Can acetylcysteine ameliorate cisplatin‐induced toxicities and oxidative stress without decreasing antitumor efficacy? A randomized, double‐blind, placebo‐controlled trial involving patients with head and neck cancer

Cisplatin-induced human peripheral blood mononuclear cells’ oxidative stress and nephrotoxicity in head and neck cancer patients: the influence of hydrogen peroxide

(2017) Júlia C. F. Quintanilha et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Synergistic protective effect of N-acetylcysteine and taurine against cisplatin-induced nephrotoxicity in rats

(2017) Wessam Abdel-Wahab et al.   Drug Design Development and Therapy

Synthetic and natural antioxidants attenuate cisplatin-induced vomiting

(2017) Javaid Alam et al.   BMC Pharmacology & Toxicology

Adverse drug reactions and kinetics of cisplatin excretion in urine of patients undergoing cisplatin chemotherapy and radiotherapy for head and neck cancer: a prospective study

(2017) Marília Berlofa Visacri et al.   DARU-Journal of Pharmaceutical Sciences

A minireview on N -acetylcysteine: An old drug with new approaches

(2016) Ines Elbini Dhouib et al.   LIFE SCIENCES

Effects of High-Dose Cisplatin Chemotherapy and Conventional Radiotherapy on Urinary Oxidative and Nitrosative Stress Biomarkers in Patients with Head and Neck Cancer

(2015) Bruna T. Tuan et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Organic Anion Transporter 5 (Oat5) Urinary Excretion Is a Specific Biomarker of Kidney Injury: Evaluation of Urinary Excretion of Exosomal Oat5 after N-Acetylcysteine Prevention of Cisplatin Induced Nephrotoxicity

(2015) Romina Paula Bulacio et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Vetiver oil (Java) attenuates cisplatin-induced oxidative stress, nephrotoxicity and myelosuppression in Swiss albino mice

(2015) Sonali Sinha et al.   FOOD AND CHEMICAL TOXICOLOGY

Mechanism of Cisplatin-Induced Cytotoxicity Is Correlated to Impaired Metabolism Due to Mitochondrial ROS Generation

(2015) Yong-Min Choi et al.   PLoS One

N-acetylcysteine chemoprotection without decreased cisplatin antitumor efficacy in pediatric tumor models

(2014) Leslie L. Muldoon et al.   JOURNAL OF NEURO-ONCOLOGY

Antioxidants Accelerate Lung Cancer Progression in Mice

(2014) V. I. Sayin et al.   Science Translational Medicine

Protective effects of N-acetylcysteine on cisplatin-induced oxidative stress and DNA damage in HepG2 cells

(2014) FUGEN WANG et al.   Experimental and Therapeutic Medicine

Cisplatin Induces a Mitochondrial-ROS Response That Contributes to Cytotoxicity Depending on Mitochondrial Redox Status and Bioenergetic Functions

(2013) Rossella Marullo et al.   PLoS One

Assessment of 8-isoprostane (8-isoPGF2α) in Urine of Non-Small Cell Lung Cancer (NSCLC) Patients Undergoing Chemotherapy

(2012) Nutjaree Pratheepawanit Johns et al.   Asian Pacific Journal of Cancer Prevention

Antioxidant supplementation has a positive effect on oxidative stress and hematological toxicity during oncology treatment in cervical cancer patients

(2012) Vanessa Fuchs-Tarlovsky et al.   SUPPORTIVE CARE IN CANCER

Possible mechanisms for N-acetyl cysteine and taurine in ameliorating acute renal failure induced by cisplatin in rats

(2011) Aziza B. Shalby et al.   TOXICOLOGY MECHANISMS AND METHODS

Effects of Acute In vivo Cisplatin and Selenium Treatment on Hematological and Oxidative Stress Parameters in Red Blood Cells of Rats

(2010) Snežana D. Marković et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

N-acetylcysteine improves renal hemodynamics in rats with cisplatin-induced nephrotoxicity

(2009) Aly M. Abdelrahman et al.   JOURNAL OF APPLIED TOXICOLOGY

New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)

(2008) E.A. Eisenhauer et al.   EUROPEAN JOURNAL OF CANCER

Role of oxidative and nitrosative stress in cisplatin-induced nephrotoxicity

(2008) Yolanda I. Chirino et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Impact of antioxidant supplementation on chemotherapeutic toxicity: A systematic review of the evidence from randomized controlled trials

(2008) Keith I. Block et al.   INTERNATIONAL JOURNAL OF CANCER

The molecular mechanisms of the attenuation of cisplatin-induced acute renal failure by N-acetylcysteine in rats

(2008) J. Luo et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Multicenter Approach to Recurrent Acute and Chronic Pancreatitis in the United States: The North American Pancreatitis Study 2 (NAPS2)

(2008) David C. Whitcomb et al.   PANCREATOLOGY