Non-canonical Notch Signaling Regulates Actin Remodeling in Cell Migration by Activating PI3K/AKT/Cdc42 Pathway

Inhibition of Notch signaling pathway enhanced the radiosensitivity of breast cancer cells

(2018) Jian-Heng Peng et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Benzo[a]pyrene-7,8-diol-9,10-epoxide suppresses the migration and invasion of human extravillous trophoblast Swan 71 cells due to the inhibited filopodia formation and down-regulated PI3K/AKT/CDC42/PAK1 pathway mediated by the increased miR-194-3p

(2018) Zhen Tian et al.   TOXICOLOGICAL SCIENCES

Notch and its oncogenic activity in human malignancies

(2017) Marlena Brzozowa-Zasada et al.   European Surgery-Acta Chirurgica Austriaca

Intersectin 2 controls actin cap formation and meiotic division in mouse oocytes through the Cdc42 pathway

(2017) Jiaqi Zhang et al.   FASEB JOURNAL

Notch signaling pathway networks in cancer metastasis: a new target for cancer therapy

(2017) Li Li et al.   MEDICAL ONCOLOGY

A non-canonical Notch complex regulates adherens junctions and vascular barrier function

(2017) William J. Polacheck et al.   NATURE

Notch-out for breast cancer therapies

(2017) Márcia Lamy et al.   New Biotechnology

Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma

(2017) Mitsuteru Natsuizaka et al.   Nature Communications

Role of Rac1/WAVE2 Signaling in Mediating the Inhibitory Effects of γ-Tocotrienol on Mammary Cancer Cell Migration and Invasion

(2016) Ibrahim Gayadh Algayadh et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

MICAL1 controls cell invasive phenotype via regulating oxidative stress in breast cancer cells

(2016) Wenjie Deng et al.   BMC CANCER

EGF-stimulated activation of Rab35 regulates RUSC2–GIT2 complex formation to stabilize GIT2 during directional lung cancer cell migration

(2016) Biao Duan et al.   CANCER LETTERS

The relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemia

(2016) R. D. Mendes et al.   HAEMATOLOGICA

Regulators of actin filament barbed ends at a glance

(2016) Shashank Shekhar et al.   JOURNAL OF CELL SCIENCE

Notch-1 signaling activates NF-κB in human breast carcinoma MDA-MB-231 cells via PP2A-dependent AKT pathway

(2016) Li Li et al.   MEDICAL ONCOLOGY

KRT19 directly interacts with β-catenin/RAC1 complex to regulate NUMB-dependent NOTCH signaling pathway and breast cancer properties

(2016) S K Saha et al.   ONCOGENE

Unravelling the Actin Cytoskeleton: A New Competitive Edge?

(2016) Andrew J. Davidson et al.   TRENDS IN CELL BIOLOGY

Notch signalling pathway as an oncogenic factor involved in cancer development

(2016) Marlena Brzozowa-Zasada et al.   Wspolczesna Onkologia-Contemporary Oncology

The relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemia

(2016) R. D. Mendes et al.   HAEMATOLOGICA

Rho GTPase signalling in cell migration

(2015) Anne J Ridley   CURRENT OPINION IN CELL BIOLOGY

The Notch pathway in colorectal cancer

(2015) Kaitlyn E. Vinson et al.   INTERNATIONAL JOURNAL OF CANCER

Akt inhibitors in cancer treatment: The long journey from drug discovery to clinical use (Review)

(2015) GEORGE MIHAI NITULESCU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Notch1 signaling regulates the epithelial–mesenchymal transition and invasion of breast cancer in a Slug-dependent manner

(2015) Shan Shao et al.   Molecular Cancer

Inhibition of triple-negative and Herceptin-resistant breast cancer cell proliferation and migration by Annexin A2 antibodies

(2014) P Chaudhary et al.   BRITISH JOURNAL OF CANCER

Movers and shakers: cell cytoskeleton in cancer metastasis

(2014) C M Fife et al.   BRITISH JOURNAL OF PHARMACOLOGY

Small GTPase RhoE/Rnd3 Is a Critical Regulator of Notch1 Signaling

(2014) Z. Zhu et al.   CANCER RESEARCH

Homeostatic Actin Cytoskeleton Networks Are Regulated by Assembly Factor Competition for Monomers

(2014) Thomas A. Burke et al.   CURRENT BIOLOGY

Rho GTPases control specific cytoskeleton-dependent functions of hematopoietic stem cells

(2014) Ramesh C. Nayak et al.   IMMUNOLOGICAL REVIEWS

Melatonin Suppresses Hypoxia-Induced Migration of HUVECs via Inhibition of ERK/Rac1 Activation

(2014) Ling Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Notch signaling and EMT in non-small cell lung cancer: biological significance and therapeutic application

(2014) Xun Yuan et al.   Journal of Hematology & Oncology

Notch1 controls cell invasion and metastasis in small cell lung carcinoma cell lines

(2014) Wael Abdo Hassan et al.   LUNG CANCER

Rac1-Dependent Lamellipodial Motility in Prostate Cancer PC-3 Cells Revealed by Optogenetic Control of Rac1 Activity

(2014) Takuma Kato et al.   PLoS One

The Cytoplasmic Tail of FPC Antagonizes the Full-Length Protein in the Regulation of mTOR Pathway

(2014) Shixuan Wang et al.   PLoS One

Promotion of Colorectal Cancer Invasion and Metastasis through Activation of NOTCH–DAB1–ABL–RHOGEF Protein TRIO

(2014) Masahiro Sonoshita et al.   Cancer Discovery

Non-Canonical Notch Signaling in Cancer and Immunity

(2014) Furkan Ayaz et al.   Frontiers in Oncology

New insights into Notch1 regulation of the PI3K–AKT–mTOR1 signaling axis: Targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia

(2013) Eric C. Hales et al.   CELLULAR SIGNALLING

Notch1 Receptor Regulates AKT Protein Activation Loop (Thr308) Dephosphorylation through Modulation of the PP2A Phosphatase in Phosphatase and Tensin Homolog (PTEN)-null T-cell Acute Lymphoblastic Leukemia Cells

(2013) Eric C. Hales et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-Wide Analysis of N1ICD/RBPJ Targets In Vivo Reveals Direct Transcriptional Regulation of Wnt, SHH, and Hippo Pathway Effectors by Notch1

(2012) Yaochen Li et al.   STEM CELLS

Non-canonical Notch signaling: emerging role and mechanism

(2012) Peter Andersen et al.   TRENDS IN CELL BIOLOGY

RhoA-Mediated Signaling in Notch-Induced Senescence-Like Growth Arrest and Endothelial Barrier Dysfunction

(2011) Deepak Venkatesh et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Notch1 promotes glioma cell migration and invasion by stimulating β-catenin and NF-κB signaling via AKT activation

(2011) Xiaohua Zhang et al.   CANCER SCIENCE

Noncanonical notch function in motor axon guidance is mediated by Rac GTPase and the GEF1 domain of trio

(2011) Jeong K. Song et al.   DEVELOPMENTAL DYNAMICS

Activation of Notch-1 enhances epithelial-mesenchymal transition in gefitinib-acquired resistant lung cancer cells

(2011) Mian Xie et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Notch1 is involved in migration and invasion of human breast cancer cells

(2011) Feng Gu   ONCOLOGY REPORTS

Tuberous Sclerosis Complex 2 (TSC2) Regulates Cell Migration and Polarity through Activation of CDC42 and RAC1

(2010) Yan Larson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EMT, the cytoskeleton, and cancer cell invasion

(2009) Mahmut Yilmaz et al.   CANCER AND METASTASIS REVIEWS

A hierarchical cascade activated by non-canonical Notch signaling and the mTOR–Rictor complex regulates neglect-induced death in mammalian cells

(2009) L R Perumalsamy et al.   CELL DEATH AND DIFFERENTIATION

Mechanics of the F-actin cytoskeleton

(2009) Jonathan Stricker et al.   JOURNAL OF BIOMECHANICS

The WASP and WAVE family proteins

(2009) Shusaku Kurisu et al.   GENOME BIOLOGY

Cellular signaling for activation of Rho GTPase Cdc42

(2008) Soniya Sinha et al.   CELLULAR SIGNALLING

Notch signaling mediates hypoxia-induced tumor cell migration and invasion

(2008) C. Sahlgren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA