Article
Microbiology
Hui Zuo, Yo Sugawara, Shizuo Kayama, Sayoko Kawakami, Koji Yahara, Motoyuki Sugai
Summary: The spread of the gene encoding NDM-type carbapenemase poses a serious threat to clinical practice and public health. This study analyzed IncX3-type plasmids carrying bla (NDM-5) and bla (NDM-16b) in Japan, revealing their high similarity and widespread dissemination in Asian countries.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Baomo Liu, Yingyi Guo, Ningjing Liu, Jiong Wang, Feifeng Li, Likang Yao, Chao Zhuo
Summary: IncX3 plasmids have been prevalent in China over the last 10 years, and are specifically associated with hospital-isolated Escherichia coli ST410. Despite the highly conservative backbone, the resistance genetic contexts on these plasmids could fall into different subtypes, indicating the spread of resistance gene environment across different bacterial genera. It is crucial to adopt stringent infection control measures to target IncX3 plasmid spread.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Zhichen Zhu, Xiaofang Xie, Hua Yu, Wei Jia, Bin Shan, Bin Huang, Fen Qu, Siqiang Niu, Jinnan Lv, Qizhao Gao, Feinan Qian, Xiangxiang Tian, Yaxuan Zhai, Yicheng Wen, Chengcheng Yang, Jie Zhu, Yiwei Tang, Liang Chen, Hong Du
Summary: This study conducted a genomic analysis on 92 isolates of Enterobacter-caused infections from multiple tertiary health centres in China, revealing that the most common CR-Ent species in China was E. xiangfangensis and the major lineages were ST171 and ST116 E. xiangfangensis. Additionally, the prevalent carbapenemase-encoding plasmid carried by CR-Ent strains was identified as bla(NDM)-harbouring IncX3-type plasmid. This study provides the first detailed genomic and clinical characteristics of CR-Ent in China.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Microbiology
Guoxiu Xiang, Kai Lan, Yimei Cai, Kang Liao, Mei Zhao, Jia Tao, Yi Ma, Jianming Zeng, Weizheng Zhang, Zhongwen Wu, Xuegao Yu, Yuyang Liu, Yang Lu, Caixia Xu, Liang Chen, Yi-Wei Tang, Cha Chen, Wei Jia, Bin Huang
Summary: The study revealed that a clade of M. morganii is prone to acquiring resistance genes, leading to an increasing number of multidrug resistant strains with a variety of mobile genetic elements (MGEs), including two newly discovered ones in the species. This highlights the potential for M. morganii to pose a more extensive and challenging antimicrobial resistance issue.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Environmental Sciences
Congcong Gu, Xuewen Li, Huiyun Zou, Ling Zhao, Chen Meng, Chengxia Yang, Hui Zhang, Bjorn Berglund
Summary: The emergence and dissemination of carbapenem-resistant Enterobacteriaceae (CRE) is a major global health problem. This study investigates the occurrence and environmental transmission of CRE in groundwater in large animal breeding areas in northern China, suggesting that groundwater may be an underappreciated reservoir and source of CRE dissemination.
ENVIRONMENTAL POLLUTION
(2022)
Article
Biology
Wei-Hsuan Huang, Chin-Chuan Kao, Yan-Chiao Mao, Chih-Sheng Lai, Kuo-Lung Lai, Chung-Hsu Lai, Chien-Hao Tseng, Yao-Ting Huang, Po-Yu Liu
Summary: Naja atra bites can result in severe soft tissue injury and are prone to infections. This study reports the first coinfection with Shewanella algae and Morganella morganii from a Naja atra bite wound, with resistome analysis using whole genome sequencing.
Article
Immunology
Peng Wang, Cuidan Li, Zhe Yin, Xiaoyuan Jiang, Xinyue Li, Xiaofei Mu, Nier Wu, Fei Chen, Dongsheng Zhou
Summary: This study conducted a genomic epidemiology analysis on global Providencia isolates and revealed diverse antimicrobial resistance genes and high resistance ratios in Providencia. The study also investigated the genetic basis for the spread of bla(NDM-1) in Providencia. The findings provide a comprehensive genomic view of species differentiation, antimicrobial resistance prevalence, and plasmid-mediated bla(NDM-1) dissemination in Providencia.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Medicine, General & Internal
Ji-Na Gu, Lin Chen, Xing-Bei Weng, Xiao-Yan Yang, Dan-Mei Pan
Summary: The research revealed that Escherichia coli Huamei202001 belongs to sequence type 410 and carries a blaNDM-5-encoding IncX3-type plasmid responsible for carbapenem resistance spreading. Only the patient was detected as having a positive faecal sample screening test for CRE.
FRONTIERS IN MEDICINE
(2021)
Article
Infectious Diseases
Min Yang, Gufeng Xu, Zhi Ruan, Yue Wang
Summary: This study reports the genomic characteristics of a multidrug-resistant Escherichia coli strain harboring blaNDM-5 and blaCTX-M-14 genes detected in a pediatric patient. These data would help us better understand the prevalence, genetic characteristics, and mechanisms of antimicrobial resistance of this recently identified multidrug-resistant bacteria in children.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Infectious Diseases
Lin Sun, Guiling Li, Nan Meng, Zhenyu Wang, Hanyun Wang, Jing Wang, Xinan Jiao
Summary: A carbapenem-resistant Klebsiella quasipneumoniae isolate harboring the blaNDM-7 gene was recovered from a patient in Jiangsu Province, China. This is the first identification of an IncX3 plasmid carrying blaNDM-7 in K. quasipneumoniae in China. Controlling the dissemination of IncX3 plasmids is important due to their potential for horizontal transfer.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Environmental Sciences
Qian Zhao, Bjorn Berglund, Huiyun Zou, Ziyu Zhou, Huiyu Xia, Ling Zhao, Lennart E. Nilsson, Xuewen Li
Summary: The study identified antibiotic-resistant bacteria such as Escherichia coli, Klebsiella pneumoniae in the environment of large-scale vegetable production areas, posing potential transmission risks. Particularly, feces and hands of farmers may play a role in the dissemination of antibiotic-resistant bacteria.
ENVIRONMENTAL POLLUTION
(2021)
Article
Immunology
Jiankang Zhao, Yulin Zhang, Yanyan Fan, Jiajing Han, Zhujia Xiong, Xinmeng Liu, Binbin Li, Binghuai Lu, Bin Cao
Summary: The first emergence of NDM-5-producing Klebsiella pneumoniae isolates in a lung transplant recipient was reported. The strain was hypervirulent, carrying the bla(NDM-5) gene on an IncX3-type plasmid. The findings raise concerns about horizontal spread of the gene and the need for stricter control measures.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Microbiology
Isaac Prah, Yoko Nukui, Shoji Yamaoka, Ryoichi Saito
Summary: This study highlights the emergence of a high-risk Klebsiella michiganensis clone harboring carbapenemase genes. It confirms that the recent spread of IncX3-bla(NDM-5) plasmids might be due to their low fitness cost and stability, but not their competitive prowess.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Infectious Diseases
Xiaofeng Hu, Lang Yang, Nian Dong, Yanfeng Lin, Ling Zhang, Xu Wang, Xudong Guo, Ying Xiang, Lianqun Jin, Chuanfu Zhang, Yansong Sun, Shaofu Qiu, Peng Li, Hongbin Song
Summary: This study investigated the dissemination of the bla(NDM-5) gene in carbapenem-resistant Escherichia coli isolates from different regions in China. Seven bla(NDM-5)-positive E. coli strains were detected, which showed resistance to multiple antibiotics and carried other antimicrobial resistance genes. The bla(NDM-5) gene was located on 46 kb IncX3 plasmids in all isolates. This study confirms the widespread dissemination of bla(NDM-5)-carrying plasmids in E. coli isolates in China, highlighting the need for stringent surveillance and control measures.
MICROBIAL DRUG RESISTANCE
(2022)
Article
Infectious Diseases
Tian Jiang, Guoli Li, Linyao Huang, Ding Ding, Zhi Ruan, Jianxin Yan
Summary: This study characterized the microbiological and genomic features of a carbapenem-resistant K. michiganensis strain carrying the blaNDM-1 gene in China, emphasizing the need for ongoing surveillance of this pathogen in clinical settings.
INFECTION AND DRUG RESISTANCE
(2023)