RAA) assay successfully identified bla(NDM) genes in children's stool samples, with some samples also testing positive for carbapenem-resistant bacteria. The presence of bla(NDM) and multidrug resistance genes poses significant challenges for pediatric treatment.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Sabahat Abdullah, Abdulrahman Almusallam, Mei Li, Muhammad Shahid Mahmood, Muhammad Ahmad Mushtaq, Nahla O. Eltai, Mark A. Toleman, Mashkoor Mohsin
Summary: Carbapenem resistance among Enterobacterales has become a global health concern. Clinical Escherichia coli isolates producing the metallo ss-lactamase NDM have been isolated from two hospitals in Faisalabad, Pakistan. The E. coli strains showed high levels of multidrug resistance and blaNDM-5 was the most prevalent subtype. Strong infection control management in hospitals is necessary to prevent the emergence of carbapenem resistance in Gram-negative bacteria.
MICROBIOLOGY SPECTRUM
(2023)
