Article
Oncology
Santhalingam Jegatheeswaran, Panagiotis Stathakis, Harry V. M. Spiers, Fawwaz Mohammed, Panagiotis Petras, Thomas Satyadas, Michael J. Parker, Angela Lamarca, Saurabh Jamdar, Aali J. Sheen, Ajith K. Siriwardena
Summary: This study suggests that routine staging laparoscopy may not be necessary in the pre-operative work-up for patients undergoing surgery for PH-CCA. The results show that with careful attention to patient fitness and cross-sectional and interventional radiologic/endoscopic imaging, a very low non-therapeutic laparotomy rate can be achieved and sustained.
Article
Oncology
Guo-Liang Yao
Summary: This case report presents the first reported case of laparoscopic hepatopancreaticoduodenectomy (LHPD) for synchronous gallbladder cancer (GBC) and extrahepatic cholangiocarcinoma (ECC). The study concludes that LHPD is a safe and feasible treatment option for selected cases of GBC or ECC.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Mike van Dooren, Elise A. J. de Savornin Lohman, Eva Brekelmans, Pauline A. J. Vissers, Joris I. Erdmann, Andries E. Braat, Jeroen Hagendoorn, Freek Daams, Ronald M. van Dam, Marieke T. de Boer, Peter B. van den Boezem, Bas Groot Koerkamp, Philip R. de Reuver
Summary: For patients with gallbladder cancer, disseminated disease is often found during (re-)exploration. This study aimed to assess the effectiveness of staging laparoscopy and identify predictive factors for disseminated disease. The results showed that staging laparoscopy can identify disseminated disease in some cases, and cholecystitis and primary R1/R2 resection are independent factors predicting disseminated disease.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Yubizhuo Wang, Jiayuan Shao, Pan Wang, Lintao Chen, Mingliang Ying, Siyuan Chai, Shijian Ruan, Wuwei Tian, Yongna Cheng, Hongbin Zhang, Xiuming Zhang, Xiangming Wang, Yong Ding, Wenjie Liang, Liming Wu
Summary: Two classifiers based on computed tomography images were developed successfully, showing high performance in predicting lymph node staging for hilar cholangiocarcinoma patients, which will serve as reliable evaluation tools to enhance decision-making in clinical practice.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Zhaowei Sun, Jingyun Guo, Xueliang Li, Qinlei Wang, Na Su, Menshou Chen, Guanghua Cao, Yanan Yu, Maobing Wang, Haoran Li, Haochen Zhong, Hao Zou, Kai Ma, Fangzhen Shen, Bingyuan Zhang, Xiaozhi Sun, Yujie Feng
Summary: The study aimed to investigate the impact of stratification factors in Mayo staging on the prognosis of hilar cholangiocarcinoma patients and assess the predictive value of Mayo staging in prognosis. Results showed that Mayo staging was correlated with survival time and had better predictive ability compared to TNM staging.
Review
Oncology
Kevin C. Soares, William R. Jarnagin
Summary: Hilar cholangiocarcinoma is a rare and highly aggressive biliary tract neoplasm, with management strategies based on retrospective experiences and limited data. Surgical resection offers the best chance for long-term survival, although local and distant recurrences are common.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Meng-yu Zhang, Ming Luo, Jie-ping Wang
Summary: This study aimed to investigate the expression of farnesoid X receptor (FXR) in a rat model of hilar cholangiocarcinoma and found that FXR expression in hilar cholangiocarcinoma was significantly lower than that in normal hilar bile duct tissues. This finding provides a new approach for the development of drugs targeting FXR for the treatment of hilar cholangiocarcinoma.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Leonardo Solaini, Maria Bencivenga, Alessia D'ignazio, Marco Milone, Elisabetta Marino, Stefano De Pascale, Fausto Rosa, Michele Sacco, Uberto Fumagalli Romario, Luigina Graziosi, Giovanni De Palma, Daniele Marrelli, Paolo Morgagni, Giorgio Ercolani
Summary: This study aimed to investigate the benefits of staging laparoscopy for gastric cancer patients. The results showed that tumor type, tumor location, and staging could provide additional diagnostic information for patients undergoing laparoscopic surgery. The study concluded that staging laparoscopy is a useful tool to guide the most appropriate treatment strategy for gastric cancer patients.
Article
Multidisciplinary Sciences
Meng-yu Zhang, Jie-ping Wang, Kai He, Xian-ming Xia
Summary: By injecting QBC939 cell suspension into rats, a rat model of hilar cholangiocarcinoma was established, and a significant decrease in Bsep expression was observed in hilar cholangiocarcinoma tissues, suggesting that targeting Bsep could be a new strategy for the treatment of hilar cholangiocarcinoma.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Marcel Autran C. Machado, Bruno V. Mattos, Murillo Macedo Lobo Filho, Fabio Makdissi
Summary: This video shows the robotic treatment of a patient with incidental gallbladder cancer diagnosed after laparoscopic cholecystectomy. The operation consisted of a robotic bisegmentectomy and a hilar lymphadenectomy. The results were successful with a smooth postoperative recovery.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Riccardo Inchingolo, Fabrizio Acquafredda, Valentina Ferraro, Letizia Laera, Gianmarco Surico, Alessia Surgo, Alba Fiorentino, Stefania Marini, Nicola de'Angelis, Riccardo Memeo, Stavros Spiliopoulos
Summary: Hilar cholangiocarcinoma, also known as Klatskin tumor, is a rare and aggressive type of cancer with poor prognosis. Surgical resection, liver transplantation, radiotherapy, chemotherapy, and minimally invasive procedures are treatment options, but only a small percentage of patients are eligible for surgery or transplant at the time of diagnosis.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Surgery
Long Huang, Chenjun Zhang, Yifeng Tian, Chengyu Liao, Maolin Yan, Funan Qiu, Songqiang Zhou, Zhide Lai, Yaodong Wang, Ye Lin, Shi Chen
Summary: This study aimed to investigate the safety, effectiveness, and short-term prognosis of laparoscopic segment 4b+5 liver resection for T3 stage gallbladder cancer. The results showed that this procedure is safe, effective, and can prolong disease-free survival.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Oncology
Alexander B. J. Borgstein, Kammy Keywani, Wietse J. Eshuis, Mark I. van Berge Henegouwen, Suzanne S. Gisbertz
Summary: This study determined the value of staging laparoscopy in patients with advanced gastric cancer in a Western population, showing high accuracy in detecting non-curable disease and avoiding futile treatment.
Article
Oncology
Stefan Stremitzer, Judith Stift, Johannes Laengle, Christoph Schwarz, Klaus Kaczirek, Robert P. Jones, Leonard M. Quinn, Stephen W. Fenwick, Rafael Diaz-Nieto, Graeme J. Poston, Hassan Z. Malik
Summary: Resection margin status is associated with different clinical outcomes in patients undergoing resection for hilar cholangiocarcinoma, with isolated positive circumferential margin potentially serving as a novel prognostic biomarker.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Oncology
Andrea Lauterio, Riccardo De Carlis, Leonardo Centonze, Vincenzo Buscemi, Niccolo Incarbone, Ivan Vella, Luciano De Carlis
Summary: The treatment of peri-hilar and intrahepatic cholangiocarcinoma continues to evolve with different strategies and surgical approaches, including advancements in radiological and chemotherapeutic techniques. Surgical resection remains the main curative option for intrahepatic cholangiocarcinoma, with liver transplantation now being considered as a potential treatment for CCA patients thanks to recent improvements in outcomes and survival rates.