Editorial Material
Biochemical Research Methods
Yafei Mao, Guojie Zhang
Summary: The release of the first telomere-to-telomere human genome sequence is a significant milestone in human genomics research, offering potential insights for evolutionary genomics. This article describes the advances of this new genome assembly and discusses the challenges of applying this sequencing strategy to various extant species.
Article
Environmental Sciences
Yue He, Chengxiang Hu, Yuan Zhang, Xiaoting Fan, Wenhui Gao, Jiaxin Fang, Yanfang Wang, Yan Xu, Lina Jin
Summary: A study on 921 participants aged 6-19 found that perfluoroalkyl and polyfluoroalkyl substances (PFAS) may disrupt sex hormone balance. In female adolescents, there was a negative correlation between sex hormone binding globulin (SHBG) and n-PFOA. Testosterone levels in boys and girls were associated with PFAS concentration.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biotechnology & Applied Microbiology
Neharika Bhadouria, Alycia G. Berman, Joseph M. Wallace, Nilsson Holguin
Summary: Raloxifene, an estrogen agonist, protects intervertebral discs in mice from degeneration and pain-related substance P expression induced by aging and biological sex.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Cell Biology
Francesca Rossiello, Diana Jurk, Joao F. Passos, Fabrizio D'Adda di Fagagna
Summary: The article reviews the impact of telomere shortening and dysfunction on aging and a variety of age-related diseases in humans. Accumulation of senescent cells in aging organisms is believed to contribute to bodily dysfunction. Telomere shortening and damage are known causes of cellular senescence and aging. The authors argue that telomeric dysfunction plays a broad role in human pathologies associated with normal aging.
NATURE CELL BIOLOGY
(2022)
Article
Cell Biology
Sebastian R. Schreglmann, Tomas Goncalves, Melissa Grant-Peters, Demis A. Kia, Lilach Soreq, Mina Ryten, Nicholas W. Wood, Kailash P. Bhatia, Kazunori Tomita
Summary: Age is a risk factor for neurodegenerative diseases, and telomere shortening with age is a known phenomenon. However, the changes in telomere length in the brain and its association with neurodegenerative diseases are still unknown.
Article
Cell Biology
Peter M. Lansdorp
Summary: Telomerase levels in most human cells are insufficient to prevent loss of telomeric DNA with each replication cycle. The resulting Hayflick limit may have allowed lifespan to increase by suppressing early tumor development but compromising cellular responses later in life. Average telomere length in leukocytes varies considerably between individuals, with females having longer telomeres than males. This difference in telomere length already exists at birth and corresponds to reported differences in average life expectancy between the sexes. The hypothesis that embryonic telomerase levels contribute to the sex differences in telomere length and lifespan requires further investigation.
Article
Environmental Sciences
Keewan Kim, Anna Z. Pollack, Carrie J. Nobles, Lindsey A. Sjaarda, Jessica R. Zolton, Jeannie G. Radoc, Enrique F. Schisterman, Sunni L. Mumford
Summary: In healthy reproductive-aged women, cadmium was associated with endocrine features central to PCOS, but not with metabolic markers. These suggest its potential role in the hormonal milieu associated with PCOS even at low levels of exposure.
ENVIRONMENTAL HEALTH
(2021)
Article
Endocrinology & Metabolism
Ross J. Marriott, Kevin Murray, Charley A. Budgeon, Veryan Codd, Jennie Hui, Gillian M. Arscott, John P. Beilby, Graeme J. Hankey, Gary A. Wittert, Frederick C. W. Wu, Bu B. Yeap
Summary: Lower testosterone concentrations in middle-aged and older men are associated with shorter telomeres, suggesting that testosterone may contribute to biological aging in men.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Pharmacology & Pharmacy
Cosimo Andrea Stamerra, Paolo Di Giosia, Claudio Ferri, Paolo Giorgini, Zeljko Reiner, Thomas P. Johnston, Amirhossein Sahebkar
Summary: Statins may slightly impair adrenal and/or gonadal steroid hormone production, but do not cause clinically-relevant harmful effects on erectile function and spermatogenesis in men. They have beneficial effects in the treatment of polycystic ovary syndrome in women. Additional research is needed to provide specific clinical recommendations on this topic.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Immunology
Linlin Xu, Yuan Yuan, Zhaodi Che, Xiaozhi Tan, Bin Wu, Cunchuan Wang, Chengfang Xu, Jia Xiao
Summary: Sex hormones and sex-related hormones play important roles in liver diseases, depending on biological sex, disease stage, and other factors. Lifestyle factors also affect the mechanisms of these hormones in liver diseases. Hormone therapy may be a strategy for treating metabolic liver disease, cirrhosis, and liver cancer, but adverse hormone-induced liver injury needs to be carefully studied and monitored.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mathilde L. Tissier, Patrick Bergeron, Dany Garant, Sandrine Zahn, Francois Criscuolo, Denis Reale
Summary: Understanding the role of telomeres in life-history strategies is important in biology. In this study, the telomere length in wild Eastern chipmunks was examined and it was found that telomeres elongate with age and do not limit lifespan in this species. Furthermore, the findings suggest that telomere length is associated with life-history strategies in a sex-specific way.
Article
Immunology
Clara Van Ommen, Anthony Y. Y. Hsieh, Arianne R. Albert, Elana Kimmel, Helene C. F. Cote, Evelyn C. Maan, Jerilynn Prior, Neora Pick, Melanie C. M. Murray
Summary: This study aimed to understand factors associated with ovarian aging in women with HIV. It found that women with HIV had shorter leukocyte telomere length (LTL) and lower anti-Mullerian hormone (AMH) levels compared to HIV-negative women. This suggests that HIV may initially have a detrimental effect on ovarian reserve and that the association between shorter LTL and lower AMH levels is more important for women aged 35 years or older.
Article
Public, Environmental & Occupational Health
Nuozhou Liu, Ying Feng, Xinyao Luo, Xue Ma, Fang Ma
Summary: This study reveals an association between a proinflammatory diet and decreased levels of SHBG in women, particularly in premenopausal women.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Engineering, Environmental
Mei-Xia Ye, Xiao-Jun Luo, Yu Liu, Chu-Hong Zhu, Qun-Jie Feng, Yan-Hong Zeng, Bi-Xian Mai
Summary: The effects of sex and pregnancy on the bioaccumulation and tissue distribution of legacy and emerging per-and polyfluoroalkyl substances (PFASs) in Chinese water snakes were investigated. PFAS bioaccumulation was correlated with log KPW and hindered by steric effects. Female snakes had lower PFAS levels than males, and pregnant females had significantly different chemical compositions compared to non-pregnant females and males. Maternal transfer of perfluorooctane sulfonic acid was higher than other PFASs, and transfer efficiency correlated with log KPW. Tissues with high phospholipid content had higher PFAS concentrations.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Haktan Bagis Erdem, Taha Bahsi, Mehmet Ali Ergun
Summary: Telomeres are specialized non-coding DNA repeat sequences that play a crucial role in maintaining genome integrity. Short telomeres have been associated with age-related diseases, but factors influencing telomere length are not well understood. Future research is expected to lead to clinical applications of telomere length analysis.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Thitipong Panthum, Nattakan Ariyaphong, Pish Wattanadilokchatkun, Worapong Singchat, Syed Farhan Ahmad, Ekaphan Kraichak, Sahabhop Dokkaew, Narongrit Muangmai, Kyudong Han, Prateep Duengkae, Kornsorn Srikulnath
Summary: This study analyzed DNA barcodes of fighting fish and found errors in public sequence databases, leading to incorrect species identification. The COI gene was identified as the main barcode marker for fighting fish.
Review
Green & Sustainable Science & Technology
Kornsorn Srikulnath, Nattakan Ariyaraphong, Worapong Singchat, Thitipong Panthum, Artem Lisachov, Syed Farhan Ahmad, Kyudong Han, Narongrit Muangmai, Prateep Duengkae
Summary: Mitochondrial displacement loop (mt D-loop) sequence analyses have improved assessments of genetic diversity and population dynamics of endangered species facing climate change and habitat loss. Tracking population haplotypes of these species using mitochondrial-based markers has advanced conservation genomics and biodiversity research. Studies on Asian elephants have used mt D-loop sequences to assess genetic diversity and population-scale hypotheses, shedding light on evolutionary processes and facilitating conservation efforts.
Editorial Material
Genetics & Heredity
Shaokui Yi, Cong Zeng, Yanhe Li, Narongrit Muangmai
FRONTIERS IN GENETICS
(2023)
Article
Forestry
Sangsuree Thippawan, Kanisorn Chowtiwuttakorn, Nanthachai Pongpattananurak, Ekaphan Kraichak
Summary: Seedlings are important for understanding plant growth, and their abundance and health can indicate future forest structure changes. This study aims to predict seedling biomass by investigating 205 two-year-old seedlings from different tree species. The results suggest that root collar diameter, shoot height, and wood density can accurately predict seedling biomass.
Article
Green & Sustainable Science & Technology
Wongsathit Wongloet, Prach Kongthong, Aingorn Chaiyes, Worapong Singchat, Warong Suksavate, Nattakan Ariyaraphong, Thitipong Panthum, Artem Lisachov, Kitipong Jaisamut, Jumaporn Sonongbua, Trifan Budi, Wannapa Wannakan, Worawit Thienpreecha, Paanwaris Paansri, Syed Farhan Ahmad, Kriangsak Sribuarod, Umphornpimon Prayoon, Pakpoom Aramsirirujiwet, Wiyada Chamchumroon, Narongrit Muangmai, Prateep Duengkae, Kornsorn Srikulnath
Summary: Developing successful conservation programs for genetically depleted species is challenging, as survival and adaptive potential are related to genetic and habitat factors. The greater mouse-deer, a true forest species, has experienced a significant decline in the wild and currently only exists in captive populations. A restoration program has been successful in increasing their population, but maintaining genetic diversity in small captive populations is crucial for long-term recovery.
Article
Agriculture, Dairy & Animal Science
Wongsathit Wongloet, Worapong Singchat, Aingorn Chaiyes, Hina Ali, Surachai Piangporntip, Nattakan Ariyaraphong, Trifan Budi, Worawit Thienpreecha, Wannapa Wannakan, Autchariyapron Mungmee, Kittipong Jaisamut, Thanyapat Thong, Thitipong Panthum, Syed Farhan Ahmad, Artem Lisachov, Warong Suksavate, Narongrit Muangmai, Rattanaphon Chuenka, Mitsuo Nunome, Wiyada Chamchumroon, Kyudong Han, Aniroot Nuangmek, Yoichi Matsuda, Prateep Duengkae, Kornsorn Srikulnath
Summary: This study investigated the socio-cultural, environmental, and genetic aspects of the Mae Hong Son chicken breed in North Thailand. The breed was found to have high levels of genetic diversity and a unique DNA fingerprint. Genetic introgression from red junglefowl and indigenous breeds was identified, supporting the hypothesis of its crossbreeding origin. These findings contribute to our understanding of the genetic blueprint and potential for improving domestic chickens using this breed.
Article
Agronomy
Pongpitak Yuanjit, Supachai Vuttipongchaikij, Passorn Wonnapinij, Hernan Ceballos, Ekaphan Kraichak, Choosak Jompuk, Piya Kittipadakul
Summary: The study assessed the combining ability of six Thai cassava elite varieties for key traits such as yield and starch content. It found that the parental lines had significant effects on the traits, with specific combining ability being more important for yield. The study provides valuable insights for cassava breeding programs and the genetic control of important traits.
Article
Biology
Nattakan Ariyaraphong, Wongsathit Wongloet, Pish Wattanadilokchatkun, Thitipong Panthum, Worapong Singchat, Thanyapat Thong, Artem Lisachov, Syed Farhan Ahmad, Narongrit Muangmai, Kyudong Han, Prateep Duengkae, Yosapong Temsiripong, Kornsorn Srikulnath
Summary: Morphological divergence between Siamese and other crocodiles has been observed, leading to questions about potential crocodile hybrids. Genetic analysis revealed evidence of introgression between Siamese and saltwater crocodiles, highlighting the importance of identifying hybrids for conservation efforts.
Article
Agriculture, Dairy & Animal Science
Paramintra Vinitchaikul, Veerasak Punyapornwithaya, Suvaluk Seesupa, Sitthinon Phuykhamsingha, Orapun Arjkumpa, Chalutwan Sansamur, Chaiwat Jarassaeng
Summary: This study aimed to determine the influence of lumpy skin disease (LSD) outbreaks on monthly milk production levels in the dairy industry in Thailand. The study found that LSD outbreaks had a significant impact on the milk production of dairy farms located in Khon Kaen Province, Thailand, resulting in estimated economic losses of 2,413,000 Thai Baht (68,943 USD) over the outbreak period. The monthly farm milk production level differed in May compared to June and August, and dairy farmers experienced monthly income losses between 4180 and 14,440 Thai Baht (119.43 and 412.57 USD).
Article
Horticulture
Chulalack Sitthichoptham, Narong Wongkantrakorn, Ekaphan Kraichak, Nuttha Sanevas
Summary: Due to habitat modifications and climate change, Sphagnum moss has disappeared from many tropical areas, including Thailand. This study focused on the cultivation of S. cuspidatulum using tissue culture techniques in order to conserve and mass produce the species. The results showed that the 1/6MS treatment produced the highest dry weight, and the addition of 1.5% to 2% glucose to the 1/4MS treatment further increased the dry weight. This study is the first to use MS media for Sphagnum cultivation.
HORTICULTURAL SCIENCE & TECHNOLOGY
(2023)
Article
Plant Sciences
Nopparat Anantaprayoon, Jason Hollinger, Abigail Robison, Ekaphan Kraichak, Heather Root, Steven D. Leavitt
Summary: Species of lichen-forming fungi exhibit a variety of geographical distribution patterns, with some species having their diversity and biogeographical patterns masked by unrecognized diversity or taxonomic limitations. This study reveals that the widely distributed Lecidea atrobrunnea s. lat. is likely a complex of distinct species-level lineages, with unsettled species boundaries in both phenotype and molecular-based approaches.
Article
Biology
Ryan Rasoarahona, Pish Wattanadilokchatkun, Thitipong Panthum, Thanyapat Thong, Worapong Singchat, Syed Farhan Ahmad, Aingorn Chaiyes, Kyudong Han, Ekaphan Kraichak, Narongrit Muangmai, Akihiko Koga, Prateep Duengkae, Agostinho Antunes, Kornsorn Srikulnath
Summary: The research aims to enhance the ant colony optimization algorithm by integrating marker effectiveness indicators, providing cost-effective solutions for genetic assessments, breeding, and conservation efforts. The study addresses the trade-off between accuracy and cost, and provides valuable insights into real-world genetic studies.
Article
Fisheries
Thitipong Panthum, Pish Wattanadilokchatkun, Kitipong Jaisamut, Worapong Singchat, Syed Farhan Ahmad, Narongrit Muangmai, Prateep Duengkae, Agostinho Antunes, Kornsorn Srikulnath
Summary: In this study, the male-linked region of the jade perch was identified on chromosome 19, and a remnant of the amh gene was found in this region, which is considered a candidate gene for sex determination in teleosts.
Article
Biology
Thitipong Panthum, Nattakan Ariyaraphong, Wongsathit Wongloet, Pish Wattanadilokchatkun, Nararat Laopichienpong, Ryan Rasoarahona, Worapong Singchat, Syed Farhan Ahmad, Ekaphan Kraichak, Narongrit Muangmai, Prateep Duengkae, Yusuke Fukuda, Sam Banks, Yosapong Temsiripong, Tariq Ezaz, Kornsorn Srikulnath
Summary: Hybrids between the Siamese crocodile and saltwater crocodile pose a challenge for conservation efforts. This study used DArT sequencing to identify genome-wide SNPs in both species and confirm hybrid scenarios. PCR-based detection of SNP loci successfully distinguished species and hybridization levels.
