Review
Pharmacology & Pharmacy
Yanhong Bu, Hong Wu, Ran Deng, Yan Wang
Summary: Sphingosine kinase 1 (SphK1) plays a crucial role in maintaining the dynamic balance of sphingolipid-rheostat in cells and is involved in various cellular processes. Abnormal expression and activity of SphK1 are associated with a variety of inflammatory and immune-related diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Applied
Yoon Kyung Park, Youngbuhm Huh, Dokyoung Kim
Summary: Cycloparaphenylenes (CPPs) are attracting attention in various fields for their high molecular symmetry and unique topology characteristics. However, their non-fluorescence properties and low water solubility hinder their use in bio-related applications. In this study, an oxidized product (Oxi-[5]CPP) with stable and bright blue fluorescence was prepared. To improve water solubility, Lip-[5]CPP, a liposomal nanoparticle, was produced. It showed non-cytotoxicity and remarkable imaging capability in HeLa cells. The two-photon emission characteristics of Lip-[5]CPP confirmed its potential as a two-photon imaging probe. This work serves as a guide for CPP basic research and the development of new bio-imaging probes.
Article
Clinical Neurology
Rafael Pazinatto de Aguiar, Adrian Newman-Tancredi, Jos Prickaerts, Rubia Maria Weffort de Oliveira
Summary: This review focuses on the roles and mechanisms of 5-HT1A receptors in neuroprotection in experimental models of cerebral ischemia, with experimental evidence suggesting that 5-HT1A receptor agonists can prevent neuronal damage and promote functional recovery induced by ischemia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Chemistry, Medicinal
Maali D. Alshammari, Pavel V. Kucheryavy, Nicole M. Ashpole, David A. Colby
Summary: The synthesis of flavones with fluorine substitutions has been reported, and their biological evaluation showed enhanced antioxidant activity and conserved neuroprotective activity compared to their non-fluorinated counterparts. Additionally, 3-fluoro-3',4',5'-trihydroxyflavone can serve as an NMR probe to detect structural changes during its action as a radical scavenger.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Physical
Feng Hai, Xiaolu Tian, Yikun Yi, Zhendi Wu, Shentuo Zheng, Jingyu Guo, Wei Tang, Weibo Hua, Mingtao Li
Summary: We report a dispersed aggregate (AGG) electrolyte that enhances the content of AGGs at a common salt concentration. This strategy provides a new way to develop electrolytes for next-generation high-performance batteries.
ENERGY STORAGE MATERIALS
(2023)
Article
Astronomy & Astrophysics
Ming Feng Qin, Yu Zhang, Jinzhong Liu, Fangfang Song, Qingshun Hu, Haozhi Wang, Shuo Ma, Guoliang Lu
Summary: In this study, open clusters surrounding Pismis 5 in the Vela molecular ridge were determined using high-quality data from Gaia Data Release 3 (DR3). Eight open clusters were identified using two clustering algorithms. The investigation revealed a potential open binary cluster candidate and a triple open-cluster candidate, which are believed to be primordial aggregates based on their similar age, position, and motion.
ASTRONOMY & ASTROPHYSICS
(2023)
Article
Environmental Sciences
Cui-Ping Yu, Yu-Lin Pan, Xiao-Li Wang, Rui Xin, Hong-Qiu Li, Ya-Ting Lei, Fang-Fang Zhao, Dan Zhang, Xiao-Rong Zhou, Wei-Wei Ma, Sheng-Yuan Wang, Yong-Hui Wu
Summary: This study reveals the protective role of SphK1 in ACR-induced nerve injury. The content of SphK1 and S1P in the ACR-exposed group is lower than that in the non-exposed group. Activating SphK1 improves the survival rate and decreases apoptosis rate of nerve cells. Additionally, activation of SphK1 regulates the activity of the MAPK signaling pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Cell Biology
Yilin Pang, Xinjie Liu, Xu Wang, Xuelian Shi, Lei Ma, Yan Zhang, Tiangang Zhou, Chenxi Zhao, Xu Zhang, Baoyou Fan, Jian Hao, Wenxiang Li, Xiaoqing Zhao, Rong Zhang, Songlin Zhou, Xiaohong Kong, Shiqing Feng, Xue Yao
Summary: Edaravone, an FDA-approved drug, has a neuroprotective effect on spinal cord injury and other central nervous system diseases. It exerts this effect by inhibiting ferroptosis and reducing neuroinflammation. The mechanism may be applicable to other neurological diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Xin Peng, Xiaoli Liu, Wanshan Hu, Yanling Zhou, Lianlian Ouyang, Xintong Peng, Yao Long, Jingyue Sun, Tania Tao, Ling Chen, Ying Shi, Yongguang Tao, Desheng Xiao, Shuang Liu
Summary: In lung adenocarcinoma, overexpression of HOXC11 is associated with worse survival and is regulated by IKK alpha. HOXC11 promotes lung cancer progression by enhancing the expression of SPHK1 through directly binding to its promoter region.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Vinay Kumar Sharma, Xuyu Yang, Soo-Kyung Kim, Amirhossein Mafi, Daniel Saiz-Sanchez, Patricia Villanueva-Anguita, Lan Xiao, Asuka Inoue, William A. Goddard, Y. Peng Loh
Summary: Interaction between NF-alpha 1/CPE and 5-HTR1E activates the beta-arrestin/ERK/CREB/BCL2 pathway to protect neurons from oxidative stress and neuroexcitotoxicity, preventing cognitive dysfunction.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Geriatrics & Gerontology
Yuchen Wu, Shuang Guo, Kunli Wang, Jingjing Kang
Summary: This study identified a peptide with potential therapeutic effects for Alzheimer's disease through crystal structure analysis and molecular docking. The peptide was found to significantly inhibit the aggregation of Alzheimer's disease-related protein.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Cell Biology
Lu Jin, Jin Zhu, Linya Yao, Gang Shen, Bo-xin Xue, Wei Tao
Summary: This study found that SphK1 and SphK2 are upregulated in human prostate cancer tissues. The use of SKI-178 effectively inhibits the growth and migration of prostate cancer cells, exerting cytotoxic effects through the inhibition of SphK activity and induction of ceramide production.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Xuan Zhu, Xinlin Wang, Tianhao Ying, Xiaoli Li, Yidi Tang, Yanfang Wang, Tao Yu, Mengmeng Sun, Jianing Zhao, Yuan Du, Leiming Zhang
Summary: This study investigated the anti-sepsis effects and mechanisms of kaempferol in a lipopolysaccharide-induced sepsis model. The results demonstrated that kaempferol alleviated inflammatory response and stabilized the endothelial barrier in LPS-induced sepsis by regulating the SphK1/S1P signaling pathway. The study also revealed that kaempferol exhibited cell-specific effects on the regulation of SphK1 expression.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Immunology
Linlu Tian, Yongxia Wu, Hee-Jin Choi, Xiaohui Sui, Xinlei Li, M. Hanief Sofi, Mohamed Faisal Kassir, Xiao Chen, Shikhar Mehrotra, Besim Ogretmen, Xue-Zhong Yu
Summary: The Sphk1/S1P/S1PR1 pathway plays a crucial role in modulating T cell immune responses and mitochondrial activity, providing potential therapeutic targets for GVHD and leukemia.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Engineering, Chemical
Yan Wang, Sai Li, Yanchao Liu, Jiajun Zheng, Xiaobo Sun, Yanze Du, Zhiping Liu, Bo Qin, Wenlin Li, Guangshuai Wang, Meng Pan, Ruifeng Li
Summary: Hierarchical ZSM-5 catalyst synthesized by traditional hydrothermal method exhibits prolonged catalysis life and excellent catalytic performance, attributed to the shortened diffusion path and autogenetic carbon nanotubes.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2022)
Article
Oncology
Francesco Di Meo, Stefania Filosa, Michele Madonna, Gerarda Giello, Alba Di Pardo, Vittorio Maglione, Alfonso Baldi, Stefania Crispi
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Alba Di Pardo, John Monyror, Luis Carlos Morales, Vaibhavi Kadam, Susanne Lingrell, Vittorio Maglione, Richard W. Wozniak, Simonetta Sipione
HUMAN MOLECULAR GENETICS
(2020)
Article
Biochemistry & Molecular Biology
Johannes Burtscher, Alba Di Pardo, Vittorio Maglione, Christoph Schwarzer, Ferdinando Squitieri
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Cell Biology
Alba Di Pardo, Elena Ciaglia, Monica Cattaneo, Anna Maciag, Francesco Montella, Valentina Lopardo, Anna Ferrario, Francesco Villa, Michele Madonna, Enrico Amico, Albino Carrizzo, Antonio Damato, Giuseppe Pepe, Federico Marracino, Alberto Auricchio, Carmine Vecchione, Vittorio Maglione, Annibale A. Puca
CELL DEATH & DISEASE
(2020)
Article
Neurosciences
A. Di Pardo, G. Pepe, L. Capocci, F. Marracino, E. Amico, L. Del Vecchio, S. Giova, S. K. Jeong, B. M. Park, B. D. Park, V Maglione
NEUROBIOLOGY OF DISEASE
(2020)
Review
Biochemistry & Molecular Biology
Johannes Burtscher, Vittorio Maglione, Alba Di Pardo, Gregoire P. Millet, Christoph Schwarzer, Luca Zangrandi
Summary: Neurodegenerative diseases are characterized by adverse cellular environments and pathological alterations leading to neurodegeneration in distinct brain regions, triggered or facilitated by conditions such as hypoxia, ischemia or inflammation. Specific reversal methods for these pathological changes are difficult to translate to clinical settings, thus holistic approaches to establish a healthy cellular environment may be more effective. This review discusses potential molecular pathways as drug targets in neurodegenerative diseases, with a focus on Huntington's disease characteristics that may make it suitable for conditioning techniques.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Giuseppe Pepe, Enrica Calce, Valentina Verdoliva, Michele Saviano, Vittorio Maglione, Alba Di Pardo, Stefania De Luca
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Giuseppe Pepe, Maria Cotugno, Federico Marracino, Susy Giova, Luca Capocci, Maurizio Forte, Rosita Stanzione, Franca Bianchi, Simona Marchitti, Alba Di Pardo, Sebastiano Sciarretta, Speranza Rubattu, Vittorio Maglione
Summary: The study found abnormalities in sphingolipid metabolism in the brains and kidneys of hypertensive rats, particularly more noticeable in the stroke-prone rats. These findings suggest that defects in specific lipid molecules and metabolic pathways may contribute to the pathogenesis of hypertensive target organ damage. Further research is needed to fully understand the significance of these findings and their potential as therapeutic targets for reducing vascular consequences of hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Alessandra Mingione, Francesca Pivari, Nicoletta Plotegher, Michele Dei Cas, Aida Zulueta, Tommaso Bocci, Marco Trinchera, Elisabetta Albi, Vittorio Maglione, Anna Caretti, Luigi Bubacco, Rita Paroni, Daniele Bottai, Riccardo Ghidoni, Paola Signorelli
Summary: Parkinson's disease is associated with alpha-synuclein aggregation and lipid-protein inclusion formation, leading to impaired autophagy, protein aggregation, and inflammation. Myr treatment may help improve these conditions by reducing intracellular aggregates and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Maurizio Forte, Franca Bianchi, Maria Cotugno, Simona Marchitti, Rosita Stanzione, Vittorio Maglione, Sebastiano Sciarretta, Valentina Valenti, Roberto Carnevale, Francesco Versaci, Giacomo Frati, Massimo Volpe, Speranza Rubattu
Summary: UCP2 plays a protective role in high-salt-induced oxidative stress and autophagy, preserving the viability of endothelial and renal tubular cells. Excessive ROS accumulation upon UCP2 silencing and high-salt exposure inhibits autophagy, while an exogenous autophagy inducer can rescue cellular damage.
CELL DEATH & DISEASE
(2021)
Article
Neurosciences
Johannes Burtscher, Giuseppe Pepe, Federico Marracino, Luca Capocci, Susy Giova, Gregoire P. Millet, Alba Di Pardo, Vittorio Maglione
Summary: Huntington's disease (HD) is a rare hereditary neurodegenerative disorder characterized by defects in mitochondrial homeostasis and functions, including age-related changes in respiratory capacities. The study found differential expression of ETS components in the cortex and striatum of symptomatic R6/2 mice, indicating transcription, translation and/or mitochondrial import defects in R6/2 mouse brains.
Article
Biochemistry & Molecular Biology
Paolo Rosa, Sofia Scibetta, Giuseppe Pepe, Giorgio Mangino, Luca Capocci, Sam J. Moons, Thomas J. Boltje, Francesco Fazi, Vincenzo Petrozza, Alba Di Pardo, Vittorio Maglione, Antonella Calogero
Summary: This study investigated the effect of PSA inhibition on GBM cells under low oxygen concentrations and found that it could inhibit GBM cell migration and differentiation. This finding suggests that PSA may be a potential target for developing therapies for GBM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Giuseppe Pepe, Luca Capocci, Federico Marracino, Natalia Realini, Paola Lenzi, Katiuscia Martinello, Tiziana Francesca Bovier, Terry Jo Bichell, Pamela Scarselli, Clotilde Di Cicco, Aaron B. Bowman, Filomena A. Digilio, Sergio Fucile, Francesco Fornai, Andrea Armirotti, Rosanna Parlato, Alba Di Pardo, Vittorio Maglione
Summary: Huntington's disease (HD) is a fatal neurodegenerative disorder with no cure. Abnormal sphingolipid metabolism, particularly sphingosine-1-phosphate (S1P), has been implicated in HD. This study investigated the therapeutic potential of inhibiting the S1P degradative enzyme SGPL1 using the inhibitor 2-acetyl-5-tetrahydroxybutyl imidazole (THI). THI was found to improve motor dysfunctions, activate pro-survival pathways, restore normal metabolite levels, and reduce nuclear inclusions in HD models.
Article
Biochemistry & Molecular Biology
Giuseppe Pepe, Paola Lenzi, Luca Capocci, Federico Marracino, Ludovica Pizzati, Pamela Scarselli, Alba Di Pardo, Francesco Fornai, Vittorio Maglione
Summary: Huntington's disease is a neurodegenerative disorder caused by a mutation in huntingtin protein, and glycosphingolipid dysfunction may play a major role in its pathogenesis. In this study, the potential link between sphingolipid modulation and myelin structure was investigated. The glycosphingolipid modulator THI treatment preserved myelin thickness and structure, reduced pathologically giant axons, and restored the expression of myelin marker proteins. It also increased levels of GM1, which is associated with reduced toxicity of mutant huntingtin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Giuseppe Pepe, Salvatore Fioriniello, Federico Marracino, Luca Capocci, Vittorio Maglione, Maurizio D'Esposito, Alba Di Pardo, Floriana Della Ragione
Summary: Rett syndrome is a severe neurodevelopmental disorder caused by pathogenetic variants in the MECP2 gene. This study found that Rett syndrome patients have impaired brain vascular homeostasis and blood-brain barrier breakdown, which may contribute to the cognitive impairment. The study provides evidence of impaired blood-brain barrier integrity in Rett syndrome and offers new perspectives for novel therapeutic strategies.