期刊
ELIFE
卷 8, 期 -, 页码 -出版社
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/elife.37102
关键词
-
类别
资金
- National Science Foundation [DGE-114747, 0801700]
- Stanford University DARE Doctoral Fellowship Program
- Academy of Finland [315795, 320072]
- National Institutes of Health [R01-DC04154, R01-NS072406, P30-NS069375]
- Academy of Finland (AKA) [320072, 320072, 315795, 315795] Funding Source: Academy of Finland (AKA)
- Direct For Education and Human Resources
- Division Of Graduate Education [0801700] Funding Source: National Science Foundation
The rate and temporal pattern of neural spiking each have the potential to influence computation. I n the cerebellum, it has been hypothesized that the irregularity of interspike intervals in Purkinje cells affects their ability to transmit information to downstream neurons. Accordingly, during oculomotor behavior in mice and rhesus monkeys, mean irregularity of Purkinje cell spiking varied with mean eye velocity. However, moment-to-moment variations revealed a tight correlation between eye velocity and spike rate, with no additional information conveyed by spike irregularity. Moreover, when spike rate and irregularity were independently controlled using optogenetic stimulation, the eye movements elicited were well-described by a linear population rate code with 3-5 ms temporal precision. Biophysical and random-walk models identified biologically realistic parameter ranges that determine whether spike irregularity influences responses downstream. The results demonstrate cerebellar control of movements through a remarkably rapid rate code, with no evidence for an additional contribution of spike irregularity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据