Article
Polymer Science
Ujjal Haldar, Sanjoy Mondal, Soumyajit Hazra, Sayandeep Guin, Lamyea Yeasmin, Dhruba P. Chatterjee, Arun K. Nandi
Summary: In this study, a novel water-soluble polythiophene graft block copolymer was synthesized using various polymerization techniques. The self-assembly behavior and conductivity properties of the copolymer were investigated under different pH conditions.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Yunpeng Feng, Sean P. Quinnell, Alison M. Lanzi, Arturo J. Vegas
Summary: Structured nanoassemblies are biomimetic structures with potential applications in fields ranging from nanomedicine to catalysis. Self-assembling ABC-type alginate-based triblock copolymers, with the backbones of three distinct biomaterials, were synthesized using a facile conjugation approach. These particles provide a versatile platform for co-encapsulation of hydrophilic and hydrophobic small molecules, spatiotemporal release, and show promise as a drug delivery system for combination therapy.
Article
Engineering, Environmental
Venkanna Azmeera, Ujjal Haldar, Saswati Ghosh Roy, Tota Rajasekhar, Priyadarsi De
Summary: The study presents a method for preparing amphiphilic block copolymers containing biocompatible and biodegradable segments, synthesized through metal-free ring-opening polymerization and reversible addition-fragmentation chain transfer polymerization of ε-caprolactone and amino acid-based acrylate monomers. The resulting block copolymers exhibit pH-responsive properties and self-assembling behavior after the deprotection of Boc groups under acidic conditions.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2021)
Article
Chemistry, Multidisciplinary
Zhengyu Deng, Xiaoli Liang, Elizabeth R. Gillies
Summary: In this study, a click to self-immolation strategy based on a Curtius rearrangement and alcohol-isocyanate reaction was developed to functionalize self-immolative polymer precursors with varying trigger units, enabling the facile construction of diverse SIPs. This strategy can also be applied to polymer-polymer coupling to access fully depolymerizable block copolymer amphiphiles.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Polymer Science
Mariya-Desislava Atanasova, Georgy Grancharov, Petar D. Petrov
Summary: Novel micellar carriers with pendant cinnamyl moieties were successfully synthesized to enhance the solubilization of CAPE in water. Characterization of both blank and loaded carriers was performed using dynamic and electrophoretic light scattering, and transmission electron microscopy.
JOURNAL OF POLYMER SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Sevgi Gulyuz, Umut Ugur Ozkose, Melek Parlak Khalily, Mehmet Seckin Kesici, Polen Kocak, Zeynep Busra Bolat, Asli Kara, Naile Ozturk, Salih Ozcubukcu, Asuman Bozkir, Onur Alpturk, Dilek Telci, Fikrettin Sahin, Imran Vural, Ozgur Yilmaz
Summary: The study focuses on the design of self-assembled polymeric micelles as potential delivery systems for therapeutic agents, with a specific targeting approach for breast and prostate cancer. The conjugation of peptides to the block copolymers shows promise in creating targeted therapeutic delivery systems with tunable properties, as confirmed by various characterization techniques.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Polymer Science
Honggang Mei, Bingjie Zhao, Yuan Gao, Lei Li, Liyue Liu, Sixun Zheng
Summary: This contribution presents a novel synthesis method for block copolymer networks composed of PCL and PE. The materials exhibit phase-separated morphology and shape memory properties. The combination of PCL with PE results in triple shape memory properties, triggered by the melting and crystallization of PCL and PE blocks.
CHINESE JOURNAL OF POLYMER SCIENCE
(2022)
Article
Polymer Science
Xing Li, Wenqing Xu, Xiaohua Chang, Ying Zheng, Lingling Ni, Guorong Shan, Yongzhong Bao, Pengju Pan
Summary: This study reports on the controlled synthesis, stepwise crystallization kinetics, and crystallization-induced microphase separation and structural evolution of a novel end-functionalized supramolecular polymer PCL-Thy. The double-crystalline nature of PCL-Thy was observed, with thymine units and PCL blocks crystallizing and melting in a sequential manner. This work provides important insights into crystallization-induced microphase separation and hierarchical ordering in double-crystalline supramolecular polymers.
Article
Nanoscience & Nanotechnology
Hyuna Jo, Seunghyun Sim
Summary: This study reports the first programmable living materials constructed with a dynamic covalent interface between designed synthetic polymers and engineered B. subtilis cells. These living materials can exhibit various functionalities, such as biosensing and on-demand elution of recombinant proteins. Moreover, the materials can be recycled and provide a platform for understanding the biology of confined cells within materials.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Polymer Science
Xuechen Yin, David R. O. Hewitt, Bingqian Zheng, Suan P. Quah, Christopher B. Stanley, Robert B. Grubbs, Surita R. Bhatia
Summary: This study presents the nanoscale assembly of PLA-PEOPLA triblock copolymers in water, with a focus on the effect of stereochemistry on micellar properties. Different L/D ratios of PLA blocks were found to impact aggregation numbers and interactions between PLA chains, demonstrating the potential for tuning micellar properties for specific applications.
Article
Biochemistry & Molecular Biology
Huikang Yang, Li-Ming Zhang
Summary: Novel hollow organic/inorganic hybrid nanoparticles based on dextran and poly(glutamate) were prepared with increased drug loading capacity and prolonged drug release time through the synthesis and functionalization process. Characteristics such as molecular structures, physicochemical properties, and self-assembly were analyzed, demonstrating good biocompatibility and enhanced drug delivery performance compared to their non-cross-linked counterparts.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Mohammad Javad Taghizadeh, Ali Saadatinia
Summary: Well-defined star, di-block, and tri-block copolymers were synthesized using ATRP and click reaction. The addition of these copolymers to epoxy resin resulted in smaller nanostructures and improved thermomechanical properties. The star copolymer/epoxy resin formulation exhibited the highest tensile strength, elongation at break, and thermal properties compared to the di-block and tri-block copolymer/epoxy resin formulations.
JOURNAL OF POLYMER RESEARCH
(2022)
Article
Polymer Science
Lu Lian, Jiaman Hu, Yong Lin, Youliang Zhao
Summary: The rational design of architecture-transformable polymers can optimize their physicochemical properties. In this study, a couplable and self-immolative ATRP initiator was used for one-shot copolymerization, resulting in polymers with different block numbers and connection modes. The incorporation of anthracene dimerization and thiolactone groups enabled the construction of graft copolymers with complex structures. Heating the polymers resulted in the cleavage of anthracene dimers and ester groups, generating mixtures of polymers with different block compositions. This approach provides a promising platform for achieving a wide range of complex macromolecular architectures through topological transformation.
Article
Polymer Science
Lu Lian, Jiaman Hu, Yong Lin, Youliang Zhao
Summary: The rational design and synthesis of architecture-transformable polymers allows for the optimization of physicochemical properties. Through a cascade synthesis involving multiple steps, diverse macromolecular architectures can be achieved. These polymers have tunable compositions and functions and serve as a promising platform for the generation of complex macromolecular structures.
Article
Polymer Science
Leanne M. Stafast, Nora Engel, Helmar Goerls, Christine Weber, Ulrich S. Schubert
Summary: In this study, 2-(4-(iodomethyl)benzyl)isoindoline-1,3-dione was used as a protected amine-functionalized initiator for the cationic ring opening-polymerization (CROP) of 2-ethyl-2-oxazoline. The polymerization was well-controlled and terminated with sodium azide. Subsequent deprotection allowed for attachment of targeting ligands to the polymer. The heterotelechelic PEtOx was then coupled to end-functionalized polylactide to form block copolymers for nanomedicine.
EUROPEAN POLYMER JOURNAL
(2023)
