Article
Biochemistry & Molecular Biology
Wei-Lin Teng, Pao-Hsien Huang, Hui-Chun Wang, Chih-Hua Tseng, Feng-Lin Yen
Summary: PTS can protect keratinocytes from PM-induced damage by inhibiting ROS production and related protein cascades, maintaining moisturizing protein expression. PTS has the potential to become a cosmetic ingredient.
Article
Oncology
Hyun Ju Ko, Jeongtae Kim, Meejung Ahn, Jin Hwa Kim, Geun Soo Lee, Taekyun Shin
Summary: Our study demonstrates that EGT can protect skin cells from UVB-induced photoaging by inhibiting ROS production, apoptosis, and inflammation, as well as reducing the expression of collagen degradation-related genes in fibroblasts.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Environmental Sciences
Yuanxu Li, Gaolong Zhong, Ting He, Jinwen Quan, Siying Liu, Zhonghua Liu, Zhaoxin Tang, Wenlan Yu
Summary: The exposure to arsenic and copper can activate the Nrf2 antioxidant pathway to reduce oxidative stress and induce kidney cell pyroptosis and apoptosis. Knocking out Nrf2 decreases antioxidant capacity and leads to more severe apoptosis, pyroptosis, and nephrotoxicity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Liping Wu, Fan Yang, Sufei Du, Ting Hu, Shaofeng Wei, Guoze Wang, Qibing Zeng, Peng Luo
Summary: Chronic exposure to high-dose inorganic arsenic promotes apoptosis of human keratinocytes through the TGF-beta 1/ERK signaling pathway.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Plant Sciences
Bingyu Shen, Yeling Wang, Jiaqi Cheng, Yi Peng, Qiaoling Zhang, Zheng Li, Lilei Zhao, Xuming Deng, Haihua Feng
Summary: This study provides insights into the mechanism of PTE affecting oxidative stress and autophagy in NAFLD mice.
Article
Multidisciplinary Sciences
Tatsuro Miyoshi, Brian C. Keller, Takashi Ashino, Satoshi Numazawa
Summary: The study confirmed the activation of Nrf2 by GDS-23 and elucidated its underlying mechanisms. GDS-23 treatment resulted in increased levels of antioxidant proteins and stabilization of Nrf2 in the nucleus. Additionally, GDS-23 protected cells against hydroquinone-induced cytotoxicity.
Article
Biochemistry & Molecular Biology
Fatemeh Yarmohammadi, Samira Barangi, Seyed Hamid Aghaee-Bakhtiari, Hossein Hosseinzadeh, Zahra Moosavi, Russel J. J. Reiter, A. Wallace Hayes, Soghra Mehri, Gholamreza Karimi
Summary: Chronic arsenic exposure, mainly through contaminated water, is associated with cardiovascular diseases. Mitochondrial dysfunction, oxidative stress, inflammation, apoptosis, and autophagy are suggested as the molecular mechanisms of arsenic cardiotoxicity. Melatonin, as a powerful antioxidant, improves diabetic cardiomyopathy, cardiac remodeling, and heart failure. Pretreatment with melatonin can alleviate arsenic-induced prolongation of QT interval, oxidative stress, autophagy, and apoptosis, and modify the expression of Sirt1 and Nrf2. It also reverses the reduced expression of miR-34a and miR-144 caused by arsenic and moderates histopathological changes of cardiac injury.
Article
Biochemistry & Molecular Biology
You-Cheng Hseu, Yugandhar Vudhya Gowrisankar, Li-Wei Wang, Yan-Zhen Zhang, Xuan-Zao Chen, Pei-Jane Huang, Hung-Rong Yen, Hsin-Ling Yang
Summary: Research has shown that Pterostilbene has anti-melanogenic effects by inhibiting melanin production through autophagy induction. Experimental results indicate that Pt can suppress melanin synthesis by activating the Nrf2 antioxidant pathway and downregulating genes related to the CREB-MITF pathway, such as TRP-1/-2 and tyrosinase.
Article
Environmental Sciences
Ana P. Ferragut Cardoso, Alexandra N. Nail, Mayukh Banerjee, Sandra S. Wise, J. Christopher States
Summary: Chronic inorganic arsenic (iAs) exposure in drinking water is a global issue affecting over 225 million people, with skin being the major target organ for iAs. Dysregulation of miRNA and chromosomal instability (CIN) are proposed mechanisms of iAs-induced carcinogenesis. This study suggests that overexpression of miR-186 contributes to iAs-induced transformation of keratinocytes by targeting mitotic regulators and inducing CIN.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Goutham Ganesh, Kunka Mohanram Ramkumar
Summary: Pterostilbene (PTS) has been found to activate nuclear factor erythroid-2 related factor (Nrf2) and shows potential for treating diabetic foot ulcers (DFUs). The study demonstrated that PTS can regulate Nrf2 in diabetic wounds and improve wound closure by modulating the macrophage-mediated wound healing response. These findings have implications for the development of targeted therapies for chronic wounds, including DFUs.
MOLECULAR IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Jinping Zhang, Yongchun Zheng, Bo Hong, Lina Ma, Yingchun Zhao, Shuai Zhang, Shuwen Sun, Qiteng Ding, Yue Wang, Wencong Liu, Chuanbo Ding
Summary: The study found that Dihydroquercetin composite nanofiber membrane (CPD) can reduce skin inflammation and photodamage caused by UVA radiation by enhancing the activity of antioxidant enzymes and reducing ROS expression. CPD also prevents inflammation, apoptosis, and oxidative stress induced by MAPK/Nrf2 signaling pathway. Immunofluorescence experiments showed that CPD can reduce the fluorescence intensity of Caspase-3 and TNF-alpha.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Omchit Surien, Siti Fathiah Masre, Dayang Fredalina Basri, Ahmad Rohi Ghazali
Summary: Cancer incidence is increasing globally, causing significant physical, mental, and financial burdens. Conventional cancer treatments have limitations such as drug resistance and side effects. Chemoprevention, including the use of natural compounds like pterostilbene, shows promise in reducing the cancer burden. Pterostilbene has various pharmacological properties and can induce apoptosis to prevent cancer progression. This review discusses pterostilbene's role as a chemopreventive agent against different types of cancer by modulating the apoptosis pathway at the molecular level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Goutham Ganesh, Kunka Mohanram Ramkumar
Summary: Macrophages play a vital role in wound healing, and their response to hemin can be regulated by pterostilbene, leading to enhanced wound closure. This study provides insights into the involvement of Nrf2 in macrophage response and suggests it as a potential therapeutic target in the management of diabetic foot ulcers.
INFLAMMOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sara Salman, Cyprien Guermonprez, Laurent Peno-Mazzarino, Elian Lati, Audrey Rousseaud, Lieve Declercq, Saadia Kerdine-Romer
Summary: Photobiomodulation (PBM) is a valuable tool in dermatology for treating inflammatory skin conditions using low levels of light, but the physiological pathways responsible for its anti-inflammatory effect have not been well defined. This study found that PBM activated the Nrf2 pathway to control inflammation and played a key role in reducing inflammatory response. The findings support the role of PBM in skin immunomodulation and suggest it as a promising alternative or complementary therapeutic approach for skin-related inflammatory diseases.
Article
Food Science & Technology
Jikai Xu, Jingyu Liu, Qing Li, Yan Mi, Di Zhou, Qingqi Meng, Gang Chen, Ning Li, Yue Hou
Summary: Pterostilbene alleviates Aβ(1-42)-induced cognitive dysfunction in mice possibly by inhibiting oxidative stress through the Nrf2 signaling pathway.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)