Article
Chemistry, Medicinal
Letizia Pruccoli, Carlo Breda, Gabriella Teti, Mirella Falconi, Flaviano Giorgini, Andrea Tarozzi
Summary: The study found that esculetin (ESC) can partially inhibit neuronal death caused by mHTT, counteract oxidative stress and mitochondrial impairment, and reduce the progression of Huntington's disease. ESC also showed the ability to counteract neuronal death in a Drosophila model and had a positive impact on the HD phenotype.
Article
Food Science & Technology
Eliana Jardim Fernandes, Elize Aparecida Santos Musachio, Luana Barreto Meichtry, Dieniffer Espinosa Janner, Franciele Romero Machado Balok, Magna Sotelo Barrientos, Nathalie Savedra Gomes, Ketnne Hanna Poleto Pinto, Mustafa Munir Mustafa Dahleh, Andrieli Rodrigues, Sandra Elisa Haas, Silvana Peterini Boeira, Marina Prigol, Gustavo Petri Guerra
Summary: We investigated the potential toxic effects of chronic exposure to free curcumin and curcumin-loaded nanocapsules in Drosophila melanogaster, demonstrating the safe applications of nanoencapsulated curcumin.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Karolina-Theresa Sirocko, Hanna Angstmann, Stephanie Papenmeier, Christina Wagner, Michael Spohn, Daniela Indenbirken, Birte Ehrhardt, Draginja Kovacevic, Barbara Hammer, Cecilie Svanes, Klaus F. Rabe, Thomas Roeder, Karin Uliczka, Susanne Krauss-Etschmann
Summary: This study demonstrates that early life exposure to cigarette smoke can affect airway development pathways and epithelial stress responses, leading to an increased risk for chronic respiratory diseases, especially in male Drosophila larvae.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Mohamed Alaraby, Aliro Villacorta, Doaa Abass, Alba Hernandez, Ricard Marcos
Summary: Plastic pollution poses a growing threat to wildlife and humans. This study investigated the risks associated with micro/nanoplastics (MNPLs) by examining environmental samples obtained from plastic waste. The results showed that exposure to MNPLs could induce oxidative stress and DNA damage in organisms.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Qing Zhang, Lichong Hao, Yu Hong
Summary: The study revealed that Triclosan has negative impacts on the development, reproduction, and behavior of Drosophila, with high concentrations causing impaired metamorphosis, decreased fertility, and potential damage to larval intestinal cells.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Biochemistry & Molecular Biology
Guilherme Wildner, Julia Sepel Loreto, Pamela de Almeida, Mariana Torri Claro, Sabrina Antunes Ferreira, Nilda Vargas Barbosa
Summary: This study found that both MeHg and EtHg can reduce the lifespan, impair climbing ability, induce lipid peroxidation in fruit flies, with additional physiological changes at high concentrations. Oxidative stress was identified as a key factor behind the toxicity of these mercury compounds.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yoonjeong Lee, Jaehyeon Kim, Hyunjin Kim, Ji Eun Han, Sohee Kim, Kyong-Hwa Kang, Donghoon Kim, Jong-Min Kim, Hyongjong Koh
Summary: DJ-1 is a causative gene of early-onset familial Parkinson's disease (PD), and it influences the pathogenesis of sporadic PD by affecting reactive oxygen species (ROS) levels. PDK and PDP have been shown to play critical roles in protecting against oxidative stress by regulating glucose metabolism in the mitochondria, which is a major source of intracellular ROS.
MOLECULES AND CELLS
(2021)
Article
Biochemistry & Molecular Biology
Kun Yang, Qiaowei Li, Guocai Zhang, Chao Ma, Xianjun Dai
Summary: Carrageenan oligosaccharides (COS) have been found to extend the lifespan of female Drosophila by improving antioxidant defense system. Additionally, COS contributes to the diversity and abundance of intestinal flora in H2O2-induced female Drosophila. The antioxidant mechanism of COS may be closely related to intestinal microorganisms and involve inhibition of the mTOR pathway and activation of autophagy.
Article
Environmental Sciences
Qifang Wu, Xueting Du, Xucong Feng, Huimin Cheng, Yingjun Chen, Chenying Lu, Mingjiang Wu, Haibin Tong
Summary: Exposure to chlordane has been shown to decrease the survival rate of Drosophila and disrupt glucose and lipid metabolism, leading to increased insulin secretion and impaired signaling. Additionally, it results in ROS production, lipid peroxidation, and disruption of redox homeostasis despite the activation of Nrf2 signaling pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Cell Biology
Olga I. I. Bolshakova, Alina A. A. Borisenkova, Ilya M. M. Golomidov, Artem E. E. Komissarov, Alexandra D. D. Slobodina, Elena V. V. Ryabova, Irina S. S. Ryabokon, Evgenia M. M. Latypova, Elizaveta E. E. Slepneva, Svetlana V. V. Sarantseva
Summary: Huntington's disease (HD) is a neurodegenerative disease without effective treatment. This study investigated the neuroprotective activity of fullerene derivatives in a Drosophila transgenic model of HD. The results showed that hydroxylated fullerenes could reduce oxidative stress and neurodegeneration in the flies' brains, indicating their neuroprotective potential.
Article
Food Science & Technology
Elize Aparecida Santos Musachio, Shanda de Freitas Couto, Marcia Rosula Poetini, Vandreza Cardoso Bortolotto, Mustafa Munir Mustafa Dahleh, Dieniffer Espinosa Janner, Stifani Machado Araujo, Bruna Piaia Ramborger, Rafael Rohers, Gustavo Petri Guerra, Marina Prigol
Summary: The study demonstrated that embryonic exposure of Drosophila melanogaster to BPA resulted in developmental, behavioral, and biochemical changes. These changes included decreased pupal eclosion rate, shortened lifespan of hatched flies, and abnormal behaviors in the exposed generation.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Aghogho Oyibo, Amos O. Abolaji, Damilola A. Omoboyowa, Oyeronke A. Odunola
Summary: The Ethyl Acetate Fraction (EACF) of Ethanol Leaf Extract of Vitellaria paradoxa (ELVp) was found to increase the longevity of Drosophila melanogaster and mitigate Sodium Arsenite (SA)-induced toxicity. The GC-MS analysis of EACF revealed compounds that exhibited varying degrees of binding affinity against the fly's glutathione-S-transferase-2 (GST-2). By augmenting the fly's antioxidant system and possessing high antioxidant properties, EACF prevented SA-induced oxidative stress.
Article
Cell Biology
Paula Climent-Canto, Cristina Molnar, Paula Santabarbara-Ruiz, Cristina Prieto, Josep F. Abril, Florenci Serras, Cayetano Gonzalez
Summary: This study focuses on the hyperplastic l(3)mbt mutant wing imaginal discs and reveals the involvement of oxidative stress in their growth. The presence of genes related to reactive oxygen species metabolism in the l(3)mbt wing disc tumor transcriptome is identified. Furthermore, the reduction of wing disc overgrowths by chemically blocking oxidative stress highlights the importance of oxidative stress in the hyperplastic growth of l(3)mbt wing discs.
Article
Chemistry, Applied
Xianjun Dai, Qianyi Zhang, Guocai Zhang, Chao Ma, Runxin Zhang
Summary: Agar oligosaccharide (AOS) is a marine functional oligosaccharide with various biological activities. By conducting experiments on Drosophila, it was found that AOS can improve antioxidant capacity and intestinal function, thus extending the lifespan of the organism under oxidative stress. Electron microscopic observation also revealed that AOS can alleviate oxidative damage in the intestine. The activation of the Keap1-Nrf2 signaling pathway and regulation of intestinal microflora may be the underlying mechanisms for the improved antioxidant capacity.
CARBOHYDRATE POLYMERS
(2023)
Article
Plant Sciences
Brijesh Singh Chauhan, Rohit Kumar, Pradeep Kumar, Prabhat Kumar, Saket T. Sinha, Sunil Kumar Mishra, Kavindra Nath Tiwari, Alan T. Critchley, Balakrishnan Prithiviraj, Saripella Srikrishna
Summary: FRAN extract, rich in flavonoids, shows strong neuroprotective activity against A beta(42) aggregation in eye tissue of Drosophila. It acts by dissolving A beta(42) fibrils and altering cellular and molecular events involved in neurotoxicity.
Article
Genetics & Heredity
Heiko Praxenthaler, Anja C. Nagel, Adriana Schulz, Mirjam Zimmermann, Markus Meier, Hannes Schmid, Anette Preiss, Dieter Maier
Article
Multidisciplinary Sciences
Anette Preiss, Anja C. Nagel, Heiko Praxenthaler, Dieter Maier
Article
Multidisciplinary Sciences
Anja C. Nagel, Jasmin S. Auer, Adriana Schulz, Jens Pfannstiel, Zhenyu Yuan, Courtney E. Collins, Rhett A. Kovall, Anette Preiss
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Fabienne E. Bayer, Mirjam Zimmermann, Patrick Fischer, Christian Gromoll, Anette Preiss, Anja C. Nagel
SCIENTIFIC REPORTS
(2017)
Article
Genetics & Heredity
Fabienne E. Bayer, Mirjam Zimmermann, Anette Preiss, Anja C. Nagel
Article
Multidisciplinary Sciences
Ludmilla Kober, Mirjam Zimmermann, Michaela Kurz, Melanie Bayer, Anja C. Nagel
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Donna Wolf, Thomas K. Smylla, Jan Reichmuth, Philipp Hofmeister, Ludmilla Kober, Mirjam Zimmermann, Aleksandra Turkiewicz, Tilman Borggrefe, Anja C. Nagel, Franz Oswald, Anette Preiss, Dieter Maier
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2019)
Article
Cell Biology
Bernd M. Gahr, Franziska Braendle, Mirjam Zimmermann, Anja C. Nagel
Article
Genetics & Heredity
Dieter Maier, Anja C. Nagel, Anette Preiss
Article
Genetics & Heredity
Fabienne E. Bayer, Sebastian Deichsel, Pascal Mahl, Anja C. Nagel
Article
Genetics & Heredity
Anja C. Nagel, Dieter Maier, Janika Scharpf, Manuela Ketelhut, Anette Preiss
Article
Genetics & Heredity
Dorina B. Wolf, Dieter Maier, Anja C. Nagel
Summary: CSL transcription factors play crucial roles in the Notch signaling pathway by inducing activation or repression of Notch target genes through recruiting specific cofactors. Research in fruit flies and mice has revealed that CSL homologues depend on cofactors for nuclear entry and exhibit dynamic nucleo-cytoplasmic shuttling.
Article
Biochemistry & Molecular Biology
Anja C. Nagel, Dominik Mueller, Mirjam Zimmermann, Anette Preiss
Summary: The membrane-bound Notch regulator (Mnr) supports Notch signaling by promoting the cleavage of the Notch receptor, which in turn enhances Notch receptor activation. Overexpression of Mnr stimulates γ-secretase activity, while knockdown of Mnr inhibits this activity, demonstrating Mnr as a positive regulator of Notch signaling.
Article
Biochemistry & Molecular Biology
Johannes Fechner, Manuela Ketelhut, Dieter Maier, Anette Preiss, Anja C. Nagel
Summary: The primary role of Notch is to specify cellular identities by responding to small changes in Notch signaling activity. CSL proteins play a central role in Notch signal transduction and their stability is regulated similarly across species. The study shows that the fly homologue Su(H) is stabilized in transcription complexes and its stability is controlled by MAPK-dependent phosphorylation and binding to other proteins. These findings highlight the conservation of CSL protein stability in regulating Notch signaling output at the transcription level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)