Article
Medicine, Research & Experimental
Yingying Liu, Yanzhen Tan, Guojie Cao, Lei Shi, Yujie Song, Wenju Shan, Miao Zhang, Panpan Li, Haitao Zhou, Bing Zhang, Yang Sun, Wei Yi
Summary: This study demonstrates that bergenin attenuates myocardial apoptosis and oxidative damage induced by MI/R through the SIRT1 signaling pathway. Bergenin significantly reduces cardiomyocyte apoptosis and ROS production, and improves cardiac function in vitro and in vivo.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Tao Zheng, Jun Yang, Jing Zhang, Chaojun Yang, Zhixing Fan, Qi Li, Yuhong Zhai, Haiyin Liu, Jian Yang
Summary: The study found that downregulation of miR-327 could inhibit oxidative stress and apoptosis induced by H/R and TBHP in vitro experiments. Additionally, the downregulation enhanced the expression of fibroblast growth factor 10 (FGF10), activated p-PI3K and p-Akt, and promoted the translocation of Nrf2.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Piotr Frydrychowski, Marcin Michalek, Iwona Bil-Lula, Elzbieta Chelmecka, Alina Kafel, Agnieszka Noszczyk-Nowak, Dominika Stygar
Summary: The study evaluated the cardioprotective effect of intracoronary administered aspirin on myocardial ischemia-reperfusion injury using an experimental animal model. The results showed that aspirin reduced oxidative stress levels in heart tissue and serum compared to the control group.
Article
Plant Sciences
Haiyang Chen, Huifen Zhou, Jiehong Yang, Haitong Wan, Yu He
Summary: This study investigated the protective mechanism of Guhong injection (GHI) on myocardial ischemia/reperfusion (MI/R) injury. The results showed that GHI activated glutathione S-transferase P (GST P) to inhibit the ASK1-JNK/p38 pathway, thereby alleviating oxidative stress and apoptosis, and exerting cardioprotective effects.
Article
Pharmacology & Pharmacy
Boyu Xia, Qi Li, Jingjing Wu, Xiaomei Yuan, Fei Wang, Xu Lu, Chao Huang, Koulong Zheng, Rongrong Yang, Le Yin, Kun Liu, Qingsheng You
Summary: Sinomenine has cardioprotective effects in a mouse model of myocardial ischemia-reperfusion injury by attenuating oxidative stress, inflammation, and apoptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Rui-Ying Su, Wei-Yan Tai, Hong -Shan Yin, Xiao-Yong Geng
Summary: This study demonstrates that miR-432 plays an important role in myocardial ischemia/reperfusion (MI/R) injury. MiR-432 is upregulated in the heart following MI/R injury and its overexpression can decrease the infarct area and levels of serum CPK, while knockdown of miR-432 has the opposite effect. MiR-432 protects against MI/R injury by activating the beta-catenin/ HIF-1 alpha pathway and augmenting NRF2-mediated anti-oxidative stress.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Oncology
Rui-Ying Su, Wei-Yan Tai, Hong -Shan Yin, Xiao-Yong Geng
Summary: This study demonstrates that miR-432 plays a crucial role in myocardial ischemia/reperfusion injury by activating the beta-catenin/HIF-1α pathway and enhancing NRF2-mediated anti-oxidative stress.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
L-Q Chen, W-S Wang, S-Q Li, J-H Liu
Summary: The study demonstrates that minocycline (MC) can reduce inflammation and oxidative stress levels in myocardial ischemia-reperfusion injury (MIRI) rat model or H9c2 cells, thereby inhibiting cardiomyocyte apoptosis.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Qi Xiao, Yuan Liu, XingJian Zhang, ZhongZhong Liu, JianSheng Xiao, QiFa Ye, BiQi Fu
Summary: Mild hypothermia protects the liver from ischemia reperfusion-induced injury by upregulating RBM3 expression, reducing p38 and JNK signaling pathway activation, oxidative stress injury, and apoptosis.
Article
Immunology
Rui-ming Deng, Juan Zhou
Summary: Myocardial ischemia/reperfusion injury (MIRI) is a common and serious condition with no effective clinical treatments. The activation of the PI3K/Akt signaling pathway has been shown to have significant protective effects against MIRI through its involvement in antioxidant, anti-inflammatory, autophagy, mitochondrial function, and apoptosis regulation. This review highlights the molecular regulation of PI3K/Akt in MIRI, the effects of ischemic preconditioning and postconditioning, and the potential therapeutic applications of drugs targeting PI3K/Akt.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Shixia Zhang, Jilang Tang, Chen Sun, Nuannuan Zhang, Xiaqing Ning, Xueqin Li, Jiaqi Wang
Summary: Dexmedetomidine (DEX) protects the liver against ischemia-reperfusion injury (IRI) by reducing oxidative stress, endoplasmic reticulum stress (ERS), and apoptosis. DEX increases antioxidant activity and reduces oxidative damage in BRL-3A cells. It also inhibits MAPK signaling pathway activation and ERS to prevent cell apoptosis. Animal studies confirm that DEX alleviates histopathological injury and improves liver function.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Dawei Wang, Hongyan Cao, Xu Wang, Jinchun Wang, Manli Wang, Jian Zhang, Lin Wang
Summary: SIRT1 plays a protective role against oxidative stress after MI/R injury by activating downstream PGC-1α and promoting the production of antioxidant enzymes. Exercise-induced cardioprotection requires the involvement of SIRT1, reducing myocardial apoptosis and maladaptive ventricular remodeling induced by MI/R injury.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Lixia Li, Jiahong Gao, Lin Gao, Le Li, Hongfei Zhang, Wei Zhao, Shiyuan Xu
Summary: Bilateral superior cervical sympathectomy protects against myocardial ischemia-reperfusion injury in mice, potentially through the activation of the STAT3 signal and reduction of oxidative stress, inflammation, and apoptosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Qi Li, Boyu Xia, Jingjing Wu, Xiaomei Yuan, Xu Lu, Chao Huang, Hongcheng Gu, Koulong Zheng, Qingsheng You, Kun Liu
Summary: The study demonstrates that administration of indole-3-carbinol (I3C) protects the heart from myocardial ischemia/reperfusion injury (MIRI) through its anti-apoptotic, antioxidant, and anti-inflammatory effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Meng Sun, Rong Wang, Rui Xia, Zhengyuan Xia, Zhilin Wu, Tingting Wang
Summary: Mechanisms contributing to myocardial ischemia-reperfusion (I/R) injury are complex, but Dexmedetomidine (DEX) shows potential in ameliorating this injury in diabetic states. DEX activates the PI3K/Akt and associated GSK-3 beta pathway, alleviates endoplasmic reticulum stress, and inhibits apoptosis. Additionally, DEX up-regulates autophagy, reduces ROS production, and inhibits inflammation via HMGB1 pathways, leading to the protection against diabetic myocardial I/R injury.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Masafumi Ono, Mariusz Tomaniak, Wolfgang Koenig, Ramzi Khamis, Ranil de Silva, Ply Chichareon, Hideyuki Kawashima, Hironori Hara, Chao Gao, Rutao Wang, Kurt Huber, Mathias Vrolix, Pawel Jasionowicz, Joanna J. Wykrzykowska, Jan J. Piek, Peter Juni, Christian Hamm, Philippe Gabriel Steg, Stephan Windecker, Yoshinobu Onuma, Robert F. Storey, Patrick W. Serruys
Summary: This study investigated the efficacy and safety of ticagrelor monotherapy in patients undergoing percutaneous coronary intervention (PCI) stratified according to their baseline white blood cell (WBC) count. The findings showed that ticagrelor monotherapy was more effective than aspirin monotherapy in reducing the primary endpoint in patients with lower WBC counts. However, there was no significant difference in the effectiveness of the two treatment strategies in patients with higher WBC counts, and there were no significant differences in bleeding risks between the two strategies regardless of the WBC groups.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Kuniaki Takahashi, Daniel J. F. M. Thuijs, Chao Gao, Masafumi Ono, David R. Holmes, Michael J. Mack, Marie-Claude Morice, Friedrich-Wilhelm Mohr, Nick Curzen, Piroze M. Davierwala, Milan Milojevic, Keith D. Dawkins, Joanna J. Wykrzykowska, Robbert J. de Winter, John William McEvoy, Yoshinobu Onuma, Stuart J. Head, Arie Pieter Kappetein, Patrick W. Serruys
Summary: This study evaluated the impact of different smoking statuses on 10-year all-cause mortality and the relative treatment benefit of CABG vs. PCI according to smoking habits. The results showed that current smokers had a higher risk of 10-year all-cause mortality compared to never smokers, while former smokers did not. There was no significant difference in the treatment effect of CABG vs. PCI based on smoking status.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Kai Ninomiya, Patrick W. Serruys, Scot Garg, Chao Gao, Shinichiro Masuda, Mattia Lunardi, Jens F. Lassen, Adrian P. Banning, Antonio Colombo, Francesco Burzotta, Marie-Claude Morice, Michael J. Mack, David R. Holmes, Piroze M. Davierwala, Daniel J. F. M. Thuijs, David van Klaveren, Yoshinobu Onuma
Summary: This study investigated the impact of bifurcation lesions on the predicted and observed all-cause 10-year mortality in the SYNTAX trial. The results showed that patients with >1 bifurcation lesion treated with PCI had a significantly higher risk of all-cause death compared to those without bifurcation lesions.
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Article
Medicine, General & Internal
Fangju Su, Chao Gao, Jianzheng Liu, Zhongping Ning, Beng He, Yi Liu, Yawei Xu, Bing Yang, Yuechun Li, Junfeng Zhang, Xianxian Zhao, Yushun Zhang, Hao Hu, Xianfeng Du, Ruiqin Xie, Ling Zhou, Jie Zeng, Zhongbao Ruan, Haitao Liu, Jun Guo, Rutao Wang, Scot Garg, Osama Soliman, David R. Holmes, Patrick W. Serruys, Ling Tao
Summary: This study aimed to investigate the outcomes and risks of left atrial appendage occlusion (LAAO) procedures in Chinese patients. The results showed that patients with a high risk of stroke and moderate to high risk of bleeding who underwent LAAO implantation in Chinese centers had high rates of procedural success and low rates of short-term ischemic and bleeding events.
Article
Cardiac & Cardiovascular Systems
Yuan He, Rutao Wang, Jianzheng Liu, Fei Li, Jiayi Li, Chengxiang Li, Jingyu Zhou, Zhijing Zhao, Wangwei Yang, Fangjun Mou, Jing Wang, Jing Kan, Xiaobo Li, Yan Li, Ming Zheng, Shaoliang Chen, Chao Gao, Ling Tao
Summary: This study compared the vascular healing of Firehawk and Xience stents in patients with STEMI who underwent PCI. The Firehawk stent was found to be non-inferior to the Xience stent in terms of neointimal thickness at 6 months. Both stents exhibited good strut coverage and healing.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Masafumi Ono, Hironori Hara, Chao Gao, Hideyuki Kawashima, Rutao Wang, Neil O'Leary, Joanna J. Wykrzykowska, Jan J. Piek, Michael J. Mack, David Holmes, Marie-Claude Morice, Stuart Head, Arie Pieter Kappetein, Thilo Noack, Piroze M. Davierwala, Friedrich W. Mohr, Scot Garg, Yoshinobu Onuma, Patrick W. Serruys
Summary: This study investigated whether there are differences in long-term clinical outcomes between percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) in patients with three-vessel disease and lesions in the proximal left anterior descending artery. The results showed that regardless of the presence or absence of lesions in the proximal left anterior descending artery, the incidence of major adverse cardiac or cerebrovascular events was significantly higher with PCI compared to CABG. However, there was no significant difference in 10-year mortality between the two procedures.
Article
Cardiac & Cardiovascular Systems
Robbert J. de Winter, Azfar Zaman, Hironori Hara, Chao Gao, Masafumi Ono, Scot Garg, Pieter C. Smits, Pim A. L. Tonino, Sjoerd H. Hofma, Raul Moreno, Anirban Choudhury, Ivo Petrov, Angel Cequier, Antonio Colombo, Upendra Kaul, Yoshinobu Onuma, Patrick W. Serruys
Summary: In the TALENT study, the ultrathin strut Supraflex stent showed similar safety and efficacy to the XIENCE stent at 3-year follow-up. There were no significant differences between the two groups in terms of cardiac death, target vessel myocardial infarction, or clinically indicated target lesion revascularisation.
Article
Cardiac & Cardiovascular Systems
Masafumi Ono, Patrick W. Serruys, Scot Garg, Hideyuki Kawashima, Chao Gao, Hironori Hara, Mattia Lunardi, Rutao Wang, Neil O'Leary, Joanna J. Wykrzykowska, Jan J. Piek, Michael J. Mack, David R. Holmes, Marie-Claude Morice, Arie Pieter Kappetein, Daniel J. F. M. Thuijs, Thilo Noack, Friedrich W. Mohr, Piroze M. Davierwala, John A. Spertus, David J. Cohen, Yoshinobu Onuma
Summary: In patients with left-main CAD or 3-vessel disease, self-reported preprocedural physical and mental health status was strongly associated with long-term mortality. Patients with the best physical and mental health had better 10-year survival with CABG compared with PCI.
Article
Cardiac & Cardiovascular Systems
Masafumi Ono, Patrick W. Serruys, Hideyuki Kawashima, Mattia Lunardi, Rutao Wang, Hironori Hara, Chao Gao, Scot Garg, Neil O'Leary, Joanna J. Wykrzykowska, Jan J. Piek, David R. Holmes, Marie-Claude Morice, Arie Pieter Kappetein, Thilo Noack, Piroze M. Davierwala, John A. Spertus, David J. Cohen, Yoshinobu Onuma
Summary: The aim of this study was to investigate the impact of patient-reported anginal status at 1 year following percutaneous coronary intervention (PCI) or coronary artery bypass graft (CABG) on 10-year survival in patients with left main coronary artery disease (LMCAD) and/or three-vessel CAD (3VD). The study found that while angina at 1 year was associated with repeat revascularization at 5 years, it did not significantly increase 10-year mortality.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Cell Biology
Ruzhou Zhao, Yixin Xu, Xiaobo Wang, Xiang Zhou, Yanqi Liu, Shuai Jiang, Lin Zhang, Zhibin Yu
Summary: In extremely hypoxic environments, WA can protect cells by affecting the mitophagy and mitochondrial biogenesis pathways to reduce myocardial damage, maintain cardiac function, and improve survival. Enhanced mitophagy eliminates damaged mitochondria and prevents apoptosis induction, while enhanced mitochondrial biogenesis can supplement functional mitochondria and maintain mitochondrial respiration to ensure mitochondrial ATP production under acute extreme hypoxia.
Review
Respiratory System
Yong-Ming He, Shinichiro Masuda, Chao Gao
Summary: The authors have recently developed the CatLet or Hexu angiographic scoring system, which can be used to predict clinical outcomes for patients with acute myocardial infarction. This system takes into account the diversity of coronary anatomy, the degree of stenosis in the coronary artery, and the myocardial territory supplied by the diseased artery. It has significant value for clinical practice and coronary artery disease research. Rating: 9 out of 10.
JOURNAL OF THORACIC DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Lanyan Guo, Zhiling Ma, Weiping Yang, Fuyang Zhang, Hong Shao, Liwen Liu, Chao Gao, Ling Tao
Summary: This study aimed to develop a pragmatic model based on common 12-lead ECG features for the initial identification of obstructive hypertrophic cardiomyopathy (HOCM) and nonobstructive hypertrophic cardiomyopathy (HNCM). The study found that 10 variables out of 30 ECG parameters were significantly different between HOCM and HNCM. The constructed model using P wave interval and SV1 showed a useful ability to discriminate between HOCM and HNCM, and demonstrated good fitness and clinical utility.
Meeting Abstract
Cardiac & Cardiovascular Systems
Patrick Serruys, Shinichiro Masuda, Kai Ninomiya, Shigetaka Kageyama, Chao Gao, Michael Mack, David Holmes, Milan Milojevic, Marie-Claude Morice, Scot Garg, Yoshinobu Onuma
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Masafumi Ono, Hironori Hara, Hideyuki Kawashima, Chao Gao, Rutao Wang, Joanna J. Wykrzykowska, Jan J. Piek, Scot Garg, Christian Hamm, Philippe Gabriel Steg, Marco Valgimigli, Stephan Windecker, Pascal Vranckx, Yoshinobu Onuma, Patrick W. Serruys
Summary: This study compared ticagrelor monotherapy with aspirin monotherapy in the second year post-PCI, and found that patients who were event-free at the end of the first year and adhered to their prescribed regimen had a reduced risk of ischemic events with ticagrelor monotherapy in the second year.
Meeting Abstract
Cardiac & Cardiovascular Systems
Chao Gao, Fangju Su, Jianzheng Liu, David R. Holmes, Patrick W. Serruys, Ling Tao
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)