Article
Oncology
Alberto Zanetto, Marco Senzolo, Elena Campello, Cristiana Bulato, Sabrina Gavasso, Sarah Shalaby, Martina Gambato, Alessandro Vitale, Umberto Cillo, Fabio Farinati, Francesco Paolo Russo, Paolo Simioni, Patrizia Burra
Summary: The study reveals a significant association between altered platelet function and hepatocellular carcinoma in patients with cirrhosis, suggesting the potential benefit of inhibiting hyper-functional platelets. The differences in platelet function may have important clinical implications for treatment.
Review
Gastroenterology & Hepatology
Alberto Zanetto, Elena Campello, Filippo Pelizzaro, Fabio Farinati, Patrizia Burra, Paolo Simioni, Marco Senzolo
Summary: Venous thrombosis is a common complication in cancer, Hepatocellular carcinoma (HCC) is the most common primary liver cancer. It is associated with preexisting cirrhosis in 90% of cases. Patients with cirrhosis are more prone to bleed or thrombotic complications. There is evidence that HCC may increase the risk of venous thrombosis in cirrhosis patients. However, there are currently no specific guidelines for risk stratification and management of thromboprophylaxis in patients with cirrhosis and HCC.
LIVER INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Sharad Khare, Tripti Khare, Raghu Ramanathan, Jamal A. Ibdah
Summary: This review discusses the role and involvement of microRNAs (miRs) in the heterogeneity and metastasis of hepatocellular carcinoma, with a special emphasis on their potential as diagnostic and prognostic tools in the risk prediction, early detection, and treatment of hepatocellular carcinoma.
Review
Oncology
Manon Falette Puisieux, Anna Pellat, Antoine Assaf, Claire Ginestet, Catherine Brezault, Marion Dhooge, Philippe Soyer, Romain Coriat
Summary: Hepatocellular carcinoma (HCC) is a major health problem and the fourth leading cause of cancer-related mortality worldwide. The prognosis for advanced HCC is poor, and the selection of optimal treatment remains a challenge. However, recent studies have shown that the combination of atezolizumab and bevacizumab can significantly improve survival and is recommended as the first-line treatment for advanced HCC. Other treatments, such as regorafenib and cabozantinib, can be considered for disease progression. Transarterial chemoembolization is also an alternative treatment for patients with intermediate-stage HCC. The accurate estimation of liver function is crucial for therapeutic management.
Article
Health Care Sciences & Services
Evgenia Kotsifa, Chrysovalantis Vergadis, Michael Vailas, Nikolaos Machairas, Stylianos Kykalos, Christos Damaskos, Nikolaos Garmpis, Georgios D. Lianos, Dimitrios Schizas
Summary: HCC is the most common primary liver malignancy associated with liver cirrhosis and chronic liver disease. Key risk factors for HCC development include viral infections, alcoholic liver disease, and nonalcoholic fatty liver disease. Treatment options for HCC depend on tumor burden, liver function, and patient's health status, with surgical resection, transplantation, ablation, TACE, and systemic therapy being potential strategies.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, Research & Experimental
Natasa Pavlovic, Maria Kopsida, Par Gerwins, Femke Heindryckx
Summary: The study revealed that activated platelets promote tumor cell proliferation and contribute to the adverse tumor-stroma interactions that fuel tumor progression. Additionally, inhibiting platelet activation with the P2Y12-inhibitor Clopidogrel was shown to decrease the number of tumors in a chemically induced mouse model for HCC.
Review
Biochemistry & Molecular Biology
Francesco Paolo Russo, Alberto Zanetto, Elisa Pinto, Sara Battistella, Barbara Penzo, Patrizia Burra, Fabio Farinati
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer-related death, with chronic viral hepatitis being a significant contributing factor. The pathophysiology of viral-related HCC involves liver inflammation, oxidative stress, and deregulation of cell signaling pathways. Regular ultrasound surveillance is recommended for patients with cirrhosis and high-risk individuals with chronic HBV infection. Antiviral therapy reduces the risks of HCC development and recurrence. Various scoring systems have been developed to predict the risk of HCC development in patients with chronic hepatitis B.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Reina Sasaki-Tanaka, Ranjit Ray, Mitsuhiko Moriyama, Ratna B. Ray, Tatsuo Kanda
Summary: Alcohol is a major cause of liver diseases, such as liver cirrhosis and hepatocellular carcinoma. This is due to the conversion of alcohol to acetaldehyde in hepatocytes, leading to various liver damage, as well as the production of toxins from intestinal bacteria aggravating inflammation. Genetic factors also play a role in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Gastroenterology & Hepatology
Daniel Q. Huang, Darren J. H. Tan, Cheng Han Ng, Maral Amangurbanova, Nancy Sutter, Phoebe Wen Lin Tay, Wen Hui Lim, Jie Ning Yong, Ansel Tang, Nicholas Syn, Mark D. Muthiah, Eunice X. X. Tan, Shravan Dave, Benjamin Tay, Abdul M. Majzoub, Danielle Gerberi, Beom Kyung Kim, Rohit Loomba
Summary: A pooled analysis of time-to-event data revealed that the incidence of hepatocellular carcinoma (HCC) in alcohol-associated cirrhosis is significant, with cumulative risks of 3% and 9% at 5 and 10 years, respectively.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medical Laboratory Technology
Zhiying Liu, Hongtao Liu, Zhiji Chen, Chao Deng, Li Zhou, Siyuan Chen, Juan Kang, Yao Chen, Song He, Zhihang Zhou
Summary: In this study, potential plasma metabolite biomarkers of hepatocellular carcinoma (HCC) were identified and validated using gas chromatography-mass spectrometry. The combination of plasma N-formylglycine, oxoglutaric acid, citrulline, and heptaethylene glycol showed better diagnostic performance than alpha-fetoprotein (AFP). Additionally, this combination could effectively discriminate early stage HCC from cirrhosis. Moreover, heptaethylene glycol had inhibitory effects on the proliferation, migration, and invasion of HCC cells in vitro.
CLINICA CHIMICA ACTA
(2023)
Review
Oncology
Maria Tampaki, George V. Papatheodoridis, Evangelos Cholongitas
Summary: Patients with decompensated hepatocellular carcinoma (HCC) have limited therapeutic options and are often excluded from clinical trials. Liver transplantation is the best treatment option, but strict criteria and donor shortages limit its availability. Locoregional treatments may provide a survival benefit if well tolerated. Systemic treatments, particularly immunotherapy, may be the safest choice based on real-life data. Close monitoring is necessary due to the high risk of liver disease deterioration.
Article
Gastroenterology & Hepatology
K. Rajender Reddy, Dale McLerran, Tracey Marsh, Neehar Parikh, Lewis R. Roberts, Myron Schwartz, Mindie H. Nguyen, Alex Befeler, Stephanie Page-Lester, Runlong Tang, Sudhir Srivastava, Jo Ann Rinaudo, Ziding Feng, Jorge A. Marrero
Summary: This is the largest prospective and geographically diverse study of a U.S. cohort of patients with cirrhosis, validating known risk factors for HCC.
Review
Medicine, Research & Experimental
Enjun Lv, Jiaqi Sheng, Chengpeng Yu, Dean Rao, Wenjie Huang
Summary: Long noncoding RNAs (lncRNAs) have gained widespread attention as new and crucial molecules involved in biological function regulation, particularly in tumor metastasis such as hepatocellular carcinoma; despite the incomplete understanding of their mechanisms, lncRNAs have been shown to be closely associated with various stages of tumor growth, invasion, and metastasis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Immunology
Defa Huang, Dingyu Rao, Qing Jin, Mi Lai, Jiali Zhang, Zhonghong Lai, Haibin Shen, Tianyu Zhong
Summary: Hepatocellular carcinoma (HCC) is a common liver cancer with a poor prognosis. CD147, a glycoprotein, plays a crucial role in HCC invasion, metastasis, and angiogenesis. This review discusses the molecular structure of CD147 and its potential as a diagnostic and therapeutic target for HCC.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Gastroenterology & Hepatology
Robyn Laube, Abdul-Hamid Sabih, Simone Strasser, Lynn Lim, Maria Cigolini, Ken Liu
Summary: Hepatocellular carcinoma is a common cancer with poor prognosis, leading to high economic costs and significant burden of disease. While palliative care has the potential to improve quality of life and prolong survival, it is underutilized in hepatocellular carcinoma, with referrals often being late.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Ranjan Kumar Patel, Karamvir Chandel, Taraprasad Tripathy, Ashok Choudhury, Amar Mukund
Summary: This article presents three cases of bleeding stomal varices managed with an endovascular approach.
JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
A. Mukund, S. Srinivasan, S. Rana, R. Vijayaraghavan, Y. Patidar, V Arora, A. Jindal, A. Choudhury, S. M. Shasthry, S. K. Sarin
Summary: This study evaluated the response of combined hepatocellular-cholangiocarcinoma (cHCC-CC) and intrahepatic cholangiocarcinoma (IHC) patients to locoregional therapy (LRT) and compared their outcomes with hepatocellular carcinoma (HCC) patients. The results showed that cHCC-CC and IHC patients had shorter survival and poorer objective response after LRT compared to HCC patients.
CLINICAL RADIOLOGY
(2022)
Letter
Gastroenterology & Hepatology
Ankur Jindal, Amar Mukund
Letter
Gastroenterology & Hepatology
Puja Sahai, Ankur Jindal, Amar Mukund
Article
Radiology, Nuclear Medicine & Medical Imaging
Tanya Yadav, Ranjan K. Patel, Akash Bansal, Navojit Chatterjee, Yashwant Patidar, Amar Mukund
Summary: Percutaneous drainage is a safe and effective treatment for caudate lobe amebic abscesses, with high technical and clinical success rates achieved through percutaneous interventions, reducing hospital stay and complications.
ABDOMINAL RADIOLOGY
(2022)
Article
Gastroenterology & Hepatology
V. S. Shyam, Shaleen Rana, B. R. Vinay Kumar, Ashok Choudhury, Amar Mukund
Summary: The article reports two cases of suppurative pylephlebitis secondary to acute pancreatitis, which is a rare and highly fatal condition that is difficult to diagnose. The diagnosis was made after pus was seen coming out during portal vein thrombolysis. These cases highlight the difficulty in diagnosing suppurative pylephlebitis and the need for high suspicion.
JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yashwant Patidar, Karamvir Chandel, Naveen K. Condati, Shyam V. Srinivasan, Amar Mukund, Shiv K. Sarin
Summary: The combination of TACE with sorafenib showed better outcomes in terms of disease control rate, time to progression, and overall survival compared to TACE alone in treating advanced-stage hepatocellular carcinoma.
JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY
(2022)
Article
Surgery
Viniyendra Pamecha, Nilesh Sadashiv Patil, Kumaraswamy Parthasarathy, Piyush Kumar Sinha, Nihar Mohapatra, Archana Rastogi, Karthika Rudrakumar, Amar Mukund, Ashok Chaudhary, Uma Kanal
Summary: This study examines the feasibility of live liver donation in potential donors with non-alcoholic steatohepatitis (NASH) after successful donor optimization. The results suggest that with careful selection and optimization, NASH patients can become live liver donors, expanding the organ pool for liver transplantation. However, post-operative recovery may take longer for these donors.
LANGENBECKS ARCHIVES OF SURGERY
(2022)
Letter
Gastroenterology & Hepatology
Ankur Jindal, Amar Mukund
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
A. Mukund, S. Rana, A. Choudhury, S. Vasantrao Sasturkar, Y. Patidar, Shiv K. Sarin
Summary: This study evaluated the outcomes of percutaneous transhepatic biliary interventions (PTBI) using the ADDFREE technique in patients with biliary enteric anastomotic strictures (BEAS) and hepatolithiasis. The results showed that PTBI was a safe and effective technique for improving symptoms and clearing stones in these patients.
CLINICAL RADIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Amar Mukund, Shakti Prasad Choudhury, Tara Prasad Tripathy, Venkatesh Hosur Ananthashayana, Rakesh Kumar Jagdish, Vinod Arora, Satender Pal Singh, Ajay Kumar Mishra, Shiv Kumar Sarin
Summary: This study evaluated the effects of shunt occlusion on liver volume and function in cirrhosis patients with spontaneous portosystemic shunts (SPSS). The results showed that shunt occlusion increased liver volume, improved synthetic function, reduced serum ammonia levels, and decreased the recurrence of hepatic encephalopathy (HE).
HEPATOLOGY INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Vijay Kubihal, Amar Mukund, Yasha Pandey, Chitranshu Vashistha, Rakhi Maiwall, Yashwant Patidar, Anil Yogendra Yadav, Roshan Lal Koul, Shiv Kumar Sarin
Summary: The purpose of this study was to investigate the prevalence of back pain in patients with Budd-Chiari syndrome (BCS) and inferior vena cava (IVC) obstruction, and to evaluate the effectiveness of IVC recanalization in relieving back pain. A total of 52 patients with BCS and IVC obstruction, excluding those with degenerative spine diseases, were assessed for the presence and severity of back pain. Results showed that 65.4% of the patients had back pain, with a pain score ranging from 3 to 9. Engorged epidural venous plexus and degree of luminal narrowing were significantly associated with back pain. Following IVC recanalization, 85.3% of the patients experienced immediate pain relief, particularly in those with engorged epidural venous plexus. In conclusion, back pain is an underreported symptom of IVC obstruction in BCS, and IVC recanalization can effectively relieve back pain by decompressing the engorged epidural veins.
Article
Critical Care Medicine
Nupur B. Patel, Gaurav Jain, Udit Chauhan, Ajeet Singh Bhadoria, Saurabh Chandrakar, Haritha Indulekha
Summary: This study investigated the utility of diaphragmatic dysfunction (DD) detected 2 hours after non-invasive ventilation (NIV) initiation in predicting NIV failure in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The results showed that DD assessed by specific criteria (DD-CC) had a better predictive profile for NIV failure.
ACUTE AND CRITICAL CARE
(2023)
Review
Surgery
Anvin Mathew, Deepti Ramachandra, Anuj Goyal, Mithun Nariampalli Karthyarth, Princy Joseph, Nirjhar Raj Rakesh, Gourav Kaushal, Abhishek Agrawal, Ajeet Singh Bhadoria, Puneet Dhar
Summary: A network meta-analysis was conducted to rank various reconstruction techniques following low anterior resection. Colonic J pouch showed better functional outcomes compared to other techniques. Transverse coloplasty showed increased anastomotic leak and stricture rate.
BRITISH JOURNAL OF SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Amar Mukund, Akash Bansal, Yashwant Patidar, Shalini Thapar, Manoj Kumar Sharma, Shiv Kumar Sarin
Summary: This study evaluated the role of perfluorobutane in guiding microwave ablation of HCC and compared the treatment response using contrast-enhanced US (CEUS) with Sonazoid at 3 hours of ablation with 1-month follow-up contrast-enhanced CT/MRI. The results showed that CEUS with Sonazoid is an excellent modality for precise needle placement for ablation.
ABDOMINAL RADIOLOGY
(2022)