期刊
MICROMACHINES
卷 10, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/mi10040268
关键词
silver-mesoporous silica nanoparticles; hydrogen peroxide; electrochemical sensor; live cells
类别
资金
- National Natural Science Foundation of China [81773684]
- Natural Science Foundation of Zhejiang Province [LY17H260003]
- Guangdong Natural Science Funds for Distinguished Young Scholars [2018B030306033]
- Pearl River S&T Nova Program of Guangzhou [201806010060]
- Ningbo Natural Science Foundation [2017A610226]
- Science Program of Ningbo University [XYL17021]
- K.C. Wong Magna Fund in Ningbo University
In this study, a silver doped mesoporous silica nanoparticles-based enzyme-less electrochemical sensor for the determination of hydrogen peroxide (H2O2) released from live cells was constructed for the first time. The presented electrochemical sensor exhibited fast response (2 s) towards the reduction of H2O2 concentration variation at an optimized potential of -0.5 V with high selectivity over biological interferents such as uric acid, ascorbic acid, and glucose. In addition, a wide linear range (4 M to 10 mM) with a low detection limit (LOD) of 3 M was obtained. Furthermore, the Ag-mSiO(2) nanoparticles/glass carbon electrode (Ag-mSiO(2) NPs/GCE) based enzyme-less sensor showed good electrocatalytic performance, as well as good reproducibility, and long-term stability, which provided a successful way to in situ determine H2O2 released from live cells. It may also be promising to monitor the effect of reactive oxygen species (ROS) production in bacteria against oxidants and antibiotics.
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