Review
Public, Environmental & Occupational Health
Mohan Narasimhamurthy, Santhosh Upadhyaya Kafle
Summary: Nepal has a high burden of cervical cancer due to limited screening programs. Despite efforts by the Ministry of Health and Population and international collaborations, the current prevention and treatment methods are inadequate to meet WHO's goals. This article provides an overview of Nepal's efforts to address the growing burden of cervical cancer and discusses potential challenges and solutions.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Yvonne T. Nartey, Kwabena H. Amo-Antwi, Philip M. Hill, Edward Dassah, Richard O. Asmah, Kofi Nyarko, Ramatu Agambire, Thomas Konney, Joel Yarney, Nelson Damale, Brian Cox
Summary: This study aimed to compare the distribution of high-risk human papillomavirus (HR-HPV) genotypes in women with and without cervical cancer in order to develop a population-based prevention strategy for cervical cancer in Ghana. The results showed that the most common HR-HPV genotypes among women with cervical cancer were 16, 18, 45, 35, and 52, while 66, 52, 35, 43, and 31 were frequently detected in women without cancer. HPV DNA testing and multivalent vaccines targeting HPV 16, 18, 45, and 35 genotypes are crucial for cervical cancer control in Ghana.
Article
Medicine, General & Internal
David Robert Grimes, Edward M. A. Corry, Talia Malagon, Ciaran O'Riain, Eduardo L. Franco, Donal J. Brennan
Summary: The study compared different cervical cancer screening modalities on a simulated population of women aged >= 25 years, considering the increasing uptake of the HPV vaccine. HPV-based modalities outperformed LBC-based approaches, with reflex approaches and appropriate test intervals maximizing therapeutic efficacy. Increasing HPV vaccination rates resulted in fewer unnecessary colposcopies with HPV-based screening approaches.
Review
Public, Environmental & Occupational Health
J. Andrew Dykens, Caryn E. Peterson, Hunter K. Holt, Diane M. Harper
Summary: Human papillomavirus (HPV) infection is a major cause of cancer, including cervical cancer, and prevention efforts such as HPV vaccination are crucial. However, many countries still have low vaccine coverage rates, hindering the elimination of cervical cancer. Implementing gender-neutral HPV vaccination programs can help reduce infections, combat misinformation, and promote gender equality. Research and understanding of stakeholders' perspectives is necessary to develop effective policies and programs to overcome barriers and improve vaccine uptake.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Oncology
Hilary A. Robbins, Aida Ferreiro-Iglesias, Tim Waterboer, Nicole Brenner, Mari Nygard, Noemi Bender, Lea Schroeder, Allan Hildesheim, Michael Pawlita, Gypsyamber D'Souza, Kala Visvanathan, Hilde Langseth, Nicolas F. Schlecht, Lesley F. Tinker, Ilir Agalliu, Sylvia Wassertheil-Smoller, Eivind Ness-Jensen, Kristian Hveem, Sara Grioni, Rudolf Kaaks, Maria-Jose Sanchez, Elisabete Weiderpass, Graham G. Giles, Roger L. Milne, Qiuyin Cai, William J. Blot, Wei Zheng, Stephanie J. Weinstein, Demetrius Albanes, Wen-Yi Huang, Neal D. Freedman, Aimee R. Kreimer, Mattias Johansson, Paul Brennan
Summary: Seropositivity for HPV16-E6 oncoprotein is a promising marker for early detection of oropharyngeal cancer (OPC), but the absolute risk of OPC after a positive or negative test is unknown. This study constructed an OPC risk prediction model and found that a substantial proportion of HPV16-E6 seropositive individuals will develop OPC.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Review
Oncology
Nikoletta Daponte, George Valasoulis, Georgios Michail, Ioulia Magaliou, Athina-Ioanna Daponte, Antonios Garas, Ioanna Grivea, Dimitrios P. Bogdanos, Alexandros Daponte
Summary: Dynamic adaptations in global health during the SARS-CoV-2 pandemic have led to the increased use of self-sampling for cervical screening, which plays a crucial role in improving screening uptake and coverage. Self-sampling is an important component of the WHO's global strategy to eliminate cervical cancer and has the potential to reduce health disparities. However, there is a need for effective strategies to ensure follow-up testing and management for individuals with positive self-sampling results.
Article
Immunology
Mariko Taniguchi, Yutaka Ueda, Asami Yagi, Ai Miyoshi, Yusuke Tanaka, Ryoko Minekawa, Masayuki Endo, Takuji Tomimatsu, Kei Hirai, Tomio Nakayama, Tadashi Kimura
Summary: Women born between 1994 and 1999 with high HPV vaccination rates in Japan are now at the age for cervical cancer screening. Research showed that vaccinated women had better health awareness, while unvaccinated women were more influenced by fear of cancer. Tailored leaflets recommending screening increased rates slightly for both groups, indicating potential for improving cervical cancer control measures tailored to HPV vaccination status.
Article
Immunology
Gabriella Di Giuseppe, Lucio Folcarelli, Raffaele Lanzano, Francesco Napolitano, Maria Pavia
Summary: This study assessed the awareness, attitudes, and uptake of HPV vaccination and cervical cancer screening in detained women. The findings showed a low level of awareness of HPV infection and a lack of adherence to prevention measures. Evidence-based interventions are needed to promote participation in HPV vaccination and cervical cancer screening programs among incarcerated women.
Article
Obstetrics & Gynecology
Sylvia Kaljouw, Erik E. L. Jansen, Clare A. Aitken, Inge M. C. M. de Kok
Summary: The harms and benefits of cervical cancer screening in the first three rounds of the Dutch hrHPV screening program were evaluated. The number of screening tests and CIN2(+) diagnoses decreased over the rounds, while the efficiency of screening varied based on age groups. Longer screening intervals were found to be more efficient for older women. This study highlights the importance of considering age-specific factors in cervical cancer screening programs.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Oncology
Brittney L. Dickey, Belinda Nedjai, Matthew D. Preece, Michael J. Schell, David Boulware, Junmin Whiting, Bradley Sirak, Martha Abrahamsen, Kimberly A. Isaacs-Soriano, Kayoko Kennedy, Christine H. Chung, Anna R. Giuliano
Summary: As the incidence of oropharyngeal cancer (OPC) associated with human papillomavirus (HPV) increases in men, early diagnosis through a screening test becomes crucial. This study found a correlation between methylation of the host EPB41L3 tumor suppressor gene and HPV16 in the oral gargle and these biomarkers in the tumor. The study also evaluated the utility of HPV16/EPB41L3 methylation in distinguishing early and late stage OPC, with promising results.
Review
Immunology
Ayazhan Akhatova, Azliyati Azizan, Kuralay Atageldiyeva, Aiymkul Ashimkhanova, Aizada Marat, Yerbolat Iztleuov, Assem Suleimenova, Saikal Shamkeeva, Gulzhanat Aimagambetova
Summary: Immunization is a highly successful method for preventing infectious diseases, including HPV infection. Multiple HPV vaccines have been developed and proven to be effective and safe. However, concerns and negative perceptions have hindered the implementation of HPV vaccination campaigns in some countries. Therefore, it is important to promote health education interventions to increase acceptance of HPV vaccines.
Article
Immunology
Gulzhanat Aimagambetova, Aisha Babi, Torgyn Issa, Alpamys Issanov
Summary: The study found that Kazakhstani women have contrasting attitudes towards the HPV vaccine, with approximately half having positive attitudes and almost half having negative or neutral attitudes. Women with low education levels, high number of children, belief in alternative medicine, and impacted by the failed vaccination program in 2013 are less likely to have a positive attitude towards the vaccine.
Review
Oncology
Mehmet Gunduz, Esra Gunduz, Shunji Tamagawa, Keisuke Enomoto, Muneki Hotomi
Summary: Although progress has been made in understanding cancer stem cells, particularly in oropharyngeal cancer, much remains unknown. These stem cells play roles in tumor invasion, metastasis, drug resistance, and recurrence, but there are still many unanswered questions.
Article
Public, Environmental & Occupational Health
Michael W. Ross, Sarah L. Bennis, C. Mark Nichols, I. Niles Zoschke, J. Michael Wilkerson, B. R. Simon Rosser, Cyndee L. Stull, Alan G. Nyitray, Charlene Flash, Samir S. Khariwala
Summary: This study aimed to investigate the potential uptake and quality of oropharyngeal selfies taken by gay/bisexual men as a screening method for HPV-associated oropharyngeal cancer. The results showed that one-third of the invited men sent selfie images, and 28.3% of the images were of clinically acceptable quality.
FRONTIERS IN PUBLIC HEALTH
(2023)
Editorial Material
Virology
Guorong Li, Maryame Lamsisi, Sara Chenafi, Louise Moniod, Abdelhamid Benlghazi, Moulay Mustapha Ennaji, Celine Chauleur, Thomas Bourlet
Summary: Cervical cancer can be prevented by detecting the human papillomavirus (HPV). The World Health Organization called for the elimination of cervical cancer by 2030 and regular screening programs are crucial. However, low screening rates in both developing and developed countries hinder progress due to women's reluctance to participate in gynecologic examinations. Urine-based HPV detection is a convenient and affordable solution to improve screening coverage, but standardized tests are currently lacking. Optimizing protocols and standardizing urinary HPV detection will facilitate its clinical implementation, contributing significantly to WHO's goal of global elimination of cervical cancer.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Surgery
Sydney T. Yee, Jeffrey A. Fearon, Arun K. Gosain, Mary R. Timbang, Frank A. Papay, Gaby Doumit
JOURNAL OF CRANIOFACIAL SURGERY
(2015)
Article
Medicine, Research & Experimental
Mary R. Timbang, Samuel J. Trosman, Robert R. Lorenz
Article
Surgery
Elie Nasr, Mary Roz Timbang, Lena Naffaa, Gaby D. Doumit
JOURNAL OF CRANIOFACIAL SURGERY
(2014)
Article
Surgery
Mary Roz Timbang, Bahar Bassiri Gharb, Antonio Rampazzo, Frank Papay, James Zins, Gaby Doumit
PLASTIC AND RECONSTRUCTIVE SURGERY
(2014)
Article
Pediatrics
Thomas Heye, Mary Roz Timbang, Lawrence Greiten, Gresham Richter
Summary: Thoracic Outlet Syndrome (TOS) is a condition caused by compression of neurovascular vessels, with different types including nTOS which is rare when caused by a cervical rib. This case report demonstrates successful surgical treatment for a 13-year-old male patient with nTOS caused by a cervical rib.
JOURNAL OF PEDIATRIC SURGERY CASE REPORTS
(2022)
