Continuous flow production in the final step of vortioxetine synthesis. Piperazine ring formation on a flow platform with a focus on productivity and scalability

Co-immobilized whole-cells with ω-transaminase and ketoreductase activity for continuous-flow cascade reaction

(2018) László Nagy-Győr et al.   CHEMBIOCHEM

The serotonergic system in the neurobiology of depression: Relevance for novel antidepressants

(2016) Stephan Köhler et al.   JOURNAL OF PSYCHOPHARMACOLOGY

On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system

(2016) A. Adamo et al.   SCIENCE

Continuous-Flow Technology-A Tool for the Safe Manufacturing of Active Pharmaceutical Ingredients

(2015) Bernhard Gutmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Vortioxetine, a novel antidepressant with multimodal activity: Review of preclinical and clinical data

(2015) Connie Sanchez et al.   PHARMACOLOGY & THERAPEUTICS

New Synthetic Process for Bosutinib

(2015) Yongjun Mao et al.   SYNTHESIS-STUTTGART

Diazo Compounds in Continuous-Flow Technology

(2014) Simon T. R. Müller et al.   ChemSusChem

End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation

(2013) Salvatore Mascia et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Novel Process Windows for Enabling, Accelerating, and Uplifting Flow Chemistry

(2013) Volker Hessel et al.   ChemSusChem

Vortioxetine: First Global Approval

(2013) Andrew Gibb et al.   DRUGS

4-Substituted-2-phenylquinazolines as inhibitors of BCRP

(2012) Kapil Juvale et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal–Knorr pyrrole formation and gas concentration measurement by inline flow titration

(2012) Philippa B. Cranwell et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Deciding Whether To Go with the Flow: Evaluating the Merits of Flow Reactors for Synthesis

(2011) Ryan L. Hartman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ten key issues in modern flow chemistry

(2011) Jens Wegner et al.   CHEMICAL COMMUNICATIONS

Discovering Small-Molecule Estrogen Receptor α/Coactivator Binding Inhibitors: High-Throughput Screening, Ligand Development, and Models for Enhanced Potency

(2011) Aiming Sun et al.   ChemMedChem

Continuous flow reactors: a perspective

(2011) Charlotte Wiles et al.   GREEN CHEMISTRY

Discovery of 1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): A Novel Multimodal Compound for the Treatment of Major Depressive Disorder

(2011) Benny Bang-Andersen et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Flow’s the Thing…︁Or Is It? Assessing the Merits of Homogeneous Reactions in Flask and Flow

(2010) Fernando E. Valera et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design and Packaging of Microreactors for High Pressure and High Temperature Applications

(2010) Samuel Marre et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Continuous flow multi-step organic synthesis

(2010) Damien Webb et al.   Chemical Science