期刊
THORACIC SURGERY CLINICS
卷 29, 期 2, 页码 123-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.thorsurg.2018.12.001
关键词
T lymphocytes; Epithelial cells; Immunosenescence; T-cell development
资金
- NIAID NIH HHS [U01 AI100119] Funding Source: Medline
The thymus is a primary lymphoid organ essential for the development of T lymphocytes, which orchestrate adaptive immune responses. T-cell development in the thymus is spatially regulated; key checkpoints in T-cell maturation and selection occur in cortical and medullary regions to eliminate self-reactive T cells, establish central tolerance, and export naive T cells to the periphery with the potential to recognize diverse pathogens. Thymic output is also temporally regulated due to age-related involution of the thymus accompanied by loss of epithelial cells. This review discusses the structural and age-related control of thymus function in humans.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据