Article
Nutrition & Dietetics
Yasuhisa Ano, Rena Ohya, Akihiko Takashima, Kazuyuki Uchida, Hiroyuki Nakayama
Summary: Research indicates that consuming beta-lactolin can prevent neural inflammation and alleviate aging-related cognitive decline.
FRONTIERS IN NUTRITION
(2021)
Article
Nutrition & Dietetics
Aleksandra Bramorska, Wanda Zarzycka, Wiktoria Podolecka, Katarzyna Kuc, Aneta Brzezicka
Summary: The study found that the frequency of food consumption moderates the relationship between age and cognitive functioning, with dietary patterns having a stronger impact on cognitive performance in older adults.
Article
Psychology, Multidisciplinary
Chenwei Xie, Manson Cheuk-Man Fong, Matthew King-Hang Ma, Juliahna Wang, William Shiyuan Wang
Summary: The study reveals that both declarative and procedural memory decline with age, but declarative memory is relatively preserved compared to procedural memory. Additionally, older adults show different patterns in recognizing familiar and unfamiliar items, contradicting the retrogenesis hypothesis.
FRONTIERS IN PSYCHOLOGY
(2023)
Review
Cell Biology
Rui Zhou, Shufang Qian, William C. S. Cho, Jinyun Zhou, Chentao Jin, Yan Zhong, Jing Wang, Xiaohui Zhang, Zhoujiao Xu, Mei Tian, Lawrence W. C. Chan, Hong Zhang
Summary: Aging affects gut microbiota compositions, microglia, and cognition abilities, and is recognized as a risk factor for neurodegenerative diseases. The communication between gut microbiota and microglia plays a crucial role in age-related cognitive declines. This review discusses the changes in gut microbiota compositions, brain changes, especially morphology and functions of microglia, and highlights the role of microbiota-microglia connections in neurodegenerative diseases.
Article
Behavioral Sciences
Felipe Jacques Sanches, Jessica Cardia de Melo, Sabrina Palha Ferreira, Luzia Aparecida Trinca, Omar Gurrola Arambula, Flavia Helena Pereira Padovani, Arthur Oscar Schelp, Rogerio Martins Amorim
Summary: Episodic memory in elderly dogs declines similar to humans, regardless of gender and size, which may be related to the physiological aging process or preclinical pathological manifestation of cognitive impairment. Further studies are needed to evaluate episodic-like memory in dogs with canine cognitive dysfunction syndrome to better understand its physiological and pathological behavior in canine species.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Nutrition & Dietetics
Ning Ding, Hanxiu Meng, Chao Wu, Wallace Yokoyama, Hui Hong, Yongkang Luo, Yuqing Tan
Summary: This study found that whey protein hydrolysate has the potential to improve cognitive degeneration. Interventions with whey protein hydrolysate improved cognitive abilities and reduced the levels of A beta(1-42) in the brain tissue and serum of mice. It also alleviated neuronal damage in the hippocampus and altered the abundance of gut microbe related to Alzheimer's disease.
Review
Cell Biology
Josh Turknett, Thomas R. Wood
Summary: This article highlights the importance of lifestyle and environment in the development of Alzheimer's Disease. It suggests that previous approaches focusing solely on biological processes have been inadequate, and calls for a holistic approach that incorporates cognitive demand as a primary factor for intervention.
Article
Neurosciences
Alessandra Gargano, Bolanle Fatimat Olabiyi, Michela Palmisano, Andreas Zimmer, Andras Bilkei-Gorzo
Summary: Aging is associated with a decline in cognitive abilities, and this may be due to histological changes in the brain. The loss of noradrenergic neurons in the locus coeruleus (LC) may contribute to cognitive deficits. By treating young mice with DSP-4, a toxin that kills LC neurons, it was found that the loss of LC neurons impairs attention and memory.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Katy Pilarzyk, William R. Capell, Latarsha Porcher, Audrey Rips-Goodwin, Michy P. Kelly
Summary: Age-related abnormalities in phosphodiesterase 11A (PDE11A), enriched in the ventral hippocampus, drive age-related cognitive decline (ARCD) of social memories. In this study, lentiviral expression of an isolated PDE11A4-GAFB domain in the hippocampal CA1 region of aged mice reversed age-related PDE11A4 accumulations and ARCD of social transmission of food preference memory (STFP). This suggests that disrupting PDE11A4 homodimerization may hold therapeutic potential for age-related PDE11A4 proteinopathies.
NEUROBIOLOGY OF AGING
(2023)
Review
Pharmacology & Pharmacy
Chloe G. McKee, Madison Hoffos, Haley A. Vecchiarelli, Marie-Eve Tremblay
Summary: As individuals age, microglia, the resident immune cells of the central nervous system (CNS), become less effective at preserving brain circuits. Increases in microglial inflammatory activity are thought to contribute to age-related declines in cognitive functions and to transitions toward mild cognitive impairment (MCI) and Alzheimer's disease (AD). Preclinical and early phase clinical trials investigating the therapeutic effects of pharmacological agents acting on microglia are currently underway, but important questions about target selectivity and microglial heterogeneity remain unanswered.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Bjorn Herrmann, Burkhard Maess, Molly J. Henry, Jonas Obleser, Ingrid S. Johnsrude
Summary: Listening in everyday life requires the dynamic deployment of attention in order to conserve mental resources, especially for older adults. This study used electroencephalography and magnetoencephalography to investigate the neural and behavioral mechanics of attention regulation during listening and how aging affects these processes. The results showed that younger and older adults employ different neural control strategies to regulate attention in time under listening challenges, with a notable difference in the sources of alpha activity between age groups.
Article
Clinical Neurology
Patricia A. Boyle, Tianhao Wang, Lei Yu, Robert S. Wilson, Robert Dawe, Konstantinos Arfanakis, Julie A. Schneider, David A. Bennett
Summary: The study found that cognitive decline in old age is driven by a wide array of neuropathologies, with Alzheimer's disease, infarcts, non-Alzheimer's disease neurodegenerative diseases, and cerebrovascular conditions playing significant roles. While most pathological indices were associated with faster decline, they only accounted for a portion of the variation in decline, highlighting the complexity of cognitive ageing.
Article
Veterinary Sciences
Alejandra Mondino, Michael Khan, Beth Case, Gilad Fefer, Wojciech K. Panek, Margaret E. Gruen, Natasha J. Olby
Summary: The study found that in aging dogs, the food-motivated gait speed off leash is associated with fractional lifespan and cognitive performance, particularly in the domains of attention and working memory. Therefore, this variable can serve as an effective indicator of age-related deterioration and cognitive decline in dogs.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Cell Biology
Medha Kaushik, Pooja Kaushik, Suhel Parvez
Summary: Age-related cognitive decline is a major concern globally, with a 70% higher incidence than dementia. Aging is also a significant risk factor for Alzheimer's disease, which is associated with progressive memory loss. Learning and memory are fundamental brain processes, and the mechanisms underlying memory decline are still being investigated. Several molecular signatures have been identified as crucial for the maintenance and stabilization of long-term memory in the brain, and abnormalities in these signatures have been linked to memory decline in Alzheimer's disease.
AGEING RESEARCH REVIEWS
(2022)
Article
Biology
Weiwei Liu, Yan Cao, Yue Lin, Keai Sinn Tan, Haishan Zhao, Haihua Guo, Wen Tan
Summary: The study found that inhibition of BChE improved episodic and spatial memories. It also suggested the potential application of (R)-bambuterol as a BChE inhibitor in the treatment of post-traumatic stress disorder (PTSD) and early cognitive decline.